Cited by 481Neuroscience and Neuropharmacology ResearchNerve injury and regenerationMemory and Neural Mechanisms

Neurotrophins and Time: Different Roles for TrkB Signaling in Hippocampal Long-Term Potentiation

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Kang, Hyejin, Welcher, Andy A, Shelton, David, Schuman, Erin M·1997·Neuron

Abstract

We examined the role of TrkB ligands in hippocampal long-term potentiation (LTP) using function-blocking TrkB antiserum (Ab) and Trk-IgG fusion proteins. Incubation of hippocampal slices with TrkB Ab had no effect on basal synaptic transmission, short-term plasticity, or LTP induced by several trains of tetanic stimulation. The TrkB Ab-treated slices, however, showed significant deficits in LTP induced by either theta-burst stimulation (TBS) or "pairing." Slices exposed to the same number of inducing stimuli, delivered either as TBS or as a single 100 Hz epoch, only exhibited TrkB-sensitive LTP when TBS was used, indicating that the temporal pattern of stimulation determines the neurotrophin dependence. The late phase of LTP (2-3 hr) was also significantly impaired in slices pretreated with TrkB Ab or a TrkB-IgG. The application of a TrkB-IgG 30 min after LTP induction caused previously potentiated synaptic transmission to return to baseline levels, indicating that TrkB ligands are required to maintain LTP for up to 1 hr after induction. Taken together, these results indicate that both the temporal patterns of synaptic activity and the different temporal phases of synaptic enhancement are important in determining the neurotrophin dependence of plasticity in the hippocampus.

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Crossref · 10.1016/s0896-6273(00)80378-5

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Authors
Kang, H., Welcher, A. A., Shelton, D., & Schuman, E. M.
Affiliations
  • California Institute of Technology (US)
  • Amgen (United States) (US)
  • Genentech (US)
Corresponding author
Schuman, Erin M
Venue
Neuron
Publisher
Elsevier BV
Published
1997-09
Volume
19
Issue
3
Pages
653-664
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2023390598
Cited by
481
References
7
Citations by year
2026: 3 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 7 · 2021: 11 · 2020: 7 · 2019: 11 · 2018: 18 · 2017: 7 · 2016: 22 · 2015: 16 · 2014: 25 · 2013: 23 · 2012: 11
FWCI
9.58
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
California Institute of Technology
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
neurotrophins, TrkB signaling, hippocampal long-term potentiation, theta burst stimulation, pairing, late-phase LTP, synaptic plasticity, synaptic transmission
MeSH terms
Animals, Antibody Specificity, Binding, Competitive, Electrophysiology, Hippocampus, Immunoglobulin G, Male, Synaptic Transmission, Neuronal Plasticity, Organ Culture Techniques, Rabbits, Time Factors, Signal Transduction, Gene Expression, 3T3 Cells, Rats, Sprague-Dawley, Receptors, Nerve Growth Factor, Long-Term Potentiation, Brain-Derived Neurotrophic Factor, Receptor Protein-Tyrosine Kinases, Receptor, Ciliary Neurotrophic Factor, Mice, Rats

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