KB-R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, does not modify secondary pathology in the thalamus following focal cerebral stroke in rats
Abstract
Remote areas connected to cortical infarcts, such as the thalamus, are affected by stroke due to delayed retrograde degeneration of afferent connections. This is temporally associated with the accumulation of β-amyloid (Aβ) and calcium. Here we tested a hypothesis that prevention of excessive Ca(2+) influx into the axoplasm via the reverse Na(+)/Ca(2+) exchanger (NCX) would provide axonal protection and eventually lessen the Aβ and calcium load in the thalamus. We found that chronic treatment with a specific inhibitor of the reverse NCX, KB-R7943 (30mg/kg once daily, 27 days) after middle cerebral artery occlusion did not prevent atypical secondary pathology in the thalamus or improve functional outcome. The present data do not support a role for reverse NCX activity in the complex pathology within the thalamus after cerebral ischemia.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Acquisition of the standard plane is a prerequisite step and is crucial for subsequent biometric measurements and diagnosis in fetal US diagnosis.
“Among the workflow of fetal US diagnosis, acquisition of the standard plane is the prerequisite step and is crucial for subsequent biometric measurements and diagnosis [114].”
From Deep Learning in Medical Ultrasound Analysis: A Review (2019) · cites this paper as [114]
Cites
Reversible middle cerebral artery occlusion without craniectomy in rats.
Longa, E. Z., Weinstein, P. R., Carlson, S., & Cummins, R. (1989) · Stroke · doi:10.1161/01.str.20.1.84 · Cited by 7,463 · see citing works
Calcium in Ischemic Cell Death
Kristián, T., & Siesjö, B. K. (1998) · Stroke · doi:10.1161/01.str.29.3.705 · Cited by 825 · see citing works
Iwamoto, T., Watano, T., & Shigekawa, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22391 · Cited by 504 · see citing works
Mechanisms of neural plasticity following brain injury
Wieloch, T. W., & Nikolich, K. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.05.011 · Cited by 352 · see citing works
Matsuda, T., Arakawa, N., Takuma, K., Kishida, Y., Kawasaki, Y., Sakaue, M., Takahashi, K., Takahashi, T., Suzuki, T., Ota, T., et al. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29375-7 · Cited by 345 · see citing works
General mechanisms of axonal damage and its prevention
Stys, P. K. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.031 · Cited by 314 · see citing works
Pharmacology of Brain Na+/Ca2+ Exchanger: From Molecular Biology to Therapeutic Perspectives
Annunziato, L., Pignataro, G., & Renzo, G. F. D. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.4.5 · Cited by 307 · see citing works
Watano, T., Kimura, J., Morita, T., & Nakanishi, H. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15708.x · Cited by 303 · see citing works
Behavioral tests for preclinical intervention assessment
Schallert, T. J. (2006) · NeuroRx · doi:10.1016/j.nurx.2006.08.001 · Cited by 246 · see citing works
Zhang, J., Zhang, Y., Xing, S., Liang, Z., & Zeng, J. (2012) · Stroke · doi:10.1161/strokeaha.111.632448 · Cited by 211 · see citing works
Stys, P. K., Waxman, S. G., & Ransom, B. R. (1991) · Annals of Neurology · doi:10.1002/ana.410300309 · Cited by 197 · see citing works
van Groen, T., Puurunen, K., Mäki, H.-M., Sivenius, J., & Jolkkonen, J. (2005) · Stroke · doi:10.1161/01.str.0000169933.88903.cf · Cited by 185 · see citing works
Self-citationProgressive shrinkage of the thalamus following middle cerebral artery occlusion in rats.
