Cited by 197Treatment of Major DepressionMitochondrial Function and PathologyStress Responses and Cortisol

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression

Rezin, Gislaine T., Cardoso, Mariane R., Gonçalves, Cinara L., Scaini, Giselli, Fraga, Daiane B., Riegel, Rafael E., Comim, Clarissa M., Quevedo, João, Streck, Emilio L.·2008·Neurochemistry International

DOI 10.1016/j.neuint.2008.09.012

Open this paper in CoChat — free account

Abstract

Depressive disorders, including major depression, are serious and disabling. However, the exact pathophysiology of depression is not clearly understood. Life stressors contribute in some fashion to depression and are an extension of what occurs normally. In this context, chronic stress has been used as an animal model of depression. Based on the hypothesis that metabolism impairment might be involved in the pathophysiology of depression, in the present work we evaluated the activities of mitochondrial respiratory chain complexes and creatine kinase in brain of rats subjected to chronic stress. After 40 days of mild stress, a reduction in sweet food ingestion was observed, as well as increased adrenal gland weight, when compared to control group. We also verified that control group gained weight after 40 days, but stressed group did not. Moreover, our findings showed that complex I, III and IV were inhibited in stress group only in cerebral cortex and cerebellum. On the other hand, complex II and creatine kinase were not affected in stressed group. Although it is difficult to extrapolate our findings to the human condition, the inhibition of mitochondrial respiratory chain by chronic stress may be one mechanism in the pathophysiology of depressive disorders.

Integrity signals

Registry

Crossref · 10.1016/j.neuint.2008.09.012

Cites

63 of 63 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the “phosphocreatine circuit” for cellular energy homeostasis
Wallimann, T., Wyss, M., Brdiczka, D., Nicolay, K., & Eppenberger, H. M. (1992) · Biochemical Journal · doi:10.1042/bj2810021 · Cited by 2,011
Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant
Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993
Biochemical and molecular investigations in respiratory chain deficiencies
Rustin, P., Chrétien, D., Bourgeron, T., Gérard, B., Rötig, A., Saudubray, J., & Münnich, A. (1994) · Clinica Chimica Acta · doi:10.1016/0009-8981(94)90055-8 · Cited by 1,265
Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress
Prabakaran, S., SWATTON, J. E., Ryan, M. M., Huffaker, S. J., Huang, J.-J., Griffin, J. L., Wayland, M. T., Freeman, T., Dudbridge, F., Lilley, K. S., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001511 · Cited by 985
THE CREATINE-CREATINE PHOSPHATE ENERGY SHUTTLE
Bessman, S. P., & Carpenter, C. L. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.004151 · Cited by 776
Differential Inhibitory Action of Nitric Oxide and Peroxynitrite on Mitochondrial Electron Transport
Cassina, A., & Radí, R. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0178 · Cited by 721
The mitochondrial energy transduction system and the aging process
Navarro, A., & Boveris, A. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00213.2006 · Cited by 646
A method for the estimation of serum creatine kinase and its use in comparing creatine kinase and aldolase activity in normal and pathological sera
Hughes, B. P. (1962) · Clinica Chimica Acta · doi:10.1016/0009-8981(62)90137-7 · Cited by 550
An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress
Papp, M., Willner, P., & Muscat, R. (1991) · Psychopharmacology · doi:10.1007/bf02244188 · Cited by 542

