Oxidative Stress and Psychological Disorders

Salim, Samina

doi:10.2174/1570159x11666131120230309

Cited by 557Antioxidant Activity and Oxidative StressTryptophan and brain disordersRedox biology and oxidative stress

Oxidative Stress and Psychological Disorders

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Salim, Samina·2014·Current Neuropharmacology

DOI 10.2174/1570159x11666131120230309PMC PMC3964745

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Abstract

Oxidative stress is an imbalance between cellular production of reactive oxygen species and the counteracting antioxidant mechanisms. The brain with its high oxygen consumption and a lipid-rich environment is considered highly susceptible to oxidative stress or redox imbalances. Therefore, the fact that oxidative stress is implicated in several mental disorders including depression, anxiety disorders, schizophrenia and bipolar disorder, is not surprising. Although several elegant studies have established a link between oxidative stress and psychiatric disorders, the causal relationship between oxidative stress and psychiatric diseases is not fully determined. Another critical aspect that needs much attention and effort is our understanding of the association between cellular oxidative stress and emotional stress. This review examines some of the recent discoveries that link oxidative status with anxiety, depression, schizophrenia and bipolar disorder. A discussion of published results and questions that currently exist in the field regarding a causal relationship between oxidative and emotional stress is also provided.

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Oxidative stress has been implicated in various mental and psychiatric disorders, including anxiety, depression, schizophrenia, bipolar disorder.
“The brain is rich in lipids and has a high partial pressure of oxygen, therefore similarly to neurological diseases, oxidative stress has been implicated in various mental and psychiatric disorders, including behavioral, emotional, and cognitive abnormalities, such as anxiety, depression, schizophrenia, bipolar disorder and other diseases (Ng et al. 2008; Salim 2014).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Salim 2014
Among other pathologies, impaired neurotransmission, autoimmune dysfunction, abnormal neuronal development, and oxidative stress have been proposed in schizophrenia.
“Among other pathologies, impaired neurotransmission, autoimmune dysfunction, abnormal neuronal development, and oxidative stress have been proposed (Kessler 1997; Salim 2014).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Salim 2014
In panic disorder, latest studies describe a strong connection between antioxidant enzymes activity and panic symptomatology.
“In PD context, the latest studies also describe a strong connection between antioxidant enzymes activity and panic symptomatology [42, 43].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [42]
Free-floating calcium phosphate clusters resembling Posner molecules have been found to be stable in simulated body fluids.
“Whereas free-floating calcium phosphate clusters resembling Posner molecules have been found to be stable in simulated body fluids 202 , there is still some uncertainty as to whether they are present in vivo 84,85 .”
From Quantum effects in the brain: A review (2020) · cites this paper as [202]

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Authors: Salim, S.
Affiliations: University of Houston (US)
Corresponding author: Salim, Samina
ORCID: Salim, Samina
Venue: Current Neuropharmacology
Publisher: Bentham Science Publishers Ltd.
Published: 2014-03-31
Volume: 12
Issue: 2
Pages: 140-147
ISSN: 1570-159X (ISSN-L)
DOI: 10.2174/1570159x11666131120230309
PMC: PMC3964745
OpenAlex: W2033009565
Cited by: 557
References: 123
Citations by year: 2026: 34 · 2025: 56 · 2024: 52 · 2023: 45 · 2022: 86 · 2021: 50 · 2020: 114 · 2019: 37 · 2018: 31 · 2017: 22 · 2016: 13 · 2015: 14 · 2014: 2
FWCI: 11.93
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Current Neuropharmacology (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (R15MH093918)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: oxidative stress, reactive oxygen species, antioxidants, redox imbalance, brain, depression, anxiety disorders, schizophrenia, bipolar disorder, emotional stress

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