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Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice
Abstract
Perfluorinated compounds (PFCs) are found in applications such oil/water repellents for clothing fabrics, carpets, food packaging, lubricants, surfactants and fire extinguishers. PFCs are persistent in the environment. They have been found in humans and in wildlife. We reported earlier that persistent organic pollutants (POPs), such as DDT, PCBs and BFRs, caused developmental neurotoxic defects in mice, manifested as persistent aberrations in spontaneous behaviour, habituation capability, learning and memory, and changes in the cholinergic system in adults, when mice were exposed during a critical period of neonatal brain development. The present study was conducted to see whether PFCs can cause similar developmental neurotoxic effects as earlier observed for POPs as PCBs and PBDEs. NMRI male mice were exposed to a single-oral dose, either 1.4 or 21 micromol/kg body weight of PFOS (0.75 or 11.3 mg), PFOA (0.58 or 8.70 mg), or PFDA (0.72 or 10.8 mg), via a metal gastric-tube at the age of 10 days. The control animals received in the same manner 10 ml/kg body weight of the 20% fat emulsion vehicle. Spontaneous behaviour (locomotion, rearing, and total activity), and habituation were observed in 2- and 4-month-old mice. The susceptibility of the cholinergic system was explored in a nicotine-induced spontaneous behaviour test in 4-month-old mice. Deranged spontaneous behaviour was observed in mice exposed to PFOS and PFOA, manifested as reduced and/or lack of habituation and hyperactivity in adult mice. These effects were also seen to worse with age. Neonatal exposure to PFOS and PFOA affected the cholinergic system, manifested as a hypoactive response to nicotine, compared to a hyperactive response to nicotine in controls. These developmental neurotoxic effects are similar to those we reported earlier for PCBs and PBDEs. This suggests that PFOS and PFOA be included in the group of POPs known to be developmental neurotoxicants.
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“Decreased habituation was observed in the mice after exposure to 8.7 mg/kg PFOA or 11.3 mg/kg PFOS, whereas altered spontaneous behavior was observed after exposure to 0.58 mg/kg PFOA or 0.75 mg/kg PFOS (Johansson et al., 2008; Hallgren et al., 2015).”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Johansson et al., 2008
In the citing paper
“While concentrations of PFAS measured in adult tissues were often low following developmental exposure, those exposures still caused neurobehavioral toxicity persisting into adulthood (Johansson et al., 2008; Chen et al., 2013).”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Johansson et al., 2008
In the citing paper
“While studies on PFAS exposure in adult animals have not reported altered motor activity, several compounds have been shown to elicit developmental impairment of motor activity in mice, rats, and zebrafish (Johansson et al., 2008; Butenhoff et al., 2009b; Huang et al., 2010; Wang M. et al., 2011; Chen et al., 2013; Spulber et al., 2014; Hallgren et al., 2015; Goulding et al., 2017; Guo et al., 201”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Johansson et al., 2008
In the citing paper
“In inbred male NMRI mice, a single oral exposure of PFOA or PFOS at PND 10 caused a long-lasting hyperactive phenotype at 2 and 4 months of age, characterized by decreased habituation and altered spontaneous behavior (Johansson et al., 2008; Hallgren et al., 2015).”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Johansson et al., 2008
Citations
Cites
Rice, D., & Barone, S. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s3511 · Cited by 2,944
Global Distribution of Perfluorooctane Sulfonate in Wildlife
Giesy, J. P., & Kannan, K. (2001) · Environmental Science & Technology · doi:10.1021/es001834k · Cited by 2,750
The use of a plus-maze to measure anxiety in the mouse
Lister, R. G. (1987) · Psychopharmacology · doi:10.1007/bf00177912 · Cited by 2,617
Developmental neurotoxicity of industrial chemicals
Grandjean, P., & Landrigan, P. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69665-7 · Cited by 1,984
Organisation for Economic Co-Operation and Development
Mercadal, T. (2016) · Sage eBooks · doi:10.4135/9781483349985.n291 · Cited by 1,389
Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries
Kannan, K., Corsolini, S., Falandysz, J., Fillmann, G., Kumar, K. S., Loganathan, B. G., Mohd, M. A., Olivero, J., Wouwe, N. V., Yang, J. H., et al. (2004) · Environmental Science & Technology · doi:10.1021/es0493446 · Cited by 1,056
Ellis, D. A., Martin, J. W., De Silva, A. O., Mabury, S. A., Hurley, M. D., Sulbaek Andersen, M. P., & Wallington, T. J. (2004) · Environmental Science & Technology · doi:10.1021/es049860w · Cited by 1,000
The Developmental Toxicity of Perfluoroalkyl Acids and Their Derivatives
Lau, C., Butenhoff, J. L., & Rogers, J. M. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.11.031 · Cited by 867
Neuronal nicotinic receptors in the human brain
Paterson, D., & Nordberg, A. K. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00045-3 · Cited by 792
Acetylcholine in mind: a neurotransmitter correlate of consciousness?
