Treatment with Adjunctive N -Acetylcysteine in an Adolescent with Selective Serotonin Reuptake Inhibitor-Resistant Anxiety

Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety

Walkup, J. T., Albano, A. M., Piacentini, J., Birmaher, B., Compton, S. N., Sherrill, J. T., Ginsburg, G. S., Rynn, M. A., McCracken, J., Waslick, B., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0804633 · Cited by 1,442 · see citing works

N-Acetylcysteine, a Glutamate Modulator, in the Treatment of Trichotillomania: A Double-blind, Placebo-Controlled Study

Grant, J. E., Odlaug, B. L., & Won Kim, S. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.60 · Cited by 424 · cited 1× · see citing works

A Double-Blind Randomized Controlled Trial of <i>N</i> -Acetylcysteine in Cannabis-Dependent Adolescents

Gray, K. M., Carpenter, M. J., Baker, N. L., DeSantis, S. M., Kryway, E., Hartwell, K. J., McRae-Clark, A. L., & Brady, K. T. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12010055 · Cited by 306 · see citing works

A randomized controlled pilot trial of oral N-acetylcysteine in children with autism

Hardan, A. Y., Fung, L. K., Libove, R. A., Obukhanych, T. V., Nair, S., Herzenberg, L. A., Frazier, T. W., & Tirouvanziam, R. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.014 · Cited by 293 · see citing works

N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder

Lafleur, D. L., Pittenger, C., Kelmendi, B., Gardner, T., Wasylink, S., Malison, R. T., Sanacora, G., Krystal, J. H., & Coric, V. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0246-6 · Cited by 200 · see citing works

Anterior cingulate neurochemistry in social anxiety disorder: 1H-MRS at 4???Tesla

Phan, K. L., Fitzgerald, D. A., Cortese, B. M., Seraji-Bozorgzad, N., Tancer, M. E., & Moore, G. J. (2005) · NeuroReport · doi:10.1097/00001756-200502080-00024 · Cited by 95 · see citing works

Psychopharmacologic Treatment of Children and Adolescents with Anxiety Disorders

Strawn, J. R., Sakolsky, D. J., & Rynn, M. A. (2012) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2012.05.003 · Cited by 57 · see citing works

Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review

Deepmala, Slattery, J., Kumar, N., Delhey, L., Berk, M., Dean, O., Spielholz, C., & Frye, R. (2015) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.015 · Cited by 463 · see citing works

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Smaga, I., Niedzielska, E., Gawlik, M., Moniczewski, A., Krzek, J., Przegaliński, E., Pera, J., & Filip, M. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2014.12.015 · Cited by 252 · see citing works

Anxiety and Brain Mitochondria: A Bidirectional Crosstalk

Filiou, M. D., & Sandi, C. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.07.002 · Cited by 164 · see citing works

N-acetylcysteine in the treatment of psychiatric disorders: current status and future prospects

Minarini, A., Ferrari, S., Galletti, M., Giambalvo, N., Perrone, D., Rioli, G., & Galeazzi, G. M. (2016) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2017.1251580 · Cited by 121 · see citing works

Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches

Balmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103 · see citing works

Glutamate Systems in DSM-5 Anxiety Disorders: Their Role and a Review of Glutamate and GABA Psychopharmacology

Nasir, M., Trujillo, D., Levine, J. L. S., Dwyer, J. B., Rupp, Z. W., & Bloch, M. H. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.548505 · Cited by 89 · see citing works

The Potential of N-Acetyl-L-Cysteine (NAC) in the Treatment of Psychiatric Disorders

Bradlow, R. C. J., Berk, M., Kalivas, P. W., Back, S. E., & Kanaan, R. A. (2022) · CNS Drugs · doi:10.1007/s40263-022-00907-3 · Cited by 87 · see citing works

N‐acetylcysteine as a new prominent approach for treating psychiatric disorders

Smaga, I., Frankowska, M., & Filip, M. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15456 · Cited by 73 · see citing works

Glutamate drugs and pharmacogenetics of OCD: a pathway-based exploratory approach

Grados, M. A., Specht, M. W., Sung, H.-M., & Fortune, D. (2013) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.845553 · Cited by 49 · see citing works

Effects of N‐acetylcysteine on oxidative stress biomarkers, depression, and anxiety symptoms in patients with multiple sclerosis

Mohseni, G. K., Hosseini, S., Majdinasab, N., & Cheraghian, B. (2023) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12360 · Cited by 34 · see citing works

Pharmacological targeting of redox regulation systems as new therapeutic approach for psychiatric disorders: A literature overview.

