Peripheral Markers of Depression

Nobis, Aleksander; Zalewski, Daniel; Waszkiewicz, Napoleon

doi:10.3390/jcm9123793

Cited by 197Tryptophan and brain disordersTreatment of Major DepressionStress Responses and Cortisol

Peripheral Markers of Depression

Open access

Nobis, Aleksander, Zalewski, Daniel, Waszkiewicz, Napoleon·2020·Journal of Clinical Medicine

DOI 10.3390/jcm9123793PMC PMC7760788

Open this paper in CoChat — free account Open PDF

Abstract

Major Depressive Disorder (MDD) is a leading cause of disability worldwide, creating a high medical and socioeconomic burden. There is a growing interest in the biological underpinnings of depression, which are reflected by altered levels of biological markers. Among others, enhanced inflammation has been reported in MDD, as reflected by increased concentrations of inflammatory markers—C-reactive protein, interleukin-6, tumor necrosis factor-α and soluble interleukin-2 receptor. Oxidative and nitrosative stress also plays a role in the pathophysiology of MDD. Notably, increased levels of lipid peroxidation markers are characteristic of MDD. Dysregulation of the stress axis, along with increased cortisol levels, have also been reported in MDD. Alterations in growth factors, with a significant decrease in brain-derived neurotrophic factor and an increase in fibroblast growth factor-2 and insulin-like growth factor-1 concentrations have also been found in MDD. Finally, kynurenine metabolites, increased glutamate and decreased total cholesterol also hold promise as reliable biomarkers for MDD. Research in the field of MDD biomarkers is hindered by insufficient understanding of MDD etiopathogenesis, substantial heterogeneity of the disorder, common co-morbidities and low specificity of biomarkers. The construction of biomarker panels and their evaluation with use of new technologies may have the potential to overcome the above mentioned obstacles.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/jcm9123793

