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Plasma interleukin-6 and executive function in crack cocaine-dependent women.

Levandowski, Mateus Luz, Hess, Adriana Raquel Binsfeld, Grassi-Oliveira, Rodrigo, de Almeida, Rosa Maria Martins·2016·Neuroscience Letters
DOI 10.1016/j.neulet.2016.06.023
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Abstract

Aim The aim of this study was to investigate the association between plasma interleukin 6 (IL-6) levels and executive function (EF) in crack cocaine-dependent women. Methods 42 crack cocaine-dependent women (CRACK) and 52 healthy women (CONTROL) were evaluated with respect to EF using the Wisconsin Card Sorting Test (WCST). Plasma IL-6 levels were quantitatively determined using the multiplexed cytometric bead assay. Results The CRACK group had poor performance on WSCT scores (Non-perseverative Errors and Percent Conceptual Level Responses) and higher plasma IL-6 levels when compared with the CONTROL group. Furthermore, IL-6 was correlated with worsening of several WCST sub-scores and a linear regression model showed that IL-6 levels predicted worse cognitive flexibility within the CRACK group independently of intelligence quotient and education. Conclusions The results of this study indicated that low performances in EF task are associated with higher IL-6 levels in crack cocaine-dependent women. These data bolster previous works that link the cognitive decline observed in drug addicts with mechanisms of inflammation.

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  • Cocaine is associated with increased immune reactivity and inflammation in humans and neuroinflammation in animal models.

    “Cocaine is a highly potent and addictive brain stimulant that is associated with increased immune reactivity and inflammation in humans (Fox et al., 2012; Ersche et al., 2014; Levandowski et al., 2016; Moreira et al., 2016; Pianca et al., 2017) and neuroinflammation in animal models (Guo et al., 2015; Periyasamy et al., 2017).”

    From Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia (2020) · cites this paper as Levandowski et al., 2016

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Authors
Levandowski, M. L., Hess, A. R. B., Grassi-Oliveira, R., & de Almeida, R. M. M.
ORCID
Grassi-Oliveira, Rodrigo
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2016-08
Volume
628
Pages
85-90
ISSN
0304-3940
DOI
10.1016/j.neulet.2016.06.023
Cited by
40
References
6
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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