The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
25-Hydroxycholesterol regulates cholesterol homeostasis in the murine CATH.a neuronal cell line
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“25-hydroxycholesterol (25HC), reported to decrease cholesterol synthesis and increase ABCA1 and APOE (Waltl et al., 2013)”
From Cholesterol and matrisome pathways dysregulated in astrocytes and microglia (2022) · cites this paper as Waltl et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
Joseph, S. B., Castrillo, A., Laffitte, B. A., Mangelsdorf, D. J., & Tontonoz, P. (2003) · Nature Medicine · doi:10.1038/nm820 · Cited by 1,158
Cholesterol metabolism in neurons and astrocytes
Pfrieger, F. W., & Ungerer, N. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.06.002 · Cited by 500
Lund, E. G., Xie, C., Kotti, T., Turley, S. D., Dietschy, J. M., & Russell, D. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303415200 · Cited by 421
Bauman, D. R., Bitmansour, A. D., McDonald, J. G., Thompson, B. M., Liang, G., & Russell, D. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909142106 · Cited by 329
Flagged first, then by citations
Research works printed but not linked: 37
- Bavner, 2010, On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase, Journal of Lipid Research, 51, 2722, 10.1194/jlr.M008326 · DOI
- Bjorkhem, 2002, Do oxysterols control cholesterol homeostasis?, Journal of Clinical Investigation, 110, 725, 10.1172/JCI0216388 · DOI
- Bjorkhem, 2004, Brain cholesterol: long secret life behind a barrier, Arteriosclerosis, Thrombosis, and Vascular Biology, 24, 806, 10.1161/01.ATV.0000120374.59826.1b · DOI · Paper page
- Brahimi, 2001, Control of apolipoprotein E secretion in the human hepatoma cell line KYN-2, Cell Biochemistry and Function, 19, 51, 10.1002/cbf.899 · DOI
- Castrillo, 2003, Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages, Journal of Biological Chemistry, 278, 10443, 10.1074/jbc.M213071200 · DOI
- Chen, 2007, Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice, Cell Metabolism, 5, 73, 10.1016/j.cmet.2006.11.012 · DOI
- DeBose-Boyd, 2001, Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands, Proceedings of the National Academy of Sciences of the United States of America, 98, 1477, 10.1073/pnas.98.4.1477 · DOI · Paper page
- Diczfalusy, 2009, Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide, Journal of Lipid Research, 50, 2258, 10.1194/jlr.M900107-JLR200 · DOI · Paper page
- Dietschy, 2004, Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal, Journal of Lipid Research, 45, 1375, 10.1194/jlr.R400004-JLR200 · DOI · Paper page
- Du, 2004, Effects of 25-hydroxycholesterol on cholesterol esterification and sterol regulatory element-binding protein processing are dissociable: implications for cholesterol movement to the regulatory pool in the endoplasmic reticulum, Journal of Biological Chemistry, 279, 47010, 10.1074/jbc.M408690200 · DOI
- Dzeletovic, 1995, Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry, Analytical Biochemistry, 225, 73, 10.1006/abio.1995.1110 · DOI
- Field, 1983, Regulation of acyl CoA:cholesterol acyltransferase by 25-hydroxycholesterol in rabbit intestinal microsomes and absorptive cells, Journal of Lipid Research, 24, 1049, 10.1016/S0022-2275(20)37919-0 · DOI
- Goldstein, 1990, Regulation of the mevalonate pathway, Nature, 343, 425, 10.1038/343425a0 · DOI · Paper page
- Goldstein, 2006, Protein sensors for membrane sterols, Cell, 124, 35, 10.1016/j.cell.2005.12.022 · DOI · Paper page
- Honda, 2011, Cholesterol 25-hydroxylation activity of CYP3A, Journal of Lipid Research, 52, 1509, 10.1194/jlr.M014084 · DOI
- Hutter-Paier, 2004, The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease, Neuron, 44, 227, 10.1016/j.neuron.2004.08.043 · DOI · Paper page
- Kotti, 2006, Brain cholesterol turnover required for geranylgeraniol production and learning in mice, Proceedings of the National Academy of Sciences of the United States of America, 103, 3869, 10.1073/pnas.0600316103 · DOI