Cites

451 of 451 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In medical research, depression is often conceptualized as a clinical disorder with a specific set of symptoms that can be identified and treated.
“In medical research, depression is often conceptualized as a clinical disorder with a specific set of symptoms that can be identified and treated (4, 5).”
From Anti-stigmatizing: a collaborative autoethnography on recovery from depression (2024) · cites this paper as [5]
Recent evidence suggests a possible role of immune dysregulation in the etiopathogenesis of depression.
“Furthermore, recent evidence suggested a possible role of immune dysregulation in the etiopathogenesis of depression [13,14,15,16].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [15]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032 · see citing works
A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · cited 2× · see citing works
“There are several psychometric scales which help clinicians to assess different dimensions of depressive functioning, of which the most commonly used are the Hamilton Depression Rating Scale (HDRS) [27], Montgomery-Asberg Depression Rating Scale (MADRS) [28] and Beck Depression Inventory [29].”
Method
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962 · see citing works
Selective Cortical Undercutting As a Means of Modifying and Studying Frontal Lobe Function in Man
Scoville, W. B. (1949) · Journal of neurosurgery · doi:10.3171/jns.1949.6.1.0065 · Cited by 7,373 · see citing works
Research domain criteria (RDoC): toward a new classification framework for research on mental disorders
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067 · see citing works
Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
Biomarkers Definitions Working Group (2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.113989 · Cited by 6,771 · see citing works
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies
Luppino, F. S., de Wit, L. M., Bouvy, P. F., Stijnen, T., Cuijpers, P., Penninx, B. W. J. H., & Zitman, F. G. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.2 · Cited by 4,322 · see citing works
An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999 · see citing works
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848 · see citing works
Oxidative Stress, Glutamate, and Neurodegenerative Disorders
Coyle, J. T., & Puttfarcken, P. (1993) · Science · doi:10.1126/science.7901908 · Cited by 3,762 · see citing works
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works
Neurobiology of Depression
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works
Toward the future of psychiatric diagnosis: the seven pillars of RDoC
Cuthbert, B. N., & Insel, T. R. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-126 · Cited by 3,053 · see citing works
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009 · see citing works
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889 · see citing works
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766 · see citing works
A Specific Laboratory Test for the Diagnosis of Melancholia: Standardization, Validation, and Clinical Utility
Carroll, B. J. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780260017001 · Cited by 2,243 · see citing works
Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109 · see citing works
The mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works
Depression and poor glycemic control: a meta-analytic review of the literature.
Lustman, P. J., Anderson, R. J., Freedland, K. E., de Groot, M., Carney, R. M., & Clouse, R. E. (2000) · Diabetes Care · doi:10.2337/diacare.23.7.934 · Cited by 1,854 · see citing works
Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation
Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832 · see citing works
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795 · see citing works
Synaptic scaling mediated by glial TNF-α
Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715 · see citing works
A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression.
Goldsmith, D. R., Rapaport, M. H., & Miller, B. J. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.3 · Cited by 1,683 · see citing works
Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: A Meta-analysis
Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J., & Merikangas, K. R. (2009) · JAMA · doi:10.1001/jama.2009.878 · Cited by 1,655 · see citing works
A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression: The Role of Baseline Inflammatory Biomarkers
Raison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., Haroon, E., & Miller, A. H. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.4 · Cited by 1,617 · see citing works
Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies
Köhler, C. A., Freitas, T. H., Maes, M., de Andrade, N. Q., Liu, C. S., Fernandes, B. S., Stubbs, B., Solmi, M., Veronese, N., Herrmann, N., et al. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12698 · Cited by 1,443 · see citing works
N-Acetylaspartate in the CNS: From neurodiagnostics to neurobiology
MOFFETT, J., Ross, B., Arun, P., Madhavarao, C. N., & Namboodiri, A. M. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.12.003 · Cited by 1,413 · see citing works
The role of corticotropin-releasing factor in depression and anxiety disorders
Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378 · see citing works
Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice
O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278 · see citing works
The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis
Steptoe, A., Hamer, M., & Chida, Y. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.03.011 · Cited by 1,278 · see citing works
Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
Gold, P. W., & Chrousos, G. P. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001032 · Cited by 1,274 · see citing works
Oxidative Stress and the Central Nervous System
Salim, S. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.237503 · Cited by 1,268 · see citing works
Childhood maltreatment predicts adult inflammation in a life-course study
Danese, A., Pariante, C. M., Caspi, A., Taylor, A., & Poulton, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610362104 · Cited by 1,264 · see citing works
Cytokines and major depression
Schiepers, O. J. G., Wichers, M. C., & Maes, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.003 · Cited by 1,235 · see citing works
Decreased serum brain-derived neurotrophic factor levels in major depressed patients
Karege, F., Perret, G., Bondolfi, G., Schwald, M., Bertschy, G., & Aubry, J.-M. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00005-7 · Cited by 1,232 · see citing works
Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications
Sen, S., Duman, R., & Sanacora, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.005 · Cited by 1,232 · see citing works
Adult hippocampal neurogenesis in depression
Sahay, A., & Hen, R. (2007) · Nature Neuroscience · doi:10.1038/nn1969 · Cited by 1,206 · see citing works
Adverse Childhood Experiences and Adult Risk Factors for Age-Related Disease: Depression, Inflammation, and Clustering of Metabolic Risk Markers
Danese, A., Moffitt, T. E., Harrington, H., Milne, B. J., Polanczyk, G., Pariante, C. M., Poulton, R., & Caspi, A. (2009) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2009.214 · Cited by 1,165 · see citing works
Mental health: a world of depression
Smith, K. (2014) · Nature · doi:10.1038/515180a · Cited by 1,148 · see citing works
A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness
Maes, M., Galecki, P., Chang, Y. S., & Berk, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.004 · Cited by 1,140 · see citing works
A cholinergic-adrenergic hypothesis of mania and depression
Janowsky, D., Davis, J., El-Yousef, M. K., & Sekerke, H. J. (1972) · The Lancet · doi:10.1016/s0140-6736(72)93021-8 · Cited by 1,134 · see citing works
Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder
Haapakoski, R., Mathieu, J., Ebmeier, K. P., Alenius, H., & Kivimäki, M. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.06.001 · Cited by 1,129 · see citing works
Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research
Stetler, C., & Miller, G. E. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31820ad12b · Cited by 1,123 · see citing works
A mega-analysis of genome-wide association studies for major depressive disorder
Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke, S., Wray, N. R., Lewis, C. M., Hamilton, S. P., Weissman, M. M., Breen, G., Byrne, E. M., Blackwood, D. H. R., Boomsma, D. I., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.21 · Cited by 1,120 · see citing works
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer
Bak, L. K., Schousboe, A., & Waagepetersen, H. S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03913.x · Cited by 1,114 · see citing works
Oxidative stress in psychiatric disorders: evidence base and therapeutic implications
Ng, F., Berk, M., Dean, O., & Bush, A. I. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008401 · Cited by 1,069 · see citing works
Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
Wulff, K., Gatti, S., Wettstein, J. G., & Foster, R. G. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2868 · Cited by 1,055 · see citing works
IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6
Rose-John, S. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4989 · Cited by 1,040 · cited 1× · see citing works
“The activation of soluble IL-6 receptors (sIL-6R) is responsible for IL-6 trans-signaling [44], which is characteristic of inflammation, while IL-6 classic signaling contributes to anti-inflammatory effects [97].”
Background
Systemic Effects of Smoking
Yanbaeva, D. G., Dentener, M. A., Creutzberg, E. C., Wesseling, G., & Wouters, E. F. �. (2007) · CHEST Journal · doi:10.1378/chest.06-2179 · Cited by 1,022 · see citing works
Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels
Fernstrom, J. D., & Wurtman, R. J. (1971) · Science · doi:10.1126/science.173.3992.149 · Cited by 1,017 · see citing works
Selective neuronal vulnerability to oxidative stress in the brain
Wang, X. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00012 · Cited by 1,008 · see citing works
Evidence for an immune response in major depression: A review and hypothesis
Maes, M. (1995) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(94)00101-m · Cited by 1,003 · see citing works
Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics
Wu, L., Chiou, C.-C., Chang, P.-Y., & Wu, J. T. (2003) · Clinica Chimica Acta · doi:10.1016/j.cccn.2003.09.010 · Cited by 992 · see citing works
The stress system in the human brain in depression and neurodegeneration
Swaab, D. F., Bao, A.-M., & Lucassen, P. J. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.003 · Cited by 984 · see citing works
Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it?
Kapur, S., Phillips, A. G., & Insel, T. R. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.105 · Cited by 980 · see citing works
CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies.
Valkanova, V., Ebmeier, K. P., & Allan, C. L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.004 · Cited by 972 · see citing works
A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression
Brunoni, A. R., Lopes, M., & Fregni, F. (2008) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009309 · Cited by 972 · see citing works
Interleukin (IL)-6, Tumour Necrosis Factor Alpha (TNF-α) and Soluble Interleukin-2 Receptors (SIL-2R) Are Elevated in Patients with Major Depressive Disorder: A Meta-Analysis and Meta-Regression
Liu, Y., Ho, R. C.-M., & Mak, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.003 · Cited by 948 · see citing works
Effect of Anti-inflammatory Treatment on Depression, Depressive Symptoms, and Adverse Effects: A Systematic Review and Meta-analysis of Randomized Clinical Trials
Köhler, O., Benros, M. E., Nordentoft, M., Farkouh, M. E., Iyengar, R. L., Mors, O., & Krogh, J. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1611 · Cited by 941 · see citing works
Inflammatory markers in depression: a meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls
Osimo, E. F., Pillinger, T., Rodriguez, I. M., Khandaker, G. M., Pariante, C. M., & Howes, O. D. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.02.010 · Cited by 937 · see citing works
The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression
Maes, M., Yirmyia, R., Noraberg, J., Brene, S., Hibbeln, J., Perini, G., Kubera, M., Bob, P., Lerer, B., & Maj, M. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-008-9118-1 · Cited by 894 · see citing works
Examining a Bidirectional Association Between Depressive Symptoms and Diabetes
Golden, S. H. (2008) · JAMA · doi:10.1001/jama.299.23.2751 · Cited by 890 · see citing works
Altered Gene Expression of Brain-Derived Neurotrophic Factor and Receptor Tyrosine Kinase B in Postmortem Brain of Suicide Subjects
Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875 · see citing works
The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity
Castrén, E., & Rantamäki, T. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20758 · Cited by 864 · see citing works
Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus
Åberg, M. A. I., Åberg, N. D., Hedbäcker, H., Oscarsson, J., & Eriksson, P. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02896.2000 · Cited by 852 · see citing works
Depression and obesity
Stunkard, A. J., Faith, M. S., & Allison, K. C. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00608-5 · Cited by 820 · see citing works
Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression
Leonard, B., & Maes, M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.005 · Cited by 805 · see citing works
The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine
Müller, N., Schwarz, M. J., Dehning, S., Douhe, A., Cerovecki, A., Goldstein-Müller, B., Spellmann, I., Hetzel, G., Maino, K., Kleindienst, N., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001805 · Cited by 794 · see citing works
Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters
Del Giudice, M., & Gangestad, S. W. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.02.013 · Cited by 779 · see citing works
TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants – past, present and future
Sedger, L. M., & McDermott, M. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.07.016 · Cited by 774 · see citing works
THE EFFECTS OF PSYCHOLOGICAL STRESS ON HUMANS: INCREASED PRODUCTION OF PRO-INFLAMMATORY CYTOKINES AND Th1-LIKE RESPONSE IN STRESS-INDUCED ANXIETY
Maes, M., Song, C., Lin, A., De Jongh, R., Van Gastel, A., Kenis, G., Bosmans, E., De Meester, I., Benoy, I., Neels, H., et al. (1998) · Cytokine · doi:10.1006/cyto.1997.0290 · Cited by 772 · cited 1× · see citing works
“Psychological stressors induce cytokine production and an inflammatory response [162] which facilitates the generation of reactive oxygen and nitrogen species (ROS/RNS), leading to a pro-oxidant state.”
Background
INCREASED SERUM IL-6 AND IL-1 RECEPTOR ANTAGONIST CONCENTRATIONS IN MAJOR DEPRESSION AND TREATMENT RESISTANT DEPRESSION
Maes, M., Bosmans, E., De Jongh, R., Kenis, G., Vandoolaeghe, E., & Neels, H. (1997) · Cytokine · doi:10.1006/cyto.1997.0238 · Cited by 728 · see citing works
Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments
Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00199-3 · Cited by 718 · see citing works
Is depression associated with increased oxidative stress? A systematic review and meta-analysis
Black, C. N., Bot, M., Scheffer, P. G., Cuijpers, P., & Penninx, B. W. J. H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.025 · Cited by 711 · see citing works
Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484)
Molendijk, M. L., Spinhoven, P., Polak, M., Bus, B. A. A., Penninx, B. W. J. H., & Elzinga, B. M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.105 · Cited by 702 · cited 3× · see citing works
“Peripheral BDNF is neither a sufficient measure of MDD severity [260], nor does it discriminate between MB, BPD and schizophrenia.”
Background
The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression
Maes, M., Leonard, B. E., Myint, A. M., Kubera, M., & Verkerk, R. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.12.017 · Cited by 700 · see citing works
Biomarkers of Oxidative Stress Study II: Are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?
Kadiiska, M. B., Gladen, B. C., Baird, D. D., Germolec, D. R., Graham, L., Parker, C. E., Nyska, A., Wachsman, J. T., Ames, B. N., Basu, S., et al. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.09.017 · Cited by 699 · see citing works
Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression
Lamers, F., Vogelzangs, N., Merikangas, K. R., de Jonge, P., Beekman, A. T. F., & Penninx, B. W. J. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.144 · Cited by 691 · see citing works
Inflammation and clinical response to treatment in depression: A meta-analysis
Strawbridge, R., Arnone, D., Danese, A., Papadopoulos, A., Herane Vives, A., & Cleare, A. J. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.06.007 · Cited by 666 · see citing works
Hippocampal Neurogenesis: Regulation by Stress and Antidepressants
Dranovsky, A., & Hen, R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.082 · Cited by 663 · see citing works
What did STAR*D teach us? Results from a large-scale, practical, clinical trial for patients with depression
Gaynes, B. N., Warden, D., Trivedi, M. H., Wisniewski, S. R., Fava, M., & Rush, A. J. (2009) · Psychiatric Services · doi:10.1176/ps.2009.60.11.1439 · Cited by 661 · see citing works
Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions
Kappelmann, N., Lewis, G., Dantzer, R., Jones, P. B., & Khandaker, G. M. (2018) · Molecular Psychiatry · doi:10.1038/mp.2016.167 · Cited by 659 · see citing works
Neuroendocrine Regulation in Depression
Carroll, B. J. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770090041003 · Cited by 638 · see citing works
World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders, Part 1: Update 2013 on the acute and continuation treatment of unipolar depressive disorders
Bauer, M., Pfennig, A., Severus, E., Whybrow, P. C., Angst, J., Möller, H.-J., & Šon behalf of the Task Force on Unipolar Depressive Disorders (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.804195 · Cited by 632 · see citing works
Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways
Maes, M., Berk, M., Goehler, L., Song, C., Anderson, G., Gałecki, P., & Leonard, B. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-66 · Cited by 629 · see citing works
Interleukin‐2 is essential for CD4+CD25+ regulatory T cell function
Rosa, M. D. L., Rutz, S., Dorninger, H., & Scheffold, A. (2004) · European Journal of Immunology · doi:10.1002/eji.200425274 · Cited by 624 · see citing works
Major Depressive Disorder
D, M. F. M., & Kendler, K. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00112-4 · Cited by 619 · see citing works
Major Depression and Activation of The Inflammatory Response System
Maes, M. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_2 · Cited by 617 · see citing works
Astrocyte-derived ATP modulates depressive-like behaviors
Cao, X., Li, L.-P., Wang, Q., Wu, Q., Hu, H.-H., Zhang, M., Fang, Y.-Y., Zhang, J., Li, S.-J., Xiong, W.-C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3162 · Cited by 615 · see citing works
Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors
Banasr, M., & Duman, R. S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.008 · Cited by 606 · see citing works
Human disease classification in the postgenomic era: A complex systems approach to human pathobiology
Loscalzo, J., Kohane, I. S., & Barabási, A.-Ĺ. (2007) · Molecular Systems Biology · doi:10.1038/msb4100163 · Cited by 603 · see citing works
The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?
Anacker, C., Zunszain, P. A., Carvalho, L. A., & Pariante, C. M. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.03.007 · Cited by 592 · see citing works
IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s Disease: Systematic Review and Meta-Analysis
Ng, A., Tam, W. W., Zhang, M. W., Ho, C. S., Husain, S. F., McIntyre, R. S., & Ho, R. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-30487-6 · Cited by 572 · see citing works
Cytokines and psychopathology: Lessons from interferon-α
Capuron, L., & Miller, A. H. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.009 · Cited by 562 · see citing works
Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function
Thornton, A. M., Donovan, E. E., Piccirillo, C. A., & Shevach, E. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.6519 · Cited by 559 · see citing works
Depression and C-Reactive Protein in US Adults: Data From the Third National Health and Nutrition Examination Survey
Ford, D. E., & Erlinger, T. P. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.9.1010 · Cited by 544 · see citing works
Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression
Maes, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.014 · Cited by 544 · see citing works
A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression
Lin, P.-Y., Huang, S.-Y., & Su, K.-P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.018 · Cited by 530 · see citing works
Kynurenine pathway in major depression: Evidence of impaired neuroprotection
Myint, A.-M., Kim, Y. K., Verkerk, R., Scharpé, S., Steinbusch, H., & Leonard, B. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.07.013 · Cited by 527 · see citing works
The Dexamethasone Suppression Test for Diagnosis and Prognosis in Psychiatry: Commentary and Review
Arana, G. W. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790350067012 · Cited by 526 · see citing works
Is depression an inflammatory disorder?
Raison, C. L., & Miller, A. H. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0232-0 · Cited by 524 · see citing works
Clinical Factors Associated With Treatment Resistance in Major Depressive Disorder: Results From a European Multicenter Study
Souery, D., Oswald, P., Massat, I., Bailer, U., Bollen, J., Demyttenaere, K., Kasper, S., Lecrubier, Y., Montgomery, S., Serretti, A., et al. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0713 · Cited by 521 · see citing works
Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health
Babenko, O., Kovalchuk, I., & Metz, G. A. S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.013 · Cited by 513 · see citing works
N-Acetyl Cysteine for Depressive Symptoms in Bipolar Disorder—A Double-Blind Randomized Placebo-Controlled Trial
Berk, M., Copolov, D. L., Dean, O., Lu, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., & Bush, A. I. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.022 · Cited by 500 · see citing works
Overview of the Genetics of Major Depressive Disorder
Lohoff, F. W. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0150-6 · Cited by 498 · see citing works
Interferon-γ and Tumor Necrosis Factor-α Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guérin
O’Connor, J. C., André, C., Wang, Y., Lawson, M. A., Szegedi, S. S., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5032-08.2009 · Cited by 498 · see citing works
Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons
Guillemin, G. J., Smythe, G., Takikawa, O., & Brew, B. J. (2005) · Glia · doi:10.1002/glia.20090 · Cited by 497 · cited 1× · see citing works