Fujie, W., Kirino, T., Tomukai, N., Iwasawa, T., & Tamura, A. (1990) · Stroke · doi:10.1161/01.str.21.10.1485 · Cited by 150 · see citing works
Minelli, A., Castaldo, P., Gobbi, P., Salucci, S., Magi, S., & Amoroso, S. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.06.004 · Cited by 149 · see citing works
Differential expression of the Na+‐Ca2+ exchanger transcripts and proteins in rat brain regions
Papa, M., Canitano, A., Boscia, F., Castaldo, P., Sellitti, S., Porzig, H., Taglialatela, M., & Annunziato, L. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10665 · Cited by 115 · see citing works
Mechanisms of calcium and sodium fluxes in anoxic myelinated central nervous system axons
Stys, P. K., & LoPachin, R. M. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00230-3 · Cited by 113 · see citing works
Pignataro, G., Tortiglione, A., Scorziello, A., Giaccio, L., Secondo, A., Severino, B., Santagada, V., Caliendo, G., Amoroso, S., Renzo, G. D., et al. (2003) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.09.015 · Cited by 105 · see citing works
Potentiation of a sodium–calcium exchanger in the nuclear envelope by nuclear GM1 ganglioside
Xie, X., Wu, G., Lu, Z., & Ledeen, R. W. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00917.x · Cited by 100 · see citing works
Jolkkonen, J., Puurunen, K., Rantakömi, S. H., Härkönen, A., Haapalinna, A., & Sivenius, J. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00409-x · Cited by 99 · see citing works
Self-citationPuurunen, K., Jolkkonen, J., Sirviö, J., Haapalinna, A., & Sivenius, J. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00182-9 · Cited by 97 · see citing works
Self-citationBoscia, F., Gala, R., Pignataro, G., de Bartolomeis, A., Cicale, M., Ambesi‐Impiombato, A., Renzo, G. D., & Annunziato, L. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600207 · Cited by 87 · see citing works
Schröder, U. H., Breder, J., Sabelhaus, C. F., & Reymann, K. G. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(98)00198-1 · Cited by 85 · see citing works
Shimizu, S., Simon, R. P., & Graham, S. H. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00915-4 · Cited by 77 · see citing works
Wu, G., Xie, X., Lu, Z., & Ledeen, R. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903408106 · Cited by 75 · see citing works
Fréret, T., Chazalviel, L., Roussel, S., Bernaudin, M., Schumann‐Bard, P., & Boulouard, M. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.6.1285 · Cited by 74 · see citing works
Hiltunen, M. O., Mäkinen, P. M., Peräniemi, S., Sivenius, J., van Groen, T., Soininen, H. S., & Jolkkonen, J. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.04.009 · Cited by 65 · see citing works
Self-citationMäkinen, S., van Groen, T., Clarke, J., Thornell, A., Corbett, D., Hiltunen, M. O., Soininen, H. S., & Jolkkonen, J. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600529 · Cited by 64 · see citing works
Self-citationZhang, Y., Xing, S., Zhang, J., Li, J., Li, C., Pei, Z., & Zeng, J. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.127 · Cited by 62 · see citing works
NCX1 and NCX3: Two new effectors of delayed preconditioning in brain ischemia
Pignataro, G., Boscia, F., Esposito, E., Sirabella, R., Cuomo, O., Vinciguerra, A., Renzo, G. D., & Annunziato, L. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.10.007 · Cited by 58 · see citing works
Mitterreiter, S., Page, R. M., Kamp, F., Hopson, J., Winkler, E., Ha, H., Hamid, R., Herms, J. W., Mayer, T. U., Nelson, D. J., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1199-10.2010 · Cited by 55 · see citing works
Axonal Injury Caused by Focal Cerebral Ischemia in the Rat
Yam, P. S., Dewar, D., & McCulloch, J. (1998) · Journal of Neurotrauma · doi:10.1089/neu.1998.15.441 · Cited by 52 · see citing works
Barsukova, A. G., Forte, M. A., & BOURDETTE, D. N. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0408-12.2012 · Cited by 40 · see citing works
Pilitsis, J. G., Diaz, F. G., O’Regan, M. H., & Phillis, J. W. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02896-7 · Cited by 37 · see citing works
The effects of the Na+/Ca++ exchange blocker on osmotic blood–brain barrier disruption
Bhattacharjee, A. K., Nagashima, T., Kondoh, T., & Tamaki, N. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02253-3 · Cited by 35 · see citing works
