The contagion of social defeat stress: Insights from rodent studies
Open accessAbstract
Stressful experiences can be transmitted among individuals through social interactions. Like humans, rodents are social creatures whose behavior and physiology can be influenced by the emotional state of fellow rodents. This paper will review rodent studies which have explored two conditions of potential social stress contagion using the social defeat paradigm. In the vicarious social defeat model, mice and rats that witness a conspecific being socially defeated exhibit physiological stress responses and develop a host of depressive- and anxiety-like behavioral deficits. Likewise, social interaction with a stressed partner in the aftermath of social defeat stress results in physiological stress responses and social avoidance behavior. After summarizing the existing literature on this newly emerging area of social defeat stress contagion in rodents, we will discuss the potential utility of these rodent models for investigating the neurobiological processes and sensory channels of information that allow for the spread of psychophysiological effects of stress across individuals.
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- Authors
- Carnevali, L., Montano, N., Tobaldini, E., Thayer, J. F., & Sgoifo, A.
- Affiliations
- University of Parma (IT)
- University of Milan (IT)
- University of California, Irvine (US)
- Corresponding author
- Carnevali, Luca
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 111
- Pages
- 12-18
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2999845559
- Cited by
- 100
- References
- 64
- Citations by year
- 2026: 10 · 2025: 27 · 2024: 17 · 2023: 20 · 2022: 13 · 2021: 7 · 2020: 5
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- social defeat stress, stress contagion, depression-like behavior, anxiety-like behavior, social avoidance, physiological stress response
- MeSH terms
- Social Interaction, Social Defeat, Animals, Behavior, Animal, Empathy, Stress, Physiological, Stress, Psychological, Mice, Rats
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