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Cited by 103Traumatic Brain Injury ResearchAlzheimer's disease research and treatmentsTraumatic Brain Injury and Neurovascular Disturbances

The DOI matches its Crossref record; 224 of the 228 references it cites were found in a registry or an index.

A critical review of chronic traumatic encephalopathy

Iverson, Grant L., Gardner, Andrew J., McCrory, Paul, Zafonte, Ross, Castellani, Rudy J.·2015·Neuroscience & Biobehavioral Reviews
DOI 10.1016/j.neubiorev.2015.05.008
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Abstract

Chronic traumatic encephalopathy (CTE) has been described in the literature as a neurodegenerative disease with: (i) localized neuronal and glial accumulations of phosphorylated tau (p-tau) involving perivascular areas of the cerebral cortex, sulcal depths, and with a preference for neurons within superficial cortical laminae; (ii) multifocal axonal varicosities and axonal loss involving deep cortex and subcortical white matter; (iii) relative absence of beta-amyloid deposits; (iv) TDP-43 immunoreactive inclusions and neurites; and (v) broad and diverse clinical features. Some of the pathological findings reported in the literature may be encountered with age and other neurodegenerative diseases. However, the focality of the p-tau cortical findings in particular, and the regional distribution, are believed to be unique to CTE. The described clinical features in recent cases are very similar to how depression manifests in middle-aged men and with frontotemporal dementia as the disease progresses. It has not been established that the described tau pathology, especially in small amounts, can cause complex changes in behavior such as depression, substance abuse, suicidality, personality changes, or cognitive impairment. Future studies will help determine the extent to which the neuropathology is causally related to the diverse clinical features.

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Research works printed but not linked: 3

  1. Millspaugh, 1937, Dementia pugilistica, U. S. Naval Med. Bull., 35, 297
  2. Randolph, 2014, Is chronic traumatic encephalopathy a real disease?, Curr. Sports Med. Rep., 13, 33
  3. White, 2009, Brain lesions at autopsy in older Japanese-American men as related to cognitive impairment and dementia in the final years of life: a summary report from the Honolulu-Asia Aging Study, J. Alzheimers Dis., 18, 713, 10.3233/JAD-2009-1178 · DOI · Paper page

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Metadata

Authors
Iverson, G. L., Gardner, A. J., McCrory, P., Zafonte, R., & Castellani, R. J.
Affiliations
  • Harvard University (US)
  • Hunter New England Local Health District (AU)
  • Florey Institute of Neuroscience and Mental Health (AU)
  • Brigham and Women's Hospital (US)
  • University of Maryland, Baltimore (US)
Corresponding author
Iverson, Grant L.
ORCID
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2015-09
Volume
56
Pages
276-293
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/j.neubiorev.2015.05.008
OpenAlex
W929294836
Cited by
103
References
228
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 8 · 2020: 10 · 2019: 12 · 2018: 12 · 2017: 23 · 2016: 20 · 2015: 2
FWCI
2.47
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • NOVA (University of Newcastle Australia) (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
chronic traumatic encephalopathy, tau phosphorylation, axonal varicosities, axonal loss, TDP-43 inclusions, amyloid-beta, neurodegeneration, depression, frontotemporal dementia, behavioral symptoms, cognitive impairment, neuropathology
MeSH terms
Cognition Disorders, Dementia, DNA-Binding Proteins, Humans, tau Proteins, Disease Progression, Brain Injury, Chronic

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