Single molecule profiling of tau gene expression in Alzheimer’s disease
Open accessAbstract
Tau is a microtubule‐associated protein that is important for establishing and maintaining neuronal morphology. In addition to its role in normal cells, tau protein is involved in many neurodegenerative diseases, e.g. Alzheimer’s disease (AD) and frontotemporal dementia, as the main component of intraneuronal aggregates. Alternative splicing of tau gene in the brain can give rise to at least six protein variants. A causative role of skewed tau exon 10 inclusion has been defined in frontotemporal dementia; however, no link was established between the aberrant splicing of tau and AD. Here, we applied a single‐molecule‐based technology, polymerase colony or polony, to simultaneously monitor tau splicing variant and haplotype profile in sporadic AD and normal brains. We found that the coordinated expression of tau exons 2 and 10 is altered in AD. Additional investigations of cis and trans mechanisms of this observation revealed a decreased protein expression of a known tau splicing factor, htra2‐beta‐1 in AD, thereby implicating a trans mechanism. Our results demonstrate that dysregulation of combinatorial splicing might serve as a signature for aging‐related diseases, and the polony assay could be widely adapted for the study of other tauopathies. Furthermore, splicing‐based therapeutics is an emerging area of drug development, and a well‐defined and quantitative assay for monitoring single‐gene transcriptome will be relevant for such development.
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4R tau expression is increased in vulnerable brain regions and NFT bearing neurons in AD brain.
“Expression of tau isoforms in AD brain is complicated; although it is still under debate that whether the overall 3R:4R tau ratio is altered, several studies support a notion that 4R tau expression is increased in vulnerable brain regions and NFT bearing neurons in AD brain [111, 113–118].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [117]
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Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216 · see citing works
Goedert, M., Spillantini, M. G., Jakes, R., Rutherford, D., & Crowther, R. A. (1989) · Neuron · doi:10.1016/0896-6273(89)90210-9 · Cited by 2,492 · see citing works
Buée, L., Bussière, T., Buée‐Scherrer, V., Delacourte, A., & Hof, P. R. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00019-9 · Cited by 2,007 · see citing works
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
Spillantini, M. G., Murrell, J. R., Goedert, M., Farlow, M. R., Klug, A., & Ghetti, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7737 · Cited by 1,474 · see citing works
Accurate Multiplex Polony Sequencing of an Evolved Bacterial Genome
Shendure, J., Porreca, G. J., Reppas, N. B., Lin, X., McCutcheon, J. P., Rosenbaum, A. M., Wang, M. D., Zhang, K., Mitra, R. D., & Church, G. M. (2005) · Science · doi:10.1126/science.1117389 · Cited by 1,402 · see citing works
Self-citationGoedert, M., Spillantini, M. G., Potier, M. C., Ulrich, J., & Crowther, R. A. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03390.x · Cited by 1,037 · see citing works
Association of an Extended Haplotype in the Tau Gene with Progressive Supranuclear Palsy
Baker, M., Litvan, I., Houlden, H., Adamson, J., Dickson, D., Perez-Tur, J., Hardy, J., Lynch, T., Bigio, E., & Hutton, M. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.4.711 · Cited by 781 · see citing works
Alternative pre-mRNA splicing and proteome expansion in metazoans
Maniatis, T., & Tasic, B. (2002) · Nature · doi:10.1038/418236a · Cited by 766 · see citing works
Early Aβ accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain
Ingelsson, M., Fukumoto, H., Newell, K. L., Growdon, J. H., Hedley–Whyte, E. T., Frosch, M. P., Albert, M. S., Hyman, B. T., & Irizarry, M. C. (2004) · Neurology · doi:10.1212/01.wnl.0000115115.98960.37 · Cited by 666 · see citing works
