Cited by 21Pain Mechanisms and TreatmentsPain Management and TreatmentPain Management and Placebo Effect

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Subliminal (latent) processing of pain and its evolution to conscious awareness

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Borsook, David, Youssef, Andrew M., Barakat, Nadia, Sieberg, Christine B., Elman, Igor·2018·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2018.02.015PMC PMC5985199

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Abstract

By unconscious or covert processing of pain we refer to nascent interactions that affect the eventual deliverance of pain awareness. Thus, internal processes (viz., repeated nociceptive events, inflammatory kindling, reorganization of brain networks, genetic) or external processes (viz., environment, socioeconomic levels, modulation of epigenetic status) contribute to enhancing or inhibiting the presentation of pain awareness. Here we put forward the notion that for many patients, ongoing sub-conscious changes in brain function are significant players in the eventual manifestation of chronic pain. In this review, we provide clinical examples of nascent or what we term pre-pain processes and the neurobiological mechanisms of how these changes may contribute to pain, but also potential opportunities to define the process for early therapeutic interventions.

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Authors: Borsook, D., Youssef, A. M., Barakat, N., Sieberg, C. B., & Elman, I.
Affiliations: Center for Pain and the Brain (US)
Dayton VA Medical Center (US)
Corresponding author: Borsook, David
ORCID: Borsook, David
Youssef, Andrew M.
Barakat, Nadia
Sieberg, Christine B.
Elman, Igor
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2018-05
Volume: 88
Pages: 1-15
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2018.02.015
PMC: PMC5985199
OpenAlex: W2793055948
Cited by: 21
References: 273
Citations by year: 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 5 · 2018: 1
FWCI: 0.33
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD083133)
National Institutes of Health
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords: chronic pain, pain awareness, brain network reorganization, epigenetic modulation, socioeconomic factors, early therapeutic intervention, nociception
MeSH terms: Animals, Awareness, Brain, Consciousness, Humans, Pain, Unconscious, Psychology, Unconsciousness

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Subliminal (latent) processing of pain and its evolution to conscious awareness

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