Cited by 121Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/ΔE9 mice

Lalonde, R., Kim, H.D., Fukuchi, K.·2004·Neuroscience Letters

Abstract

Bigenic APPswe + PS1/DeltaE9 mice with Abeta plaque formation in neocortex and hippocampus were evaluated in three tests measuring exploratory activity. By comparison to a non-transgenic group controlled for age and gender, 7-month-old APPswe + PS1/DeltaE9 mice spent more time in the open arms and had higher open/total entries and duration in the elevated plus-maze, indicative of disinhibitory tendencies. On the contrary, the groups did not differ in T-maze and open-field tests. Moreover, the motor coordination of the bigenic group was equivalent to that of controls in stationary beam, coat-hanger, rotorod, and grip strength tests. No mouse displayed neurological signs, such as pathological reflexes, myoclonus, or convulsions. The results in the elevated plus-maze test are akin to the loss of inhibitory control observed in some patients with Alzheimer's disease.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.neulet.2004.07.069

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 1

  1. Lalonde, 1999, Motor performance of spontaneous murine mutations with cerebellar atrophy, vol. 13, 627

Cited by

Sorted by citations

See all 121

Metadata

Authors
Lalonde, R., Kim, H. D., & Fukuchi, K.
Affiliations
  • Inserm (FR)
  • University of Alabama at Birmingham (US)
Corresponding author
Lalonde, R.
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2004-10
Volume
369
Issue
2
Pages
156-161
ISSN
0304-3940 (ISSN-L)
OpenAlex
W1969424555
Cited by
121
References
30
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 5 · 2014: 3 · 2013: 18 · 2012: 7
FWCI
1.65
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
APPswe, Alzheimer's disease, exploratory activity, anxiety, motor coordination, elevated plus maze, disinhibition, amyloid plaques, open field behavior, T-maze, beam walking, grip strength
MeSH terms
Animals, Anxiety, Behavior, Animal, Chromosomal Proteins, Non-Histone, Exploratory Behavior, Female, Male, Mice, Transgenic, Psychomotor Performance, Amyloid beta-Protein Precursor, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review