Cited by 121Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroscience and Neuropharmacology Research

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Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/ΔE9 mice

Lalonde, R., Kim, H.D., Fukuchi, K.·2004·Neuroscience Letters

DOI 10.1016/j.neulet.2004.07.069

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Abstract

Bigenic APPswe + PS1/DeltaE9 mice with Abeta plaque formation in neocortex and hippocampus were evaluated in three tests measuring exploratory activity. By comparison to a non-transgenic group controlled for age and gender, 7-month-old APPswe + PS1/DeltaE9 mice spent more time in the open arms and had higher open/total entries and duration in the elevated plus-maze, indicative of disinhibitory tendencies. On the contrary, the groups did not differ in T-maze and open-field tests. Moreover, the motor coordination of the bigenic group was equivalent to that of controls in stationary beam, coat-hanger, rotorod, and grip strength tests. No mouse displayed neurological signs, such as pathological reflexes, myoclonus, or convulsions. The results in the elevated plus-maze test are akin to the loss of inhibitory control observed in some patients with Alzheimer's disease.

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Authors: Lalonde, R., Kim, H. D., & Fukuchi, K.
Affiliations: Inserm (FR)
University of Alabama at Birmingham (US)
Corresponding author: Lalonde, R.
ORCID: Lalonde, R.
Venue: Neuroscience Letters
Publisher: Elsevier BV
Published: 2004-10
Volume: 369
Issue: 2
Pages: 156-161
ISSN: 0304-3940 (ISSN-L)
DOI: 10.1016/j.neulet.2004.07.069
OpenAlex: W1969424555
Cited by: 121
References: 30
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 5 · 2014: 3 · 2013: 18 · 2012: 7
FWCI: 1.65
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: APPswe, Alzheimer's disease, exploratory activity, anxiety, motor coordination, elevated plus maze, disinhibition, amyloid plaques, open field behavior, T-maze, beam walking, grip strength
MeSH terms: Animals, Anxiety, Behavior, Animal, Chromosomal Proteins, Non-Histone, Exploratory Behavior, Female, Male, Mice, Transgenic, Psychomotor Performance, Amyloid beta-Protein Precursor, Mice

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Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/ΔE9 mice

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