Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors

Dai, Hongmei; Kaneko, Kenya; Kato, Hiroshi; Fujii, Satoshi; Jing, Yuhong; Xu, Ajing; Sakurai, Eiko; Kato, Motohisa; Okamura, Nobuyuki; Kuramasu, Atsuo; Yanai, Kazuhiko

doi:10.1016/j.neures.2006.10.020

Cited by 136Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors

Dai, Hongmei, Kaneko, Kenya, Kato, Hiroshi, Fujii, Satoshi, Jing, Yuhong, Xu, Ajing, Sakurai, Eiko, Kato, Motohisa +3 more·2007·Neuroscience Research

DOI 10.1016/j.neures.2006.10.020

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Abstract

Previous pharmacological experiments provide conflicting findings that describe both facilitatory and inhibitory effects of neuronal histamine on learning and memory. Here, we examined learning and memory and synaptic plasticity in mice with a null mutation of gene coding histamine H1 or H2 receptor in order to clarify the role of these receptors in learning and memory processes. Learning and memory were evaluated by several behavioral tasks including object recognition, Barnes maze and fear conditioning. These behavioral tasks are highly dependent on the function of prefrontal cortex, hippocampus or amygdala. Object recognition and Barnes maze performance were significantly impaired in both H1 receptor gene knockout (H1KO) and H2 receptor gene knockout (H2KO) mice when compared to the respective wild-type (WT) mice. Conversely, both H1KO and H2KO mice showed better auditory and contextual freezing acquisition than their respective WT mice. Furthermore, we also examined long-term potentiation (LTP) in the CA1 area of hippocampus in H1KO and H2KO mice and their respective WT mice. LTP in the CA1 area of hippocampus was significantly reduced in both H1KO and H2KO mice when compared with their respective WT mice. In conclusion, our results demonstrate that both H1 and H2 receptors are involved in learning and memory processes for which the frontal cortex, amygdala and hippocampus interact.

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In histamine H1-R and H2-R knockout mice, LTP in the hippocampus CA1 area was decreased together with impairment of NOP memory.
“In histamine H1-R and H2-R knockout mice, LTP in the hippocampus CA1 area was decreased together with impairment of NOP memory”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Dai et al., 2007

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Authors: Dai, H., Kaneko, K., Kato, H., Fujii, S., Jing, Y., Xu, A., Sakurai, E., Kato, M., Okamura, N., Kuramasu, A., & Yanai, K.
Affiliations: Tohoku University (JP)
Yamagata University (JP)
Corresponding author: Yanai, Kazuhiko
ORCID: Dai, Hongmei
Kato, Hiroshi
Fujii, Satoshi
Jing, Yuhong
Xu, Ajing
Okamura, Nobuyuki
Kuramasu, Atsuo
Yanai, Kazuhiko
Venue: Neuroscience Research
Publisher: Elsevier BV
Published: 2007-02
Volume: 57
Issue: 2
Pages: 306-313
ISSN: 0168-0102 (ISSN-L)
DOI: 10.1016/j.neures.2006.10.020
OpenAlex: W2047066043
Cited by: 136
References: 50
Citations by year: 2026: 2 · 2025: 5 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 7 · 2016: 10 · 2015: 5 · 2014: 11 · 2013: 12 · 2012: 8
FWCI: 3.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neuroscience Research (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science
Ministry of Education, Culture, Sports, Science and Technology
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: histamine H1 receptor, histamine H2 receptor, knockout mice, learning and memory, synaptic plasticity, long-term potentiation, hippocampal CA1, object recognition, Barnes maze, fear conditioning, prefrontal cortex, amygdala, cognitive impairment
MeSH terms: Analysis of Variance, Animals, Cognition Disorders, Conditioning, Psychological, Fear, Hippocampus, Neuropsychological Tests, Receptors, Histamine H1, Receptors, Histamine H2, Long-Term Potentiation, Mice, Knockout, Maze Learning, Mice

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Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors

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