Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research

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Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-κB) activation and cell death by tea extracts in neuronal cultures11Abbreviations: BT, Black Tea; EMSA, Electromobility Shift Assay; EGCG, (-)-Epigallocatechin-3-gallate; GT, Green Tea; NB SH-SY5Y cells, Human neuroblastoma SH-SY5Y cells; 6-OHDA, 6-hydroxydopamine; IL, Interleukin; LDH, Lactate Dehydrogenase; MPTP, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NF-κB, nuclear factor-κB; OS, Oxidative Stress; PD, Parkinson’s Disease; ROS, Reactive Oxygen Species; SNPC, Substantia Nigra Pars Compacta; TBARS, thiobarbituric acid reactive substances.

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Structure-Activity Relationship Study of the Neuritogenic Potential of the Glycan of Starfish Ganglioside LLG-3 ‡

Yamagishi, M., Hosoda‐Yabe, R., Tamai, H., Konishi, M., Imamura, A., Ishida, H., Yabe, T., Ando, H., & Kiso, M. (2015) · Marine Drugs · doi:10.3390/md13127062 · Cited by 18

Dynamics of the association of heat shock protein HSPA6 (Hsp70B’) and HSPA1A (Hsp70–1) with stress-sensitive cytoplasmic and nuclear structures in differentiated human neuronal cells

Shorbagi, S. H., & Brown, I. R. (2016) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0724-2 · Cited by 20

Suppressing nNOS Enzyme by Small-Interfering RNAs Protects SH-SY5Y Cells and Nigral Dopaminergic Neurons from 6-OHDA Injury

Titze-de-Almeida, R., Titze-de-Almeida, S. S., Ferreira, N. R., Fontanari, C., Faccioli, L. H., & Del Bel, E. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00043-9 · Cited by 18

Changes in Gene Expression Profiling of Apoptotic Genes in Neuroblastoma Cell Lines upon Retinoic Acid Treatment

Celay, J., Blanco‐Luquin, I., Lázcoz, P., Rotinen, M., Castresana, J. S., & Encı́o, I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062771 · Cited by 17

SH‐SY5Y and LUHMES cells display differential sensitivity to MPP+, tunicamycin, and epoxomicin in 2D and 3D cell culture

Ko, K. R., Tam, N. W., Teixeira, A. G., & Frampton, J. P. (2019) · Biotechnology Progress · doi:10.1002/btpr.2942 · Cited by 17

Superoxide dismutase 1 (SOD1) and cadmium: A three models approach to the comprehension of its neurotoxic effects

Bovio, F., Sciandrone, B., Urani, C., Fusi, P. A., Forcella, M. E., & Regonesi, M. E. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.03.007 · Cited by 18

Cellular Lipidome Changes during Retinoic Acid (RA)-Induced Differentiation in SH-SY5Y Cells: A Comprehensive In Vitro Model for Assessing Neurotoxicity of Contaminants

Camdzic, M., Aga, D. S., & Atilla‐Gokcumen, G. E. (2023) · Environment & Health · doi:10.1021/envhealth.3c00022 · Cited by 16

Exploring Neuronal Differentiation Profiles in SH-SY5Y Cells through Magnetic Levitation Analysis

Bilginer-Kartal, R., & Yıldız, A. A. (2024) · ACS Omega · doi:10.1021/acsomega.3c08962 · Cited by 17

Parkinson's disease cybrids, differentiated or undifferentiated, maintain morphological and biochemical phenotypes different from those of control cybrids

Appukuttan, T. A., Ali, N., Varghese, M., Singh, A., Tripathy, D., Padmakumar, M., Gangopadhyay, P. K., & Mohanakumar, K. P. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23241 · Cited by 17

Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous β-carboline norharman: evidence for a novel detoxification pathway

Thomas, M. G., Sartini, D., Emanuelli, M., van Haren, M. J., Martin, N. I., Mountford, D. M., Barlow, D. J., Klamt, F., Ramsden, D. B., Reza, M., et al. (2016) · Biochemical Journal · doi:10.1042/bcj20160219 · Cited by 17

Computational identification of preservatives with potential neuronal cytotoxicity

Kan, H.-L., Wang, C., Lin, Y., & Tung, C.-W. (2020) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2020.104815 · Cited by 17

The use of a viral 2A sequence for the simultaneous over-expression of both the vgf gene and enhanced green fluorescent protein (eGFP) in vitro and in vivo

Lewis, J. E., Brameld, J. M., Hill, P. J., Barrett, P., Ebling, F. J. P., & Jethwa, P. H. (2015) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.08.013 · Cited by 21

Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells

Chin-Chan, M., Segovia, J., Quintanar, L., Arcos‐López, T., Hersh, L. B., Chow, K. M., Rodgers, D. W., & Quintanilla‐Vega, B. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv037 · Cited by 17

Cystine glutamate exchanger upregulation by retinoic acid induces neuroprotection in neural stem cells

Crockett, S., Clarke, M., Reeves, S., & Sims, B. (2011) · Neuroreport · doi:10.1097/wnr.0b013e3283494359 · Cited by 17

Metformin Promotes Neuronal Differentiation via Crosstalk between Cdk5 and Sox6 in Neuroblastoma Cells

Binlateh, T., Tanasawet, S., Rattanaporn, O., Sukketsiri, W., & Hutamekalin, P. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/1765182 · Cited by 17

Ropivacaine-loaded, hydroxypropyl chitin thermo-sensitive hydrogel combined with hyaluronan: an injectable, sustained-release system for providing long-lasting local anesthesia in rats

Qiao, Q., Fu, X., Huang, R., Lei, S., Leng, Y., Liu, Z., Xia, Z., & Jiang, X. (2022) · Regional Anesthesia & Pain Medicine · doi:10.1136/rapm-2021-102726 · Cited by 16