Self-citationD'Souza, I., Poorkaj, P., Hong, M., Nochlin, D., Lee, V., Bird, T., & Schellenberg, G. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.10.5598 · Cited by 545 · see citing works
Hecker, K. H., & Roux, K. H. (1996) · BioTechniques · doi:10.2144/19962003478 · Cited by 415 · see citing works
LoPresti, P., Szuchet, S., Papasozomenos, S. C., Zinkowski, R. P., & Binder, L. I. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10369 · Cited by 388 · see citing works
Dysregulation of human brain microtubule-associated tau mRNA maturation in myotonic dystrophy type 1
Sergeant, N. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.19.2143 · Cited by 281 · see citing works
Myers, A., Pittman, A. M., Zhao, A. S., Rohrer, K., Kaleem, M. A., Marlowe, L., Lees, A. J., Leung, D. G., McKeith, I. G., Perry, R. H., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.10.018 · Cited by 254 · see citing works
Family-Based Association between Alzheimer's Disease and Variants inUBQLN1
Bertram, L., Hiltunen, M. O., Parkinson, M., Ingelsson, M., Lange, C., Ramasamy, K., Mullin, K., Menon, R., Sampson, A. J., Hsiao, M., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042765 · Cited by 227 · see citing works
Self-citationTau alteration and neuronal degeneration in tauopathies: mechanisms and models
Brandt, R., Hundelt, M., & Shahani, N. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.06.018 · Cited by 222 · see citing works
The H1c haplotype at the MAPT locus is associated with Alzheimer's disease
Myers, A. J., Kaleem, M., Marlowe, L., Pittman, A. M., Lees, A. J., Fung, H., Duckworth, J., Leung, D. G., Gibson, A., Morris, C. M., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi241 · Cited by 221 · see citing works
Stoilov, P. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh051 · Cited by 179 · see citing works
Regulation of tau isoform expression and dementia
D’Souza, I., & Schellenberg, G. D. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.08.009 · Cited by 151 · see citing works
Glatz, D. C., Rujescu, D., Tang, Y., Berendt, F. J., Hartmann, A. M., Faltraco, F., Rosenberg, C. K., Hulette, C., Jellinger, K., Hampel, H. J., et al. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03552.x · Cited by 145 · see citing works
Self-citationHaplotype-specific expression of exon 10 at the human MAPT locus
Caffrey, T. M., Joachim, C. L., Paracchini, S., Esiri, M. M., & Wade‐Martins, R. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl429 · Cited by 135 · see citing works
Expression of microtubule-associated proteins MAP2 and tau in cultured rat brain oligodendrocytes
Müller, R., Heinrich, M., Heck, S., Blohm, D., & Richter-Landsberg, C. (1997) · Cell and Tissue Research · doi:10.1007/s004410050809 · Cited by 127 · see citing works
Rießland, M., Brichta, L., Hahnen, E., & Wirth, B. (2006) · Human Genetics · doi:10.1007/s00439-006-0186-1 · Cited by 126 · see citing works
Ginsberg, S. D., Che, S., Counts, S. E., & Mufson, E. J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03641.x · Cited by 111 · see citing works
de Silva, R., Lashley, T., Strand, C., Shiarli, A.-M., Shi, J., Tian, J., Bailey, K. L., Davies, P., Bigio, E. H., Arima, K., et al. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0048-x · Cited by 108 · see citing works
Single Molecule Profiling of Alternative Pre-mRNA Splicing
Zhu, J., Shendure, J., Mitra, R. D., & Church, G. M. (2003) · Science · doi:10.1126/science.1085792 · Cited by 99 · see citing works
Self-citationHigh-Resolution Semi-Quantitative Real-Time PCR without the Use of a Standard Curve
Gentle, A., Anastasopoulos, F., & McBrien, N. A. (2001) · BioTechniques · doi:10.2144/01313st03 · Cited by 96 · see citing works
Andreadis, A., Broderick, J. A., & Kosik, K. S. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.17.3585 · Cited by 89 · see citing works
