The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: A possible role for lithium antioxidant effects
Open accessAbstract
Studies have proposed the involvement of oxidative stress and neuronal energy dysfunctions in the pathophysiology of bipolar disorder (BD). This study evaluates plasma levels of the oxidative/energy metabolism markers, thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), and neuron-specific enolase (NSE) during initial episodes of mania compared to controls in 75 subjects. Two groups of manic subjects (unmedicated n=30, and lithium-treated n=15) were age/gender matched with healthy controls (n=30). TBARS and antioxidant enzymes activity (SOD and CAT) were increased in unmedicated manic patients compared to controls. Conversely, plasma NSE levels were lower during mania than in the controls. In contrast, acute treatment with lithium showed a significant reduction in both SOD/CAT ratio and TBARS levels. These results suggest that initial manic episodes are associated with both increased oxidative stress parameters and activated antioxidant defenses, which may be related to dysfunctions on energy metabolism and neuroplasticity pathways. Antioxidant effects using lithium in mania were shown, and further studies are necessary to evaluate the potential role of these effects in the pathophysiology and therapeutics of BD.
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Cited by
Berk, M., Kapczinski, F., Andreazza, A. C., Dean, O. M., Giorlando, F., Maes, M., Yücel, M., Gama, C. S., Dodd, S., Dean, B., et al. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.001 · Cited by 1,178
Self-citationOxidative stress in psychiatric disorders: evidence base and therapeutic implications
Ng, F., Berk, M., Dean, O., & Bush, A. I. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008401 · Cited by 1,069
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Oxidative Stress and Psychological Disorders
Salim, S. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120230309 · Cited by 557
Oxidative stress markers in bipolar disorder: A meta-analysis
Andreazza, A. C., Kauer-Sant'Anna, M., Frey, B. N., Bond, D. J., Kapczinski, F., Young, L. T., & Yatham, L. N. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.04.013 · Cited by 526
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Metadata
- Authors
- Machado-Vieira, R., Andreazza, A. C., Viale, C. I., Zanatto, V., Cereser, V., Vargas, R. D. S., Kapczinski, F., Portela, L. V., Souza, D. O., Salvador, M., & Gentil, V.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 421
- Issue
- 1
- Pages
- 33-36
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2047511549
- Cited by
- 314
- References
- 40
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Machado-Vieira, R., Andreazza, A. C., Viale, C. I., Zanatto, V., Cereser, V., Vargas, R. D. S., Kapczinski, F., Portela, L. V., Souza, D. O., Salvador, M., & Gentil, V. (2007). Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: A possible role for lithium antioxidant effects. Neuroscience Letters. https://doi.org/10.1016/j.neulet.2007.05.016
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