Flagged first, then by citations

Show all 63 references

Sorted by citations

Items 101–197 of 197

Putative Inflammatory Sensitive Mechanisms Underlying Risk or Resilience to Social Stress
Finnell, J. E., & Wood, S. K. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00240 · Cited by 33
“For example, chronic immobilization stress and chronic mild stress inhibit the activity of the respiratory chain complexes within the rat brain cortex (Madrigal et al., 2001; Rezin et al., 2008) and was shown to reduce hippocampal Na, K-ATPase activity (Gamaro et al.”
Background
TLR4 signaling modulation of PGC1-α mediated mitochondrial biogenesis in the LPS-Chronic mild stress model: Effect of fluoxetine and pentoxiyfylline
Khedr, L. H., Nassar, N. N., Rashed, L. A., El-denshary, E. D., & Abdel-Tawab, A. M. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116869 · Cited by 32
Blood-based mitochondrial respiratory chain function in major depression
Fernström, J., Mellon, S. H., McGill, M. A., Picard, M. A., Reus, V. I., Hough, C. M., Lin, J., Epel, E. S., Wolkowitz, O. M., & Lindqvist, D. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01723-x · Cited by 39
“The rationale behind this was based on (i) the finding that individuals suffering from mitochondrial cytopathies, which decreases RC capacity on a per-mitochondrion basis, or MHI, often display depressive symptoms [14], (ii) several animal and human studies linking decreased mitochondrial function to depressive sympto…”
Background
How stress mediators can cumulatively contribute to Alzheimer’s disease An allostatic load approach
Matos, T. M., & Souza‐Talarico, J. N. (2019) · Dementia & Neuropsychologia · doi:10.1590/1980-57642018dn13-010002 · Cited by 35
A novel mechanism of depression: role for connexins
Xia, C., Wang, Z.-Z., Yamakuni, T., & Chen, N. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.01.009 · Cited by 32
Metabolism-Associated Markers and Childhood Autism Rating Scales (CARS) as a Measure of Autism Severity
El-Ansary, A. K., Bjørklund, G., Khemakhem, A. M., AL-Ayadhi, L. Y., Chirumbolo, S., & Bacha, A. G. B. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1091-5 · Cited by 31
Brain creatine kinase activity is increased by chronic administration of paroxetine
Santos, P. M. L., Scaini, G., Rezin, G. T., Benedet, J., Rochi, N., Jeremias, G. C., Carvalho‐Silva, M., Quevedo, J., & STRECK, E. L. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.09.007 · Cited by 33
Self-citation
Molecular markers of neuroendocrine function and mitochondrial biogenesis associated with early life stress
Ridout, K. K., Coe, J. L., Parade, S. H., Marsit, C. J., Kao, H., Porton, B., Carpenter, L. L., Price, L. H., & Tyrka, A. R. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104632 · Cited by 29
“Depressive disorders include MDD, dysthymia, and depression not otherwise specified.”
BackgroundInfluential
Effects of transcranial photobiomodulation and methylene blue on biochemical and behavioral profiles in mice stress model
Meynaghizadeh-Zargar, R., Sadigh‐Eteghad, S., Mohaddes, G., Salehpour, F., & Rasta, S. H. (2019) · Lasers in Medical Science · doi:10.1007/s10103-019-02851-z · Cited by 30
Involvement of Nrf2 in Development of Anxiety-Like Behavior by Linking Bcl2 to Oxidative Phosphorylation: Estimation in Rat Hippocampus, Amygdala, and Prefrontal Cortex
Khalifeh, S., Oryan, S., Digaleh, H., Shaerzadeh, F., Khodagholi, F., Maghsoudi, N., & Zarrindast, M. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0370-z · Cited by 29
“Intriguingly, our data opposed against previous studies in which anxious mice revealed inhibition of some ETC components (Rezin et al. 2008; Yan et al. 2007).”
Result
Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach
Xu, L., Lu, Z. Z., Ji, C., Cong, M., Li, F., Shan, X., & Wu, H. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113333 · Cited by 29
Insights into the potential antidepressant mechanisms of cilostazol in chronically restraint rats: impact on the Nrf2 pathway
Abuelezz, S. A., & Hendawy, N. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000335 · Cited by 28
“CMS rats showed decreased activity of the prefrontal cortex mitochondrial complexes I and IV (Liu and Zhou, 2012), and cerebral cortex and cerebellum complexes I, III, and IV (Rezin et al., 2008, 2010).”
Background
Activation of the kynurenine pathway and mitochondrial respiration to face allostatic load in a double-hit model of stress
Nold, V., Sweatman, C., Karabatsiakis, A., Böck, C., Bretschneider, T., Lawless, N., Fundel‐Clemens, K., Kolassa, I., & Allers, K. A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.006 · Cited by 27
Effects of resveratrol on the levels of ATP, 5-HT and GAP-43 in the hippocampus of mice exposed to chronic unpredictable mild stress
Shen, J.-D., Zhang, Y.-W., Wang, B., Bai, L., Lu, S., Zhu, L., Bai, M., Li, Y., & Xu, E. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135232 · Cited by 30
Age-dependent effects of esculetin on mood-related behavior and cognition from stressed mice are associated with restoring brain antioxidant status
Martín‐Aragón, S., Villar, Á., & Benedı́, J. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.08.007 · Cited by 29
Olanzapine plus fluoxetine treatment alters mitochondrial respiratory chain activity in the rat brain
Agostinho, F. R., Réus, G. Z., Stringari, R. B., Ribeiro, K. F., Ferreira, G. K., Jeremias, I. C., Scaini, G., Rezin, G. T., STRECK, E. L., & Quevedo, J. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00569.x · Cited by 27
“Therefore, it is important to investigate the mechanisms of action of this combination in order to not only better understand the aetiology of the clinical syndromes, but also to eventually facilitate the development of improved drugs to treat them (4,20).”
