The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Neuronal vs glial glutamate uptake: Resolving the conundrum
Open accessAbstract
Neither normal brain function nor the pathological processes involved in neurological diseases can be adequately understood without knowledge of the release, uptake and metabolism of glutamate. The reason for this is that glutamate (a) is the most abundant amino acid in the brain, (b) is at the cross-roads between several metabolic pathways, and (c) serves as the major excitatory neurotransmitter. In fact most brain cells express glutamate receptors and are thereby influenced by extracellular glutamate. In agreement, brain cells have powerful uptake systems that constantly remove glutamate from the extracellular fluid and thereby limit receptor activation. It has been clear since the 1970s that both astrocytes and neurons express glutamate transporters. However the relative contribution of neuronal and glial transporters to the total glutamate uptake activity, however, as well as their functional importance, has been hotly debated ever since. The present short review provides (a) an overview of what we know about neuronal glutamate uptake as well as an historical description of how we got there, and (b) a hypothesis reconciling apparently contradicting observations thereby possibly resolving the paradox.
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Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse
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Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation
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Self-citationFurness, D. N., Dehnes, Y., Akhtar, A. Q., Rossi, D. J., Hamann, M., Grutle, N. J., Gundersen, V., Holmseth, S., Lehre, K. P., Ullensvang, K., et al. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.08.043 · Cited by 254
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Antibodies as valuable neuroscience research tools versus reagents of mass distraction
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Andersen, J. V., Markussen, K. H., Jakobsen, E., Schousboe, A., Waagepetersen, H. S., Rosenberg, P. A., & Aldana, B. I. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108719 · Cited by 371
Astrocyte Biomarkers in Alzheimer’s Disease
Carter, S. F., Herholz, K., Rosa-Neto, P., Pellerin, L., Nordberg, A., & Zimmer, E. R. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.11.006 · Cited by 355
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Sears, S. M., & Hewett, S. J. (2021) · Experimental Biology and Medicine · doi:10.1177/1535370221989263 · Cited by 336
Glutamatergic Signaling Along The Microbiota-Gut-Brain Axis
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Metadata
- Authors
- Danbolt, N. C., Furness, D. N., & Zhou, Y.
- Venue
- Neurochemistry International
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 98
- Pages
- 29-45
- ISSN
- 0197-0186 (ISSN-L)
- OpenAlex
- W2395225545
- Cited by
- 215
- References
- 11
- FWCI
- 13.85
- Type
- journal article
- Language
- en
- Open access
- green
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