Perry, E. K., Walker, M. P., Grace, J., & Perry, R. H. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01361-7 · Cited by 764
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Levengood, J. M., Soucek, D. J., Sass, G. G., & Epifanio, J. M. (2015) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/s00128-015-1646-x · Cited by 2
Perfluoroalkyl Chemicals and Neurological Disorders: From Exposure to Preventive Interventions
Niazi, S. G., Javed, C., Suleman, T., Sadiq, S., & Tahir, I. M. (2021) · Emerging contaminants and associated treatment technologies · doi:10.1007/978-3-030-66376-6_14 · Cited by 1
Zhang, Y., Qin, N., Wang, Y., Feng, H., Zhang, Z., Wang, C., Qin, Z., Duo, H., Yin, X., Shi, Y., et al. (2025) · NeuroToxicology · doi:10.1016/j.neuro.2025.103323 · Cited by 1
Chaojie, C., Shanshan, Y., Tong, L., & Cai, Z. (2025) · Journal of Hazardous Materials Advances · doi:10.1016/j.hazadv.2025.100990 · Cited by 1
Jiang, Z., Wei, C., & Ma, A. (2026) · Neurotoxicity Research · doi:10.1007/s12640-026-00780-8 · Cited by 1
Paré, A., Ratier, A., Desroziers, E., Mhaouty‐Kodja, S., Chardon, K., & Zeman, F. (2026) · Environmental Research · doi:10.1016/j.envres.2026.123933 · Cited by 1
Photoperiod perturbations impact perfluorohexane sulfonate (PFHxS) induced developmental toxicity
Ferdous, S. R., Rojas, A., Frank, C., Berry, Y., Sabatini, H. M., Luo, X., Sharma, S., Thummel, R., Chouinard, C. D., & Dasgupta, S. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.141607 · Cited by 2
Hu, Y., Sherman, J., Davern, M. J., Alsebai, Z., Kim, Y., Zhang, Y., Bi, C., Turpin, B. J., & Surratt, J. D. (2026) · The Analyst · doi:10.1039/d5an01352f · Cited by 1
Sun, T., Yang, M., Ma, Y., Zheng, Z., Wan, J., Wei, J., Pan, M., Zhou, Y., Yuan, X., Li, Y., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104543 · Cited by 1
Wang, H., Zhang, Y., Zhao, L., He, Z., Zhang, J., Liu, B., Liu, X., & Zhang, Y. (2023) · Chemical Research in Chinese Universities · doi:10.1007/s40242-023-3046-9 · Cited by 1
Ninomiya, A., Haijima, A., Fujiwara, Y., Kawabata‐Iwakawa, R., Amano, I., & Koibuchi, N. (2025) · The Journal of Toxicological Sciences · doi:10.2131/jts.50.223 · Cited by 1
Huang, M., Yong, L., Xu, J., Zuo, Y., Yi, Z., & Liu, H. (2021) · ChemistrySelect · doi:10.1002/slct.202100863 · Cited by 1
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DeWitt, J. C., Peden‐Adams, M. M., & Keil, D. E. (2014) · Wiley eBooks · doi:10.1002/9783527676965.ch13 · Cited by 1
Borg, D. (2013) · Figshare · Cited by 1
Lewis, S. J., & Byrne, M. M. (2009) · NEW SOLUTIONS A Journal of Environmental and Occupational Health Policy · doi:10.2190/ns.19.1.d · Cited by 1
Wang, W., Liu, H., Shao, Y., Ying, Y., Jiang, Q., & Zhu, J.-J. (2010) · International Conference on Bioinformatics and Biomedical Engineering · doi:10.1109/icbbe.2010.5517499 · Cited by 1
Liew, Z., Olsen, J., Ritz, B. R., & Arah, O. A. (2018) · ISEE Conference Abstracts · doi:10.1289/isesisee.2018.s02.01.12 · Cited by 1
Greaves, A. K. (2012) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2012-07332 · Cited by 1
Oh, J., Shin, H., Kannan, K., Busgang, S. A., Schmidt, R. J., Schweitzer, J. B., Hertz‐Picciotto, I., & Bennett, D. H. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4111404 · Cited by 1
Examining perfluorohexane sulfonate (PFHxS) impacts on sensorimotor and circadian rhythm developmentPreprint
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O’Brien, J. M. (2011) · Library and Archives Canada (Government of Canada) · doi:10.20381/ruor-4542 · Cited by 1
Pelletier, M. (2017) · theses.fr (ABES) · doi:10.70675/8de5b5d3zfc7cz4ad2z845bz5e9bfa4ab384 · Cited by 1