The BE (2)-M17 cell line has a better dopaminergic phenotype than the traditionally used for Parkinson´s research SH-SY5Y, which is mostly serotonergic

Carvajal-Oliveros, A., Urióstegui-Arcos, M., Zurita, M., Melchy-Pérez, E., Narváez‐Padilla, V., & Reynaud, E. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.11.007 · Cited by 16

DNA Targeting Sequence Improves Magnetic Nanoparticle-Based Plasmid DNA Transfection Efficiency in Model Neurons

Vernon, M., Dean, D. A., & Dobson, J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160819369 · Cited by 16

Effects of MgSO 4 and magnesium transporters on 6-hydroxydopamine-induced SH-SY5Y cells

Lin, L., Zili, K., Lv, M., Lin, R., Wu, B., & Zheng, Z. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.12.010 · Cited by 16

Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells

Ho, C. F., Bon, C. P.-E., Ng, Y., Herr, D. R., Wu, J., Lin, T., & Ong, W. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2448-9 · Cited by 16

Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models

Kung, P.-J., Tao, Y.-C., Hsu, H.-C., Chen, W.-L., Lin, T.-H., Janreddy, D., Yao, C.-F., Chang, K.-H., Lin, J.-Y., Su, M.-T., et al. (2014) · Drug Design, Development and Therapy · doi:10.2147/dddt.s67376 · Cited by 17

Hypothermia Reduces but Hyperthermia Augments T Cell-Derived Release of Interleukin-17 and Granzyme B that Mediate Neuronal Cell Death

Matsui, T., Kawahara, N., Kimoto, A., & Yoshida, Y. (2014) · Neurocritical Care · doi:10.1007/s12028-014-0094-5 · Cited by 16

The neuroprotective effect of BSA-based nanocurcumin against 6-OHDA-induced cell death in SH-SY5Y cells.

Sookhaklari, R., Geramizadeh, B., Abkar, M., & Moosavi, M. (2019) · Europe PMC (PubMed Central) · doi:10.22038/ajp.2018.11592 · Cited by 16

Schizophrenia risk candidate EGR3 is a novel transcriptional regulator of RELN and regulates neurite outgrowth via the Reelin signal pathway in vitro

Nie, F., Zhang, Q., Ma, J., Wang, P., Gu, R., Han, J., & Zhang, R. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15225 · Cited by 16

Loss of DEK Expression Induces Alzheimer’s Disease Phenotypes in Differentiated SH-SY5Y Cells

Greene, A. N., Parks, L. G., Solomon, M. B., & Vinnedge, L. M. P. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.594319 · Cited by 15

The secretome of adipose-derived mesenchymal stem cells protects SH-SY5Y cells from arsenic-induced toxicity, independent of a neuron-like differentiation mechanism

Curtis, T. M., Hannett, J. M., Harman, R. M., Puoplo, N., & de Walle, G. R. V. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.04.009 · Cited by 15

Neuroprotective effects of insulin-like growth factor-2 in 6-hydroxydopamine-induced cellular and mouse models of Parkinson’s disease

Ke, K., Gu, X.-S., Zhang, H., Jiang, Y.-C., Li, J.-R., Yan, J., Wang, X.-J., & Shen, J. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.355815 · Cited by 15

A novel function of N-linked glycoproteins, alpha-2-HS-glycoprotein and hemopexin: Implications for small molecule compound-mediated neuroprotection

Kanno, T., Yasutake, K., Tanaka, K., Hadano, S., & Ikeda, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186227 · Cited by 15

Evaluation of antioxidant activity of caffeic acid phenethyl ester loaded block copolymer micelles

Yoncheva, K., Tzankova, V., Yordanov, Y., Tzankov, B., Grancharov, G., Aluani, D., Bankova, V. S., Popova, M., Trusheva, B., Kondeva-Burdina, M., et al. (2019) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2018.1537753 · Cited by 15

Retinoic acid differentiated SH-SY5Y human neuroblastoma cells: an in vitro model to assess drug neurotoxicity.

Nicolini, G., Miloso, M., Zoia, C., Silvestro, A. D., Cavaletti, G., & Tredici, G. (1998) · PubMed · Cited by 64

RA Differentiation Enhances Dopaminergic Features, Changes Redox Parameters, and Increases Dopamine Transporter Dependency in 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells

Lopes, F. M., da Motta, L. L., Bastiani, M. A. D., Pfaffenseller, B., de Aguiar, B. W., de Souza, L. F., Zanatta, G., de Vargas, D. M., Schönhofen, P., Londero, G. F., et al. (2017) · Neurotoxicity Research · doi:10.1007/s12640-016-9699-0 · Cited by 62

Changes in Cell Cycle and Up-Regulation of Neuronal Markers During SH-SY5Y Neurodifferentiation by Retinoic Acid are Mediated by Reactive Species Production and Oxidative Stress

Kunzler, A., Zeidán‐Chuliá, F., Gasparotto, J., Girardi, C. S., Klafke, K., Petiz, L. L., Bortolin, R. C., Rostirolla, D. C., Zanotto‐Filho, A., Pasquali, M. A. D. B., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0189-4 · Cited by 40

Undifferentiated versus retinoic acid-differentiated SH-SY5Y cells in investigation of markers of neural function in toxicological research

Vulin, I., Tenji, D., Teodorović, I., & Kaišarević, S. (2024) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2024.2385968 · Cited by 6

Refinement of a differentiation protocol using neuroblastoma SH-SY5Y cells for use in neurotoxicology research

Simões, R. F., Ferrão, R., Silva, M. R., Pinho, S. L. C., Ferreira, L., Oliveira, P. J., & Cunha‐Oliveira, T. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.111967 · Cited by 50