Bone marrow-derived mesenchymal stem cells reduce brain amyloid-β deposition and accelerate the activation of microglia in an acutely induced Alzheimer's disease mouse model
Abstract
The therapeutic potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) has recently been explored in various pathological conditions of the central nervous system (CNS). However, the application of BM-MSCs in acutely induced Alzheimer's disease (AD) has not yet been reported. Herein the feasibility of using the BM-MSCs, as a therapeutic agent for AD has been tested. To assess this possibility, an acutely induced AD model induced by injecting amyloid-beta (Abeta) into the dentate gyrus (DG) of hippocampus of C57BL/6 mice was used. Intracerebral transplantation of BM-MSCs into the brain of an induced AD model reduced their Abeta levels when compared to sham-transplanted animals. The diminution of Abeta deposits was accompanied by the activation of microglia. In addition, the activated microglia was located near the Abeta deposits, and their morphology was changed from ramified to ameboid as a sign of microglial phagocytosis. This study provides evidence that BM-MSCs can promote the reduction of Abeta through the microglial activation in this acutely induced AD brain, suggesting a potential therapeutic agent against AD.
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BM-MSCs can accelerate microglia activation, reduce amyloid-β deposition and ameliorate cognitive abilities in AD mouse models.
“In AD treatment, the MSCs bone marrow-derived (BM-MSCs) are particularly interesting since they can accelerate microglia activation, reduce amyloid-β deposition and ameliorate cognitive abilities in AD mouse models [171].”
From Treatment of Alzheimer’s Disease: Beyond Symptomatic Therapies (2023) · cites this paper as [171]
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- Authors
- Lee, J. K., Jin, H. K., & Bae, J.-S.
- Affiliations
- Kyungpook National University (KR)
- Corresponding author
- Jin, Hee Kyung
- Bae, Jae-sung
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 450
- Issue
- 2
- Pages
- 136-141
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2081269354
- Cited by
- 189
- References
- 24
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 9 · 2023: 8 · 2022: 7 · 2021: 17 · 2020: 15 · 2019: 8 · 2018: 8 · 2017: 13 · 2016: 15 · 2015: 13 · 2014: 21 · 2013: 19 · 2012: 9
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (KRF2007-313-E00042)
- Korea Science and Engineering Foundation
- Ministry of Education, Science and Technology (R01-2007-000-20487-0)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- bone marrow-derived mesenchymal stem cells, Alzheimer's disease, amyloid-beta deposition, microglial activation, intracerebral transplantation, dentate gyrus, hippocampus, microglial phagocytosis, ameboid microglia, cell therapy
- MeSH terms
- Alzheimer Disease, Animals, Brain, Calcium-Binding Proteins, Cell Count, Disease Models, Animal, Mice, Inbred C57BL, Microfilament Proteins, Bone Marrow Transplantation, Amyloid beta-Peptides, Microglia, Mesenchymal Stem Cell Transplantation, Mice
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