Sone, H., Win‐Shwe, T., Qin, X., Akanuma, H., & Imanishi, S. (2012) · InTech eBooks · doi:10.5772/30745
Toxicología del sulfonato de perfluorooctano (PFOS) como modelo de compuesto orgánico fluorado
Pereiro, N., & Lafuente, A. (2012) · Redalyc (Universidad Autónoma del Estado de México)
Assessment of environmental contaminants' neurotoxicity : in vitro and in vivo experimental studies
Ibrahim, W. N. W., & Norhamidah, W. I. W. (2012) · Figshare
Rosmini, R., & Pagliuca, G. (2012)
Garcia, J. S., & Harbison, R. D. (2015) · John Wiley & Sons, Inc. eBooks · doi:10.1002/9781118834015.ch69
Fetal Exposure to Perfluorinated Compounds and Attention Deficit Hyperactivity Disorder in Childhood
Rignell‐Hydbom, A., Ode, A., Källén, K., Gustafsson, P., Rylander, L., Jönsson, B., Olofsson, P., Ivarsson, S. A., & Lindh, C. H. (2014) · ISEE Conference Abstracts · doi:10.1289/isee.2014.o-180
Polluants in materials of everyday life and neurodevelopment in children
Étiemble, J., & Cordier, S. (2022) · Environnement Risques Santé · doi:10.1684/ers.2021.1612 · Cited by 1
Zhang, Y., zhang, Y., Zhang, L., Liu, X., He, Z., Zhang, J., & Liu, B. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4067095
Trends of Perfluoroalkyl Acids in Water Bodies: A Case Study of the Taihu Lake, China (2009-2021)Preprint
Yu, L. H., Liu, X., Hua, Z., Zhang, Y., & Xue, H. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3928365
Zhang, B., Wang, Z., Zhang, J., Dai, Y., Zhang, L., Guo, J., Qi, X., Chang, X., Wu, C., & Zhou, Z. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4192385
Kim, J. H., Moon, N., Ji, E., & Moon, H. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4171440
Liew, Z. (2014) · eScholarship (California Digital Library)
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Minocha-Mckenney, R. D. (2023) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2023-15503
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Tan, J. A., Wardle, T. A., & Xu, Y. (2023) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781837671410-00081
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Hanosh, S., & George, S. D. (2023) · doi:10.1002/9781394198375.ch8
Lee, Y., Liu, Y.-H., Hu, C., Lin, J.-C., Kuo, J., & Lo, S. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4668507 · Cited by 1
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Rathnayake, N., Sivaram, A. K., Hakeem, I. G., Pabba, S., Patel, S., Gupta, R. P., Paz‐Ferreiro, J., Sharma, A., Megharaj, M., Surapaneni, A., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4676576
Biomimetic approaches to the design of smart textiles
Namli, E. M., & Şendemir, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15471-3.00027-3
Boyd, S., Carstens, K. E., Lowit, A., Méndez, E., Perron, M. M., Mangas, I., & Shafer, T. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00282-5
Shrestha, S. (2014) · Scholars Archive - University at Albany (University at Albany, State University of New York) · doi:10.54014/9rcc-rm4s
Jiang, D. Q. Y., Eldefrawy, F., Navarro, J. I., & Guo, T. L. (2025) · Sci · doi:10.3390/sci7030118
Mousavi, M. K., Mesripour, A., Neisiani, A. K., Soltani, M., & Aliomrani, M. (2025) · Environmental Research Health · doi:10.1088/2752-5309/ae1380
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Karimi, F., Sadri, F., Soleimani, A., Azhdari, S., Karbasi, S., & Hosseini, S. F. (2025) · Nutritional Neuroscience · doi:10.1080/1028415x.2025.2573225
Paré, A., Ratier, A., Desroziers, E., Mhaouty‐Kodja, S., Chardon, K., & Zeman, F. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5669541
Beck, I. H., Bilenberg, N., Andersen, H. R., Trecca, F., Bleses, D., & Jensen, T. K. (2023) · Figshare · doi:10.6084/m9.figshare.23265207
