Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies
Abstract
Abnormalities in tau mRNA splicing cause frontotemporal dementia and parkinsonism linked to chromosome 17, and similar alterations are suggested in sporadic tauopathies such as progressive supranuclear palsy (PSP) or corticobasal degeneration (CBD). We have analyzed the expression of three-repeat (3R) and four-repeat (4R) tau isoforms in brains with familial and sporadic tauopathies. By RT-PCR analysis, decreased levels of 3R tau mRNA were detected not only in severely affected cases with progressive supranuclear palsy or corticobasal degeneration but also in cases with Alzheimer's disease or Pick's disease. Levels of 3R tau transcripts were closely correlated with levels of neurofilament transcripts. By contrast, expressions of glial fibrillary acidic protein and myelin basic protein were similar in all brains. These results suggest that decrease of 3R tau mRNA associated with loss of neuronal element may largely contribute to the increased ratio of 4R/3R tau mRNA in sporadic tauopathies.
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4R tau expression is increased in vulnerable brain regions and NFT bearing neurons in AD brain.
“Expression of tau isoforms in AD brain is complicated; although it is still under debate that whether the overall 3R:4R tau ratio is altered, several studies support a notion that 4R tau expression is increased in vulnerable brain regions and NFT bearing neurons in AD brain [111, 113–118].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [114]
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Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
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- Authors
- Umeda, Y., Taniguchi, S., Arima, K., Piao, Y.-S., Takahashi, H., Iwatsubo, T., Mann, D., & Hasegawa, M.
- Affiliations
- Tokyo Institute of Psychiatry (JP)
- Brain Research Institute, Niigata University (JP)
- The University of Tokyo (JP)
- University of Manchester (GB)
- Corresponding author
- Hasegawa, Masato
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 359
- Issue
- 3
- Pages
- 151-154
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2127547734
- Cited by
- 39
- References
- 18
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2013: 2 · 2012: 2
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- tau isoforms, four-repeat tau, neurofilaments, progressive supranuclear palsy, corticobasal degeneration, frontotemporal dementia, Alzheimer's disease, Pick's disease, glial fibrillary acidic protein, myelin basic protein, neuronal loss
- MeSH terms
- Brain, Cells, Cultured, Chromosomes, Human, Pair 17, Gene Expression Regulation, Genetic Testing, Humans, Mutation, Nerve Tissue Proteins, Reference Values, Statistics as Topic, Transcription Factors, Transcription, Genetic, tau Proteins, Trinucleotide Repeats, Protein Isoforms, Gene Expression Profiling, Tauopathies, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors
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