“An interesting distinction regarding the role of different types of glial cells in the kynurenic pathway has been made: KYNA—neuroprotective kynurenine metabolite—originates from astrocytes, while neurotoxic QA is produced only by microglia [359].”
Background
Elevated C-Reactive Protein Levels, Psychological Distress, and Depression in 73 131 Individuals
Wium-Andersen, M. K., Ørsted, D. D., Nielsen, S. F., & Nordestgaard, B. G. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.102 · Cited by 489 · see citing works
BDNF as a biomarker for successful treatment of mood disorders: A systematic & quantitative meta-analysis
Polyakova, M., Stuke, K., Schuemberg, K., Mueller, K., Schoenknecht, P., & Schroeter, M. L. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.11.044 · Cited by 488 · see citing works
Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems
Sarandol, A., Sarandol, E., Eker, S. S., Erdinc, S., Vatansever, E., & Kirli, S. (2007) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.829 · Cited by 486 · see citing works
A Meta-analysis of oxidative stress markers in depression
Liu, T., Zhong, S., Liao, X., Chen, J., He, T., Lai, S., & Jia, Y. (2015) · PLOS ONE · doi:10.1371/journal.pone.0138904 · Cited by 485 · see citing works
Prognosis and improved outcomes in major depression: a review
Kraus, C., Kadriu, B., Lanzenberger, R., Zarate, C. A., & Kasper, S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0460-3 · Cited by 482 · see citing works
Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy
Capuron, L., Ravaud, A., Neveu, P. J., Miller, A. H., Maes, M., & Dantzer, R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000995 · Cited by 473 · see citing works
Oxidative stress, inflammation and treatment response in major depression
Lindqvist, D., Dhabhar, F. S., James, S. J., Hough, C. M., Jain, F. A., Bersani, F. S., Reus, V. I., Verhoeven, J. E., Epel, E. S., Mahan, L., et al. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.11.031 · Cited by 473 · see citing works
Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients
Edwards, R. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(97)00166-3 · Cited by 470 · see citing works
Functional Biomarkers of Depression: Diagnosis, Treatment, and Pathophysiology
Schmidt, H. D., Shelton, R., & Duman, R. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.151 · Cited by 468 · see citing works
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review
Deepmala, Slattery, J., Kumar, N., Delhey, L., Berk, M., Dean, O., Spielholz, C., & Frye, R. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.015 · Cited by 463 · see citing works
Tumor Necrosis Factor Receptor 1 Is a Negative Regulator of Progenitor Proliferation in Adult Hippocampal Neurogenesis
Iosif, R. E., Ekdahl, C. T., Ahlenius, H., Pronk, C. J., Bonde, S., Kokaia, Z., Jacobsen, S. E. W., & Lindvall, O. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2723-06.2006 · Cited by 462 · see citing works
Cytokines as mediators of depression: what can we learn from animal studies?
Dunn, A. J., Swiergiel, A. H., & Beaurepaire, R. D. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.023 · Cited by 459 · see citing works
Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors
Khanzode, S. D., Dakhale, G. N., Khanzode, S. S., Saoji, A., & Palasodkar, R. (2003) · Redox Report · doi:10.1179/135100003225003393 · Cited by 458 · see citing works
Neuroendocrine aspects of hypercortisolism in major depression
Parker, K. J., Schatzberg, A. F., & Lyons, D. M. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00016-8 · Cited by 455 · see citing works
Lowered ω3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients
Maes, M. H. J., Christophe, A. B., Delanghe, J., Altamura, C. A., Neels, H. M., & Meltzer, H. Y. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00014-1 · Cited by 452 · see citing works
Peripheral alterations in cytokine and chemokine levels after antidepressant drug treatment for major depressive disorder: systematic review and meta-analysis
Köhler, C. A., Freitas, T. H., Stubbs, B., Maes, M., Solmi, M., Veronese, N., de Andrade, N. Q., Morris, G., Fernandes, B. S., Brunoni, A. R., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0632-1 · Cited by 449 · see citing works
NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder
Alcocer-Gómez, E., de Miguel, M., Casas-Barquero, N., Núñez-Vasco, J., Sánchez-Alcazar, J. A., Fernández-Rodríguez, A., & Cordero, M. D. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.10.017 · Cited by 443 · see citing works
The Heterogeneity Problem: Approaches to Identify Psychiatric Subtypes
Feczko, E., Miranda-Dominguez, O., Marr, M., Graham, A. M., Nigg, J. T., & Fair, D. A. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.03.009 · Cited by 443 · see citing works
Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression
Maes, M. H. J., Scharpé, S., Meltzer, H. Y., Bosmans, E., Suy, E., Calabrese, J. R., & Cosyns, P. R. (1993) · Psychiatry Research · doi:10.1016/0165-1781(93)90027-e · Cited by 439 · see citing works
Increased Depressive Ratings in Patients With Hepatitis C Receiving Interferon-α–Based Immunotherapy Are Related to Interferon-α–Induced Changes in the Serotonergic System
Bonaccorso, S., Marino, V., Puzella, A., Pasquini, M., Biondi, M., Artini, M., Almerighi, C., Verkerk, R., Meltzer, H., & Maes, M. (2002) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200202000-00014 · Cited by 437 · see citing works
Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors’ and Longitudinal ‘Targets’
Cattaneo, A., Gennarelli, M., Uher, R., Breen, G., Farmer, A., Aitchison, K. J., Craig, I. W., Anacker, C., Zunsztain, P. A., McGuffin, P., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.191 · Cited by 436 · see citing works
Peripheral Cytokine Levels and Response to Antidepressant Treatment in Depression: A Systematic Review and Meta-Analysis
Liu, J. J., Wei, Y. B., Strawbridge, R., Bao, Y., Chang, S., Shi, L., Que, J., Gadad, B. S., Trivedi, M. H., Kelsoe, J. R., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0474-5 · Cited by 429 · see citing works
Free radicals, antioxidant defense systems, and schizophrenia
Wu, J. Q., Kosten, T. R., & Zhang, X. Y. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.02.015 · Cited by 420 · see citing works
An Inflammatory Biomarker as a Differential Predictor of Outcome of Depression Treatment With Escitalopram and Nortriptyline
Uher, R., Tansey, K. E., Dew, T., Maier, W., Mors, O., Hauser, J., Dernovsek, M. Z., Henigsberg, N., Souery, D., Farmer, A., et al. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010094 · Cited by 418 · see citing works
Fatty acid composition in major depression: decreased ω3 fractions in cholesteryl esters and increased C20:4ω6C20:5ω3 ratio in cholesteryl esters and phospholipids
Maes, M., Smith, R., Christophe, A., Cosyns, P., Desnyder, R., & Meltzer, H. (1996) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00092-5 · Cited by 417 · see citing works
Biomarkers for depression: recent insights, current challenges and future prospects
Strawbridge, R., Young, A. H., & Cleare, A. J. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s114542 · Cited by 415 · see citing works
Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression
Raadsheer, F. C., van Heerikhuize, J. J., Lucassen, P. J., Hoogendijk, W. J. G., Tilders, F. J. H., & Swaab, D. F. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.9.1372 · Cited by 411 · see citing works
Inflammation and depression: a causal or coincidental link to the pathophysiology?
Leonard, B. E. (2018) · Acta Neuropsychiatrica · doi:10.1017/neu.2016.69 · Cited by 409 · see citing works
Oxidative & nitrosative stress in depression: Why so much stress?
Moylan, S., Berk, M., Dean, O. M., Samuni, Y., Williams, L. J., O'Neil, A. E., Hayley, A. C., Pasco, J. A., Anderson, G., Jacka, F. N., et al. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.05.007 · Cited by 401 · see citing works
Treatment-resistant depression and peripheral C-reactive protein.
Chamberlain, S. R., Cavanagh, J., de Boer, P., Mondelli, V., Jones, D. N. C., Drevets, W. C., Cowen, P. J., Harrison, N. A., Pointon, L., Pariante, C. M., et al. (2019) · British Journal of Psychiatry · doi:10.1192/bjp.2018.66 · Cited by 400 · see citing works
Interleukin-1 (IL-1): A central regulator of stress responses
Goshen, I., & Yirmiya, R. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.10.001 · Cited by 399 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 396 · see citing works
Depression: an inflammatory illness?: Figure 1
Krishnadas, R., & Cavanagh, J. (2012) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2011-301779 · Cited by 392 · see citing works
Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: A systematic review and meta-regression analysis
Fernandes, B. S., Gama, C. S., Maria Ceresér, K., Yatham, L. N., Fries, G. R., Colpo, G., de Lucena, D., Kunz, M., Gomes, F. A., & Kapczinski, F. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.03.002 · Cited by 389 · see citing works
Lymphocyte Function in Major Depressive Disorder
Schleifer, S. J. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790160070008 · Cited by 382 · see citing works
Emerging role of glutamate in the pathophysiology of major depressive disorder
Hashimoto, K. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.05.005 · Cited by 381 · see citing works
The importance of norepinephrine in depression
Briley, M., & Chantal, M. (2011) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s19619 · Cited by 373 · see citing works
A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers
Lopresti, A. L., Maker, G. L., Hood, S. D., & Drummond, P. D. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.09.017 · Cited by 371 · see citing works
A Systematic Review and Meta-analysis of the Association Between Depression and Insulin Resistance
Kan, C., Silva, N., Golden, S. H., Rajala, U., Timonen, M., Stahl, D. R., & Ismail, K. (2013) · Diabetes Care · doi:10.2337/dc12-1442 · Cited by 363 · see citing works
Lower serum high‐density lipoprotein cholesterol (HDL‐C) in major depression and in depressed men with serious suicidal attempts: relationship with immune‐inflammatory markers
Maes, M. H. J., Smith, R., Christophe, A., Vandoolaeghe, E., Gastel, A. V., Neels, H. M., Demedts, P., Wauters, A., & Meltzer, H. Y. (1997) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1997.tb09622.x · Cited by 356 · see citing works
Updated systematic review and meta-analysis of the effects of n−3 long-chain polyunsaturated fatty acids on depressed mood
Appleton, K. M., Rogers, P. J., & Ness, A. R. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28313 · Cited by 353 · see citing works
Plasma Protein Biomarkers for Depression and Schizophrenia by Multi Analyte Profiling of Case-Control Collections
Domenici, E., Willé, D. R., Tozzi, F., Prokopenko, I., Miller, S. L., McKeown, A., Brittain, C. F., Rujescu, D., Giegling, I., Turck, C. W., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009166 · Cited by 347 · see citing works
Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs
Maes, M. H. J., Delange, J., Ranjan, R., Meltzer, H. Y., Desnyder, R., Cooremans, W., & Scharpé, S. (1997) · Psychiatry Research · doi:10.1016/s0165-1781(96)02915-0 · Cited by 341 · see citing works
Classifying Depression: Should Paradigms Lost Be Regained?
Parker, G. B. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.8.1195 · Cited by 340 · see citing works
Influence of Obesity on Immune Function
Nieman, D. C., Henson, D. A., Nehlsen‐Cannarella, S. L., Ekkens, M. J., Utter, A. C., Butterworth, D. E., & Fagoaga, O. R. (1999) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(99)00077-2 · Cited by 340 · see citing works
Immune suppression and immune activation in depression
