The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/ΔE9 mice
Abstract
Bigenic APPswe + PS1/DeltaE9 mice with Abeta plaque formation in neocortex and hippocampus were evaluated in three tests measuring exploratory activity. By comparison to a non-transgenic group controlled for age and gender, 7-month-old APPswe + PS1/DeltaE9 mice spent more time in the open arms and had higher open/total entries and duration in the elevated plus-maze, indicative of disinhibitory tendencies. On the contrary, the groups did not differ in T-maze and open-field tests. Moreover, the motor coordination of the bigenic group was equivalent to that of controls in stationary beam, coat-hanger, rotorod, and grip strength tests. No mouse displayed neurological signs, such as pathological reflexes, myoclonus, or convulsions. The results in the elevated plus-maze test are akin to the loss of inhibitory control observed in some patients with Alzheimer's disease.
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“As expected (27), PS1-APP, PS1-APP-CX3CR1+/−, and WT littermate mice showed no difference in exploratory behavior (data not shown).”
From Heterozygous CX3CR1 Deficiency in Microglia Restores Neuronal β-Amyloid Clearance Pathways and Slows Progression of Alzheimer's Like-Disease in PS1-APP Mice (2019) · cites this paper as [27]
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Cites
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
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β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
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Research works printed but not linked: 1
- Lalonde, 1999, Motor performance of spontaneous murine mutations with cerebellar atrophy, vol. 13, 627
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Webster, S. J., Bachstetter, A. D., Nelson, P. T., Schmitt, F. A., & Van Eldik, L. J. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00088 · Cited by 755
“No deficits were seen in alternation tasks of working memory for this model (Lalonde et al., 2004; Cao et al., 2007).”
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Impaired spatial learning in the APPSwe + PSEN1ΔE9 bigenic mouse model of Alzheimer’s disease
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Hippocampal neurogenesis: Learning to remember
Lazarov, O., & Hollands, C. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.12.006 · Cited by 297
Song, M., Jin, J., Lim, J.-E., Kou, J., Pattanayak, A., Rehman, J. A., Kim, H.-D., Tahara, K., Lalonde, R., & Fukuchi, K.-I. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-92 · Cited by 273
Self-citation
Metadata
- Authors
- Lalonde, R., Kim, H. D., & Fukuchi, K.
- Affiliations
- Inserm (FR)
- University of Alabama at Birmingham (US)
- Corresponding author
- Lalonde, R.
- ORCID
- Lalonde, R.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 369
- Issue
- 2
- Pages
- 156-161
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1969424555
- Cited by
- 121
- References
- 30
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 5 · 2014: 3 · 2013: 18 · 2012: 7
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- APPswe, Alzheimer's disease, exploratory activity, anxiety, motor coordination, elevated plus maze, disinhibition, amyloid plaques, open field behavior, T-maze, beam walking, grip strength
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Chromosomal Proteins, Non-Histone, Exploratory Behavior, Female, Male, Mice, Transgenic, Psychomotor Performance, Amyloid beta-Protein Precursor, Mice
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