Boutajangout, A., Boom, A., Leroy, K., & Brion, J. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.09.011 · Cited by 77 · see citing works
Wang, Y., Wang, J., Gao, L., Lafyatis, R., Stamm, S., & Andreadis, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413846200 · Cited by 75 · see citing works
Self-citationQuantitative analysis of tau isoform transcripts in sporadic tauopathies
Connell, J. W., Rodriguez-Martin, T., Gibb, G. M., Kahn, N. M., Grierson, A. J., Hanger, D. P., Revesz, T., Lantos, P. L., Anderton, B. H., & Gallo, J.-M. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.02.014 · Cited by 70 · see citing works
Laws, S. M., Friedrich, P., Diehl‐Schmid, J., Müller, J., Eisele, T., Bäuml, J., Förstl, H., Kurz, A., & Riemenschneider, M. J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001935 · Cited by 68 · see citing works
Fujino, Y., Wang, D.-S., Thomas, N., Espinoza, M., Davies, P., & Dickson, D. W. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.3.209 · Cited by 63 · see citing works
Clinical and biochemical correlates of insoluble α-synuclein in dementia with Lewy bodies
Klucken, J., Ingelsson, M., Shin, Y., Irizarry, M. C., Hedley‐Whyte, E. T., Frosch, M. P., Growdon, J. H., McLean, P. J., & Hyman, B. T. (2006) · Acta Neuropathologica · doi:10.1007/s00401-005-0027-7 · Cited by 60 · see citing works
Self-citationCouchie, D., Charrière‐Bertrand, C., & Nunez, J. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb02494.x · Cited by 58 · see citing works
Haplotype-based association analysis of the MAPT locus in Late Onset Alzheimer's disease
Mukherjee, O., Kauwe, J. S., Mayo, K., Morris, J. C., & Goate, A. (2007) · BMC Genetics · doi:10.1186/1471-2156-8-3 · Cited by 52 · see citing works
Tangled areas of Alzheimer brain have upregulated levels of exon 10 containing tau mRNA
Yasojima, K., McGeer, E. G., & McGeer, P. L. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01486-9 · Cited by 51 · see citing works
Takanashi, M., Mori, H., Arima, K., Mizuno, Y., & Hattori, N. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00382-0 · Cited by 46 · see citing works
Conrad, C., Vianna, C., Schultz, C., Thal, D. R., Ghebremedhin, E., Lenz, J., Braak, H., & Davies, P. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2004.02320.x · Cited by 42 · see citing works
Self-citationIngelsson, M., Ramasamy, K., Cantuti‐Castelvetri, I., Skoglund, L., Matsui, T., Orne, J. D., Kowa, H., Raju, S., Vanderburg, C. R., Augustinack, J. C., et al. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0095-3 · Cited by 41 · see citing works
Self-citationAlterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies
Umeda, Y., Taniguchi, S., Arima, K., Piao, Y.-S., Takahashi, H., Iwatsubo, T., Mann, D., & Hasegawa, M. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.01.060 · Cited by 39 · see citing works
Klucken, J., McLean, P. J., Gómez‐Tortosa, E., Ingelsson, M., & Hyman, B. T. (2003) · Neurochemical Research · doi:10.1023/a:1026061021946 · Cited by 38 · see citing works
Self-citationSelective vulnerability of neocortical association areas in Alzheimer's disease
Giannakopoulos, P., Hof, P. R., & Bouras, C. (1998) · Microscopy Research and Technique · doi:10.1002/(sici)1097-0029(19981001)43:1 · Cited by 31 · see citing works
Schindler, H., Wiese, A., Auer, J., & BURTSCHER, H. J. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.06.006 · Cited by 27 · see citing works
Glial tau-positive structures lack the sequence encoded by exon 3 of the tau protein gene
Nishimura, T., Ikeda, K., Akiyama, H., Arai, T., Kondo, H., Okochi, M., Furiya, Y., Mori, H., Oda, T., Kato, M., et al. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00161-4 · Cited by 23 · see citing works
Aach, J., & Church, G. M. (2004) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2003.12.003 · Cited by 14 · see citing works
Self-citationDESIGN OF A HIGH-THROUGHPUT ASSAY FOR ALTERNATIVE SPLICING USING POLYMERASE COLONIES