BackgroundSelf-citation
Single-Nucleotide Polymorphisms of Genes Involved in Repair of Oxidative DNA Damage and the Risk of Recurrent Depressive Disorder
Czarny, P. L., Kwiatkowski, D., Toma, M. M., Gałecki, P., Orzechowska, A., Bobińska, K., Bielecka-Kowalska, A., Szemraj, J., Berk, M., Anderson, G., et al. (2016) · Medical Science Monitor · doi:10.12659/msm.898091 · Cited by 28
Repeated corticosterone injections in adult mice alter stress hormonal receptor expression in the cerebellum and motor coordination without affecting spatial learning
Harlé, G., Lalonde, R., Fonte, C., Ropars, A., Frippiat, J., & Strazielle, C. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.02.035 · Cited by 27
Ultrasound stress compromises the correlates of emotional-like states and brain AMPAR expression in mice: effects of antioxidant and anti-inflammatory herbal treatment
Costa-Nunes, J. P., Вячеславовна, Г. А., Pavlov, D., Cespuglio, R., Gorovaya, A., Proshin, A. T., Umriukhin, A., Ponomarev, E. D., Kalueff, A. V., Strekalova, T. V., et al. (2020) · Stress · doi:10.1080/10253890.2019.1709435 · Cited by 26
“…pathological changes in oxidative stress, pro-inflammatory, glutamatergic, and plasticity mechanisms during stress are inter-related, and metabolic/ mitochondrial regulations can be viewed as pivotal in these dysregulatory cascades (Hussain et al., 2016; Picard & McEwen, 2018; Rezin et al., 2008).”
Background
Effects of olanzapine, fluoxetine and olanzapine/fluoxetine on creatine kinase activity in rat brain
Agostinho, F. R., Scaini, G., Ferreira, G. K., Jeremias, I. C., Réus, G. Z., Rezin, G. T., de Castro, A. A., Zugno, A. I., Quevedo, J., & STRECK, E. L. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.09.002 · Cited by 26
Self-citation
Steps Towards Developing Effective Treatments for Neuropsychiatric Disturbances in Alzheimer’s Disease: Insights From Preclinical Models, Clinical Data, and Future Directions
Clement, A., Wiborg, O., & Asuni, A. A. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00056 · Cited by 28
“Studies using a rodent model of depression have shown impairment of oxidative phosphorylation (OXPHOS) possibly caused by changes in mitochondrial membrane integrity (Rezin et al., 2008; Gong et al., 2011) which ultimately can lead to apoptosis (Wang, 2001) and neuronal cell death and thereby structural brain changes.”
Background
Hyperforin promotes mitochondrial function and development of oligodendrocytes
Wang, Y., Zhang, Y., He, J., Zhang, H., Xiao, L., Nazarali, A. J., Zhang, Z., Zhang, D., Tan, Q., Kong, J., et al. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07433.x · Cited by 24
Behavioural mating displays depend on mitochondrial function: a potential mechanism for linking behaviour to individual condition
Koch, R. E., & Hill, G. E. (2018) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12400 · Cited by 25
“Mitochondrial mediation of calcium ion flux, ATP production, and ROS signalling in neural tissue are at the core of neural signal transmission as well as synaptic plasticity in response to changing conditions and/or stressors (Massaad & Klann, 2011; Morava & Kozicz, 2013), and changes to mitochondrial form and functio…”
Background
Resilience and Vulnerability to Stress-Induced Anhedonia: Unveiling Brain Gene Expression and Mitochondrial Dynamics in a Mouse Chronic Stress Depression Model
Strekalova, T. V., Svirin, E. P., Вячеславовна, Г. А., Sheveleva, E., Burova, A., Khairetdinova, A. H., Sitdikova, K., Zakharova, E., Dudchenko, A. M., Lyundup, A. V., et al. (2023) · Biomolecules · doi:10.3390/biom13121782 · Cited by 24
Gene Expression Profile in Major Depressive Disorder Shows Reduced Mitochondrial Biogenesis
Alcocer‐Gómez, E., Núñez‐Vasco, J., Casas‐Barquero, N., Williams, M. R., Navarro-Pando, J. M., Bullón, P., & Cordero, M. D. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12568 · Cited by 23
“Consistent with these findings, mitochondrial dysfunction biomarkers have been described in patients with MDD and animal models such as mitochondrial chain dysfunction, decreased levels of ATP, or reduced levels of coenzyme Q10 (CoQ10) [3,7,8].”
Background
Metformin alleviates the depression-like behaviors of elderly apoE4 mice via improving glucose metabolism and mitochondrial biogenesis
Lin, Y., Dai, X., Zhang, J., & Chen, X. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113772 · Cited by 23
The potential benefit of combined versus monotherapy of coenzyme Q10 and fluoxetine on depressive-like behaviors and intermediates coupled to Gsk-3β in rats
Abuelezz, S. A., Hendawy, N., & Magdy, Y. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.12.018 · Cited by 23
“The increase in adrenal gland weight present in cases of chronic stress reflects the release of glucocorticoid hormones by the adrenals in response to psychological and physical stressors (Rezin et al., 2008).”
Background
Effect of subchronic administration of agomelatine on brain energy metabolism and oxidative stress parameters in rats
de Mello, A. H., Souza, L. D. R., Cereja, A. C. M., Schraiber, R. D. B., Florentino, D., Martins, M. M., Petronilho, F. C., Quevedo, J., & Rezin, G. T. (2015) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12371 · Cited by 22
“Studies have shown that major depression is associated with impairments in brain energy metabolism.(1,2,13) Mitochondrial dysfunction causes an increased production of ROS,(14,41) and the excess of ROS can cause more damage in mitochondria, undermining the ability of mitochondria to meet cell energy demand and may lea…”
BackgroundSelf-citation
