S ELECTIVITY IN N EUROTROPHIN S IGNALING : Theme and Variations

Segal, Rosalind A.

doi:10.1146/annurev.neuro.26.041002.131421

Cited by 383

The DOI matches its Crossref record, with a small difference in title or year; 10 of the 10 references it cites were found in a registry or an index.

S ELECTIVITY IN N EUROTROPHIN S IGNALING : Theme and Variations

Segal, Rosalind A.·2003·Annual Review of Neuroscience

DOI 10.1146/annurev.neuro.26.041002.131421

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Abstract

▪ Abstract Neurotrophins are a family of growth factors critical for the development and functioning of the nervous system. Although originally identified as neuronal survival factors, neurotrophins elicit many biological effects, ranging from proliferation to synaptic modulation to axonal pathfinding. Recent data indicate that the nature of the signaling cascades activated by neurotrophins, and the biological responses that ensue, are specified not only by the ligand itself but also by the temporal pattern and spatial location of stimulation. Studies on neurotrophin signaling have revealed variations in the Ras/MAP kinase, PI3 kinase, and phospholipase C pathways, which transmit spatial and temporal information. The anatomy of neurons makes them particularly appropriate for studying how the location and tempo of stimulation determine the signal cascades that are activated by receptor tyrosine kinases such as the Trk receptors. These signaling variations may represent a general mechanism eliciting specificity in growth factor responses.

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TrkB activation by BDNF initiates three major signaling cascades: phospholipase Cγ, PI3K, and ERK.
“TrkB activation by BDNF initiates three major cascades of signaling pathways: phospholipase C␥, phosphatidylinositol 3-kinase (PI3K), and extracellular signal-regulated kinase (ERK) (Huang and Reichardt, 2003;Segal, 2003).”
From BDNF-Dependent Recycling Facilitates TrkB Translocation to Postsynaptic Density during LTP via a Rab11-Dependent Pathway (2013) · cites this paper as Segal, 2003

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Authors: Segal, R. A.
Affiliations: Departments of Neurobiology and Pediatric Oncology, Harvard Medical School and Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115;
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2003-03
Volume: 26
Issue: 1
Pages: 299-330
ISSN: 0147-006X
1545-4126
DOI: 10.1146/annurev.neuro.26.041002.131421
Cited by: 383
References: 10
Language: en

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S ELECTIVITY IN N EUROTROPHIN S IGNALING : Theme and Variations

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