Buhler, J. D., Souvenir, R., ZHANG, W., & Mitra, R. D. (2003) · Pacific Symposium on Biocomputing (PSB) · doi:10.1142/9789812704856_0002 · Cited by 2 · see citing works
Kordower (1999) · doi:10.1002/1531-8249(199909)46:3
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- C. Conrad et al. Journal Compilation Ó 2007 International Society for Neurochemistry, J. Neurochem. (2007) 103, 1228-1236
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Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works
Tau pathophysiology in neurodegeneration: a tangled issue
Spires‐Jones, T. L., Stoothoff, W. H., de Calignon, A., Jones, P., & Hyman, B. T. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.11.007 · Cited by 316 · see citing works
Self-citationRichetin, K., Steullet, P., Pachoud, M., Perbet, R., Parietti, E., Maheswaran, M., Eddarkaoui, S., Bégard, S., Pythoud, C., Rey, M. J., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00728-x · Cited by 208 · see citing works
Bourdenx, M., Koulakiotis, N. S., Sanoudou, D., Bézard, E., Dehay, B., & Tsarbopoulos, A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.07.003 · Cited by 189 · see citing works
Antisense oligonucleotides: treating neurodegeneration at the level of RNA
DeVos, S. L., & Miller, T. M. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0194-5 · Cited by 164 · see citing works
Using the zebrafish model for Alzheimer’s disease research
Newman, M., Ebrahimie, E., & Lardelli, M. T. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00189 · Cited by 148 · see citing works
Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease
Chu, Y., Hirst, W. D., Federoff, H. J., Harms, A. S., Stoessl, A. J., & Kordower, J. H. (2023) · Brain · doi:10.1093/brain/awad388 · Cited by 149 · see citing works
Differential effect of three‐repeat and four‐repeat tau on mitochondrial axonal transport
Stoothoff, W., Jones, P. B., Spires‐Jones, T. L., Joyner, D., Chhabra, E., Bercury, K., Fan, Z., Xie, H., Bacskai, B., Edd, J., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06316.x · Cited by 135 · see citing works
Self-citationTau isoform composition influences rate and extent of filament formation
Zhong, Q., Congdon, E. E., Nagaraja, H. N., & Kuret, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.364067 · Cited by 122 · see citing works
NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model
Shiryaev, N., Jouroukhin, Y., Giladi, E., Polyzoidou, E., Grigoriadis, N., Rosenmann, H., & Gozes, I. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.02.011 · Cited by 122 · see citing works
Kar, A. N., Fushimi, K., Zhou, X., Ray, P., Chen, S., Chen, X., Liu, Z., Chen, S., & Wu, J. Y. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01149-10 · Cited by 120 · see citing works
Pathological Changes of Tau Related to Alzheimer’s Disease
Chu, D., & Liu, F. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00457 · Cited by 103 · see citing works
Brain pathology in myotonic dystrophy: when tauopathy meets spliceopathy and RNAopathy
Caillet‐Boudin, M., Fernández-Gómez, F.-J., Tran, H., Dhaenens, C., Buée, L., & Sergeant, N. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00057 · Cited by 99 · see citing works
Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease
Rosa, E., Mahendram, S., Ke, Y. D., Ittner, L. M., Ginsberg, S. D., & Fahnestock, M. L. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.020 · Cited by 91 · see citing works
Co-occurrence of mixed proteinopathies in late-stage Huntington’s disease
St‐Amour, I., Turgeon, A., Goupil, C., Planel, E., & Hébert, S. S. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1786-7 · Cited by 92 · see citing works
Tau alternative splicing in familial and sporadic tauopathies
Niblock, M., & Gallo, J. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120091 · Cited by 87 · see citing works
Tau splicing and the intricacies of dementia
Andreadis, A. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22842 · Cited by 83 · see citing works
Sharman, M., Nik, S. H. M., Chen, M.-Q., Ong, D., Wijaya, L. K., Laws, S., Taddei, K., Newman, M., Lardelli, M., Martins, R., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066235 · Cited by 207 · see citing works
Sidibé, H., Dubinski, A. F., & Velde, C. V. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15280 · Cited by 83 · see citing works
Liang, W. S., Dunckley, T. L., Beach, T. G., Grover, A., Mastroeni, D., Ramsey, K. M., Caselli, R. J., Kukull, W. A., McKeel, D. W., Morris, J. C., et al. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.013 · Cited by 79 · see citing works
Glycogen synthase kinase‐3β and tau genes interact in Alzheimer's disease
Kwok, J. B., Loy, C. T., Hamilton, G., Lau, E., Hallupp, M., Williams, J. H., Owen, M. J., Broe, G. A., Tang, N. L. S., LAM, L. C. W., et al. (2008) · Annals of Neurology · doi:10.1002/ana.21476 · Cited by 76 · see citing works
MAPT Isoforms: Differential Transcriptional Profiles Related to 3R and 4R Splice Variants
Chen, S., Townsend, K. P., Goldberg, T. E., Davies, P., & Conejero‐Goldberg, C. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101155 · Cited by 75 · see citing works
Kulbe, J. R., & Hall, E. D. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.08.003 · Cited by 69 · see citing works
Sutherland, G. T., Janitz, M., & Kril, J. J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07157.x · Cited by 67 · see citing works
Complex Splicing and Neural Expression of Duplicated Tau Genes in Zebrafish Embryos
Chen, M., Martins, R. N., & Lardelli, M. T. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1145 · Cited by 67 · see citing works
Glycation alter the process of Tau phosphorylation to change Tau isoforms aggregation property
Liu, K., Liu, Y., Li, L., Qin, P., Iqbal, J., Deng, Y., & Qing, H. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.002 · Cited by 60 · see citing works
Rodríguez-Martín, T., Anthony, K., García-Blanco, M. A., Mansfield, S. G., Anderton, B. H., & Gallo, J. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp264 · Cited by 57 · see citing works
Tau Aggregation and Toxicity in Tauopathic Neurodegenerative Diseases
Honson, N. S., & Kuret, J. (2008) · Journal of Alzheimer's Disease · doi:10.3233/jad-2008-14409 · Cited by 54 · see citing works
Caillierez, R., Bégard, S., Lécolle, K., Deramecourt, V., Zommer, N., Dujardin, S., Loyens, A., Dufour, N., Aurégan, G., Winderickx, J., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.66 · Cited by 43 · see citing works
Wang, Y., Wang, J., Gao, L., Stamm, S., & Andreadis, A. (2011) · Gene · doi:10.1016/j.gene.2011.06.020 · Cited by 43 · see citing works
Self-citationBrainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease
Overk, C., Kelley, C. M., & Mufson, E. J. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.004 · Cited by 42 · see citing works
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Self-citationRNA Protein Granules Modulate tau Isoform Expression and Induce Neuronal Sprouting
Moschner, K., Sündermann, F., Meyer, H., da Graça, A. P., Appel, N., Paululat, A., Bakota, L., & Brandt, R. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.541425 · Cited by 37 · see citing works
Decreased alternative splicing of estrogen receptor-α mRNA in the Alzheimer's disease brain
Ishunina, T. A., & Swaab, D. F. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.03.010 · Cited by 34 · see citing works
Bowles, K. R., Pugh, D. A., Oja, L., Jadow, B. M., Farrell, K. W., Whitney, K. R., Sharma, A., Cherry, J. D., Raj, T., Pereira, A. C., et al. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02392-2 · Cited by 32 · see citing works
Nik, S. H. M., Newman, M., Ganesan, S., Chen, M., Martins, R. N., Verdile, G., & Lardelli, M. T. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-767 · Cited by 30 · see citing works
Monitoring tau-tubulin interactions utilizing second harmonic generation in living neurons
Stoothoff, W. H., Bacskai, B. J., & Hyman, B. T. (2008) · Journal of Biomedical Optics · doi:10.1117/1.3050422 · Cited by 29 · see citing works
Self-citationThe influence of APOEε4 on the pTau interactome in sporadic Alzheimer’s disease
Thierry, M., Ponce, J., Martá-Ariza, M., Askenazi, M., Faustin, A., Leitner, D., Pires, G., Kanshin, E., Drummond, E., Ueberheide, B. M., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02744-8 · Cited by 27 · see citing works
Systematic review and meta‐analysis of bulk RNAseq studies in human Alzheimer's disease brain tissue
Heberle, B. A., Fox, K. L., Libermann, L. L., Xavier, S. R. M., Dallarosa, G. T., Santos, R. C., Fardo, D. W., Viola, T. W., & Ebbert, M. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70025 · Cited by 29 · see citing works
Wang, Y., Gao, L., Tse, S., & Andreadis, A. (2009) · Gene · doi:10.1016/j.gene.2009.11.006 · Cited by 23 · see citing works
Barron, M. R., Gartlon, J. E., Dawson, L. A., Atkinson, P. J., & Pardon, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00293 · Cited by 18 · see citing works
Bowles, K. R., Pedicone, C., Pugh, D. A., Oja, L., Sousa, F. H., Keavey, L., Fulton‐Howard, B., Weitzman, S. A., Liu, Y., Chen, J. L., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.115013 · Cited by 20 · see citing works
Das, V., Sim, D. A., & Miller, J. H. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23394 · Cited by 18 · see citing works
Advances in Genetic and Molecular Understanding of Alzheimer’s Disease
Ibáñez, L., Cruchaga, C., & Fernández, M. V. (2021) · Genes · doi:10.3390/genes12081247 · Cited by 18 · see citing works
Mutreja, Y., & Gamblin, T. C. (2017) · Methods in cell biology · doi:10.1016/bs.mcb.2017.06.007 · Cited by 16 · see citing works
Noël, A., Foveau, B., & LeBlanc, A. C. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03506-0 · Cited by 16 · see citing works
Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing
Suh, J., Im, D. S., Moon, G. J., Ryu, K.-S., de Silva, R., Choi, I. S., Lees, A. J., Guénette, S. Y., Tanzi, R. E., & Gwag, B. J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06732.x · Cited by 13 · see citing works
Targeting mRNA for Alzheimer’s and Related Dementias
Wolfe, M. S. (2014) · Scientifica · doi:10.1155/2014/757549 · Cited by 13 · see citing works
Anton, P. E., Maphis, N. M., Linsenbardt, D. N., & Coleman, L. G. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-81908-7_10 · Cited by 12 · see citing works
Ishunina, T. A. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819973-2.00012-5 · Cited by 11 · see citing works
Molecular Colony Technique: A New Tool for Biomedical Research and Clinical Practice
Chetverin, A. B., & Chetverina, H. V. (2008) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)00007-x · Cited by 10 · see citing works
Expression of 1N3R-Tau Isoform Inhibits Cell Proliferation by Inducing S Phase Arrest in N2a Cells
Li, L., Xu, Z.-P., Liu, G.-P., Xu, C., Wang, Z.-H., Li, X.-G., Liu, E., Zeng, J., Chai, D.-M., Yao, W.-L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119865 · Cited by 11 · see citing works
Nanocolonies: Detection, cloning, and analysis of individual molecules
Chetverina, H. V., & Chetverin, A. B. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908130014 · Cited by 9 · see citing works
Alpha‐Synuclein Demonstrates Varying Binding Affinities With Different Tau Isoforms
Fischer, A., Schmitz, M., Thom, T., Zafar, S., Younas, N., Correia, S., Correia, A. D. S., Canaslan, S., & Zerr, I. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70053 · Cited by 6 · see citing works
Nanocolonies and diagnostics of oncological diseases associated with chromosomal translocations
Chetverina, Е. V., & Chetverin, A. B. (2010) · Biochemistry (Moscow) · doi:10.1134/s0006297910130109 · Cited by 4 · see citing works
Bowles, K. R., Pugh, D., Pedicone, C., Oja, L., Weitzman, S. A., Liu, Y., Chen, J., Disney, M. D., & Goate, A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.02.543224 · Cited by 3 · see citing works
Systematic review and meta-analysis of bulk RNAseq studies in human Alzheimer’s disease brain tissuePreprint
Heberle, B. A., Fox, K. L., Libermann, L. L., Xavier, S. R. M., Dallarosa, G. T., Santos, R. C., Fardo, D. W., Viola, T. W., & Ebbert, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.07.622520 · Cited by 3 · see citing works
Differential expression profiles of MAPT (TAU) gene isoforms in dry age-related macular degeneration
Lak, S. S., Kanavi, M. R., Bayat, K., Ahmadieh, H., Soheili, Z., & Suri, F. (2025) · Experimental Eye Research · doi:10.1016/j.exer.2025.110517 · Cited by 2 · see citing works
Single-Cell and Regional Gene Expression Analysis in Alzheimer’s Disease
Kwong, R., Lupton, M. K., & Janitz, M. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9797-3 · Cited by 2 · see citing works
Alzheimer's disease pathology in aged chimpanzees
Edler, M. K. (2016) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 2 · see citing works
Simple In Vivo Models of Alzheimer’s Disease
Caito, S. W., & Newell-Caito, J. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802810-0.00011-8 · Cited by 2 · see citing works
Phenotypically concordant distribution of pick bodies in aphasic versus behavioral dementias
Kawles, A., Keszycki, R. M., Minogue, G., Zouridakis, A., Ayala, I. A. D. L., Gill, N. P., Macomber, A. J., Lubbat, V., Coventry, C., Rogalski, E. J., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01738-7 · Cited by 2 · see citing works
Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau
Tsefou, E., Bez, S., Birkle, T. J. Y., Foiani, M. S., Watamura, N., Bourdenx, M., Gavriouchkina, D., Turkes, E., Crawford, S., Coneys, R., et al. (2026) · Science Advances · doi:10.1126/sciadv.aeg1445 · Cited by 1 · see citing works
Simple in vivo models of Alzheimer's disease
Caito, S. W., & Newell-Caito, J. L. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30008-0.00006-5
Kawles, A., Keszycki, R. M., Minogue, G., Zouridakis, A., Ayala, I. A. D. L., Gill, N., Macomber, A. J., Lubbat, V., Coventry, C., Rogalski, E., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26684589
Chronic stress and glucocorticoid actions in brain plasticity and Tau pathology
Dioli, C. (2021) · theses.fr (ABES) · doi:10.70675/b812791ezcc0az4036zb746z0d9b5daacfab
Chronic mitochondrial DNA depletion alters MAPT splicing and increases tau levels
Weidling, I. W., Nissen, E., Wang, X., Novikova, L., Menta, B. W., Roberts, A., Ranjan, A., Kemna, R. E., Morris, J. K., Wilkins, H., et al. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261492673
- Authors
- Conrad, C., Zhu, J., Conrad, C., Schoenfeld, D., Fang, Z., Ingelsson, M., Stamm, S., Church, G., & Hyman, B. T.
- Affiliations
- Massachusetts General Hospital (US)
- Duke Medical Center (US)
- LSU New Orleans (US)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Harvard University (US)
- Corresponding author
- Conrad, Chris
- Zhu, Jun
- ORCID
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2007-07-26
- Volume
- 103
- Issue
- 3
- Pages
- 1228-1236
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2043216798
- Cited by
- 68
- References
- 48
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 4 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P50AG005134)
- National Human Genome Research Institute
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, alternative splicing, tauopathy
- MeSH terms
- High-Temperature Requirement A Serine Peptidase 2, Aged, Aged, 80 and over, Alzheimer Disease, Biological Assay, Brain, Brain Chemistry, Exons, Haplotypes, Humans, Molecular Biology, Serine Endopeptidases, Gene Expression, tau Proteins, Alternative Splicing, Genetic Predisposition to Disease, Protein Isoforms, Gene Expression Profiling, Mitochondrial Proteins
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