Cited by 100Stress Responses and CortisolNeuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on Behavior

The contagion of social defeat stress: Insights from rodent studies

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Carnevali, Luca, Montano, Nicola, Tobaldini, Eleonora, Thayer, Julian F., Sgoifo, Andrea·2020·Neuroscience & Biobehavioral Reviews

Abstract

Stressful experiences can be transmitted among individuals through social interactions. Like humans, rodents are social creatures whose behavior and physiology can be influenced by the emotional state of fellow rodents. This paper will review rodent studies which have explored two conditions of potential social stress contagion using the social defeat paradigm. In the vicarious social defeat model, mice and rats that witness a conspecific being socially defeated exhibit physiological stress responses and develop a host of depressive- and anxiety-like behavioral deficits. Likewise, social interaction with a stressed partner in the aftermath of social defeat stress results in physiological stress responses and social avoidance behavior. After summarizing the existing literature on this newly emerging area of social defeat stress contagion in rodents, we will discuss the potential utility of these rodent models for investigating the neurobiological processes and sensory channels of information that allow for the spread of psychophysiological effects of stress across individuals.

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Crossref · 10.1016/j.neubiorev.2020.01.011

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Authors
Carnevali, L., Montano, N., Tobaldini, E., Thayer, J. F., & Sgoifo, A.
Affiliations
  • University of Parma (IT)
  • University of Milan (IT)
  • University of California, Irvine (US)
Corresponding author
Carnevali, Luca
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2020-04
Volume
111
Pages
12-18
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2999845559
Cited by
100
References
64
Citations by year
2026: 10 · 2025: 27 · 2024: 17 · 2023: 20 · 2022: 13 · 2021: 7 · 2020: 5
FWCI
1.17
Type
journal article
Language
en
Open access
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
social defeat stress, stress contagion, depression-like behavior, anxiety-like behavior, social avoidance, physiological stress response
MeSH terms
Social Interaction, Social Defeat, Animals, Behavior, Animal, Empathy, Stress, Physiological, Stress, Psychological, Mice, Rats

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