Role of Na+-Ca2+ exchanger after traumatic or hypoxic/ischemic injury to spinal cord white matter
Tomes, D. J., & Agrawal, S. K. (2002) · The Spine Journal · doi:10.1016/s1529-9430(01)00151-6 · Cited by 35 · see citing works
Hayward, N., Yanev, P. G., Haapasalo, A., Miettinen, R. A., Hiltunen, M. O., Gröhn, O. H. J., & Jolkkonen, J. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.202 · Cited by 34 · see citing works
Self-citationYam, P. S., Patterson, J. C., Graham, D. I., Takasago, T., Dewar, D., & McCulloch, J. (1998) · Brain Research Protocols · doi:10.1016/s1385-299x(98)00005-1 · Cited by 34 · see citing works
Zhao, X., Gorin, F. A., Berman, R. F., & Lyeth, B. G. (2008) · Journal of Neurotrauma · doi:10.1089/neu.2008.0635 · Cited by 33 · see citing works
Forelimb use after focal cerebral ischemia in rats treated with an α2-adrenoceptor antagonist
Karhunen, H., Virtanen, T., Schallert, T. J., Sivenius, J., & Jolkkonen, J. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)01053-5 · Cited by 28 · see citing works
Self-citationSearching for a Role of NCX/NCKX Exchangers in Neurodegeneration
Gómez‐Villafuertes, R., Mellström, B., & Naranjo, J. R. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-0007-0 · Cited by 24 · see citing works
Sarajärvi, T., Lipsanen, A., Mäkinen, P. M., Peräniemi, S., Soininen, H. S., Haapasalo, A., Jolkkonen, J., & Hiltunen, M. (2012) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2012.01599.x · Cited by 21 · see citing works
Self-citationTortiglione, A., Pignataro, G., Minale, M., Secondo, A., Scorziello, A., Renzo, G. F. D., Amoroso, S., Caliendo, G., Santagada, V., & Annunziato, L. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04768.x · Cited by 20 · see citing works
Martinez, Y., & N’Gouemo, P. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.100 · Cited by 20 · see citing works
Alzheimer's factors in postischemic dementia.
Pluta, R. M., Ułamek-Kozioł, M., Januszewski, S., Ściślewska, M., Bogucka‐Kocka, A., & Kocki, J. (2012) · PubMed · Cited by 16 · see citing works
Lipsanen, A., Flunkert, S., Kuptsova, K., Hiltunen, M., Windisch, M., Hutter‐Paier, B., & Jolkkonen, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060235 · Cited by 10 · see citing works
Self-citationAxonal protection achieved by blockade of sodium/calcium exchange in a new model of ischemia in vivo
Bei, F., & Smith, K. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.04.019 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Deep Learning in Medical Ultrasound Analysis: A Review
Liu, S., Wang, Y., Yang, X., Lei, B., Liu, L., Li, S. X., Ni, D., & Wang, T. (2019) · Engineering · doi:10.1016/j.eng.2018.11.020 · Cited by 798 · see citing works
Moriguchi, S., Kita, S., Fukaya, M., Osanai, M., Inagaki, R., Sasaki, Y., Izumi, H., Horie, K., Takeda, J., Saito, T., et al. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.037 · Cited by 30 · see citing works
Aberrant Amygdala-Dependent Cued Fear Memory in Na+/Ca2+ Exchanger 1 Heterozygous Mice
Moriguchi, S., Kita, S., Inagaki, R., Yabuki, Y., Sasaki, Y., Ishikawa, S., Sakagami, H., Iwamoto, T., & Fukunaga, K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1384-2 · Cited by 3 · see citing works
Dysfunction of Na+/Ca2+ exchangers is associated with cognitive decline in Alzheimer’s disease
Moriguchi, S., Kita, S., Iwamoto, T., & Fukunaga, K. (2018) · Folia Pharmacologica Japonica · doi:10.1254/fpj.152.299 · Cited by 3 · see citing works
- Authors
- Lipsanen, A., Parkkinen, S., Khabbal, J., Mäkinen, P., Peräniemi, S., Hiltunen, M., & Jolkkonen, J.
- Affiliations
- University of Eastern Finland (FI)
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 580
- Pages
- 173-177
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2061882919
- Cited by
- 4
- References
- 46
- Citations by year
- 2019: 1 · 2018: 2 · 2017: 1
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- TEKES/EAKR (70050/10)
- The Finnish Cultural Foundation North Savo Regional Fund
- Topics
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- KB-R7943, thalamus, middle cerebral artery occlusion, axonal degeneration, retrograde degeneration, amyloid-beta, calcium overload, cerebral ischemia
- MeSH terms
- Animals, Calcium, Ischemic Attack, Transient, Male, Motor Skills, Peptide Fragments, Thalamus, Thiourea, Amyloid beta-Peptides, Rats, Wistar, Sodium-Calcium Exchanger
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
