The DOI matches its Crossref record; 273 of the 273 references it cites were found in a registry or an index.
Subliminal (latent) processing of pain and its evolution to conscious awareness
Open accessAbstract
By unconscious or covert processing of pain we refer to nascent interactions that affect the eventual deliverance of pain awareness. Thus, internal processes (viz., repeated nociceptive events, inflammatory kindling, reorganization of brain networks, genetic) or external processes (viz., environment, socioeconomic levels, modulation of epigenetic status) contribute to enhancing or inhibiting the presentation of pain awareness. Here we put forward the notion that for many patients, ongoing sub-conscious changes in brain function are significant players in the eventual manifestation of chronic pain. In this review, we provide clinical examples of nascent or what we term pre-pain processes and the neurobiological mechanisms of how these changes may contribute to pain, but also potential opportunities to define the process for early therapeutic interventions.
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Metadata
- Authors
- Borsook, D., Youssef, A. M., Barakat, N., Sieberg, C. B., & Elman, I.
- Affiliations
- Center for Pain and the Brain (US)
- Dayton VA Medical Center (US)
- Corresponding author
- Borsook, David
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 88
- Pages
- 1-15
- ISSN
- 0149-7634 (ISSN-L)
- PMC
- PMC5985199
- OpenAlex
- W2793055948
- Cited by
- 21
- References
- 273
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 5 · 2018: 1
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD083133)
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Keywords
- chronic pain, pain awareness, brain network reorganization, epigenetic modulation, socioeconomic factors, early therapeutic intervention, nociception
- MeSH terms
- Animals, Awareness, Brain, Consciousness, Humans, Pain, Unconscious, Psychology, Unconsciousness
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