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Neurotrophin gene expression in rat brain under the action of Semax, an analogue of ACTH4–10
Abstract
The heptapeptide Semax, an analogue of the N-terminal adrenocorticotropic hormone fragment (4-10) (ACTH(4-10)), has been shown to exert a number of neuroprotective effects. There are some investigations that connected these effects with the increase of neurotrophin gene expression under the peptide drug application in neuron cell cultures [M.I. Shadrina, O.V. Dolotov, I.A. Grivennikov, P.A. Slominsky, L.A. Andreeva, L.S. Inozemtseva, S.A. Limborska, N.F. Myasoedov, Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analogue, Neurosci. Lett. 308 (2001) (2) 115-118]. In this work, we examined the action of Semax on rapid changes of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) gene expression in vivo. Male Wistar rats were treated for 1h with Semax (50 microg/kg, single intranasal application) and neurotrophin gene expression in rat brain was analyzed by real-time polymerase chain reaction (PCR). It was revealed that an intranasal application of Semax increased the expression of both neurotrophin genes in rat hippocampus. Bdnf gene expression also increased in the brainstem and cerebellum. Ngf gene expression decreased in rat frontal cortex. Thus, Semax induces rapid, gene- and region-specific changes in neurotrophin gene expression in normal rat brain.
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In vivo, Semax application increases the mRNA level of Ngf in rat hippocampus.
“Subsequently, it was demonstrated in vivo that Semax application increases both protein and mRNA levels of Bdnf, and TrkB, and mRNA level of Ngf in rat hippocampus (Dolotov et al. 2006; Agapova et al. 2007).”
From Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia (2010) · cites this paper as Agapova et al. 2007
In vivo, Semax application increases both protein and mRNA levels of Bdnf in rat hippocampus.
“Subsequently, it was demonstrated in vivo that Semax application increases both protein and mRNA levels of Bdnf, and TrkB, and mRNA level of Ngf in rat hippocampus (Dolotov et al. 2006; Agapova et al. 2007).”
From Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia (2010) · cites this paper as Agapova et al. 2007
Agapova et al. (2007) registered a decrease in Ngf transcription.
“Previously, Dolotov et al. (2006) did not reveal any influence of Semax on Bdnf transcription in the cortex of intact rats, and the decrease in Ngf transcription was registered by Agapova et al. (2007).”
From Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia (2010) · cites this paper as Agapova et al. 2007
In vivo, Semax application increases both protein and mRNA levels of TrkB in rat hippocampus.
“Subsequently, it was demonstrated in vivo that Semax application increases both protein and mRNA levels of Bdnf, and TrkB, and mRNA level of Ngf in rat hippocampus (Dolotov et al. 2006; Agapova et al. 2007).”
From Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia (2010) · cites this paper as Agapova et al. 2007
Citations
Cites
Shadrina, M. I., Dolotov, O. V., Grivennikov, I. A., Slominsky, P. A., Andreeva, L. A., Inozemtseva, L. S., Limborska, S. A., & Myasoedov, N. F. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01994-2 · Cited by 46
Self-citationDolotov, O. V., Karpenko, E. A., Seredenina, T. S., Inozemtseva, L. S., Levitskaya, N. G., Zolotarev, Y. A., Kamensky, A. A., Grivennikov, I. A., Engele, J., & Myasoedov, N. F. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03658.x · Cited by 25
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Dmitrieva, V. G., Povarova, O. V., Skvortsova, V. I., Limborska, S. A., Myasoedov, N. F., & Dergunova, L. V. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9432-0 · Cited by 54
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Kolomin, T., Shadrina, M., Slominsky, P., Limborska, S., & Myasoedov, N. (2013) · Neuroscience and Medicine · doi:10.4236/nm.2013.44035 · Cited by 30
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“A large-scale study of the action mechanism at the transcriptome level was of particular interest [65, 67–70].”
Metadata
- Authors
- Agapova, T. Y., Agniullin, Y. V., Shadrina, M. I., Shram, S. I., Slominsky, P. A., Lymborska, S. A., & Myasoedov, N. F.
- Affiliations
- Russian Academy of Sciences (RU)
- Corresponding author
- Agapova, T.Y.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 417
- Issue
- 2
- Pages
- 201-205
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2011142149
- Cited by
- 18
- References
- 2
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2020: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Russian Academy of Sciences
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Receptor Mechanisms and Effects
- Keywords
- Semax, neurotrophin gene expression, nerve growth factor, brain-derived neurotrophic factor, hippocampus, brainstem, cerebellum, frontal cortex, intranasal administration, neuroprotection, rat brain
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Brain, Male, Nerve Growth Factors, Peptide Fragments, RNA, Messenger, Down-Regulation, Up-Regulation, Gene Expression, Rats, Wistar, Neuroprotective Agents, Brain-Derived Neurotrophic Factor, Nerve Growth Factor, Rats
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