Beck, I. H., Bilenberg, N., Andersen, H. R., Trecca, F., Bleses, D., & Jensen, T. K. (2023) · Figshare · doi:10.6084/m9.figshare.23265213
Beck, I. H., Bilenberg, N., Andersen, H. R., Trecca, F., Bleses, D., & Jensen, T. K. (2023) · Figshare · doi:10.6084/m9.figshare.23265216
van Larebeke, N., Gudrun, K., Craemer, S. D., Colles, A., Bruckers, L. M., Den Hond, E., Govarts, E., Morrens, B., Schettgen, T., Rémy, S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21256674
Eick, S. M., Goin, D. E., Cushing, L., DeMicco, E., Park, J.-S., Wang, Y., Smith, S., Padula, A. M., Woodruff, T. J., & Morello-Frosch, R. A. (2021) · Figshare · doi:10.6084/m9.figshare.14889715
Beck, I. H., Bilenberg, N., Andersen, H. R., Trecca, F., Bleses, D., & Jensen, T. K. (2023) · Figshare · doi:10.6084/m9.figshare.23265210
Eurasian Otter Lutra lutra (Linnaeus, 1758)
Loy, A., Chanin, P., Kranz, A., & Roos, A. (2025) · Handbook of the mammals of Europe · doi:10.1007/978-3-030-44035-0_127
Barrea, C., Dufour, P., Pirard, C., Charlier, C., Brévers, F., Parent, A., & Rousselle, L. (2026) · Journal of the Endocrine Society · doi:10.1210/jendso/bvag057
Marinello, W. P., & Zylka, M. J. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1814052
Huang, X., Wei, Y., Rao, Y., Wei, Y., Chen, H., & 鲍运平 (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1700638
Regulatory policies and risk assessment of neurotoxic pesticides
Patel, M., & Kumar, P. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44287-2.00036-3
Joseph, G., Renard-Dausset, E., Invernizzi, A., (8203), J. C., Guan, H., Wright, R. O., Wright, R. O., Rosa, M. J., Horton, M. K., Téllez‐Rojo, M. M., et al. (2026) · Environmental Research · doi:10.1016/j.envres.2026.124923
Butruille, L., Guittonneau, C., Blay, K. L., Valcárcel-Hernández, V., Aigrot, M., Fini, J.-B., Zalc, B., & Remaud, S. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120365
Santi, F., Pietropoli, E., Palmas, B. M., Polverino, G., Devigili, A., Barbarossa, A., Bardhi, A., Gasparini, C., & Pauletto, M. (2026) · Royal Society Open Science · doi:10.1098/rsos.260126
Adams, H. M., Hanrahan, J., Spring, S., Schneider, C., Sled, J. G., Jobst, K. J., & Cahill, L. S. (2026) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174426100804
Metadata
- Authors
- Johansson, N., Fredriksson, A., & Eriksson, P.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Eriksson, P.
- Venue
- NeuroToxicology
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 29
- Issue
- 1
- Pages
- 160-169
- ISSN
- 0161-813X (ISSN-L)
- OpenAlex
- W2086492898
- Cited by
- 463
- References
- 84
- Citations by year
- 2026: 19 · 2025: 30 · 2024: 28 · 2023: 44 · 2022: 31 · 2021: 27 · 2020: 29 · 2019: 20 · 2018: 27 · 2017: 22 · 2016: 23 · 2015: 27 · 2014: 22 · 2013: 20 · 2012: 27
- FWCI
- 11.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroToxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
- Keywords
- PFOS, perfluorooctanoic acid, perfluorodecanoic acid, perfluorinated compounds, developmental neurotoxicity, neonatal exposure, persistent organic pollutants, spontaneous behavior, habituation, hyperactivity, cholinergic system, learning and memory, persistent environmental pollutants
- MeSH terms
- Analysis of Variance, Animals, Animals, Newborn, Behavior, Animal, Mental Disorders, Brain Diseases, Caprylates, Disease Models, Animal, Dose-Response Relationship, Drug, Exploratory Behavior, Female, Fluorocarbons, Locomotion, Male, Nicotine, Pregnancy, Time Factors, Alkanesulfonic Acids, Nicotinic Agonists, Maze Learning, Mice
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