Blume, J., Douglas, S. D., & Evans, D. L. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.008 · Cited by 338 · see citing works
The heterogeneity of “major depression”
GOLDBERG, D. (2011) · World Psychiatry · doi:10.1002/j.2051-5545.2011.tb00061.x · Cited by 335 · see citing works
Reduced activation and expression of ERK1/2 MAP kinase in the post‐mortem brain of depressed suicide subjects
Dwivedi, Y., Rizavi, H. S., Roberts, R. C., Conley, R. C., Tamminga, C. A., & Pandey, G. N. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00300.x · Cited by 333 · see citing works
Clustering of depression and inflammation in adolescents previously exposed to childhood adversity
Miller, G. E., & Cole, S. W. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.02.034 · Cited by 331 · see citing works
New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors
Maes, M., Fišar, Z., Medina, M., Scapagnini, G., Nowak, G., & Berk, M. (2012) · Inflammopharmacology · doi:10.1007/s10787-011-0111-7 · Cited by 325 · see citing works
Untitled work
(2008) · PubMed · Cited by 325 · see citing works
Adenosine Deaminase, Nitric Oxide, Superoxide Dismutase, and Xanthine Oxidase in Patients with Major Depression: Impact of Antidepressant Treatment
Herken, H., Gurel, A., Selek, S., Armutcu, F., Ozen, M. E., Bulut, M., Kap, O., Yumru, M., Savas, H. A., & Akyol, O. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.10.005 · Cited by 322 · see citing works
Association of high-sensitivity C-reactive protein with <i>de novo</i> major depression
Pasco, J. A., Nicholson, G. C., Williams, L. J., Jacka, F. N., Henry, M. J., Kotowicz, M. A., Schneider, H. G., Leonard, B. E., & Berk, M. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.076430 · Cited by 321 · see citing works
Synaptic plasticity in depression: Molecular, cellular and functional correlates
Marsden, W. N. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.12.012 · Cited by 315 · see citing works
Insulin-like growth factor-I and neurogenesis in the adult mammalian brain
Anderson, M. F., Åberg, M. A. I., Nilsson, M., & Eriksson, P. S. (2002) · Developmental Brain Research · doi:10.1016/s0165-3806(02)00277-8 · Cited by 314 · see citing works
The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression
Czarny, P., Wigner, P., Galecki, P., & Sliwinski, T. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.06.036 · Cited by 310 · see citing works
Brain membrane lipids in major depression and anxiety disorders
Müller, C. P., Reichel, M., Mühle, C., Rhein, C., Gulbins, E., & Kornhuber, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.12.014 · Cited by 308 · see citing works
Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy.
Capuron, L., Raison, C. L., Musselman, D. L., Lawson, D. H., Nemeroff, C. B., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.7.1342 · Cited by 308 · see citing works
Increased Serum Levels of 8-Hydroxy-2′-Deoxyguanosine in Clinical Depression
Forlenza, M. J., & Miller, G. E. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000195780.37277.2a · Cited by 307 · see citing works
The Compensatory Immune-Regulatory Reflex System (CIRS) in Depression and Bipolar Disorder
Maes, M., & Carvalho, A. F. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1016-x · Cited by 306 · see citing works
Induction of IDO by Bacille Calmette-Guérin Is Responsible for Development of Murine Depressive-Like Behavior
O'Connor, J., Lawson, M., André, C., Briley, E. M., Szegedi, S., Lestage, J., Castanon, N., Herkenham, M., Dantzer, R., & Kelley, K. (2009) · Journal of Immunology · doi:10.4049/jimmunol.0802722 · Cited by 305 · see citing works
The leptin hypothesis of depression: a potential link between mood disorders and obesity?
Lu, X.-Y. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.10.010 · Cited by 303 · see citing works
Increased neopterin and interferon-gamma secretion and lower availability of L-tryptophan in major depression: Further evidence for an immune response
Maes, M., Scharpé, S., Meltzer, H. Y., Okayli, G., Bosmans, E., D'Hondt, P., Vanden Bossche, B., & Cosyns, P. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90003-5 · Cited by 302 · see citing works
Molecular studies of major depressive disorder: the epigenetic perspective
Mill, J. S., & Petronis, A. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001992 · Cited by 302 · see citing works
Cytokines, stress and depressive illness: Brain-immune interactions.
Anisman, H., & Merali, Z. (2003) · Annals of Medicine · doi:10.1080/07853890310004075 · Cited by 302 · see citing works
Depression, Antidepressants, and Neurogenesis: A Critical Reappraisal
Hanson, N. D., Owens, M. J., & Nemeroff, C. B. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.220 · Cited by 302 · see citing works
Repeated dexamethasone suppression test during depressive illness
Holsboer, F., Liebl, R., & Hofschuster, E. (1982) · Journal of Affective Disorders · doi:10.1016/0165-0327(82)90039-8 · Cited by 301 · see citing works
Receiver-operating characteristic curve analysis in diagnostic, prognostic and predictive biomarker research
Søreide, K. (2008) · Journal of Clinical Pathology · doi:10.1136/jcp.2008.061010 · Cited by 301 · see citing works
Kynurenine pathway in depression: a systematic review and meta-analysis
Ogyu, K., Kubo, K., Noda, Y., Iwata, Y., Tsugawa, S., Omura, Y., Wada, M., Tarumi, R., Plitman, E., Moriguchi, S., et al. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.023 · Cited by 301 · see citing works
The monocyte-T-lymphocyte hypothesis of major depression
Maes, M., Smith, R., & Simon, S. (1995) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)00066-j · Cited by 299 · see citing works
Cytokine levels in the blood may distinguish suicide attempters from depressed patients
Janelidze, S., Mattei, D., Westrin, Å., Träskman-Bendz, L., & Brundin, L. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.10.010 · Cited by 298 · see citing works
Interferon-Induced Depression in Chronic Hepatitis C: A Systematic Review and Meta-Analysis
Udina, M., Castellví, P., Moreno-España, J., Navinés, R., Valdés, M., Forns, X., Langohr, K., Solà, R., Vieta, E., & Martín-Santos, R. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r07694 · Cited by 297 · see citing works
Antidepressant treatment resistance is associated with increased inflammatory markers in patients with major depressive disorder
Haroon, E., Daguanno, A. W., Woolwine, B. J., Goldsmith, D. R., Baer, W. M., Wommack, E. C., Felger, J. C., & Miller, A. H. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.026 · Cited by 291 · see citing works
Establishing moderators and biosignatures of antidepressant response in clinical care (EMBARC): Rationale and design
Trivedi, M. H., McGrath, P. J., Fava, M., Parsey, R. V., Kurian, B. T., Phillips, M. L., Oquendo, M. A., Bruder, G., Pizzagalli, D., Toups, M., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.03.001 · Cited by 286 · see citing works
Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging
Lindqvist, D., Epel, E. S., Mellon, S. H., Penninx, B. W., Révész, D., Verhoeven, J. E., Reus, V. I., Lin, J., Mahan, L., Hough, C. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.007 · Cited by 285 · see citing works
Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression
Köhler-Forsberg, O., Buttenschøn, H. N., Tansey, K. E., Maier, W., Hauser, J., Dernovsek, M. Z., Henigsberg, N., Souery, D., Farmer, A., Rietschel, M., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.02.020 · Cited by 283 · see citing works
Differential association of somatic and cognitive symptoms of depression and anxiety with inflammation: findings from the Netherlands Study of Depression and Anxiety (NESDA)
Duivis, H. E., Vogelzangs, N., Kupper, N., de Jonge, P., & Penninx, B. W. J. H. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.01.002 · Cited by 282 · see citing works
Chronic Mild Stress and Sucrose Consumption: Validity as a Model of Depression
Forbes, N., Stewart, C. A., Matthews, K., & REID, I. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00305-8 · Cited by 281 · see citing works
Evidence for a systemic immune activation during depression: results of leukocyte enumeration by flow cytometry in conjunction with monoclonal antibody staining
Maes, M., Lambrechts, J., Bosmans, E., Jacobs, J., Suy, E., Vandervorst, C., De Jonckheere, C., Minner, B., & Raus, J. (1992) · Psychological Medicine · doi:10.1017/s0033291700032712 · Cited by 275 · see citing works
A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: Exploring the causes of heterogeneity
Hiles, S. A., Baker, A. L., de Malmanche, T., & Attia, J. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.06.001 · Cited by 274 · see citing works
Lower serum zinc in major depression is a sensitive marker of treatment resistance and of the immune/inflammatory response in that illness
Maes, M., Vandoolaeghe, E., Neels, H., Demedts, P., Wauters, A., Meltzer, H. Y., Altamura, C., & Desnyder, R. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00365-4 · Cited by 272 · see citing works
Homicide, suicide and CSF 5‐HIAA
Lidberg, L., Tuck, J. R., Åsberg, M., Scalia‐Tomba, G., & Bertilsson, L. (1985) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1985.tb01279.x · Cited by 269 · see citing works
Inhibition of GSK3 by lithium, from single molecules to signaling networks
Freland, L., & Beaulieu, J. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00014 · Cited by 269 · see citing works
Depression‐related disturbances in mitogen‐induced lymphocyte responses and interleukin‐1β and soluble interleukin‐2 receptor production
Maes, M., Bosmans, E., Suy, E., Vandervorst, C., DeJonckheere, C., & Raus, J. (1991) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1991.tb03163.x · Cited by 268 · see citing works
Early and Late Neurodevelopmental Influences in the Prodrome to Schizophrenia: Contributions of Genes, Environment, and Their Interactions
Cannon, T. D., van Erp, T. G. M., Bearden, C. E., Loewy, R. L., Thompson, P. M., Toga, A. W., Huttunnen, M. O., Keshavan, M. S., Seidman, L. J., & Tsuang, M. T. (2003) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007037 · Cited by 267 · see citing works
Cumulative Depression Episodes Predict Later C-Reactive Protein Levels: A Prospective Analysis
Copeland, W. E., Shanahan, L., Worthman, C., Angold, A., & Costello, E. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.023 · Cited by 265 · see citing works
Identifying Depressive Subtypes in a Large Cohort Study: Results From the Netherlands Study of Depression and Anxiety (NESDA)
Lamers, F., de Jonge, P., Nolen, W. A., Smit, J. H., Zitman, F. G., Beekman, A. T. F., & Penninx, B. W. J. H. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05398blu · Cited by 264 · see citing works
Elevated plasma nitrate levels in depressive states
Suzuki, E., Yagi, G., Nakaki, T., Kanba, S., & Asai, M. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00164-6 · Cited by 255 · see citing works
Association of Adult Body Mass Index and Height with Anxiety, Depression, and Suicide in the General Population: The HUNT Study
Bjerkeset, O. A., Romundstad, P., Evans, J., & Gunnell, D. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm280 · Cited by 248 · see citing works
Role of the Kynurenine Metabolism Pathway in Inflammation-Induced Depression: Preclinical Approaches
Dantzer, R. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_6 · Cited by 248 · see citing works
C-reactive protein concentrations across the mood spectrum in bipolar disorder: a systematic review and meta-analysis
Fernandes, B. S., Steiner, J., Molendijk, M. L., Dodd, S., Nardin, P., Gonçalves, C.-A., Jacka, F., Köhler, C. A., Karmakar, C., Carvalho, A. F., et al. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)30370-4 · Cited by 247 · see citing works

