A review of psychiatric co-morbidity described in genetic and immune mediated movement disorders
Open accessAbstract
Psychiatric symptoms are an increasingly recognised feature of movement disorders. Recent identification of causative genes and autoantibodies has allowed detailed analysis of aetiologically homogenous subgroups, thereby enabling determination of the spectrum of psychiatric symptoms in these disorders. This review evaluates the incidence and type of psychiatric symptoms encountered in patients with movement disorders. A broad spectrum of psychiatric symptoms was identified across all subtypes of movement disorder, with depression, generalised anxiety disorder and obsessive-compulsive disorder being most common. Psychosis, schizophrenia and attention deficit hyperactivity disorder were also identified, with the psychiatric symptoms often predating onset of the motor disorder. The high incidence of psychiatric symptoms across such a wide range of movement disorders suggests a degree of common or overlapping pathogenic mechanisms. Our review demonstrates the need for increased clinical awareness of such co-morbidities, which should facilitate early neuropsychiatric intervention and allied specialist treatment for patients.
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Non-motor symptoms, notably psychiatric disorders, are well recognised comorbid features of dystonia.
“There is also increasing recognition that non-motor symptoms form an important part of the disorder [1, 2].”
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Benign Hereditary Chorea of Early Onset Maps to Chromosome 14q
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- Authors
- Peall, K. J., Lorentzos, M. S., Heyman, I., Tijssen, M. A. J., Owen, M. J., Dale, R. C., & Kurian, M. A.
- Affiliations
- Cardiff University (GB)
- The University of Sydney (AU)
- Great Ormond Street Hospital (GB)
- University of Groningen (NL)
- Corresponding author
- Peall, K.J.
- Kurian, M.A.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 80
- Pages
- 23-35
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2614791664
- Cited by
- 14
- References
- 113
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 1
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- green
- research.rug.nl
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- AADC Research Trust
- Academy of Medical Sciences (AMS-SGCL11-Peall)
- Rosetrees Trust (M375‐F1)
- Petre Foundation
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Medical Research Council (MR/P008593/1, MR/L010305/1)
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- psychiatric comorbidity, movement disorders, hereditary movement disorders, autoantibodies, depression, generalized anxiety disorder, obsessive-compulsive disorder, psychosis, schizophrenia, attention deficit hyperactivity disorder, neuropsychiatric symptoms, pathophysiological mechanisms
- MeSH terms
- Mental Disorders, Humans, Movement Disorders, Comorbidity
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