Resveratrol: French Paradox Revisited

Catalgol, Betul; Batirel, Saime; Taga, Yavuz; Ozer, Nesrin Kartal

doi:10.3389/fphar.2012.00141

Cited by 449Sirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant ActivitiesAlcohol Consumption and Health Effects

Resveratrol: French Paradox Revisited

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Catalgol, Betul, Batirel, Saime, Taga, Yavuz, Ozer, Nesrin Kartal·2012·Frontiers in Pharmacology

DOI 10.3389/fphar.2012.00141PMC PMC3398412

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Abstract

Resveratrol is a polyphenol that plays a potentially important role in many disorders and has been studied in different diseases. The research on this chemical started through the "French paradox," which describes improved cardiovascular outcomes despite a high-fat diet in French people. Since then, resveratrol has been broadly studied and shown to have antioxidant, anti-inflammatory, anti-proliferative, and anti-angiogenic effects, with those on oxidative stress possibly being most important and underlying some of the others, but many signaling pathways are among the molecular targets of resveratrol. In concert they may be beneficial in many disorders, particularly in diseases where oxidative stress plays an important role. The main focus of this review will be the pathways affected by resveratrol. Based on these mechanistic considerations, the involvement of resveratrol especially in cardiovascular diseases, cancer, neurodegenerative diseases, and possibly in longevity will be is addressed.

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Resveratrol has been associated with the so-called "French paradox", based on epidemiological data from the French population known for the low incidence of cardiovascular diseases despite the consumption of a high-fat diet.
“Resveratrol has been associated with the so-called “French paradox”, which has been reported in 1992, based on epidemiological data from the French population known for the low incidence of cardiovascular diseases despite the consumption of a high-fat diet (Catalgol et al. 2012).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Catalgol et al. 2012
Low incidence of cardiovascular diseases has been linked to the consumption of red wine containing a high concentration of resveratrol, a multipurpose molecule possessing various beneficial and health-protecting properties, involving antioxidant and antitumor properties.
“A low incidence of cardiovascular diseases has been linked to the consumption of red wine containing a high concentration of resveratrol, a multipurpose molecule possessing various beneficial and health-protecting properties, involving antioxidant, and antitumor properties.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Catalgol et al. 2012

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Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525 · see citing works
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935 · see citing works
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290 · see citing works
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796 · see citing works
Wine, alcohol, platelets, and the French paradox for coronary heart disease
Renaud, S., & de Lorgeril, M. (1992) · The Lancet · doi:10.1016/0140-6736(92)91277-f · Cited by 3,654 · see citing works
Reactive oxygen species, antioxidants, and the mammalian thioredoxin system1 1This review is based on the licentiate thesis “Thioredoxin reductase—interactions with the redox active compounds 1-chloro-2,4-dinitrobenzene and lipoic acid” by Jonas Nordberg, 2001, Karolinska Institute, Stockholm, ISBN 91-631-1064-4.
Nordberg, J., & Arnér, E. S. J. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00724-9 · Cited by 2,671 · see citing works
Role of Oxidative Modifications in Atherosclerosis
Stocker, R., & Keaney, J. F. (2004) · Physiological Reviews · doi:10.1152/physrev.00047.2003 · Cited by 2,611 · see citing works
World Cancer Report
Stewart, B. W., & Kleihues, P. (2003) · Cited by 2,389 · see citing works
Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
Tsujii, M., & DuBois, R. N. (1995) · Cell · doi:10.1016/0092-8674(95)90127-2 · Cited by 2,292 · see citing works
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.
Miyashita, T., Krajewski, S., Krajewska, M., Wang, H., Lin, H., Liebermann, D. A., Hoffman‐Liebermann, B., & Reed, J. C. (1994) · PubMed · Cited by 2,143 · see citing works
HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS
Walle, T., Hsieh, F., DeLegge, M. H., Oatis, J. E., & Walle, U. K. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.000885 · Cited by 1,893 · see citing works
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868 · see citing works
Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.
Aggarwal, B. B., Bhardwaj, A., Aggarwal, R. S., Seeram, N. P., Shishodia, S., & Takada, Y. (2004) · PubMed · Cited by 1,383 · see citing works
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
Park, S. J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.017 · Cited by 1,352 · see citing works
L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation
Palmer, R. M. J., Rees, D. D., Ashton, D. S., & Moncada, S. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81362-7 · Cited by 1,348 · see citing works
Alcohol consumption and mortality among middle-aged and elderly U.S. adults
Thun, M. J., Peto, R., Lopez, A. D., Monaco, J. H., Henley, S. J., Heath, C. W., & Doll, R. (1997) · New England Journal of Medicine · doi:10.1056/nejm199712113372401 · Cited by 1,313 · see citing works
Nitric Oxide Synthases: Properties and Catalytic Mechanism
Griffith, O. W., & Stuehr, D. J. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003423 · Cited by 1,311 · see citing works
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
Pearson, K. J., Baur, J. A., Lewis, K. N., Peshkin, L., Price, N. L., Labinskyy, N., Swindell, W. R., Kamara, D., Minor, R. K., Perez, E., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.011 · Cited by 1,162 · see citing works
Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor
Gehm, B. D., McAndrews, J. M., Chien, P.-Y., & Jameson, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14138 · Cited by 1,053 · see citing works
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
Pacholec, M., Bleasdale, J. E., Chrunyk, B., Cunningham, D., Flynn, D., Garofalo, R. S., Griffith, D., Griffor, M., Loulakis, P., Pabst, B., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.088682 · Cited by 915 · see citing works
Resveratrol: A molecule whose time has come? And gone?
Soleas, G. J., Diamandis, E. P., & Goldberg, D. M. (1997) · Clinical Biochemistry · doi:10.1016/s0009-9120(96)00155-5 · Cited by 847 · see citing works
Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent
Boocock, D. J., Faust, G. E. S., Patel, K. R., Schinas, A. M., Brown, V. A., Ducharme, M. P., Booth, T. D., Crowell, J. A., Perloff, M., Gescher, A. J., et al. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0022 · Cited by 823 · see citing works
CSF-1 regulation of the wandering macrophage: complexity in action
Pixley, F. J., & Stanley, E. R. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.09.016 · Cited by 807 · see citing works
Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate
Valenzano, D. R., Tozzini, E. T., Genade, T., Cattaneo, A., Domenici, L., & Cellerino, A. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.038 · Cited by 786 · see citing works
Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides
Marambaud, P., Zhao, H., & Davies, P. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508246200 · Cited by 750 · see citing works
Absorption of three wine-related polyphenols in three different matrices by healthy subjects
Goldberg, D. M., Yan, J., & Soleas, G. J. (2003) · Clinical Biochemistry · doi:10.1016/s0009-9120(02)00397-1 · Cited by 685 · see citing works
Resveratrol, a Polyphenolic Phytoalexin Present in Red Wine, Enhances Expression and Activity of Endothelial Nitric Oxide Synthase
Wallerath, T., Deckert, G., Ternes, T. A., Anderson, H., Li, H., Witte, K. K., & Förstermann, U. (2002) · Circulation · doi:10.1161/01.cir.0000029925.18593.5c · Cited by 665 · see citing works
Mortality associated with moderate intakes of wine, beer, or spirits
Grønbæk, M., Deis, A., Sørensen, T. I. A., Becker, U., Schnohr, P., & Jensen, G. B. (1995) · BMJ · doi:10.1136/bmj.310.6988.1165 · Cited by 649 · see citing works
Colony-stimulating factor-1 in immunity and inflammation
Chitu, V., & Stanley, E. R. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.11.006 · Cited by 635 · see citing works
New insights on the anticancer properties of dietary polyphenols
Fresco, P., Borges, F., Diniz, C., & Marques, M. P. M. (2006) · Medicinal Research Reviews · doi:10.1002/med.20060 · Cited by 552 · see citing works
Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes
Hung, L. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00102-4 · Cited by 542 · see citing works
Cancer Prevention and Treatment with Resveratrol: From Rodent Studies to Clinical Trials
Bishayee, A. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0160 · Cited by 530 · see citing works
Type of Alcohol Consumed and Mortality from All Causes, Coronary Heart Disease, and Cancer
Grønbæk, M., Becker, U., Johansen, D., Gottschau, A., Schnohr, P., Hein, H. O., Jensen, G., & Sørensen, T. I. A. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-6-200009190-00008 · Cited by 525 · see citing works
Clinical trials of resveratrol
Patel, K. R., Scott, E. N., Brown, V. A., Gescher, A. J., Steward, W. P., & Brown, K. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05853.x · Cited by 524 · see citing works
Suppression of nitric oxide synthase and the down‐regulation of the activation of NFκB in macrophages by resveratrol
Tsai, S., Lin‐Shiau, S., & Lin, J. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702357 · Cited by 512 · see citing works
Wine Phenolics
Waterhouse, A. L. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02903.x · Cited by 494 · see citing works
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease
Karuppagounder, S. S., Pinto, J. T., Xu, H., Chen, H., Beal, M. F., & Gibson, G. E. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.008 · Cited by 488 · see citing works
Metabolism and Disposition of Resveratrol in Rats: Extent of Absorption, Glucuronidation, and Enterohepatic Recirculation Evidenced by a Linked-Rat Model
Marier, J., Vachon, P., Gritsas, A., Zhang, J., Moreau, J., & Ducharme, M. P. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.033340 · Cited by 480 · see citing works
Cyclooxygenase-2 and carcinogenesis
Prescott, S. M., & Fitzpatrick, F. A. (2000) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(00)00006-8 · Cited by 476 · see citing works
Biological activity of piceatannol: Leaving the shadow of resveratrol
PIOTROWSKA, H., Kucińska, M., & Murias, M. (2011) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2011.11.001 · Cited by 476 · see citing works
Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives
Kundu, J. K., & Surh, Y. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.057 · Cited by 472 · see citing works
The LDL modification hypothesis of atherogenesis: an update
Steinberg, D. H. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800087-jlr200 · Cited by 452 · see citing works
A Review of the Effects and Mechanisms of Polyphenolics in Cancer
Nichenametla, S. N., Taruscio, T. G., Barney, D. L., & Exon, J. H. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390591000541 · Cited by 446 · see citing works
Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans
Bass, T. M., Weinkove, D., Houthoofd, K., Gems, D., & Partridge, L. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.07.007 · Cited by 435 · see citing works
Pharmacokinetic and safety profile oftrans‐resveratrol in a rising multiple‐dose study in healthy volunteers
Almeida, L., Vaz‐da‐Silva, M., Falcão, A. C., Soares, E., Costa, R., Loureiro, A. I., Fernandes‐Lopes, C., Rocha, J., Nunes, T., Wright, L. C., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800177 · Cited by 427 · see citing works
Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9.
Banerjee, S., Bueso-Ramos, C., & Aggarwal, B. B. (2002) · PubMed · Cited by 423 · see citing works
Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation
Kennedy, D. O., Wightman, E. L., Reay, J. L., Lietz, G., Okello, E. J., Wilde, A., & Haskell, C. F. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28641 · Cited by 415 · see citing works
Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats
Su, H., Hung, L., & Chen, J.-K. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00487.2005 · Cited by 410 · see citing works
Role of Monocytes in Atherogenesis
Østerud, B., & Bjørklid, E. (2003) · Physiological Reviews · doi:10.1152/physrev.00005.2003 · Cited by 408 · see citing works
The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1
Potter, G. A., Patterson, L. H., Wanogho, E., Perry, P. J., Butler, P. C., Ijaz, T., Ruparelia, K. C., Lamb, J. H., Farmer, P. B., Stanley, L. A., et al. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600197 · Cited by 380 · see citing works
Inflammatory Reactions in the Pathogenesis of Atherosclerosis
Fan, J., & Watanabe, T. (2003) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.10.63 · Cited by 357 · see citing works
Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats
Sinha, K., Chaudhary, G., & Gupta, Y. K. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01691-0 · Cited by 356 · see citing works
Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo
Garvin, S., Öllinger, K. M., & Dabrosin, C. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.01.031 · Cited by 351 · see citing works
Resveratrol—A boon for treating Alzheimer's disease?
Anekonda, T. S. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.04.004 · Cited by 341 · see citing works
Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids
Frémont, L., Belguendouz, L., & Delpal, S. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00209-x · Cited by 336 · see citing works
Resveratrol Modulates Drug- and Carcinogen-Metabolizing Enzymes in a Healthy Volunteer Study
Chow, H. ‐. S., Garland, L. L., Hsu, C., Vining, D. R., Chew, W. M., Miller, J. A., Perloff, M., Crowell, J. A., & Alberts, D. S. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0155 · Cited by 333 · see citing works
Oxidized low-density lipoprotein-induced apoptosis
Salvayre, R., Augè, N., Benoist, H., & Nègre‐Salvayre, A. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00343-8 · Cited by 329 · see citing works
Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats
Sharma, M., & Gupta, Y. K. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02083-0 · Cited by 326 · see citing works
Apoptosis: definition, mechanisms, and relevance to disease
Saikumar, P., Dong, Z., Mikhailov, V. M., Denton, M. L., Weinberg, J. M., & Venkatachalam, M. A. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00259-4 · Cited by 326 · see citing works
Improving solubility and chemical stability of natural compounds for medicinal use by incorporation into liposomes
Coimbra, M., Isacchi, B., van Bloois, L., Toraño, J. S., Ket, A., Wu, X., Broere, F., Metselaar, J. M., Rijcken, C. J. F., Storm, G., et al. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.01.056 · Cited by 324 · see citing works
SIRT1, Is It a Tumor Promoter or Tumor Suppressor?
Deng, C. (2009) · International Journal of Biological Sciences · doi:10.7150/ijbs.5.147 · Cited by 323 · see citing works
Human, Rat, and Mouse Metabolism of Resveratrol
Yu, C., Shin, Y. G., Chow, A. W., Li, Y., Kosmeder, J. W., Lee, Y. S., Hirschelman, W. H., Pezzuto, J. M., Mehta, R. G., & van Breemen, R. B. (2002) · Pharmaceutical Research · doi:10.1023/a:1021414129280 · Cited by 322 · see citing works
Potent inhibitory action of red wine polyphenols on human breast cancer cells
Damianaki, A., Bakogeorgou, E., Kampa, M., Notas, G., Hatzoglou, A., Panagiotou, S., Gemetzi, C., Kouroumalis, E., Martin, P., & Castanas, E. (2000) · Journal of Cellular Biochemistry · doi:10.1002/1097-4644(20000901)78:3 · Cited by 316 · see citing works
Resveratrol protects primary rat hepatocytes against oxidative stress damage:
Rubiolo, J. A., Mithieux, G., & Vega, F. V. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.067 · Cited by 315 · see citing works
Bioavailability oftrans-resveratrol from red wine in humans
Vitaglione, P., Sforza, S., Galaverna, G., Ghidini, C., Caporaso, N., Vescovi, P. P., Fogliano, V., & Marchelli, R. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500002 · Cited by 313 · see citing works
Resveratrol Isolated from Polygonum cuspidatum Root Prevents Tumor Growth and Metastasis to Lung and Tumor-Induced Neovascularization in Lewis Lung Carcinoma-Bearing Mice
Kimura, Y., & Okuda, H. (2001) · Journal of Nutrition · doi:10.1093/jn/131.6.1844 · Cited by 311 · see citing works
Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology
Pappolla, M. A., Bryant‐Thomas, T., Herbert, D., Pacheco, J., Garcia, M. F., Manjón, M., Gironès, X., Henry, T. L., Matsubara, E., Zambón, D., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000070182.02537.84 · Cited by 308 · see citing works
Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure–activity relationship
Murias, M., Jäger, W. R., Handler, N., Erker, T., Bagó-Horváth, Z., Szekeres, T., Nohl, H., & Gille, L. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.12.001 · Cited by 304 · see citing works
Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins
Belguendouz, L., Frémont, L., & Linard, A. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00820-9 · Cited by 300 · see citing works
Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure–activity relationship
Murias, M., Handler, N., Erker, T., Pleban, K., Ecker, G. F., Saiko, P., Szekeres, T., & Jäger, W. R. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.08.008 · Cited by 288 · see citing works
Antimicrobial effect of resveratrol on dermatophytes and bacterial pathogens of the skin
Chan, M. M.-Y. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00886-3 · Cited by 287 · see citing works
Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor.
Ciolino, H. P., Daschner, P. J., & Yeh, G. C. (1998) · PubMed · Cited by 283 · see citing works
Urinary and Plasma Levels of Resveratrol and Quercetin in Humans, Mice, and Rats after Ingestion of Pure Compounds and Grape Juice
Meng, X., Maliakal, P. P., Lu, H., Lee, M., & Yang, C. S. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030582e · Cited by 281 · see citing works
Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration
Vitrac, X., Desmoulière, A., Brouillaud, B., Krisa, S., Deffieux, G., Barthe, N., Rosenbaum, J., & Mérillon, J. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00096-1 · Cited by 280 · see citing works
Effects of stilbenes on arachidonate metabolism in leukocytes
Kimura, Y., Hiromichi, O., & Arichi, S. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90167-5 · Cited by 273 · see citing works
The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors
Malarkey, K., BELHAM, C. M., Paul, A., Graham, A. M., McLees, A., Scott, P., & Plevin, R. J. (1995) · Biochemical Journal · doi:10.1042/bj3090361 · Cited by 268 · see citing works
Resveratrol increases nitric oxide synthase, induces accumulation of p53 and p21(WAF1/CIP1), and suppresses cultured bovine pulmonary artery endothelial cell proliferation by perturbing progression through S and G2.
Hsieh, T. C., Juan, G., Darżynkiewicz, Z., & WU, J. M. (1999) · PubMed · Cited by 262 · see citing works
Steady-State Pharmacokinetics and Tolerability of Trans-Resveratrol 2000 mg Twice Daily with Food, Quercetin and Alcohol (Ethanol) in Healthy Human Subjects
la Porte, C., Voduc, N., Zhang, G., Seguin, I., Tardiff, D. C., Singhal, N., & Cameron, D. W. (2010) · Clinical Pharmacokinetics · doi:10.2165/11531820-000000000-00000 · Cited by 261 · see citing works
Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxide1
Stokes, K. Y., Cooper, D., Tailor, A., & Granger, D. N. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01015-8 · Cited by 258 · see citing works
Effects of resveratrol on the rat brain respiratory chain.
Zini, R., Morin, C., Bertelli, A., Bertelli, A., & Tillement, J. P. (1999) · PubMed · Cited by 252 · see citing works
Effects of Resveratrol in Inflammatory Arthritis
Elmali, N., Baysal, Ö., Harma, A., Esenkaya, İ., & Mızrak, B. (2006) · Inflammation · doi:10.1007/s10753-006-9012-0 · Cited by 251 · see citing works
p53 and its isoforms in cancer
Bourdon, J. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603886 · Cited by 245 · see citing works
Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats
Schmatz, R., Mazzanti, C. M. D. A., Spanevello, R. M., Stefanello, N., Gutierres, J. M., Corrêa, M., da Rosa, M. M., Rubin, M. A., Schetinger, M. R. C., & Morsch, V. M. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.03.032 · Cited by 241 · see citing works
Effect of trans‐resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function
Rotondo, S., Rajtar, G., Manarini, S., Celardo, A., Rotilio, D., de Gaetano, G., Evangelista, V., & Cerletti, C. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701784 · Cited by 241 · see citing works
Resveratrol increases vascular oxidative stress resistance
Ungvari, Z. I., Orosz, Z. Z., Rivera, A., Labinskyy, N., Xiangmin, Z., Olson, S. C., Podlutsky, A. J., & Csiszár, A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01258.2006 · Cited by 239 · see citing works
Alcohol and the Cardiovascular System
Lucas, D. L., Brown, R. A., Wassef, M. K., & Giles, T. D. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.075 · Cited by 238 · see citing works
Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation
Ashikawa, K., Majumdar, S., Banerjee, S., Bharti, A. C., Shishodia, S., & Aggarwal, B. B. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.11.6490 · Cited by 238 · see citing works
SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus
Satoh, A., Brace, C. S., Ben-Josef, G., West, T., Wozniak, D. F., Holtzman, D. M., Herzog, E. D., & Imai, S.-I. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1385-10.2010 · Cited by 237 · see citing works
Bioactivity and metabolism oftrans-resveratrol orally administered to Wistar rats
Wenzel, E., Soldo, T., Erbersdobler, H. F., & Somoza, V. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500003 · Cited by 236 · see citing works
Metabolic engineering of the complete pathway leading to heterologous biosynthesis of various flavonoids and stilbenoids in Saccharomyces cerevisiae
Trantas, E., Panopoulos, N. J., & Ververidis, F. (2009) · Metabolic Engineering · doi:10.1016/j.ymben.2009.07.004 · Cited by 234 · see citing works
Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats
Periyasamy, P., & Subramanian, S. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.06.037 · Cited by 229 · see citing works
Wine, Liquor, Beer, and Mortality
Klatsky, A. L. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg184 · Cited by 228 · see citing works
Wine, Beer, and Mortality in Middle-aged Men From Eastern France
Renaud, S., Gueguen, R., Siest, G., & Salamon, R. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.16.1865 · Cited by 214 · see citing works
Resveratrol inhibition of herpes simplex virus replication
Docherty, J. J., Fu, M., Stiffler, B. S., Limperos, R. J., Pokabla, C. M., & DeLucia, A. L. (1999) · Antiviral Research · doi:10.1016/s0166-3542(99)00042-x · Cited by 212 · see citing works
Protective effects of resveratrol on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells
Jang, J., & Surh, Y. (2001) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(01)00233-9 · Cited by 209 · see citing works
Does a glass of red wine improve endothelial function?
Agewall, S. (2000) · European Heart Journal · doi:10.1053/euhj.1999.1759 · Cited by 207 · see citing works
The role of oxidative stress in atherosclerosis.
Vogiatzi, G., Tousoulis, D., & Stefanadis, C. (2009) · PubMed · Cited by 198 · see citing works
Resveratrol transport and metabolism by human intestinal Caco-2 cells
Kaldas, M. I., Walle, U. K., & Walle, T. (2003) · Journal of Pharmacy and Pharmacology · doi:10.1211/002235702612 · Cited by 189 · see citing works
Resveratrol inhibits human breast cancer cell growth and may mitigate the effect of linoleic acid, a potent breast cancer cell stimulator
Nakagawa, H., Kiyozuka, Y., Uemura, Y., Senzaki, H., Shikata, N., Hioki, K., & Tsubura, A. (2001) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s004320000190 · Cited by 181 · see citing works
Effects of resveratrol and other wine polyphenols on vascular function: an update
Gresele, P., Cerletti, C., Guglielmini, G., Pignatelli, P., de Gaetano, G., & Violi, F. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.07.004 · Cited by 178 · see citing works
Resveratrol, a Polyphenolic Phytoalexin, Attenuates Diabetic Nephropathy in Rats
Sharma, S., Anjaneyulu, M., Kulkarni, S., & Chopra, K. (2005) · Pharmacology · doi:10.1159/000089720 · Cited by 177 · see citing works
Resveratrol enhances GLUT‐4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium
Penumathsa, S. V., Thirunavukkarasu, M., Zhan, L., Maulik, G., Menon, V. P., Bagchi, D., & Maulik, N. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00251.x · Cited by 175 · see citing works
Resveratrol: From Basic Science to the Clinic
Cucciolla, V., Borriello, A., Oliva, A., Galletti, P., Zappia, V., & Ragione, F. D. (2007) · Cell Cycle · doi:10.4161/cc.6.20.4815 · Cited by 174 · see citing works
Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium
Ferrero, M. E., Bertelli, A. A. E., Fulgenzi, A., Pellegatta, F., Romanelli, M. M. C., Bonfrate, M., Ferrara, F., Caterina, R. D., Giovannini, L., & Bertelli, A. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.6.1208 · Cited by 173 · see citing works
Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol
Olson, E. R., Naugle, J. E., Zhang, X., Bomser, J. A., & Meszaros, J. G. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00763.2004 · Cited by 173 · see citing works
Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts
Wieder, T., Prokop, A., Bagci, B., Eßmann, F., Bernicke, D., Schulze‐Osthoff, K., Dörken, B., Schmalz, H.-G., Daniel, P., & Henze, G. (2001) · Leukemia · doi:10.1038/sj.leu.2402284 · Cited by 171 · see citing works
Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol
Li, Z. (2002) · Carcinogenesis · doi:10.1093/carcin/23.9.1531 · Cited by 169 · see citing works
Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms
Kumar, P., Padi, S. S., Naidu, P. S., & Kumar, A. (2006) · Behavioural Pharmacology · doi:10.1097/00008877-200609000-00014 · Cited by 167 · see citing works
Human hepatic cell uptake of resveratrol: involvement of both passive diffusion and carrier-mediated process
Lançon, A., Delma, D., Osman‐Ponchet, H., Thenot, J. P., & Latruffe, N. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.164 · Cited by 166 · see citing works
Alcohol Consumption and Risk of Ischemic Stroke
Djoussé, L., Ellison, R. C., Beiser, A., Scaramucci, A., D’Agostino, R. B., & Wolf, P. A. (2002) · Stroke · doi:10.1161/hs0402.105245 · Cited by 166 · see citing works
Hydroxytyrosol Excretion Differs between Rats and Humans and Depends on the Vehicle of Administration
Visioli, F., Galli, C., Grande, S., et al. (2003) · Journal of Nutrition · doi:10.1093/jn/133.8.2612 · Cited by 166 · see citing works
Resveratrol- induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells
Kuo, P., Chiang, L., & Lin, C. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02177-x · Cited by 165 · see citing works
Evidence for a Trade‐Off between Survival and Fitness Caused by Resveratrol Treatment of Caenorhabditis elegans
Gruber, J., Tang, S. Y., & Halliwell, B. B. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.059 · Cited by 163 · see citing works
Effect of acute intake of red wine on flow-mediated vasodilatation of the brachial artery
Hashimoto, M., Kim, S., Eto, M., Iijima, K., Ako, J., Yoshizumi, M., Akishita, M., Kondo, K. N., Itakura, H., Hosoda, K., et al. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)02137-3 · Cited by 159 · see citing works
A new insight into resveratrol as an atheroprotective compound: Inhibition of lipid peroxidation and enhancement of cholesterol efflux
Berrougui, H., Grenier, G., Loued, S., Drouin, G., & Khalil, A. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.05.017 · Cited by 157 · see citing works
Oxidative stress and vascular remodelling
Fortuño, A., José, G. S., Moreno, M. U., Dı́ez, J., & Zalba, G. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2005.030098 · Cited by 155 · see citing works
Resveratrol Induced Serine Phosphorylation Of p53 Causes Apoptosis In A Mutant p53 Prostate Cancer Cell Line
Lin, H., Shih, A., Davis, F. B., Tang, H.-Y., Martino, L. J., Bennett, J. A., & Davis, P. J. (2002) · The Journal of Urology · doi:10.1016/s0022-5347(05)64739-8 · Cited by 155 · see citing works
Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels.
Wang, Z., Zou, J., Cao, K., Hsieh, T., Huang, Y., & WU, J. M. (2005) · PubMed · Cited by 152 · see citing works
Germination of Peanut Kernels to Enhance Resveratrol Biosynthesis and Prepare Sprouts as a Functional Vegetable
Wang, K.-H., Lai, Y.-H., Chang, J., Ko, T.-F., Shyu, S., & Chiou, R. Y. ‐. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048804b · Cited by 151 · see citing works
Resveratrol and vitamin C as antioxidants in blood platelets
Olas, B., & Wachowicz, B. (2002) · Thrombosis Research · doi:10.1016/s0049-3848(02)00101-9 · Cited by 147 · see citing works
Activation of Estrogen Receptor Is Crucial for Resveratrol-Stimulating Muscular Glucose Uptake via Both Insulin-Dependent and -Independent Pathways
Deng, J.-Y., Hsieh, P., Huang, J., Lu, L., & Hung, L. (2008) · Diabetes · doi:10.2337/db07-1750 · Cited by 147 · see citing works
Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogs of piceatannol
Thakkar, K., Geahlen, R. L., & Cushman, M. (1993) · Journal of Medicinal Chemistry · doi:10.1021/jm00072a015 · Cited by 145 · see citing works
Targeting Apoptosis with Dietary Bioactive Agents
Martin, K. R. (2006) · Experimental Biology and Medicine · doi:10.1177/153537020623100201 · Cited by 140 · see citing works
Sequestering Ability of Butylated Hydroxytoluene, Propyl Gallate, Resveratrol, and Vitamins C and E against ABTS, DPPH, and Hydroxyl Free Radicals in Chemical and Biological Systems
Soares, D. G., Andreazza, A. C., & Salvador, M. M. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020864z · Cited by 140 · see citing works
Survey of the trans-Resveratrol and trans-Piceid Content of Cocoa-Containing and Chocolate Products
Hurst, W. J., Gliński, J. A., Miller, K. B., Apgar, J. L., Davey, M. H., & Stuart, D. A. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf801297w · Cited by 140 · see citing works
Uptake of Diet Resveratrol into the Human Low-Density Lipoprotein. Identification and Quantification of Resveratrol Metabolites by Liquid Chromatography Coupled with Tandem Mass Spectrometry
Urpí-Sardà, M., Jáuregui, O., Lamuela-Raventós, R. M., Jaeger, W., Miksits, M., Covas, M., & Andrés‐Lacueva, C. (2005) · Analytical Chemistry · doi:10.1021/ac0484272 · Cited by 133 · see citing works
STAT3 mediates IL-6-induced growth inhibition in the human prostate cancer cell line LNCaP
Spiotto, M. T., & Chung, T. D. (2000) · The Prostate · doi:10.1002/(sici)1097-0045(20000201)42:2 · Cited by 132 · see citing works
Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice
Do, G.-M., Kwon, E.-Y., Kim, H., Jeon, S.-M., Ha, T. Y., Park, T., & Choi, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.113 · Cited by 132 · see citing works
Distribution of [3H]trans-resveratrol in rat tissues following oral administration
El-Mohsen, M. A., Bayele, H. K., Kuhnle, G., Gibson, G., Debnam, E. S., Srai, S. K., Rice-Evans, C. A., & Spencer, J. P. E. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061810 · Cited by 128 · see citing works
Resveratrol is pro-apoptotic and thyroid hormone is anti-apoptotic in glioma cells: both actions are integrin and ERK mediated
Lin, H., Tang, H., Keating, T., Wu, Y.-H., Shih, A., Hammond, D., Sun, M., Hercbergs, A. A., Davis, F. B., & Davis, P. J. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm239 · Cited by 128 · see citing works
Combination of Lipids and Emulsifiers Enhances the Absorption of Orally Administered Quercetin in Rats
Azuma, K., Ippoushi, K., Ito, H., Higashio, H., & Terao, J. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0112421 · Cited by 126 · see citing works
Disparate In Vitro and In Vivo Antileukemic Effects of Resveratrol, a Natural Polyphenolic Compound Found in Grapes
Gao, X., Xu, Y. X., Divine, G., Janakiraman, N., Chapman, R., & Gautam, S. C. (2002) · Journal of Nutrition · doi:10.1093/jn/132.7.2076 · Cited by 126 · see citing works
Resveratrol and Resveratrol Analogues—Structure—Activity Relationship
Szekeres, T., Fritzer‐Szekeres, M., Saiko, P., & Jäger, W. R. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0090-1 · Cited by 125 · see citing works
Pivotal role of PGE2 and IL-10 in the cross-regulation of dendritic cell-derived inflammatory mediators.
Harizi, H., & Gualde, N. (2006) · PubMed · Cited by 123 · see citing works
Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells
Tang, H.-Y., Shih, A., Cao, H., Davis, F. B., Davis, P. J., & Lin, H. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0216 · Cited by 120 · see citing works
Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals
Howells, L. M., Moiseeva, E. P., Neal, C. P., Foreman, B. E., Andreadi, C., Sun, Y., Hudson, E. A., & Manson, M. M. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2007.00690.x · Cited by 119 · see citing works
D IET AND A POPTOSIS
Watson, W. H., Cai, J., & Jones, D. P. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.485 · Cited by 118 · see citing works
Resveratrol in Human Hepatoma HepG2 Cells: Metabolism and Inducibility of Detoxifying Enzymes
Lançon, A., Hanet, N., Jannin, B., Delmas, D., Heydel, J., Lizard, G., Chagnon, M., Artur, Y., & Latruffe, N. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.013664 · Cited by 117 · see citing works
Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture
Trapp, V., Parmakhtiar, B., Papazian, V., Willmott, L. J., & Fruehauf, J. P. (2010) · Angiogenesis · doi:10.1007/s10456-010-9187-8 · Cited by 117 · see citing works
Resveratrol and apoptosis
Lin, H., Tang, H., Davis, F. B., & Davis, P. J. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05846.x · Cited by 115 · see citing works
Capillary Electrophoretic Determination of Resveratrol in Wines
Gu, X., Creasy, L., Kester, A., & Zeece, M. G. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf981211e · Cited by 115 · see citing works
Resveratrol inhibition of varicella-zoster virus replication in vitro
Docherty, J. J., Sweet, T. J., Bailey, E. B., Faith, S. A., & Booth, T. D. (2006) · Antiviral Research · doi:10.1016/j.antiviral.2006.07.004 · Cited by 113 · see citing works
Effect of topically applied resveratrol on cutaneous herpes simplex virus infections in hairless mice
Docherty, J. J., SMITH, J., Fu, M., Stoner, T. D., & Booth, T. D. (2003) · Antiviral Research · doi:10.1016/j.antiviral.2003.07.001 · Cited by 112 · see citing works
Pharmacokinetics of Trans‐resveratrol Following Repeated Administration in Healthy Elderly and Young Subjects
Nunes, T., Almeida, L., Rocha, J., et al. (2009) · The Journal of Clinical Pharmacology · doi:10.1177/0091270009339191 · Cited by 111 · see citing works
Resveratrol in human cancer chemoprevention – Choosing the ‘right’ dose
Scott, E. N., Steward, W. P., Gescher, A. J., & Brown, K. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100400 · Cited by 110 · see citing works
Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells
Chao, J., Li, H., Cheng, K., Yu, M.-S., Chang, R. C., & Wang, M. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.02.004 · Cited by 104 · see citing works
Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol‐ and melatonin‐induced cardioprotection
Lamont, K. T., Somers, S., Lacerda, L., Opie, L. H., & Lecour, S. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00853.x · Cited by 104 · see citing works
Resveratrol Is Rapidly Metabolized in Athymic (Nu/Nu) Mice and Does Not Inhibit Human Melanoma Xenograft Tumor Growth
Niles, R. M., Cook, C. P., Meadows, G. G., Fu, Y., McLaughlin, J. L., & Rankin, G. O. (2006) · Journal of Nutrition · doi:10.1093/jn/136.10.2542 · Cited by 103 · see citing works
Effect of resveratrol on platelet aggregation in vivo and in vitro.
Wang, Z., Zou, J., Huang, Y., Cao, K., XU, Y., & WU, J. M. (2002) · PubMed · Cited by 102 · see citing works
Resveratrol-induced activation of the mitogen-activated protein kinases, ERK1 and ERK2, in human neuroblastoma SH-SY5Y cells
Miloso, M., Bertelli, A. A. E., Nicolini, G., & Tredici, G. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00194-9 · Cited by 101 · see citing works
Resveratrol Induces p53-independent, X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Bax Protein Oligomerization on Mitochondria to Initiate Cytochrome c Release and Caspase Activation
Gogada, R., Prabhu, V. V., Amadori, M., Scott, R., Hashmi, S., & Chandra, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202440 · Cited by 99 · see citing works
Resveratrol: A Candidate Nutritional Substance for Prostate Cancer Prevention
Stewart, J. R., Artime, M. C., & O’Brian, C. A. (2003) · Journal of Nutrition · doi:10.1093/jn/133.7.2440s · Cited by 99 · see citing works
Thyroid hormone promotes the phosphorylation of STAT3 and potentiates the action of epidermal growth factor in cultured cells
Lin, H., Shih, A., Davis, F. B., & Davis, P. J. (1999) · Biochemical Journal · doi:10.1042/bj3380427 · Cited by 98 · see citing works
Prooxidant activity of resveratrol in the presence of copper ions: Mutagenicity in plasmid DNA
Ahmad, A., Syed, F. A., Singh, S. P., & Hadi, S. M. (2005) · Toxicology Letters · doi:10.1016/j.toxlet.2005.04.001 · Cited by 98 · see citing works
Posttranslational regulation of cyclooxygenase by tyrosine phosphorylation in cerebral endothelial cells
Parfenova, H., Balabanova, L., & Leffler, C. W. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.1.c72 · Cited by 97 · see citing works
Involvement of c‐jun NH2‐terminal kinases in resveratrol‐induced activation of p53 and apoptosis
She, Q., Huang, C., Zhang, Y., & Dong, Z. (2002) · Molecular Carcinogenesis · doi:10.1002/mc.10041 · Cited by 97 · see citing works
Antioxidant and signal modulation properties of plant polyphenols in controlling vascular inflammation
Kostyuk, V. A., Potapovich, A. I., Suhan, T. O., Luca, C. D., & Korkina, L. G. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.02.022 · Cited by 94 · see citing works
Increased Transport of Resveratrol Across Monolayers of the Human Intestinal Caco-2 Cells is Mediated by Inhibition and Saturation of Metabolites
Maier‐Salamon, A., Hagenauer, B., Wirth, M., et al. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9060-z · Cited by 93 · see citing works
Synergistic Inhibition of HIV-1 in Activated and Resting Peripheral Blood Mononuclear Cells, Monocyte-Derived Macrophages, and Selected Drug-Resistant Isolates With Nucleoside Analogues Combined With a Natural Product, Resveratrol
Heredia, A., Davis, C. E. L. B., & Redfield, R. (2000) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200011010-00006 · Cited by 91 · see citing works
Resveratrol inhibits vascular smooth muscle cell proliferation and induces apoptosis
Poussier, B., Cordova, A. C., Becquemin, J., & Sumpio, B. E. (2005) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2005.08.014 · Cited by 91 · see citing works
Pro‐oxidant Activity of Low Doses of Resveratrol Inhibits Hydrogen Peroxide—Induced Apoptosis
Ahmad, K. A., Clement, M., & Pervaiz, S. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1299.067 · Cited by 90 · see citing works
Anti-apoptotic effect of trans-resveratrol on paclitaxel-induced apoptosis in the human neuroblastoma SH-SY5Y cell line
Nicolini, G., Rigolio, R., Miloso, M., Bertelli, A. A. E., & Tredici, G. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01654-8 · Cited by 90 · see citing works
Resveratrol decreases hyperalgesia induced by carrageenan in the rat hind paw
Gentilli, M., Mazoit, J. X., Bouaziz, H., et al. (2001) · Life Sciences · doi:10.1016/s0024-3205(00)01018-3 · Cited by 90 · see citing works
Matrix effects on the bioavailability of resveratrol in humans
Ortuño, J., Covas, M., Farré, M., Pujadas, M., Fitó, M., Khymenets, O., Andrés‐Lacueva, C., Roset, P. N., Joglar, J., Lamuela-Raventós, R. M., et al. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.11.032 · Cited by 87 · see citing works
Resveratrol modulates apoptosis and oxidation in human blood mononuclear cells
Losa, G. A. (2003) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2003.01219.x · Cited by 87 · see citing works
Antioxidants in Hypertension and Cardiovascular Disease
Schiffrin, E. L. (2010) · Molecular Interventions · doi:10.1124/mi.10.6.4 · Cited by 85 · see citing works
Oxidative changes in hypoxic rat heart tissue
Park, Y., Kanekal, S., & Kehrer, J. P. (1991) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1991.260.5.h1395 · Cited by 85 · see citing works
Evaluation of kinetic parameters of natural phytoalexin in resveratrol orally administered in wine to rats.
Bertelli, A. A. E., Giovannini, L., Stradi, R. D., et al. (1998) · PubMed · Cited by 84 · see citing works
Effects of resveratrol on secondary damages after acute spinal cord injury in rats.
Yang, Y., & Piao, Y.-J. (2003) · PubMed · Cited by 82 · see citing works
The NADPH Oxidase Nox4 and Aging in the Heart
Ago, T., Matsushima, S., Kuroda, J., Zablocki, D., Kitazono, T., & Sadoshima, J. (2010) · Aging · doi:10.18632/aging.100261 · Cited by 81 · see citing works
ALCOHOL CONSUMPTION AND MORTALITY AMONG MIDDLE-AGED AND ELDERLY U.S. ADULTS
Hun, J. T., Eto, R., Opez, L. D. L., Onaco, J. A. H. M., Ane, S. J., Eath, C. L. W. H., & Oll, R. I. D. (2009) · Cited by 79 · see citing works
Red Wine Acutely Induces Favorable Effects on Wave Reflections and Central Pressures in Coronary Artery Disease Patients
Karatzi, K., Papamichael, C. M., KARATZIS, E., PAPAIOANNOU, T., Aznaouridis, K., Katsichti, P., Stamatelopoulos, K., Zampelas, A., Lekakis, J. P., & Mavrikakis, M. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.03.744 · Cited by 78 · see citing works
Effects of Resveratrol on Endothelial Progenitor Cells and Their Contributions to Reendothelialization in Intima-injured Rats
Gu, J., Wang, C.-Q., Hh, F., et al. (2006) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000211764.52012.e3 · Cited by 77 · see citing works
Antioxidative and Prooxidative Action of Stilbene Derivatives
Miura, T., Muraoka, S., Ikeda, N., Watanabe, M., & Fujimoto, Y. (2000) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2000.d01-36.x · Cited by 77 · see citing works
Resveratrol causes COX‐2‐ and p53‐dependent apoptosis in head and neck squamous cell cancer cells
Lin, H., Sun, M., Tang, H., Simone, T. M., Wu, Y., Grandis, J. R., Cao, H. J., Davis, P. J., & Davis, F. B. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21772 · Cited by 77 · see citing works
Moderate consumption of red wine (cabernet sauvignon) improves ischemia‐induced neovascularization in ApoE‐deficient mice: effect on endothelial progenitor cells and nitric oxide
Lefèvre, J., Michaud, S., Haddad, P., et al. (2007) · The FASEB Journal · doi:10.1096/fj.06-7491com · Cited by 77 · see citing works
The Effect of Resveratrol on a Cell Model of Human Aging
Stefani, M., Markus, M. A., Lin, R. C. Y., Pinese, M., Dawes, I. W., & Morris, B. J. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1396.001 · Cited by 76 · see citing works
Role of Redox Regulation and Lipid Rafts in Macrophages During Ox-LDL–Mediated Foam Cell Formation
Schmitz, G., & Grandl, M. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1663 · Cited by 75 · see citing works
Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines.
Delmas, D., Jannin, B., Cherkaoui‐Malki, M., & Latruffe, N. (2000) · Oncology Reports · doi:10.3892/or.7.4.847 · Cited by 74 · see citing works
Effect of Vitamin E and Probucol on Dietary Cholesterol-Induced Atherosclerosis in Rabbits
Özer, N. K., Şïrïkçï, Ö., Taha, S., et al. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00136-6 · Cited by 74 · see citing works
3,4′,5-Trihydroxy-trans-stilbene (resveratrol) inhibits human cytomegalovirus replication and virus-induced cellular signaling
Evers, D. L., Wang, X., Huong, S.-M., et al. (2004) · Antiviral Research · doi:10.1016/j.antiviral.2004.03.002 · Cited by 72 · see citing works
Inhibitory effect of epidermal growth factor on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-alpha.
Shih, A., Zhang, S., Cao, H., et al. (2004) · PubMed · Cited by 69 · see citing works
Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice
Fukao, H., Ijiri, Y., Miura, M., Hashimoto, M., Yamashita, T., Fukunaga, C., Oiwa, K., Kawai, Y., Suwa, M., & Yamamoto, J. (2004) · Blood Coagulation & Fibrinolysis · doi:10.1097/00001721-200408000-00001 · Cited by 68 · see citing works
Resveratrol inhibits heregulin-β1-mediated matrix metalloproteinase-9 expression and cell invasion in human breast cancer cells
Tang, F.-Y., Chiang, E. I., & Sun, Y.-C. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.03.003 · Cited by 64 · see citing works
Vitamin E inhibits CD36 scavenger receptor expression in hypercholesterolemic rabbits
Özer, N. K., Neğiş, Y., Aytan, N., Villacorta, L., Ricciarelli, R., Zingg, J.-M., & Azzi, A. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.03.050 · Cited by 64 · see citing works
Antitumor activities of synthetic and natural stilbenes through antiangiogenic action
Kimura, Y., Sumiyoshi, M., & Baba, K. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00948.x · Cited by 63 · see citing works
Structure-activity relationship of trans-resveratrol and its analogues.
Ovesná, Z., & Kozics, K. (2005) · PubMed · Cited by 63 · see citing works
Trans-resveratrol, a red wine ingredient, inhibits voltage-activated potassium currents in rat hippocampal neurons
Gao, Z., & Hu, G. (2005) · Brain Research · doi:10.1016/j.brainres.2005.07.013 · Cited by 62 · see citing works
Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress
Bruder, J. L., Hsieh, T., Lerea, K. M., Olson, S. C., & WU, J. M. (2001) · BMC Cell Biology · doi:10.1186/1471-2121-2-1 · Cited by 61 · see citing works
Resveratrol induces apoptotic cell death in rat H4IIE hepatoma cells but necrosis in C6 glioma cells
Michels, G., Wätjen, W., Weber, N., et al. (2006) · Toxicology · doi:10.1016/j.tox.2006.05.014 · Cited by 60 · see citing works
Metabolism of resveratrol in breast cancer cell lines: Impact of sulfotransferase 1A1 expression on cell growth inhibition
Murias, M., Miksits, M., Aust, S., et al. (2007) · Cancer Letters · doi:10.1016/j.canlet.2007.11.008 · Cited by 60 · see citing works
Nitric Oxide Synthases: Properties and Catalytic Mechanism
Griffith, O. (1995) · Annual Review of Physiology · doi:10.1146/annurev.physiol.57.1.707 · Cited by 60 · see citing works
Inhibition of the respiratory burst by resveratrol in human monocytes: Correlation with inhibition of PI3K signaling
Poolman, T. M., Ng, L. L., Farmer, P. B., & Manson, M. M. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.036 · Cited by 56 · see citing works
Role of p53 and apoptosis in carcinogenesis.
Wang, X. W. (2000) · PubMed · Cited by 55 · see citing works
Resveratrol induces DNA double-strand breaks through human topoisomerase II interaction
Leone, S., Cornetta, T., Basso, E., et al. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.02.022 · Cited by 55 · see citing works
Polyphenolic Grape Extract Inhibits Platelet Activation Through PECAM‐1: An Explanation for the French Paradox
de Lange, D. W., Verhoef, S., Gorter, G., Kraaijenhagen, R. J., van de Wiel, A., & Akkerman, J. N. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00439.x · Cited by 54 · see citing works
Resveratrol as a novel agent for treatment of multiple myeloma with matrix metalloproteinase inhibitory activity
Sun, C., Hu, Y., Guo, T., et al. (2006) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2006.00343.x · Cited by 54 · see citing works
Isorhapontigenin and resveratrol suppress oxLDL-induced proliferation and activation of ERK1/2 mitogen-activated protein kinases of bovine aortic smooth muscle cells
Liu, Y., & Liu, G.-T. (2003) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.09.025 · Cited by 53 · see citing works
Resveratrol Inhibits N-nitrosodiethylamine-Induced Ornithine Decarboxylase and Cyclooxygenase in Mice
KANDUJA, K. L., HARDWAJ, A., & Kaushik, G. (2004) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.50.61 · Cited by 52 · see citing works

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Authors: Catalgol, B., Batirel, S., Taga, Y., & Ozer, N. K.
Affiliations: Marmara University (TR)
Venue: Frontiers in Pharmacology
Publisher: Frontiers Media SA
Published: 2012
Volume: 3
Pages: 141-141
ISSN: 1663-9812 (ISSN-L)
DOI: 10.3389/fphar.2012.00141
PMC: PMC3398412
OpenAlex: W2155903397
Cited by: 449
References: 230
Citations by year: 2026: 10 · 2025: 24 · 2024: 28 · 2023: 27 · 2022: 26 · 2021: 37 · 2020: 37 · 2019: 40 · 2018: 37 · 2017: 34 · 2016: 33 · 2015: 44 · 2014: 38 · 2013: 29 · 2012: 2
FWCI: 17.73
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Pharmacology (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Dspace Repository (Marmara Üniversitesi) (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: resveratrol, French paradox, polyphenols, oxidative stress, antioxidant activity, anti-inflammatory activity, antiproliferative activity, angiogenesis inhibition, signaling pathways, cardiovascular disease, cancer, neurodegenerative diseases, longevity

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