Flagged first, then by citations

6 of the 457 references couldn’t be matched to a known paper.

Sorted by citations

Selected biomarkers of depression: what are the effects of cytokines and inflammation
Harsanyi, S., Kupcova, I., Danisovic, L., & Klein, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010578 · Cited by 299 · see citing works
Salivary Biomarkers of Stress, Anxiety and Depression
Chojnowska, S., Ptaszyńska-Sarosiek, I., Kępka, A., Knaś, M., & Waszkiewicz, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030517 · Cited by 251 · see citing works
Self-citation
C-Reactive protein as a biomarker for major depressive disorder?
Orsolini, L., Pompili, S., Tempia Valenta, S., Salvi, V., & Volpe, U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031616 · Cited by 171 · see citing works
Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options
Kumar, A., Pramanik, J., Goyal, N., Chauhan, D., Sivamaruthi, B. S., Prajapati, B. G., & Chaiyasut, C. (2023) · Pharmaceuticals · doi:10.3390/ph16040565 · Cited by 164 · see citing works
Sodium Benzoate—Harmfulness and Potential Use in Therapies for Disorders Related to the Nervous System: A Review
Walczak, Ł. J., & Herbet, M. (2022) · Nutrients · doi:10.3390/nu14071497 · Cited by 144 · see citing works
Blood–Brain Barrier Dysfunction in the Pathogenesis of Major Depressive Disorder
Wu, S., Yin, Y., & Du, L. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01153-9 · Cited by 126 · see citing works
Biomarkers of post-covid depression
Lorkiewicz, P., & Waszkiewicz, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184142 · Cited by 102 · see citing works
Self-citation
Biological Markers in Anxiety Disorders
Łoś, K., & Waszkiewicz, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081744 · Cited by 97 · see citing works
Self-citation
Sex differences in the blood–brain barrier: Implications for mental health
Dion‐Albert, L., Binder, L. B., Daigle, B., Hong-Minh, A., Lebel, M., & Ménard, C. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100989 · Cited by 89 · see citing works
Premenstrual syndrome: new insights into etiology and review of treatment methods
Modzelewski, S., Oracz, A. J., Żukow, X., Iłendo, K., Śledzikowska, Z., & Waszkiewicz, N. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1363875 · Cited by 103 · see citing works
Self-citation
Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin
Corrigan, M., O’Rourke, A. M., Moran, B., Fletcher, J. M., & Harkin, A. (2023) · Neuronal Signaling · doi:10.1042/ns20220054 · Cited by 77 · see citing works
AKT and MAPK signaling pathways in hippocampus reveals the pathogenesis of depression in four stress-induced models
Li, X., Teng, T., Yan, W., Fan, L., Liu, X., Clarke, G. A., Zhu, D., Jiang, Y., Xiang, Y., Yu, Y., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02486-3 · Cited by 72 · see citing works
Rapid-acting antidepressants and the circadian clock
Sato, S., Bunney, B. G., Mendoza-Viveros, L., Bunney, W. E., Borrelli, E., Sassone‐Corsi, P., & Orozco-Solís, R. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01241-w · Cited by 65 · see citing works
Association between inflammatory cytokines and symptoms of major depressive disorder in adults
Min, X., Wang, G., Cui, Y., Meng, P., Hu, X., Liu, S., & Wang, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1110775 · Cited by 70 · see citing works
Potential usefulness of complete blood count parameters and inflammatory ratios as simple biomarkers of depression and suicide risk in drug-naive, adolescents with major depressive disorder
Puangsri, P., & Ninla-aesong, P. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.114216 · Cited by 62 · see citing works
False dogmas in mood disorders research: Towards a nomothetic network approach
Maes, M. H. J., & Stoyanov, D. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i5.651 · Cited by 60 · see citing works
Inflammatory biomarkers in depression: scoping review
Paganin, W., & Signorini, S. G. (2024) · BJPsych Open · doi:10.1192/bjo.2024.787 · Cited by 53 · see citing works
Intestinal Permeability and Depression in Patients with Inflammatory Bowel Disease
Iordache, M. M., Tocia, C., Aşchie, M., Dumitru, A., Manea, M., Cozaru, G. C., Petcu, L. C., Vlad, S. E., Dumitru, E., & Chisoi, A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11175121 · Cited by 51 · see citing works
Flavonols in Action: Targeting Oxidative Stress and Neuroinflammation in Major Depressive Disorder
Jembrek, M. J., Oršolić, N., Karlović, D., & Peitl, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24086888 · Cited by 54 · see citing works
Depressive and Neurocognitive Disorders in the Context of the Inflammatory Background of COVID-19
Dąbrowska, E., Galińska-Skok, B., & Waszkiewicz, N. (2021) · Life · doi:10.3390/life11101056 · Cited by 47 · see citing works
Self-citation
Omics approaches open new horizons in major depressive disorder: from biomarkers to precision medicine
Stolfi, F., Abreu, H., Sinella, R., Nembrini, S., Centonze, S., Landra, V., Brasso, C., Cappellano, G., Rocca, P., & Chiocchetti, A. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1422939 · Cited by 49 · see citing works
Phenolic Acids as Antidepressant Agents
Cordeiro, M. L. D. S., Aquino-Martins, V. G. D. Q., da Silva, A. P., Rocha, H. A. O., Soares-Rachetti, V. D. P., & Scortecci, K. C. (2022) · Nutrients · doi:10.3390/nu14204309 · Cited by 43 · see citing works
Elevated Serum Cortisol Levels in Patients with Focal Epilepsy, Depression, and Comorbid Epilepsy and Depression
Druzhkova, T. A., Yakovlev, A. A., Rider, F. K., Зинчук, М. С., Guekht, A. B., & Gulyaeva, N. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810414 · Cited by 41 · see citing works
Unraveling the Role of the Blood-Brain Barrier in the Pathophysiology of Depression: Recent Advances and Future Perspectives
Varghese, S. M., Patel, S., Nandan, A., Jose, A., Ghosh, S., Sah, R. K., Menon, B., Athira, K. V., & Chakravarty, S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04205-5 · Cited by 37 · see citing works
Clinical laboratory tests and five-year incidence of major depressive disorder: a prospective cohort study of 433,890 participants from the UK Biobank
Wainberg, M., Kloiber, S. M., Diniz, B. S., McIntyre, R. S., Felsky, D., & Tripathy, S. J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01505-5 · Cited by 35 · see citing works
Lower levels of glutathione in the anterior cingulate cortex associate with depressive symptoms and white matter hyperintensities in COVID-19 survivors
Poletti, S., Paolini, M., Mazza, M. G., Palladini, M., Furlan, R., Rovere, P. Q., & Benedetti, F. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.06.008 · Cited by 34 · see citing works
Inflammation and Blood-Brain Barrier in Depression: Interaction ofCLDN5andIL6Gene Variants in Stress-Induced Depression
Gál, Z., Török, D., Gonda, X., Eszlári, N., Anderson, I. M., Deakin, J. F. W., Juhász, G., Bagdy, G., & Petschner, P. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac079 · Cited by 35 · see citing works
Altered serum adiponectin and interleukin-8 levels are associated in the pathophysiology of major depressive disorder: A case-control study
Islam, S., Islam, T., Nahar, Z., Shahriar, M., Islam, S. M. A., Bhuiyan, M. A., & Islam, M. R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0276619 · Cited by 30 · see citing works
A randomized controlled trial to examine the impact of a multi-strain probiotic on self-reported indicators of depression, anxiety, mood, and associated biomarkers
Walden, K. E., Moon, J. M., Hagele, A. M., Allen, L. E., Gaige, C. J., Krieger, J. M., Jäger, R., Mumford, P. W., Pane, M., & Kerksick, C. M. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1219313 · Cited by 33 · see citing works
Ketamine as a therapeutic agent in major depressive disorder and posttraumatic stress disorder: Potential medicinal and deleterious effects
Sachdeva, B., Sachdeva, P., Ghosh, S., Ahmad, F., & Sinha, J. K. (2023) · Ibrain · doi:10.1002/ibra.12094 · Cited by 29 · see citing works
Immunostimulant and Antidepressant Effect of Natural Compounds in the Management of Covid-19 Symptoms
Alesci, A., Fumia, A., Cascio, P. L., Miller, A., & Cicero, N. (2021) · Journal of the American Nutrition Association · doi:10.1080/07315724.2021.1965503 · Cited by 28 · see citing works
Depression and Eye Disease—A Narrative Review of Common Underlying Pathophysiological Mechanisms and their Potential Applications
Tang, W. S. W., Min, N. L. X., Krishnan, M. N., Chin, Y. C., & Ho, C. S. H. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13113081 · Cited by 29 · see citing works
The Effects of Walnuts and Academic Stress on Mental Health, General Well-Being and the Gut Microbiota in a Sample of University Students: A Randomised Clinical Trial
Herselman, M. F., Bailey, S., Deo, P., Zhou, X., Gunn, K. M., & Bobrovskaya, L. (2022) · Nutrients · doi:10.3390/nu14224776 · Cited by 27 · see citing works
Monoamine Oxidase as a Potential Biomarker of the Efficacy of Treatment of Mental Disorders
Uzbekov, M. G. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921060146 · Cited by 27 · see citing works
Heterogeneity in major depressive disorder: The need for biomarker-based personalized treatments
Suseelan, S., & Pinna, G. (2022) · Advances in clinical chemistry · doi:10.1016/bs.acc.2022.09.001 · Cited by 26 · see citing works
A review of the pharmacological action and mechanism of natural plant polysaccharides in depression
Yang, Y., Li, C.-X., Zhang, R., Shen, Y. H., Xu, X., & Yu, Q. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1348019 · Cited by 27 · see citing works
Advances in biosensors for major depressive disorder diagnostic biomarkers
Dong, T., Yu, C., Mao, Q., Han, F., Yang, Z., Yang, Z., Pires, N. M. M., Wei, X., Jing, W., Lin, Q., et al. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116291 · Cited by 25 · see citing works
Oral health-related quality of life and depressive symptoms in adults: longitudinal associations of the English Longitudinal Study of Ageing (ELSA)
Zwick, L., Schmitz, N., & Shojaa, M. (2023) · BMC Oral Health · doi:10.1186/s12903-023-03722-4 · Cited by 24 · see citing works
Early Life Stress and Major Depressive Disorder—An Update on Molecular Mechanisms and Synaptic Impairments
Bertollo, A. G., Galvan, A. C. L., Dallagnol, C., Cortez, A. D., & Ignácio, Z. M. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03983-2 · Cited by 24 · see citing works
Comparison of cognitive impairments with lipid profiles and inflammatory biomarkers in unipolar and bipolar depression
Zhang, S.-F., Chen, H.-M., Xiong, J.-N., Liu, J., Xiong, J., Xie, J., Wang, X., Tian, Q., Xia, B., Li, Y., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.04.002 · Cited by 23 · see citing works
Bilateral repetitive transcranial magnetic stimulation ameliorated sleep disorder and hypothalamic–pituitary–adrenal axis dysfunction in subjects with major depression
Chen, X., Jiang, F., Yang, Q., Zhang, P., Zhu, H., Liu, C., Zhang, T., Li, W., Xu, J. B., & Shen, H. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.951595 · Cited by 22 · see citing works
Biomarkers of Postpartum Depression: A Narrative Review
Modzelewski, S., Oracz, A. J., Iłendo, K., Sokół, A., & Waszkiewicz, N. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12206519 · Cited by 22 · see citing works
Self-citation
Running from stress: a perspective on the potential benefits of exercise-induced small extracellular vesicles for individuals with major depressive disorder
Khoury, R., & Nagy, C. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1154872 · Cited by 18 · see citing works
Acupuncture Ameliorates Depressive Behaviors by Modulating the Expression of Hippocampal Iba-1 and HMGB1 in Rats Exposed to Chronic Restraint Stress
Chen, L., Jiang, H., Bao, T., Wang, Y., Meng, H., Sun, Y., Liu, P., Quan, S., Li, W., Qi, S., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.903004 · Cited by 19 · see citing works
Potential Psychoactive Effects of Microalgal Bioactive Compounds for the Case of Sleep and Mood Regulation: Opportunities and Challenges
McCarthy, B., O’Neill, G. J., & Abu‐Ghannam, N. (2022) · Marine Drugs · doi:10.3390/md20080493 · Cited by 19 · see citing works
The P2X7 receptor in mood disorders: Emerging target in immunopsychiatry, from bench to bedside
von Mücke-Heim, I.-A., & Deussing, J. M. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109366 · Cited by 18 · see citing works
Integrative bioinformatics and artificial intelligence analyses of transcriptomics data identified genes associated with major depressive disorders including NRG1
Bouzid, A., Almidani, A., Boyko, M., Kamzanova, A. T., İlçe, B. Y., Zholdassova, M., Yusuf, A. M., Bhamidimarri, P. M., Alhaj, H. A., Kustubayeva, A., et al. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100555 · Cited by 18 · see citing works
Corticotropin-Releasing Hormone: Biology and Therapeutic Opportunities
Caruso, A., Gaetano, A., & Scaccianoce, S. (2022) · Biology · doi:10.3390/biology11121785 · Cited by 19 · see citing works
Clinical impacts of n -3 fatty acids supplementation on depression symptoms: an umbrella review of meta-analyses
Lu, Y., Qiao, D., & Mi, G. (2023) · British Journal Of Nutrition · doi:10.1017/s000711452300226x · Cited by 17 · see citing works
High neutrophil-to-lymphocyte ratio is a significant predictor of depressive symptoms in maintenance hemodialysis patients: a cross-sectional study
Feng, J., Lu, X., Li, H., & Wang, S. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-03963-7 · Cited by 16 · see citing works
Stress Hormones Cortisol and Aldosterone, and Selected Markers of Oxidative Stress in Response to Long-Term Supplementation with Omega-3 Fatty Acids in Adolescent Children with Depression
Oravcová, H., Katrenčíková, B., Garaiová, I., Ďuračková, Z., Trebatická, J., & Ježová, D. (2022) · Antioxidants · doi:10.3390/antiox11081546 · Cited by 16 · see citing works
Integrating functional neuroimaging and serum proteins improves the diagnosis of major depressive disorder
Chen, S., Yin, Y., Yue, Y., Li, Y., Zhang, Y., Jiang, W., Hou, Z., & Yuan, Y. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.01.034 · Cited by 17 · see citing works
C-Reactive Protein (CRP): A Potent Inflammation Biomarker in Psychiatric Disorders
Orsolini, L., Pompili, S., & Volpe, U. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_7 · Cited by 17 · see citing works
Altered serum TNF-α and MCP-4 levels are associated with the pathophysiology of major depressive disorder: A case-control study results
Nayem, J., Sarker, R., Roknuzzaman, A. S. M., Qusar, M. S., Raihan, S. Z., Islam, M. R., & Mahmud, Z. A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0294288 · Cited by 16 · see citing works
Non-targeted Metabolomics Profiling of Plasma Samples From Patients With Major Depressive Disorder
Wu, Z., Yu, H., Tian, Y., Wang, Y., He, Y., Lan, T., Yan, L., Bai, M., Chen, X., Chen, Z., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.810302 · Cited by 16 · see citing works
Association of CSF sTREM2, a marker of microglia activation, with cholinergic basal forebrain volume in major depressive disorder
Teipel, S. J., Bruno, D., Plaska, C. R., Heslegrave, A., Ramos‐Cejudo, J., Osorio, R. S., Zetterberg, H., Blennow, K., & Pomara, N. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.06.030 · Cited by 15 · see citing works
Differential co-expression networks of the gut microbiota are associated with depression and anxiety treatment resistance among psychiatric inpatients
Thompson, D. S., Fu, C., Gandhi, T., Fowler, J. C., Frueh, B. C., Weinstein, B. L., Petrosino, J. F., Hadden, J. K., Carlson, M. M., Coarfa, C., et al. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110638 · Cited by 16 · see citing works
Comprehensive analysis of endoplasmic reticulum stress and immune infiltration in major depressive disorder
Zhang, J., Xie, S., Chen, Y., Zhou, X., Zheng, Z., Yang, L., & Li, Y. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1008124 · Cited by 14 · see citing works
Evaluation of metabolomics-based urinary biomarker models for recognizing major depression disorder and bipolar disorder
Wang, T., Yang, J., Zhu, Y., Niu, N., Ding, B., Wang, P., Zhao, H., Li, N., Chao, Y., Gao, S., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.03.114 · Cited by 13 · see citing works
Resting-state functional connectivity is correlated with peripheral inflammatory markers in patients with major depressive disorder and healthy controls
Kang, Y., Shin, D., Kim, A., Tae, W., Ham, B., & Han, K. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.11.017 · Cited by 14 · see citing works
The human P2X7 receptor alters microglial morphology and cytokine secretion following immunomodulation
von Mücke-Heim, I.-A., Martin, J. N., Uhr, M., Ries, C., & Deussing, J. M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1148190 · Cited by 13 · see citing works
Eveningness chronotype and depressive affective temperament associated with higher high-sensitivity C-reactive protein in unipolar and bipolar depression
Orsolini, L., Ricci, L., Pompili, S., Cicolini, A., & Volpe, U. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.04.004 · Cited by 13 · see citing works
Urine 3-Nitrotyrosine and serum HDL as potential biomarkers of depression
Nobis, A., Zalewski, D., Samaryn, E., Maciejczyk, M., Zalewska, A., & Waszkiewicz, N. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12010377 · Cited by 12 · see citing works
Self-citation
Effects of pair housing on behavior, cortisol, and clinical outcomes during quarantine‐like procedures for rhesus macaques (Macaca mulatta)
Jackson, M. N., Truelove, M. A., Williams, K., Chen, J., Moore, R. H., Wood, J., Cohen, J. K., & Mollie, B. (2023) · Journal of Medical Primatology · doi:10.1111/jmp.12635 · Cited by 12 · see citing works
Glucose Metabolic Abnormality: A Crosstalk between Depression and Alzheimer’s Disease
Yang, S., Li, Y., Tang, Q., Zhang, Y., & Shao, T. (2024) · Current Neuropharmacology · doi:10.2174/011570159x343281240912190309 · Cited by 12 · see citing works
Brain Metabolic Profile after Intranasal vs. Intraperitoneal Clomipramine Treatment in Rats with Ultrasound Model of Depression
Abramova, O. V., Zorkina, Y., Syunyakov, T., Zubkov, E. A., Ushakova, V. M., Silantyev, A., Soloveva, K., Gurina, O. I., Majouga, A. G., Morozova, A. Y., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179598 · Cited by 12 · see citing works
Chemokine (C–C motif) ligand 5 (RANTES) concentrations in the peripheral blood of patients with a depressive disorder
Małujło-Balcerska, E., Kumor‐Kisielewska, A., Szemraj, J., & Pietras, T. (2022) · Pharmacological Reports · doi:10.1007/s43440-022-00360-5 · Cited by 12 · see citing works
Predicting the diagnosis of various mental disorders in a mixed cohort using blood-based multi-protein model: a machine learning approach
Chen, S., Chen, G., Li, Y., Yue, Y., Zhu, Z., Li, L., Jiang, W., Shen, Z., Wang, T., Hou, Z., et al. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-022-01540-3 · Cited by 12 · see citing works
The Neurobiological Links between Stress and Traumatic Brain Injury: A Review of Research to Date
Zheng, L., Pang, Q., Xu, H., Guo, H., Liu, R., & Wang, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179519 · Cited by 11 · see citing works
The change of inflammatory cytokines after antidepressant treatment and correlation with depressive symptoms
Yin, M., Heng, Z., Li, J., Wang, L., Zhu, M., Wang, N., Yang, P., & Yang, Z. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.02.062 · Cited by 13 · see citing works
Mindfulness-based stress reduction combined with early cardiac rehabilitation improves negative mood states and cardiac function in patients with acute myocardial infarction assisted with an intra-aortic balloon pump: a randomized controlled trial
Wu, K., Wan, M., Zhou, H., Li, C., Zhou, X., Li, E., Li, Y., Liu, C., & Liu, L. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1166157 · Cited by 11 · see citing works
Lower antidepressant response to fluoxetine is associated with anxiety-like behavior, hippocampal oxidative imbalance, and increase on peripheral IL-17 and IFN-γ levels
dos Santos, B. M., Pereira, G. C., Piton, E., Fialho, M. F. P., Becker, G., Carlotto, M. D. S., Camargo, L. F. M., Ramanzini, L. G., Oliveira, S. M., Trevisan, G., et al. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113815 · Cited by 10 · see citing works
Expression of PON1, PON2, PON3 and MPO Genes in Patients with Depressive Disorders
Bliźniewska-Kowalska, K. M., Gałecki, P., Su, K., Halaris, A. E., Szemraj, J., & Gałecka, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11123321 · Cited by 10 · see citing works
The possible mediatory role of adipokines in the association between low carbohydrate diet and depressive symptoms among overweight and obese women
Setayesh, L., Ebrahimi, R., Pooyan, S., Yarizadeh, H., Rashidbeygi, E., Badrooj, N., Imani, H., & Mirzaei, K. (2021) · PLoS ONE · doi:10.1371/journal.pone.0257275 · Cited by 10 · see citing works
The Neurochemistry of Depression: The Good, The Bad and The Ugly.
Pearson, K., Beier, K., Mardis, T., Munoz, B., & Zaidi, A. (2024) · PubMed Central · Cited by 9 · see citing works
A Clinical Risk Prediction Model for Depressive Disorders Based on Seven Machine Learning Algorithms
Jin, W., Chen, S., Wang, M., & Lin, P. (2025) · International Journal of General Medicine · doi:10.2147/ijgm.s524016 · Cited by 9 · see citing works
The Role of Vitamin D in the Management of Major Depressive Disorder: A Systematic Review
Roșian, A., Zdrîncă, M. M., Dobjanschi, L., Vicaș, L. G., Muresan, M. E., Dindelegan, C. M., Platona, R. I., & Marian, E. (2025) · Pharmaceuticals · doi:10.3390/ph18060792 · Cited by 9 · see citing works
Negative air ion exposure ameliorates depression-like behaviors induced by chronic mild stress in mice
Hu, Y., Niu, T.-T., Xu, J., Peng, L., Sun, Q., Huang, Y., Zhou, J., & Ding, Y. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-20144-x · Cited by 9 · see citing works
Anti-Inflammatory Therapy as a Promising Target in Neuropsychiatric Disorders
Ballaz, S., & Bourin, M. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_20 · Cited by 9 · see citing works
Chronic nicotine exposure induces molecular and transcriptomic endophenotypes associated with mood and anxiety disorders in a cerebral organoid neurodevelopmental model
Proud, E., Rodríguez-Ruiz, M., Gummerson, D., Vanin, S., Hardy, D. B., Rushlow, W. J., & Laviolette, S. R. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1473213 · Cited by 9 · see citing works
Association of TNF-α and IL-6 Concentrations with Depression in Patients with Rheumatoid Arthritis
Mrdja, J., Tadić-Latinović, L., Majstorović, L. B., Mrđa, V., Mirjanić-Azarić, B., Ovčina, I., Vranić, S., & Popović-Pejičić, S. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47060419 · Cited by 8 · see citing works
Protease-activated receptor 2 activation induces behavioural changes associated with depression-like behaviour through microglial-independent modulation of inflammatory cytokines
Moudio, S., Willis, A., Pytka, K., Abulkassim, R., Brett, R. R., Webster, J. F., Wozny, C., Barbour, M., Jiang, H., Watson, D. G., et al. (2021) · Psychopharmacology · doi:10.1007/s00213-021-06040-1 · Cited by 8 · see citing works
Study on plasma metabolomics profiling of depression in Chinese community-dwelling older adults based on untargeted LC/GC‒MS
Guo, J., Han, P., Zheng, Y., Wu, Y., Zheng, K., Huang, C., Wang, Y., Chen, C., Qi, Y., Chen, X., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-60836-7 · Cited by 8 · see citing works
Diagnostic significance of LncRNA MIAT in periodontitis and the molecular mechanisms influencing periodontal ligament fibroblasts via the miR-204-5p/DKK1 axis
Ren, Y., Zheng, J., Cao, Y., Zhu, Y., Ling, Z., Zhang, Z., & Huang, M. (2024) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2024.106066 · Cited by 8 · see citing works
Intron retention as an excellent marker for diagnosing depression and for discovering new potential pathways for drug intervention
Okada, N., Oshima, K., Maruko, A., Sekine, M., Ito, N., Wakasugi, A., Mori, E., Odaguchi, H., & Kobayashi, Y. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1450708 · Cited by 9 · see citing works
Genetic variants of interleukin 1B and 6 are associated with clinical outcome of surgically treated lumbar degenerative disc disease
Biczó, Á., Bereczki, F., Koch, K., Varga, P. P., Urban, J. P. G., Fairbank, J. C. T., Heywood, C., Sivan, S. S., Roberts, S., Neidlinger-Wilke, C., et al. (2022) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-022-05711-0 · Cited by 8 · see citing works
Affective neural circuits and inflammatory markers linked to depression and anxiety symptoms in patients with comorbid obesity
Hallihan, H., Tsai, P., Lv, N., Xiao, L., Bernabé, B. P., Wu, Y., Pandey, G. N., Williams, L. M., Ajilore, O., & Ma, J. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.01.044 · Cited by 8 · see citing works
Gender differences in the relationship between nicotine exposure and symptoms of depression
Liu, Y., Zhang, L., Fu, S., Wei, S., Jin, Z., & He, L. R. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173857 · Cited by 7 · see citing works
Oxidative Stress in Treatment-Resistant and Refractory Depression: A Hidden Therapeutic Target?
Winczewska, Z., Cubała, W. J., Radziwiłłowicz, P., & Górska‐Ponikowska, M. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05715-0 · Cited by 7 · see citing works
The association between psychological resilience and hair cortisol concentration in adults: A systematic review and meta-analysis
Xiang, L., Zeng, X., Luo, Y., Tan, S., Wang, F., & Mao, X. (2023) · The International Journal of Psychiatry in Medicine · doi:10.1177/00912174231178108 · Cited by 7 · see citing works
Natural Phytochemicals for the Treatment of Major Depressive Disorder: A Mini-Review of Pre- and Clinical Studies
Réus, G. Z., Manosso, L. M., Arent, C. O., Borba, L. A., & Abelaira, H. M. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1570159x20666220329143804 · Cited by 7 · see citing works
Clinical Guidelines of the Egyptian Psychiatric Association for the Management of Treatment-Resistant Unipolar Depression in Egypt
AbdelWahab, M. A., Okasha, T. A., Shaheen, M. O., Nasr, M., Molokheya, T., Omar, A. E., Rabie, M. A., Mikhael, V. S., Hamed, H., & Ali, M. G. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.797150 · Cited by 7 · see citing works
An Elevated FIB-4 Score Is Associated with an Increased Incidence of Depression among Outpatients in Germany
Schöler, D., Kostev, K., Demir, M., Luedde, M., Konrad, M., Luedde, T., Roderburg, C., & Loosen, S. H. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11082214 · Cited by 7 · see citing works
Interleukin-1 Beta in peripheral blood mononuclear cell lysates as a longitudinal biomarker of response to antidepressants: a pilot study
Ferentinos, P., Maratou, E., Antoniou, A., Serretti, A., Smyrnis, N., & Moutsatsou, P. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.801738 · Cited by 7 · see citing works
miRNAs in Major Depression: Possible Association of miR-17 and miR-92 with Childhood Traumas
Mert, A., Yücens, B., Karagür, E. R., Akça, H., Tümkaya, S., & Ateşçi, F. Ç. (2024) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.24.1218 · Cited by 6 · see citing works
Berberine Alleviates Chronic Restraint Stress‐Induced Depression‐Like Behavior by Modulating Gut Microbiota and SCFA Production in Mice
Ru, C., Song, A., Jiang, J., Qiaolongbatu, X., Wu, Z., Qian, F., Shen, S., Zhang, L., Wang, Z., Zhao, W., et al. (2025) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.70043 · Cited by 9 · see citing works
Multiomics and blood-based biomarkers of electroconvulsive therapy in severe and treatment-resistant depression: study protocol of the DetECT study
von Mücke-Heim, I.-A., Pape, J. C., Grandi, N. C., Erhardt, A., Deussing, J. M., & Binder, E. B. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01647-1 · Cited by 6 · see citing works
Biomarkers and Mental Disorders: A Relevance Analysis Using a Random Forest Algorithm
Rodolpho, J. M. D. A., de Godoy, K. F., Fragelli, B. D. D. L., Bianchi, J., Duarte, F. O., Camillo, L., da Silva, G. G., de Andrade, P. H. M., Prado, J. A., Speglich, C., et al. (2025) · Biomolecules · doi:10.3390/biom15060793 · Cited by 6 · see citing works
Do the American guideline-based leisure time physical activity levels for civilians benefit the mental health of military personnel?
Tsai, K., Liu, P., Lin, Y., Chu, C., Huang, W., Sui, X., Lavie, C. J., & Lin, G. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1255516 · Cited by 6 · see citing works
Future Directions in Anxiolytic Therapy: A Comprehensive Review of Novel Targets and Strategies
Mahima, M., Mazumder, A., & Pentela, B. (2025) · Current Neurovascular Research · doi:10.2174/0115672026394052250808075022 · Cited by 5 · see citing works