- Laffitte, 2001, LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes, Proceedings of the National Academy of Sciences of the United States of America, 98, 507, 10.1073/pnas.98.2.507 · DOI · Paper page
- Leoni, 2002, Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis, Neuroscience Letters, 331, 163, 10.1016/S0304-3940(02)00887-X · DOI
- Lund, 1998, cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism, Journal of Biological Chemistry, 273, 34316, 10.1074/jbc.273.51.34316 · DOI · Paper page
- Lutjohann, 1996, Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation, Proceedings of the National Academy of Sciences of the United States of America, 93, 9799, 10.1073/pnas.93.18.9799 · DOI · Paper page
- Lutjohann, 2000, Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients, Journal of Lipid Research, 41, 195, 10.1016/S0022-2275(20)32052-6 · DOI
- Makoukji, 2011, Interplay between LXR and Wnt/beta-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols, Journal of Neuroscience, 31, 9620, 10.1523/JNEUROSCI.0761-11.2011 · DOI
- Omarova, 2012, Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis, Journal of Clinical Investigation, 122, 3012, 10.1172/JCI63816 · DOI
- Panzenboeck, 2007, On the mechanism of cerebral accumulation of cholestanol in patients with cerebrotendinous xanthomatosis, Journal of Lipid Research, 48, 1167, 10.1194/jlr.M700027-JLR200 · DOI
- Park, 2010, Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons, Journal of Leukocyte Biology, 88, 1081, 10.1189/jlb.0610318 · DOI
- Pfaffl, 2002, Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR, Nucleic Acids Research, 30, e36, 10.1093/nar/30.9.e36 · DOI
- Puglielli, 2001, Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide, Nature Cell Biology, 3, 905, 10.1038/ncb1001-905 · DOI · Paper page
- Qin, 2007, Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration, Glia, 55, 453, 10.1002/glia.20467 · DOI · Paper page
- Repa, 2007, Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse, Journal of Neuroscience, 27, 14470, 10.1523/JNEUROSCI.4823-07.2007 · DOI
- Russell, 2000, Oxysterol biosynthetic enzymes, Biochimica et Biophysica Acta, 1529, 126, 10.1016/S1388-1981(00)00142-6 · DOI · Paper page
- Schule, 2010, Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis, Journal of Lipid Research, 51, 819, 10.1194/jlr.M002543 · DOI
- Son, 2012, A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinson's disease induced by MPTP, British Journal of Pharmacology, 165, 2213, 10.1111/j.1476-5381.2011.01692.x · DOI
- Tam, 1992, The effect of 25-hydroxycholesterol on the regulation of apolipoprotein E mRNA levels and secretion in the human hepatoma HepG2, Atherosclerosis, 95, 137, 10.1016/0021-9150(92)90017-B · DOI
- Ullen, 2010, Mouse brain plasmalogens are targets for hypochlorous acid-mediated modification in vitro and in vivo, Free Radical Biology and Medicine, 49, 1655, 10.1016/j.freeradbiomed.2010.08.025 · DOI
- Valdez, 2010, Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers, Hippocampus, 20, 902, 10.1002/hipo.20743 · DOI
- Wang, 2008, The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome, Journal of Proteome Research, 7, 1606, 10.1021/pr7006076 · DOI
Cited by
Sorted by citations
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
TCW, J., Qian, L., Pipalia, N. H., Chao, M. J., Liang, S. A., Shi, Y., Jain, B. R., Bertelsen, S. E., Kapoor, M., Marcora, E., et al. (2022) · Cell · doi:10.1016/j.cell.2022.05.017 · Cited by 411
Metadata
- Authors
- Waltl, S., Patankar, J. V., Fauler, G., Nusshold, C., Üllen, A., Eibinger, G., Wintersperger, A., Kratky, D., Malle, E., & Sattler, W.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 539
- Pages
- 16-21
- ISSN
- 0304-3940
- PMC
- PMC3610018
- Cited by
- 24
- References
- 4
- Language
- en
- Licence
- Funders
- Austrian Science Fund (F3007)
- Austrian Nationalbank (P14534)
- Austrian Research Promotion Agency (P820107)
- Molecular Medicine of the Medical University of Graz
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review