Extremely Low-Frequency Electromagnetic Field (ELF-EMF) Increases Mitochondrial Electron Transport Chain Activities and Ameliorates Depressive Behaviors in Mice
Teranishi, M., Ito, M., Huang, Z., Nishiyama, Y., Masuda, A., Mino, H., Tachibana, M., Inada, T., & Ohno, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011315 · Cited by 22
“…glycolysis and mitochondrial tricarboxylic acid cycle (TCA cycle) in the ventral hippocampus [23]; decreased mitochondrial ETC activities in the PFC, cortex, and cerebellum [24,25]; and decreased mitochondrial membrane potential/oxygen consumption in the cortex, hippocampus, and hypothalamus [26].”
Background
Acute stress delays brain mitochondrial permeability transition pore opening
Batandier, C., Poulet, L., Hininger‐Favier, I., Couturier, K., Fontaine, E. M., Roussel, A., & Canini, F. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12811 · Cited by 21
Cross-disease analysis of depression, ataxia and dystonia highlights a role for synaptic plasticity and the cerebellum in the pathophysiology of these comorbid diseases
Huang, M., de Koning, T. J., Tijssen, M. A. J., & Verbeek, D. S. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165976 · Cited by 20
Behavioral Neurobiology of Bipolar Disorder and its Treatment
Manji, H. K., & Zarate, C. A. (2010) · Current topics in behavioral neurosciences · doi:10.1007/978-3-642-15757-8 · Cited by 20
Age-Dependent Decrease of Mitochondrial Complex II Activity in a Familial Mouse Model for Alzheimer’s Disease
Emmerzaal, T. L., Rodenburg, R. J., Tanila, H., Verweij, V., Kiliaan, A. J., & Kozicz, T. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180337 · Cited by 21
Hippocampal synaptoproteomic changes of susceptibility and resilience of male rats to chronic social isolation
Perić, I., Costina, V., Gass, P., Findeisen, P., & Filipović, D. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.11.013 · Cited by 18
Exploring the interplay between stress mediators and skin microbiota in shaping age-related hallmarks: A review
Duarte, M., Pedrosa, S. S., Khusial, P. R., & Madureira, A. R. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111956 · Cited by 23
“Chronic stress, for example, caused mitochondrial damage in the brain, in mice models, by blocking respiratory chain complexes I-III and reducing mitochondrial membrane potential (Gong et al., 2011; Madrigal et al., 2001; Rezin et al., 2008).”
General and Electrophysiological Toxic Effects of Manganese in Rats following Subacute Administration in Dissolved and Nanoparticle Form
Horváth, E., Máté, Z., Takács, S., Pusztai, P., Sápi, A., Kónya, Z., Nagymajtényi, L., & Papp, A. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/520632 · Cited by 18
“The decreased body weight gain in rats exposed to Mn NPs (oral + intratracheal treatment: groups MnL33 and MnH33) is also an indication of stress (as suggested in [25]) especially in combination with the increased weight of the adrenals in these groups (see Tables 2 and 3).”
Cinnamon intake alleviates the combined effects of dietary-induced insulin resistance and acute stress on brain mitochondria
Couturier, K., Hininger‐Favier, I., Poulet, L., Anderson, R. A., Roussel, A., Canini, F., & Batandier, C. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.10.016 · Cited by 19
“This result differs from that obtained by Usta [22] who found an inhibition of Complex I in connection with cinnamaldehyde but is closer to the results reported in an experimental model of depression [39] or a chronic mild stress [40].”
Result
Altered expression of genes involved in brain energy metabolism as adaptive responses in rats exposed to chronic variable stress; changes in cortical level of glucogenic and neuroactive amino acids
Herbet, M., Natorska‑Chomicka, D., Korga, A., Ostrowska, M., Izdebska, M., Gawrońska‑Grzywacz, M., Piątkowska‑Chmiel, I., Pawłowski, K., Ślaska, B., Poleszak, E., et al. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.9865 · Cited by 17
“The high demand for energy is mainly achieved by the production of ATP during metabolism of glucose or oxidative phosphorylation in the mitochondria (6-8).”
Background
Effect of chronic administration of ketamine on the mitochondrial respiratory chain activity caused by chronic mild stress
Rezin, G. T., Gonçalves, C. L., Daufenbach, J. F., Carvalho‐Silva, M., Borges, L. S., Vieira, J. S., Hermani, F. V., Comim, C. M., Quevedo, J., & STRECK, E. L. (2010) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2010.00500.x · Cited by 16
“Several studies showed that chronic stress induced significant reduction in body weight gain, increased adrenal weight, as well as induced anhedonia (16,25,26).”
BackgroundInfluentialSelf-citation
Gestational stress decreases postpartum mitochondrial respiration in the prefrontal cortex of female rats
Gorman‐Sandler, E., Robertson, B., Crawford, J., Wood, G., Ramesh, A., Arishe, O. O., Webb, R. C., & Hollis, F. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100563 · Cited by 16
“Preclinical studies in male rodents found that chronic stress reduced mitochondrial function in the cortex and cerebellum (Madrigal et al., 2001; Rezin et al., 2008).”
Effects of omega-3 on behavioral and biochemical parameters in rats submitted to chronic mild stress
de Mello, A. H., Gassenferth, A., Schraiber, R. D. B., Souza, L. D. R., Florentino, D., Danielski, L. G., Soares, E. D. C. C., Fortunato, J. J., Petronilho, F. C., Quevedo, J., et al. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9577-5 · Cited by 15
“Chronic mild stress (CMS) model CMS protocol was adapted from the procedure described by Gamaro et al. (2003) and Rezin et al. (2008) (Table 1).”
