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Cited by 485

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

Open access
Karuppagounder, Saravanan S., Pinto, John T., Xu, Hui, Chen, Huan-Lian, Beal, M. Flint, Gibson, Gary E.·2009·Neurochemistry International
DOI 10.1016/j.neuint.2008.10.008
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Abstract

Resveratrol, a polyphenol found in red wine, peanuts, soy beans, and pomegranates, possesses a wide range of biological effects. Since resveratrol’s properties seem ideal for treating neurodegenerative diseases, its ability to diminish amyloid plaques was tested. Mice were fed clinically feasible dosages of resveratrol for forty-five days. Neither resveratrol nor its conjugated metabolites were detectable in brain. Nevertheless, resveratrol diminished plaque formation in a region specific manner. The largest reductions in the percent area occupied by plaques were observed in medial cortex (−48%), striatum (−89%) and hypothalamus (−90%). The changes occurred without detectable activation of SIRT-1 or alterations in APP processing. However, brain glutathione declined 21% and brain cysteine increased 54%. The increased cysteine and decreased glutathione may be linked to the diminished plaque formation. This study supports the concept that onset of neurodegenerative disease may be delayed or mitigated with use of dietary chemo-preventive agents that protect against β-amyloid induced neuronal damage.

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Metadata

Authors
Karuppagounder, S. S., Pinto, J. T., Xu, H., Chen, H.-L., Beal, M. F., & Gibson, G. E.
Venue
Neurochemistry International
Publisher
Elsevier BV
Published
2009-02
Volume
54
Issue
2
Pages
111-118
ISSN
0197-0186 (ISSN-L)
DOI
10.1016/j.neuint.2008.10.008
OpenAlex
W2094789916
Cited by
485
References
61
FWCI
16.69
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. https://app.cochat.ai/papers/10.1016/j.neuint.2008.10.008
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Karuppagounder, S. S., Pinto, J. T., Xu, H., Chen, H.-L., Beal, M. F., & Gibson, G. E. (2009). Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochemistry International. https://doi.org/10.1016/j.neuint.2008.10.008

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.