Schiavone, S., & Trabace, L. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.03.019 · Cited by 33 · see citing works

Potential Role of Glutathione Antioxidant Pathways in the Pathophysiology and Adjunct Treatment of Psychiatric Disorders

Poladian, N., Navasardyan, I., Narinyan, W., Orujyan, D., & Venketaraman, V. (2023) · Clinics and Practice · doi:10.3390/clinpract13040070 · Cited by 31 · see citing works

Mechanisms underlying remediation of depression-associated anxiety by chronic N-acetyl cysteine treatment

Chakraborty, S., Tripathi, S. J., Raju, T. R., & Rao, B. S. S. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05585-x · Cited by 30 · see citing works

N-acetyl cysteine ameliorates depression-induced cognitive deficits by restoring the volumes of hippocampal subfields and associated neurochemical changes

Chakraborty, S., Tripathi, S. J., Srikumar, B. N., Raju, T. R., & Rao, B. S. S. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104605 · Cited by 26 · see citing works

Thiol disulfide homeostasis in psychiatric disorders: A comprehensive review

Tunçay, M. E., Atagün, M. İ., & Erel, Ö. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110719 · Cited by 25 · see citing works

The neuroprotective effects of N-acetylcysteine in psychiatric and neurodegenerative disorders: From modulation of glutamatergic transmission to restoration of synaptic plasticity

Chakraborty, S., Rao, S., & Tripathi, S. J. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110527 · Cited by 24 · see citing works

Effects of N-acetylcysteine and imipramine in a model of acute rhythm disruption in BALB/c mice

Pilz, L., Trojan, Y., Quiles, C., Benvenutti, R., Melo, G., Levandovski, R., Hidalgo, M. P., & Elisabetsky, E. (2015) · Chronobiology International · doi:10.3109/07420528.2014.965315 · Cited by 5 · see citing works

The therapeutic effect of N‐acetylcysteine as an add‐on to methadone maintenance therapy medication in outpatients with substance use disorders: A randomized, double‐blind, placebo‐controlled clinical trial

Padoei, F., Mamsharifi, P., Hazegh, P., Boroumand, H., Ostadmohammady, F., Abbaszadeh‐Mashkani, S., Banafshe, H. R., Matini, A. H., Ghaderi, A., & Dehkohneh, S. G. (2022) · Brain and Behavior · doi:10.1002/brb3.2823 · Cited by 8 · see citing works

Treatment effects of N-acetyl cysteine on resting-state functional MRI and cognitive performance in patients with chronic mild traumatic brain injury: a longitudinal study

Vedaei, F., Newberg, A. B., Alizadeh, M., Zabrecky, G. P., Navarreto, E., Hriso, C., Wintering, N., Mohamed, F. B., & Monti, D. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1282198 · Cited by 6 · see citing works

Nutritional-Based Nutraceuticals in the Treatment of Anxiety

Camfield, D. (2016) · Springer eBooks · doi:10.1007/978-3-319-42307-4_5 · Cited by 5 · see citing works

The Emerging Role of N-Acetylcysteine in Psychiatry: A Narrative Review of Available Data

Marazziti, D., Caruso, V., Cappellato, G., Chiarantini, I., Gurrieri, R., Perrone, P., Violi, M., Crivelli, N. S. B., Weiss, F., & Perugi, G. (2025) · Current Medicinal Chemistry · doi:10.2174/0109298673365458250901115725 · Cited by 3 · see citing works

Psychopharmacology in Pediatric Mixed Anxiety Disorder: An Evidence-based Review.

Naveed, S., Amray, A. N., Jahan, N., Motiwala, F. B., & Majeed, M. H. (2019) · PubMed Central · Cited by 2 · see citing works

Application of N-Acetylcysteine in Psychiatric Disorders

Slattery, J. M., & Frye, R. E. (2018) · Springer eBooks · doi:10.1007/978-981-10-5311-5_12 · Cited by 1 · see citing works

N-Acetylcysteine for Nonsuicidal Self-Injurious Behavior in 3 Adults With Williams Syndrome

Kandel, H., Cruz, A. R., Thom, R. P., & McDougle, C. (2025) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001976

Iron Dyshomeostasis in Schizophrenia and Potential Treatments to Mitigate Its Effects

Okafor, S. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/9781837672059-00080

N-acetylcysteine: Impact on Psychiatric Disorders

Sonia, S. B. A., Siddiki, M. N. A., Sultana, S., Chowdhury, I. H., Sinha, S., Mehta, M., & Haque, M. (2025) · Advances in Human Biology · doi:10.4103/aihb.aihb_50_25

N -Acetylcysteine as Treatment for Self-Injurious Behavior in a Child with Autism

Marler, S., Sanders, K. B., & Veenstra-VanderWeele, J. M. (2014) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2013.0137 · Cited by 22 · see citing works

N-acetylcysteine is effective as add-on therapy to risperidone-based combination for children with autistic disorders

Sun, C., Cheng, Y., & Hung, K. (2021) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/00048674211041932 · Cited by 2 · see citing works

Buspirone Treatment of Anxiety in an Adolescent Female with Avoidant/Restrictive Food Intake Disorder

Okereke, N. K. (2018) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2018.0005 · Cited by 14 · see citing works

P.4.d.006 Serotonin reuptake inhibitor augmentation with n-acetylcysteine in treatment resistant ocd: a double-blind randomized controlled trial

Costa, D. L. C., Diniz, J. B., Joaquim, M. A., Acciarito, A. C., Rodrigues, B., Oda, E., Requena, G. D. L., Miguel, E. C., & Shavitt, R. G. (2015) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(15)30798-7 · Cited by 3 · see citing works

The Role of Glutamatergic Dysfunction in Treatment-Resistant Obsessive-Compulsive Disorder: Treatment of an Adolescent Case with N -Acetylcysteine Augmentation

Yazıcı, K. U., & Perçinel, İ. (2014) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2014.0053 · Cited by 8 · see citing works