BackgroundMethodResultInfluentialSelf-citation
Effects of Xingpi Kaiyu Fang on ATP, Na/K-ATPase, and Respiratory Chain Complexes of Hippocampus and Gastrocnemius Muscle in Depressed Rats
Yuan, Q., Li, Y., Deng, X., Shi, H., Zhao, Z., Wang, C., Feng, X.-G., Guo, J., & Guo, R. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/6054926 · Cited by 16
“[30] reported that complex I, III, and IV activities were inhibited in cerebral cortex and cerebellum of depressed model rats, and complex II was not affected.”
Background
Oxidative metabolism alterations in the emotional brain of anxiety-prone rats
McCoy, C. R., Sabbagh, M. N., Huaman, J. P., Pickrell, A. M., & Clinton, S. M. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109706 · Cited by 15
Mitochondrial Dysfunction and Bipolar Disorder
Kato, T. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_52 · Cited by 14
“For instance, it was reported that chronic mild stress inhibited the mitochondrial respiratory chain ( Rezin et al. 2008 ).”
Background
Stress increases sperm respiration and motility in mice and men
Moon, N., Morgan, C. P., Marx-Rattner, R., Jeng, A., Johnson, R. L., Chikezie, I., Mannella, C. A., Sammel, M. D., Epperson, C. N., & Bale, T. L. (2024) · Nature Communications · doi:10.1038/s41467-024-52319-0 · Cited by 14
Metabonomic Studies of Schizophrenia and Psychotropic Medications: Focus on Alterations in CNS Energy Homeostasis
Ma, D., Guest, P. C., & Bahn, S. (2009) · Bioanalysis · doi:10.4155/bio.09.144 · Cited by 13
Differential effects of escitalopram administration on metabolic parameters of cortical and subcortical brain regions of Wistar rats
Gonçalves, C. L., Rezin, G. T., Ferreira, G. K., Jeremias, I. C., Cardoso, M. R., Carvalho‐Silva, M., Zugno, A. I., Quevedo, J., & STRECK, E. L. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00592.x · Cited by 13
“It has been also reported that brain Na+, K+ATPase and activities of respiratory chain complexes I, III and IV are inhibited after chronic variate stress in rats (53,54) and that complexes I–III and II–III”
BackgroundSelf-citation
Kai-Xin-San Protects Depression Mice Against CORT-Induced Neuronal Injury by Inhibiting Microglia Activation and Oxidative Stress
Bai, G., Jing, S., Cao, H., Qiao, Y., Chen, G., Duan, L., Yang, Y., Li, M., Li, W., Chang, X., et al. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/5845800 · Cited by 12
“demonstrated that complex I, III, and IV of ETC as well as creatine kinase were inhibited in depression rats’ cerebral cortex and cerebellum [53].”
Background
The reduced level of growth factors in an animal model of depression is accompanied by regulated necrosis in the frontal cortex but not in the hippocampus
Kucharczyk, M. W., Kurek, A., Pomierny, B., Detka, J., Papp, M., Tota-Glowczyk, K., & Budziszewska, B. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.008 · Cited by 11
Chronic fluoxetine or ketamine treatment differentially affects brain energy homeostasis which is not exacerbated in mice with trait suboptimal mitochondrial function
Emmerzaal, T. L., Jacobs, L., Geenen, B., Verweij, V. G. M., Morava, É., Rodenburg, R. J., & Kozicz, T. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14901 · Cited by 12
“Moreover, animal models for depression reported similar decreased mitochondrial function (Gong, Chai, Ding, Sun, & Hu, 2011; Madrigal et al., 2001; Rezin et al., 2008).”
Background
Osteocalcin Ameliorates CUMS ‐Induced Depressive‐Like Behaviors by Reducing Mitochondrial Damage in Hippocampal Neurons
Chen, H., Mao, J., Wang, M., Zhang, Q., Zheng, R., Zhang, Z., Lv, Q., Liu, Q., Wu, Y., & Ma, X. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70530 · Cited by 12
Paroxetine ameliorates changes in hippocampal energy metabolism in chronic mild stress-exposed rats
Abdel-Tawab, A. M., Khedr, L. H., Nassar, N. N., & Eldenshary, E. E.-D. S. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s87089 · Cited by 11
Composite carbohydrate interpenetrating polyelectrolyte nano-complexes (IPNC) as a controlled oral delivery system of citalopram HCl for pediatric use: in-vitro/in-vivo evaluation and histopathological examination
Kamel, R., Abbas, H., & El-Naa, M. M. (2018) · Drug Delivery and Translational Research · doi:10.1007/s13346-018-0506-8 · Cited by 10
Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue
Nielsen, B., Cejvanovic, V., Wörtwein, G., Hansen, A. R. E., Marstal, K., Weimann, A., Bjerring, P. N., Dela, F., Poulsen, H. E., & Jørgensen, M. B. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.09.061 · Cited by 10
“In comparison to a control group, the mitochondrial electron transfer system (ETS) of depressed patients has been found to have inhibited complexes [7,8], possibly”
Ameliorative Effect ofPimpinella anisumOil on Immunohistochemical and Ultrastuctural Changes of Cerebellum of Albino Rats Induced by Aspartame
Abdul‐Hamid, M., & Galaly, S. R. (2014) · Ultrastructural Pathology · doi:10.3109/01913123.2014.889259 · Cited by 10
“In addition, chronic mitochondrial alterations in cerebellum could be involved in occurrence of depression in rats [36].”
Background
Brain energy metabolism is increased by chronic administration of bupropion
Ferreira, G. K., Rezin, G. T., Cardoso, M. R., Gonçalves, C. L., Borges, L. S., Vieira, J. S., Gomes, L. M., Zugno, A. I., Quevedo, J., & STRECK, E. L. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00597.x · Cited by 9
“(45) also demonstrated that mitochondrial respiratory chain is inhibited in brain of rats after chronic variable stress (40 days), suggesting that energy metabolism impairment may occur in depressive disorders.”
BackgroundSelf-citation
The role of inflammation and oxidative stress in depression and cardiovascular disease
Wood, S. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815015-3.00008-8 · Cited by 9
Sex-specific Effects of Lipopolysaccharide on Hippocampal Mitochondrial Processes in Neuroinflammatory Model of Depression
Brkic, Z., Živanović, A., & Adžić, M. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.09.059 · Cited by 9
Comparative evaluation of natural neuroprotectives and their combinations on chronic immobilization stress-induced depression in experimental mice
Ibrahim, I. M., Alsieni, M., Almalki, S. G., Alqurashi, Y. E., & Kumar, V. (2022) · 3 Biotech · doi:10.1007/s13205-022-03438-2 · Cited by 8
Preclinical Considerations about Affective Disorders and Pain: A Broadly Intertwined, yet Often Under-Explored, Relationship Having Major Clinical Implications
Antioch, I., Ilie, O., Ciobica, A. S., Doroftei, B., & Fornaro, M. (2020) · Medicina · doi:10.3390/medicina56100504 · Cited by 9
Inflammation and Depression: Is Immunometabolism the Missing Link?
Dantzer, R., Casaril, A. M., & Vichaya, E. G. (2021) · Springer eBooks · doi:10.1007/978-3-030-71229-7_16 · Cited by 7
Glutamate-Glutamine Transfer and Chronic Stress-Induced Sex Differences in Cocaine Responses
Shimamoto, A., Rappeneau, V., Munjal, H., Farris, T., Davis, C. R., Wilson, A., Edwards, M., Moore, C., Reynolds, C., & Meshul, C. K. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.09.009 · Cited by 8
“Particularly, earlier studies have revealed an inhibition of the mitochondrial respiratory chain in the cortex of a rat model for MD that was reversed by ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist (Rezin et al., 2008; Rezin et al., 2009b).”
Common aspects of neuroplasticity, stress, mood disorders and mitochondrial functions
Hroudová, J., & Karlovu, K. (2010) · Cited by 6
Mitochondrial DNA m.13514G>A heteroplasmy is associated with depressive symptoms in the elderly
Tranah, G. J., Maglione, J. E., Yaffe, K. S., Katzman, S. M., Manini, T. M., Kritchevsky, S. B., Newman, A. B., Harris, T. B., Cummings, S. R., & for the Health, A. A. B. C. S. (2018) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4928 · Cited by 8
“This work demonstrated that mitochondrial respiratory chain complexes I, III, and IV were inhibited in the stress group but that complex II was not affected.(24) These results suggest that the impact of chronic stress on the pathophysiology on depressive disorders may be mediated through the mitochondrial DNA (mtDNA),…”
Background
Highly aggressive behavior induced by social stress is associated to reduced cytochrome c oxidase activity in mice brain cortex
Mendonça, A. P. M., Hoppe, L. Y., Gaviraghi, A., de Araújo-Jorge, T. C., de Oliveira, G. M., Mélo, R. M. F., de Oliveira, M. F., & Fragoso, V. M. D. S. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.03.017 · Cited by 7
“In rodent models of acute and chronic stresses, altered mitochondrial function, including inhibition of electron transport system (ETS), was associated to redox imbalance and apoptosis (Aboul-Fotouh, 2013; Filipović et al., 2011; Garabadu et al., 2015; Hollis et al., 2015; Picard et al., 2018; Rezin et al., 2008; van…”
Interaction of the Psychiatric Risk Gene Cacna1c With Post-weaning Social Isolation or Environmental Enrichment Does Not Affect Brain Mitochondrial Bioenergetics in Rats
Michels, S., Dolga, A. M., Braun, M. D., Kisko, T. M., Sungur, A. Ö., Witt, S. H., Rietschel, M., Dempfle, A., Wöhr, M., Schwarting, R. K. W., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00483 · Cited by 5
Molecular changes in hippocampal energy metabolism in mice selectively bred for extremes in stress reactivity: Relevance of mitochondrial dysfunction for affective disorders
Rappeneau, V., Koti, P. S., Wilmes, L., Widner-Andrä, R., Busch, K. B., & Touma, C. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16044 · Cited by 5
“In the SAGE study, we extended the gene expression analysis even more and found significant differences in a number of genes involved in oxidative phosphorylation, again supporting previous observations on chronic stress models (Rezin et al., 2008; Weger et al., 2020).”
Brain mitochondria as key drivers of cognition and behaviour
Sandi, C., Lobo, M. K., Hollis, F., Hirabayashi, Y., de Juan‐Sanz, J., & Bolaños, J. P. (2026) · Nature reviews. Neuroscience · doi:10.1038/s41583-026-01061-1 · Cited by 5
Mitochondrial function and stress resilience
Morató, L., & Sandi, C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813983-7.00009-4 · Cited by 5
Targeting ferroptosis as a novel strategy for depressive mental disorders
Qian, L., Yao, Q., Jiang, Y., Liu, W., Xiong, L., Shi, H., & Shi, Y. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06934-4 · Cited by 3
Current perspectives on circadian regulation of mitochondrial dynamics in mood disorders and perioperative stress
Verbal, F., Espinoza-Rubilar, N., Marileo, A. M., Fierro, H., Ramírez-Molina, O., Pinto-León, A., Yévenes, G. E., Fuentealba, J., & Panes-Fernández, J. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1723748 · Cited by 3
“Experimental models of depression in rats have demonstrated reduced activity of mitochondrial respiratory chain complexes, particularly Complexes I and IV (Rezin et al., 2008).”
Integrative Interventions for Improving Outcomes in Depression: A Narrative Review
Halma, M. T. J., Plothe, C., & Marik, P. E. (2024) · Psychology International · doi:10.3390/psycholint6020033 · Cited by 2
“In a rat model of depression, vital steps in the production of adenosine triphosphate (ATP) were inhibited in the cerebral cortex and cerebellum [347].”
Background
Complete mitochondrial DNA sequence analysis in patients with major depressive disorder
Yin, X., Fu, Y., Yu, H., Wang, F., Zhang, Q., Xu, Y., Cao, M., Mei, X., & Pan, J. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120206 · Cited by 3
Effects of maintenance electroshock on mitochondrial respiratory chain and creatine kinase activities in the rat brain
Réus, G. Z., Stringari, R. B., Rezin, G. T., Pezente, D. P., Scaini, G., Maggi, D. D., De-Nês, B. T., STRECK, E. L., Quevedo, J., & Feier, G. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00629.x · Cited by 3
Self-citation
Mitochondrial dysfunction and affective disorders: Focus on diet, exercise, and aging
Allen, J., Kalynchuk, L. E., & Caruncho, H. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85666-9.00017-6 · Cited by 3
Dietary Xylitol Supplement Ameliorated AD-related Neuronal Injury by Regulating Glucose Metabolism Relevant Amino Acids in Mice
Jin, M., Ji, X., Zhu, X., Shou, Y., Ge, Z., & Wang, H. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666220922112955 · Cited by 3
Creatine and α-lipoic acid improved behavioral parameters of depression induced by dexamethasone in mice
Mesripour, A., MUSAVİE, K., & Hajhashemi, V. (2021) · Hacettepe University Journal of the Faculty of Pharmacy · doi:10.52794/hujpharm.902264 · Cited by 2
Repeated Forced-Swim Stress Modulates Neural Structure and Hepatic Gene Expression in the Stressed Mice Model
Asif, A., Batool, R., Arhum, S., Ashraf, A., Iqbal, M. Z., Mehmood, A., Klar, A. S., & Mustafa, M. (2025) · Neuropsychobiology · doi:10.1159/000550173 · Cited by 1
Impaired mitochondrial bioenergetics in psychiatric disorders
Petschner, P., Gál, Z., & Gonda, X. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819621-2.00008-5 · Cited by 1
Antidepressants, mood-stabilizing drugs, and mitochondrial functions: For better or for worse
Preston, G. J., Sabbagh, D. E. S. E., Emmerzaal, T. L., Morava, É., Andreazza, A. C., Rahman, S., & Kozicz, T. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-88462-4.00016-x · Cited by 1
Metabolic Syndrome as a Risk Factor for Depression
Farooqui, A. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7318-3_9
UNIVERSIDADE FEDERAL DE SANTA CATARINA CENTRO DE CIÊNCIAS BIOLÓGICAS PÓS-GRADUAÇÃO EM NEUROCIÊNCIAS
Cunha, M. P. (2013)
Article Open Access
Lawford‐Smith, H. (2015)
Stress: A deadly weapon
Peñagarikano, O. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aal3703
A new index of psychological stress reaction: Mitochondrial DNA
Suo, L., & Liu, Z. (2019) · Psychology of China · doi:10.35534/pc.0107028
Caracterização do proteoma mitocondrial e nuclear de células neurais derivadas de iPSCs de pacientes com esquizofrenia
Zuccoli, G. S. (2018) · doi:10.47749/t/unicamp.2018.1065811
Can Mood-Stabilizing Agents Increase the Activity of Complexes I and II of the Electron Transport Chain and the Level of Two Tricarboxylic Acid Cycle Enzymes in Euthymic Bipolar Patients during the Early and Late Stages of the Disease?Preprint
Cyrino, L. A. R., de Lima, D. D., Rezin, G. T., Ferreira, G. K., Ramos, S. A., Magro, D. D. D., Cavichioli, N., Ullmann, O. M., Mayer, Y., de Oliveira, M. P., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1264378/v1
Self-citation
Crackle sounds and lung recruitment
Szalay, B. (2012) · doi:10.14232/phd.1422
FGF21 restores hippocampual mitochondrial dysfunction via enhancing Nrf2/HO-1 and AMPK/SirT1/PGC-1α signaling pathways to alleviate chronic unpredictable mild stress induced depressive like behaviors in micePreprint
Zhao, Y., Shen, L., Zhang, Y., Zhang, L., Jin, L., Chen, S., Song, C., Hu, C., & Liu, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-1003374/v1
Trajectories of Depressive Individual Symptoms over Time during Transcranial Photobiomodulation
Urata, M., Cassano, P., Norton, R., Sylvester, K. W., Watanabe, K., Iosifescu, D. V., & Sakurai, H. (2023) · Photonics · doi:10.3390/photonics10121324
“AC, available case; LOCF, last observation carried forward; t-PBM, transcranial photobiomodulation.”
Background
Rodent models of posttraumatic stress disorder
Pinna, G. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29090-9.00015-5
Serum cell-free mitochondrial DNA under a highly standardized and controlled stress induction
Herhaus, B., Daubermann, C., Neuberger, E. W. I., Simon, P. D., & Petrowski, K. (2026) · Mitochondrion · doi:10.1016/j.mito.2026.102113
Effect of Ashwagandha (Withania somnifera) on cardiac aquaporins in adolescent rats under a chronic unpredictable mild stress model
Baksi, N., Gökdemir, G. Ş., ALKLAY, A. A., & Karakoç, Z. (2026) · Polish Journal of Veterinary Sciences · doi:10.24425/pjvs.2026.1267
“Rezin et al. (2008), con - sistent with the present study, found no significant changes in CK levels.”
Photobiomodulation: multifaceted therapeutic effects on disorders in the central nervous system
Xiong, W., Su, Y., Chen, H., Verkhratsky, A., & Yi, C. (2026) · Clinical Science · doi:10.1042/cs20261472
Mechanistic advances in exercise intervention for anxiety and depression via regulation of mitochondrial function
杨荣娇, Tang, X., Shi, Y., Sun, J., Yin, Q., & Long, Q. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111972
Intranasal Human Olfactory Mucosa-Derived Neural Stem Cells Restore Neuroplasticity and Suppress Neuroinflammation in a Rat Model of Chronic Stress-Induced DepressionPreprint
Naghizadeh, F., Niknazar, S., Dadseresht, A., Seidkhani, E., Alizadeh, R., & Arezo, N. (2026) · Research Square · doi:10.21203/rs.3.rs-11106755/v1
Antidepressants, mood-stabilizing drugs, and mitochondrial function: For better or for worse
Preston, G. J., Sabbagh, D. E. S. E., Emmerzaal, T. L., Morava, É., Andreazza, A. C., Rahman, S., & Kozicz, T. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45078-5.00040-3

Authors: Rezin, G. T., Cardoso, M. R., Gonçalves, C. L., Scaini, G., Fraga, D. B., Riegel, R. E., Comim, C. M., Quevedo, J., & Streck, E. L.
Affiliations: Universidade do Extremo Sul Catarinense (BR)
Corresponding author: Streck, Emilio L.
ORCID: Rezin, Gislaine T.
Gonçalves, Cinara L.
Scaini, Giselli
Riegel, Rafael E.
Comim, Clarissa M.
Quevedo, João
Streck, Emilio L.
Venue: Neurochemistry International
Publisher: Elsevier BV
Published: 2008-12
Volume: 53
Issue: 6-8
Pages: 395-400
ISSN: 0197-0186 (ISSN-L)
DOI: 10.1016/j.neuint.2008.09.012
OpenAlex: W1996982207
Cited by: 197
References: 63
Citations by year: 2026: 8 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 19 · 2019: 21 · 2018: 20 · 2017: 11 · 2016: 14 · 2015: 7 · 2014: 12 · 2013: 9 · 2012: 7
FWCI: 7.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurochemistry International (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: depression, chronic stress, mitochondrial respiratory chain, mitochondrial complex I inhibition, complex III inhibition, complex IV inhibition, creatine kinase, brain energy metabolism, cerebral cortex, cerebellum, adrenal weight, sweets consumption, rat model of depression
MeSH terms: Adrenal Glands, Animals, Appetite Regulation, Body Weight, Brain, Brain Diseases, Metabolic, Chronic Disease, Creatine Kinase, Depressive Disorder, Disease Models, Animal, Electron Transport, Energy Metabolism, Male, Mitochondria, Organ Size, Oxidative Phosphorylation, Stress, Psychological, Biomarkers, Down-Regulation, Rats, Wistar, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks