Promotion of β-amyloid production by C-reactive protein and its implications in the early pathogenesis of Alzheimer’s disease
Abstract
C-reactive protein (CRP) and β-amyloid protein (Aβ) are involved in the development of Alzheimer's disease (AD). However, the relationship between CRP and Aβ production is unclear. In vitro and in vivo experiments were performed to investigate the association of CRP with Aβ production. Using the rat adrenal pheochromocytoma cell line (PC12 cells) to mimic neurons, cytotoxicity was evaluated by cell viability and supernatant lactate dehydrogenase (LDH) activity. The levels of amyloid precursor protein (APP), beta-site APP cleaving enzyme (BACE-1), and presenilins (PS-1 and PS-2) were investigated using real-time polymerase chain reaction and Western blotting analysis. Aβ1-42 was measured by enzyme-linked immunosorbent assay. The relevance of CRP and Aβ as well as potential mechanisms were studied using APP/PS1 transgenic (Tg) mice. Treatment with 0.5-4.0 μM CRP for 48 h decreased cell viability and increased LDH leakage in PC12 cells. Incubation with CRP at a sub-toxic concentration of 0.2 μM increased the mRNA levels of APP, BACE-1, PS-1, and PS-2, as well as Aβ1-42 production. CRP inhibitor reversed the CRP-induced upregulations of the mRNA levels of APP, BACE-1, PS-1, and PS-2, and the protein levels of APP, BACE-1, PS-1, and Aβ1-42, but did not reversed Aβ1-42 cytotoxicity. The cerebral levels of CRP and Aβ1-42 in APP/PS1 Tg mice were positively correlated, accompanied with the elevated mRNA expressions of serum amyloid P component (SAP), complement component 1q (C1q), and…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Pentameric CRP dissociation into monomeric forms is prompted by amyloid plaque in APP/PS1 mice.
“The CRP has a role in amyloid pathology as studied and shown in APP/PS1 (amyloid precursor protein/presenilin 1) mice; pentameric CRP dissociation takes place into monomeric forms prompted by amyloid plaque [50, 51].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [51]
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Greene, L., & Tischler, A. S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.7.2424 · Cited by 5,594 · see citing works
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works
Fotakis, G., & Timbrell, J. A. (2005) · Toxicology Letters · doi:10.1016/j.toxlet.2005.07.001 · Cited by 1,572 · see citing works
Holcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., et al. (1998) · Nature Medicine · doi:10.1038/nm0198-097 · Cited by 1,386 · see citing works
Amyloid β-Protein and the Genetics of Alzheimer's Disease
Selkoe, D. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18295 · Cited by 798 · see citing works
Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides
Hartmann, T., Bieger, S. C., Brühl, B., Tienari, P. J., Ida, N., Allsop, D., Roberts, G. W., Masters, C. L., Dotti, C. G., Unsicker, K., et al. (1997) · Nature Medicine · doi:10.1038/nm0997-1016 · Cited by 706 · see citing works
Targeting C-reactive protein for the treatment of cardiovascular disease.
Pepys, M. B., Hirschfield, G. M., Tennent, G. A., Ruth Gallimore, J., Kahan, M. C., Bellotti, V., Hawkins, P. N., Myers, R. M., Smith, M. D., Polara, A., et al. (2006) · Nature · doi:10.1038/nature04672 · Cited by 672 · see citing works
Krady, J. K., Basu, A., Allen, C. M., Xu, Y., LaNoue, K. F., Gardner, T. W., & Levison, S. W. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1559 · Cited by 529 · see citing works
Sahu, A., & Lambris, J. D. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1800103.x · Cited by 527 · see citing works
C-Reactive Protein Attenuates Endothelial Progenitor Cell Survival, Differentiation, and Function
Verma, S., Kuliszewski, M. A., Li, S.-H., Szmitko, P. E., Zucco, L., Wang, C., Badiwala, M. V., Mickle, D. A. G., Weisel, R. D., Fedak, P. W. M., et al. (2004) · Circulation · doi:10.1161/01.cir.0000127577.63323.24 · Cited by 523 · see citing works
Evolution of neuronal changes in the course of Alzheimer’s disease
Braak, H., & Braak, E. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6467-9_11 · Cited by 482 · see citing works
Sloane, P. D., Zimmerman, S. I., Suchindran, C., Reed, P. S., Wang, L., Boustani, M. A., & Sudha, S. (2002) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.23.100901.140525 · Cited by 461 · see citing works
Inflammation and Alzheimer's disease pathogenesis
Rogers, J., Webster, S. D., Lue, L., Brachova, L., CIVIN, W. H., Emmerling, M. R., Shivers, B. D., Walker, D. G., & McGeer, P. L. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00115-7 · Cited by 441 · see citing works
Blasko, I., Stampfer‐Kountchev, M., Robatscher, P., Veerhuis, R., Eikelenboom, P., & Grubeck‐Loebenstein, B. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00101.x · Cited by 374 · see citing works
Salminen, A., Ojala, J. O., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.01.001 · Cited by 350 · see citing works
Jiang, H., Burdick, D., Glabe, C. G., Cotman, C. W., & Tenner, A. J. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.10.5050 · Cited by 330 · see citing works
Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer’s disease
Yasojima, K., Schwab, C., McGeer, E. G., & McGeer, P. L. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02970-x · Cited by 300 · see citing works
(1979) · PubMed Central · Cited by 271 · see citing works
Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene
Botto, M., Hawkins, P. N., Bickerstaff, M. C. M., Herbert, J., Bygrave, A. E., Mcbride, A., Hutchinson, W. L., Tennent, G. A., Walportz, M. J., & Pepys, M. B. (1997) · Nature Medicine · doi:10.1038/nm0897-855 · Cited by 266 · cited 1× · see citing works
“SAP-deficient mice exhibited delayed amyloidosis development (Botto et al., 1997; Pepys et al., 1979).”
Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy
Zotova, E., Nicoll, J. A. R., Kalaria, R. N., Holmes, C., & Boche, D. (2010) · Alzheimer s Research & Therapy · doi:10.1186/alzrt24 · Cited by 257 · see citing works
Radioimmunoassay of human C-reactive protein and levels in normal sera.
Claus, D. R., Osmand, A. P., & Gewurz, H. (1976) · PubMed · Cited by 216 · see citing works
Park, S.-Y., Kim, H.-S., Cho, E.-K., Kwon, B.-Y., Phark, S., Hwang, K.-W., & Sul, D. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.05.030 · Cited by 209 · see citing works
β-Secretase (BACE) as a drug target for alzheimer’s disease
Vassar, R. J. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00157-6 · Cited by 209 · see citing works
The β-Secretase, BACE: A Prime Drug Target for Alzheimer's Disease
Vassar, R. J. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:2:157 · Cited by 186 · see citing works
Marcinkiewicz, M. M., & Seidah, N. G. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0752133.x · Cited by 185 · see citing works
McGowan, E. M., Sanders, S., Iwatsubo, T., Takeuchi, A., Saido, T. C., Zehr, C., Yu, X., Uljon, S., Wang, R., Mann, D. M. A., et al. (1999) · Neurobiology of Disease · doi:10.1006/nbdi.1999.0243 · Cited by 180 · see citing works
Regulation of complement activation at the C3-level by serum resistant leptospires
Meri, T., Murgia, R., Stefanel, P., Meri, S., & Cinco, M. (2005) · Microbial Pathogenesis · doi:10.1016/j.micpath.2005.07.003 · Cited by 169 · see citing works
Early time course of the acute phase protein response in man.
COLLEY, C. M., Fleck, A., Goode, A. W., Müller, B., & Myers, M. A. (1983) · Journal of Clinical Pathology · doi:10.1136/jcp.36.2.203 · Cited by 169 · see citing works
The amyloid precursor protein of Alzheimer’s disease and the Aβ peptide
Storey, & Cappai, R. (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00164.x · Cited by 167 · see citing works
Presenilins and Alzheimer’s disease: biological functions and pathogenic mechanisms
Czech, C., Tremp, G. L., & Pradier, L. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00033-7 · Cited by 155 · see citing works
Durairajan, S. S. K., Yuan, Q., Xie, L., Chan, W. S., Kum, W.-F., Koo, I., Liu, C., Song, Y., Huang, J., Klein, W. L., et al. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.09.006 · Cited by 149 · see citing works
Inflammatory markers in AD and MCI patients with different biomarker profiles
Schuitemaker, A., Dik, M. G., Veerhuis, R., Scheltens, P., Schoonenboom, N. S. M., Hack, C. E., Blankenstein, M. A., & Jonker, C. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.01.014 · Cited by 149 · see citing works
Association of C‐reactive protein with mild cognitive impairment
Roberts, R. O., Geda, Y. E., Knopman, D. S., Boeve, B. F., Christianson, T. J. H., Pankratz, V. S., Kullo, I. J., Tangalos, E. G., Ivnik, R. J., & Petersen, R. C. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.01.025 · Cited by 133 · see citing works
Iwamoto, N., Nishiyama, E., Ohwada, J., & Arai, H. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90035-3 · Cited by 129 · see citing works
C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer's disease
Duong, T., Nikolaeva, M. A., & Acton, P. J. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01359-5 · Cited by 127 · see citing works
Alzheimer disease and neuroinflammation
McGeer, P. L., McGeer, E. G., & Yasojima, K. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6781-6_8 · Cited by 117 · see citing works
Jiang, H., Siegel, J. N., & Gewurz, H. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.7.2324 · Cited by 113 · see citing works
Elevated C‐reactive protein levels are associated with prevalent dementia in the oldest‐old
Kravitz, B. A., Corrada, M. M., & Kawas, C. H. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.04.1230 · Cited by 98 · see citing works
The pentraxins: possible role in Alzheimer's disease and other innate inflammatory diseases.
Mcgeer, E., Yasojima, K., Schwab, C., & McGeer, P. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00288-3 · Cited by 86 · see citing works
Brade, V., Lee, G. D., Nicholson, A., Shin, H. S., & Mayer, M. M. (1973) · PubMed · Cited by 62 · see citing works
The in vitro neuronal toxicity of pentraxins associated with Alzheimer's disease brain lesions.
Duong, T., Acton, P., & Johnson, R. A. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00966-4 · Cited by 59 · see citing works
Licastro, F., Morini, M. C., Polazzi, E., & Davis, L. J. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)00163-i · Cited by 58 · see citing works
Lin, H.-B., Yang, X., Li, T., Cheng, Y., Zhang, H., & Xu, J. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1499-2 · Cited by 57 · see citing works
Self-citationIS THERE A RELATIONSHIP BETWEEN HIGH C-REACTIVE PROTEIN (CRP) LEVELS AND DEMENTIA?
Mancinella, A., Mancinella, M., Carpinteri, G., Bellomo, A., FOSSATI, C., Gianturco, V., Iori, A., Ettorre, E., Troisi, G., & Marigliano, V. (2009) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2009.09.028 · Cited by 54 · see citing works
Presenilins as therapeutic targets for the treatment of Alzheimer's disease
Golde, T. E., & Younkin, S. G. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02064-0 · Cited by 49 · see citing works
Misiti, F., Clementi, M. E., & Giardina, B. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.01.002 · Cited by 44 · see citing works
C-Reactive Protein-Mediated Vascular Injury Requires Complement
Hage, F. G., Oparil, S., Xing, D., Chen, Y.-F., McCrory, M. A., & Szalai, A. J. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.205377 · Cited by 43 · see citing works
Octave, J., Essalmani, R., Tasiaux, B., Ménager, J., Czech, C., & Mercken, L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.1525 · Cited by 42 · see citing works
Park, Y.-H., Son, I. H., Son, I. H., Kim, B., Lyu, Y.-S., Moon, H., Kang, H.-W., & Kang, H.-W. (2009) · Die Pharmazie · doi:10.31083/ph.2009.9614 · Cited by 42 · see citing works
Focal Inflammation in the Brain: Role in Alzheimer's Disease
Cooper, N. R., Bradt, B. M., O’Barr, S. A., & Yu, J. X. (2000) · Immunologic Research · doi:10.1385/ir:21:2-3:159 · Cited by 41 · see citing works
The Reaction of Zymosan with the Properdin System in Normal and C4-Deficient Guinea Pig Serum
Brade, V., Lee, G. D., Nicholson, A., Shin, H. S., & Mayer, M. M. (1973) · The Journal of Immunology · doi:10.4049/jimmunol.111.5.1389 · Cited by 40 · see citing works
Complement C1q expression induced by Aβ in rat hippocampal organotypic slice cultures
Fan, R., & Tenner, A. J. (2003) · Experimental Neurology · doi:10.1016/j.expneurol.2003.09.023 · Cited by 39 · see citing works
Okello, E. J., McDougall, G. J., Kumar, S., & Seal, C. J. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.11.004 · Cited by 38 · see citing works
Fernàndez‐Busquets, X., Ponce, J., Bravo, R., Arimon, M., Martiáñez, T., Gella, A., Cladera, J., & Durany, N. (2010) · Current Alzheimer Research · doi:10.2174/156720510791383787 · Cited by 38 · see citing works
H2O2 and PAF mediate Aβ1-42-induced Ca2+ dyshomeostasis that is blocked by EGb761
Shi, C., Wu, F., & Xu, J. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.03.016 · Cited by 35 · see citing works
Self-citationAccumulation and expression of serum amyloid P component in human atherosclerotic lesions
Song, Z.-Q., Cai, L., Guo, L., Tsukamoto, Y., Yutani, C., & Li, X.-A. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.01.046 · Cited by 31 · see citing works
Začiragić, A., Lepara, O., Valjevac, A., Arslanagić, S., Fajkić, A., Hadžović-Džuvo, A., Avdagić, N., Alajbegović, A., Mehmedika-Suljić, E., & Coric, G. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-12204 · Cited by 28 · see citing works
Editorial [Hot topic: Inflammation, Immunity, and Alzheimers Disease (Guest Editor: Terrence Town)]
Town, T. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791012008 · Cited by 27 · see citing works
Tarenflurbil for Alzheimer's disease: a “shot on goal” that missed
Vellas, B. J. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70030-2 · Cited by 16 · see citing works
The Effects of C-Reactive Protein on Human Cell-Mediated Cytotoxicity
Vetter, M. L., Gewurz, H., & Baum, L. L. (1986) · Journal of Leukocyte Biology · doi:10.1002/jlb.39.1.13 · Cited by 15 · see citing works
Distinct mechanisms account for β-amyloid toxicity in PC12 and differentiated PC12 neuronal cells
Sung, Y.-J., Cheng, C.-L., Chen, C.-S., Huang, H.-B., Huang, F.-L., Wu, P.-C., Shiao, M., & Tsay, H.-J. (2003) · Journal of Biomedical Science · doi:10.1007/bf02256429 · Cited by 14 · see citing works
Strunk, R. C., & Giclas, P. C. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.124.2.520 · Cited by 8 · see citing works
Vukovich, T., Mustafa, S., Rumpold, H., & Wagner, O. F. (2003) · Clinical Chemistry · doi:10.1373/49.3.511 · Cited by 8 · see citing works
C-Reactive Protein as Cardiovascular Risk Factor A Discovery by ECAT
Haverkate, F. (2000) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2000.157 · Cited by 3 · see citing works
Flagged first, then by citations
1 of the 66 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease
Khan, S., Barve, K. H., & Kumar, M. S. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200528142429 · Cited by 820 · see citing works
Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling
Phillips, C., Baktir, M. A., Srivatsan, M., & Salehi, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00170 · Cited by 330 · see citing works
Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/3589271 · Cited by 335 · see citing works
Brosseron, F., Traschütz, A., Widmann, C. N., Kummer, M. P., Tacik, P., Santarelli, F., Jessen, F., & Heneka, M. T. (2018) · Alzheimer's Research & Therapy · doi:10.1186/s13195-018-0353-3 · Cited by 113 · see citing works
“have described dissociation of pentameric into monomeric CRP induced by amyloid plaques [28, 29].”
BackgroundSlevin, M., Matou, S., Zeinolabediny, Y., Corpas, R., Weston, R., Liu, D., Boras, E., Di Napoli, M., Petcu, E., Sarroca, S., et al. (2015) · Scientific Reports · doi:10.1038/srep13281 · Cited by 115 · see citing works
Neuroprotective Effects of Exercise Treatments after Injury: The Dual Role of Neurotrophic Factors
Cobianchi, S., Arbat-Plana, A., Lopez-Alvarez, V. M., & Navarro, X. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666160330105132 · Cited by 94 · see citing works
Sun, P., Jun-bo, Y., Liu, L., Guo, J., Wang, S.-H., Qu, C., & Wang, C.-X. (2018) · Bioscience Reports · doi:10.1042/bsr20180902 · Cited by 89 · see citing works
Troili, F., Cipollini, V., Moci, M., Morena, E., Palotai, M., Rinaldi, V., Romano, C., Ristori, G., Giubilei, F., Salvetti, M., et al. (2020) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2020.00017 · Cited by 91 · see citing works
Elman, J. A., Puckett, O. K., Beck, A. I., Fennema‐Notestine, C., Cross, L. K., Dale, A. M., Eglit, G. M. L., Eyler, L. T., Gillespie, N. A., Granholm, E. L., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12261 · Cited by 76 · see citing works
Liu, C., Wang, R., Yi, Y., Gao, Z., & Chen, Y. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.10.014 · Cited by 77 · see citing works
Zhang, X., Wang, J., Xing, Y., Gong, L., Li, H., Wu, Z., Li, Y., Wang, J., Wang, Y., Dong, L., et al. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.027 · Cited by 72 · see citing works
Hilal, S., Ikram, M. A., Verbeek, M. M., Franco, O. H., Stoops, E., Vanderstichele, H., Niessen, W. J., & Vernooij, M. W. (2018) · Stroke · doi:10.1161/strokeaha.118.022317 · Cited by 71 · see citing works
Martins, I. J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226190 · Cited by 67 · see citing works
A Meta-Analysis of C-Reactive Protein in Patients With Alzheimer’s Disease
Gong, C., Wei, D., Wang, Y., Ma, J., Yuan, C., Zhang, W., Yu, G., & Zhao, Y. (2015) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317515602087 · Cited by 53 · see citing works
Premature Immunosenescence Is Associated with Memory Dysfunction in Rheumatoid Arthritis
Petersen, L. E., Grassi‐Oliveira, R., Baptista, T. S. A., dos Santos, S. G. R., Ilha, M., Nardi, T. D., Keisermann, M., & Bauer, M. E. (2014) · NeuroImmunoModulation · doi:10.1159/000358437 · Cited by 52 · see citing works
Nowroozpoor, A., Gutterman, D. D., & Safdar, B. (2020) · Microvascular Research · doi:10.1016/j.mvr.2020.104123 · Cited by 52 · see citing works
Plasma clusterin levels and risk of dementia, Alzheimer's disease, and stroke
Weinstein, G., Beiser, A., Preis, S. R., Courchesne, P. L., Chouraki, V. A., Levy, D. A., & Seshadri, S. S. (2016) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2016.06.005 · Cited by 44 · see citing works
Progressive inflammatory pathology in the retina of aluminum-fed 5xFAD transgenic mice
Pogue, A. I., Dua, P., Hill, J. M., & Lukiw, W. J. (2015) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2015.07.009 · Cited by 41 · see citing works
Afsar, A., Castro, M. D. C. C., Soladogun, A. S., & Li, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087258 · Cited by 42 · see citing works
Pastorello, Y., Carare, R. O., Bănescu, C. V., Potempa, L. A., Napoli, M. D., & SLEVIN, M. A. (2023) · Brain Pathology · doi:10.1111/bpa.13164 · Cited by 36 · see citing works
Pharmacological approaches for Alzheimer’s disease: neurotransmitter as drug targets
Prakash, A. K., Kalra, J., Mani, V., Ramasamy, K., & Majeed, A. B. A. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.988709 · Cited by 35 · see citing works
Kumar, D., Sharma, A., & Sharma, L. K. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200203101828 · Cited by 33 · see citing works
Alexandrov, P. N., Kruck, T. P. A., & Lukiw, W. J. (2015) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2015.07.013 · Cited by 29 · see citing works
Inflammatory biomarkers and intellectual disability in patients with Down syndrome
Manti, S., Cutrupi, M. C., Cuppari, C., Ferro, E., Dipasquale, V., Rosa, G. D., Chimenz, R., Rosa, M. A. L., Valenti, A., & Salpietro, V. (2018) · Journal of Intellectual Disability Research · doi:10.1111/jir.12470 · Cited by 20 · see citing works
APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid1
Berger, M., Cooter, M., Roesler, A. S., Chung, S., Park, J., Modliszeski, J. L., VanDusen, K. W., Thompson, J. W., Moseley, M. A., Devinney, M. J., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200747 · Cited by 15 · see citing works
Hooper, C., Barreto, P. D. S., Cantet, C., Cesari, M., Payoux, P., Salabert, A., & Vellas, B. J. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.04.014 · Cited by 16 · see citing works
Azmi, N. H., Ismail, N., Imam, M. U., Ooi, D. J., & Oslan, S. N. H. (2022) · Molecules · doi:10.3390/molecules27154907 · Cited by 15 · see citing works
PACAP: A promising disease-modifying target for Alzheimer's disease
Basri, R., Al-Kuraishy, H. M., Fawzy, M. N., Alruwaili, M., & Batiha, G. E. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.124176 · Cited by 13 · see citing works
Mureşan, S., & SLEVIN, M. A. (2024) · Cureus · doi:10.7759/cureus.59009 · Cited by 13 · see citing works
Hao, J., Qiao, Y., Li, T., Yang, J., Song, Y., Jia, L., & Jia, J. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210552 · Cited by 12 · see citing works
Self-citationPlant-based vaccines for Alzheimer's disease: an overview
Rosales‐Mendoza, S., Rubio‐Infante, N., Zarazúa, S., Govea‐Alonso, D. O., Martel‐Gallegos, G., & Moreno‐Fierros, L. (2014) · Expert Review of Vaccines · doi:10.1586/14760584.2014.874948 · Cited by 11 · see citing works
C-Reactive Protein Induces Tau Hyperphosphorylation via GSK3β Signaling Pathway in SH-SY5Y Cells
Guo, H., Wang, H., Wang, C., Cheng, Y., Zou, Z., Li, Y., Wu, J., & Xu, J. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0572-z · Cited by 10 · see citing works
Self-citationDynamic self-guiding analysis of Alzheimer's disease
Kurakin, A. V., & Bredesen, D. E. (2015) · Oncotarget · doi:10.18632/oncotarget.4221 · Cited by 7 · see citing works
Beyond the Biomarker: Monomeric CRP as a Driver of Multisystem Pathology in Rheumatoid Arthritis
Lazarut‐Nistor, A., & SLEVIN, M. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178227 · Cited by 6 · see citing works
Lewis, T. J., & Trempe, C. L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812112-2.00007-0 · Cited by 6 · see citing works
Huang, R., Tian, S., Cai, R., Sun, J. L., Xia, W., Dong, X., Shen, Y., & Wang, S. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13079 · Cited by 5 · see citing works
Fan, Y., Chou, C., Bintoro, B. S., Pan, W., & Bai, C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.791929 · Cited by 5 · see citing works
Peripheral Inflammatory Biomarkers of Alzheimer’s Disease
Hao, J., Guo, Y., Guo, K., & Yang, Q. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215422 · Cited by 5 · see citing works
Ahammad, R. U., Spencer, B. J., Quach, B., Salehi, S. N., & Rissman, R. A. (2025) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70117 · Cited by 4 · see citing works
Malek‐Ahmadi, M. H., Patel, A., & Sabbagh, M. N. (2013) · International Journal of Alzheimer s Disease · doi:10.1155/2013/242303 · Cited by 3 · see citing works
Plant-based vaccines for Alzheimer's disease: an
Dania, O., & Moreno‐Fierros, L. (2014)
Ramadhani, A., Minagawa, K., Takehara, S., Kaneko, N., Yamada, T., Kitazawa, M., Sone, H., Fitrah, Y. A., Nohno, K., & Ogawa, H. (2025) · Dentistry Journal · doi:10.3390/dj13110505
- Authors
- Bi, B.-T., Lin, H.-B., Cheng, Y.-F., Zhou, H., Lin, T., Zhang, M.-Z., Li, T.-J., & Xu, J.-P.
- Affiliations
- Southern Medical University (CN)
- Nanfang Hospital (CN)
- Venue
- Neurochemistry International
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 60
- Issue
- 3
- Pages
- 257-266
- ISSN
- 0197-0186 (ISSN-L)
- OpenAlex
- W2038378476
- Cited by
- 42
- References
- 66
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 5 · 2018: 5 · 2017: 4 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 1 · 2012: 1
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurochemistry International (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- National Science and Technology Major Project
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- C-reactive protein, amyloid-beta, Alzheimer's disease, amyloid precursor protein, BACE1, presenilin, amyloid-beta 42, PC12 cells, APP/PS1 mice, serum amyloid P component, C1q, TNF-α, neurotoxicity
- MeSH terms
- Aging, Alzheimer Disease, Animals, C-Reactive Protein, Complement C1, Coloring Agents, Enzyme-Linked Immunosorbent Assay, L-Lactate Dehydrogenase, Mice, Inbred C57BL, Mice, Transgenic, RNA, Messenger, Tetrazolium Salts, Thiazoles, Tumor Necrosis Factor-alpha, Blotting, Western, Amyloid beta-Peptides, Aspartic Acid Endopeptidases, PC12 Cells, Mice, Rats, Presenilin-1, Presenilin-2, Amyloid Precursor Protein Secretases, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