Biochemical markers of depression - an up-to-date review
Nobis, A., Zalewski, D., Dabrowska, E., & Waszkiewicz, N. (2021) · European Psychiatry · doi:10.1192/j.eurpsy.2021.1833 · Cited by 1 · see citing works
Self-citation
A review of new insights into existing major depressive disorder biomarkers
Rimti, F. H., Shahbaz, R., Bhatt, K., & Xiang, A. J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18909 · Cited by 17 · see citing works
Biomarkers of Major Depressive Disorder: Knowing is Half the Battle
Malik, S., Singh, R., Arora, G., Dangol, A., & Goyal, S. (2021) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2021.19.1.12 · Cited by 43 · see citing works
Identification of depression biomarkers: Prospects for use in clinical practice
Kashchenko, S. A., Kormachenko, K. A., Musaelyan, M. G., Galenko, D. V., & Салахова, А. М. (2025) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202512505151
Biomarkers for major depressive disorder
Hacımusalar, Y., & Eşel, E. (2017) · Nöro Psikiyatri Arşivi · doi:10.5152/npa.2017.19482 · Cited by 120 · see citing works

Authors: Nobis, A., Zalewski, D., & Waszkiewicz, N.
Affiliations: Medical University of Białystok (PL)
Corresponding author: Nobis, Aleksander
ORCID: Nobis, Aleksander
Zalewski, Daniel
Waszkiewicz, Napoleon
Venue: Journal of Clinical Medicine
Publisher: MDPI AG
Published: 2020-11-24
Volume: 9
Issue: 12
Pages: 3793
ISSN: 2077-0383 (ISSN-L)
DOI: 10.3390/jcm9123793
PMC: PMC7760788
OpenAlex: W3109252124
Cited by: 197
References: 457
Citations by year: 2026: 17 · 2025: 41 · 2024: 34 · 2023: 43 · 2022: 44 · 2021: 18
FWCI: 1.69
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Journal of Clinical Medicine (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Uniwersytet Medyczny w Białymstoku (SUB/1/DN/20/002/1147)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: major depressive disorder, biomarkers, peripheral biomarkers, inflammation, C-reactive protein, interleukin-6, TNF-α, soluble interleukin-2 receptor, oxidative stress, lipid peroxidation, cortisol, hypothalamic-pituitary-adrenal axis, brain-derived neurotrophic factor, fibroblast growth factor 2, insulin-like growth factor I, kynurenine metabolites, glutamate, total cholesterol, biomarker panel

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Peripheral Markers of Depression

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks