Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research

NeuN, a neuronal specific nuclear protein in vertebratesxs

Mullen, R. J., Buck, C. R., & Smith, A. M. (1992) · Development · doi:10.1242/dev.116.1.201 · Cited by 2,351

Sequential Treatment of SH‐SY5Y Cells with Retinoic Acid and Brain‐Derived Neurotrophic Factor Gives Rise to Fully Differentiated, Neurotrophic Factor‐Dependent, Human Neuron‐Like Cells

Encinas, M., Iglesias, M., Liu, Y., Wang, H., Muhaisen, A., Ceña, V., Gallego, C., & Comella, J. X. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750991.x · Cited by 822

Retinoic acid-induced differentiation of cultured human neuroblastoma cells: a comparison with phorbolester-induced differentiation

Påhlman, S., Ruusala, A.-I., Abrahamsson, L., Mattsson, M. E. K., & Esscher, T. (1984) · Cell Differentiation · doi:10.1016/0045-6039(84)90038-1 · Cited by 571

Involvement of Protein Kinase C Activation and Cell Survival/ Cell Cycle Genes in Green Tea Polyphenol (−)-Epigallocatechin 3-Gallate Neuroprotective Action

Levites, Y., Amit, T., Youdim, M. B. H., & Mandel, S. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202832200 · Cited by 417

Neuroprotection and neurorescue against Aβ toxicity and PKC‐dependent release of non‐amyloidogenic soluble precursor protein by green tea polyphenol (‐)‐epigallocatechin‐3‐gallate

Levites, Y., Amit, T., Mandel, S. A., & Youdim, M. B. H. (2003) · The FASEB Journal · doi:10.1096/fj.02-0881fje · Cited by 372

Activation of the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway by Retinoic Acid Is Required for Neural Differentiation of SH-SY5Y Human Neuroblastoma Cells

López‐Carballo, G., Moreno, L., Masiá, S., Pérez, P., & Barettino, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201869200 · Cited by 301

Molecular characterization of synaptophysin, a major calcium‐binding protein of the synaptic vesicle membrane.

Rehm, H., Wiedenmann, B., & Betz, H. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04243.x · Cited by 297

Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-κB) activation and cell death by tea extracts in neuronal cultures11Abbreviations: BT, Black Tea; EMSA, Electromobility Shift Assay; EGCG, (-)-Epigallocatechin-3-gallate; GT, Green Tea; NB SH-SY5Y cells, Human neuroblastoma SH-SY5Y cells; 6-OHDA, 6-hydroxydopamine; IL, Interleukin; LDH, Lactate Dehydrogenase; MPTP, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NF-κB, nuclear factor-κB; OS, Oxidative Stress; PD, Parkinson’s Disease; ROS, Reactive Oxygen Species; SNPC, Substantia Nigra Pars Compacta; TBARS, thiobarbituric acid reactive substances.

Levites, Y., Youdim, M. B. H., Maor, G., & Mandel, S. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00813-9 · Cited by 291

Developmental and cell type‐specific expression of the neuronal marker NeuN in the murine cerebellum

Weyer, A., & Schilling, K. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10655 · Cited by 266

Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against β-amyloid peptide neurotoxicity

Yu, M.-S., Leung, S. K., Lai, S.-W., Che, C., Zee, S., So, K., Yuen, W.-H., & Chang, R. C. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.06.010 · Cited by 203

Stable knockdown of Drp1 improves retinoic acid-BDNF-induced neuronal differentiation through global transcriptomic changes and results in reduced phosphorylation of ERK1/2 independently of DUSP1 and 6

Ghani, M., Peleg, Z., Ujlaki, G., Tóth, M. E., Amsalu, H., Póliska, S., & Tar, K. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1342741 · Cited by 5

Cell-Based Systems of Depression: An Overview

Jantas, D. (2016) · Springer eBooks · doi:10.1007/978-3-319-14021-6_3 · Cited by 6

Neuronal Differentiation Modulated by Polymeric Membrane Properties

Morelli, S., Piscioneri, A., Drioli, E., & Bartolo, L. D. (2017) · Cells Tissues Organs · doi:10.1159/000477135 · Cited by 6

Flusilazole Induced Cytotoxicity and Inhibition of Neuronal Growth in Differentiated SH-SY5Y Neuroblastoma Cells by All-Trans-Retinoic Acid (Atra)

Karacaoğlu, E. (2021) · Turkish Journal of Pharmaceutical Sciences · doi:10.4274/tjps.galenos.2021.30676 · Cited by 6

In vitro transcriptome response to propolis in differentiated SH‐SY5Y neurons

Türkez, H., Arslan, M. E., Yilmaz, A., Doru, F., Çağlar, Ö., Arslan, E., Tatar, A., Hacımüftüoğlu, A., El‐Aty, A. M. A., & Mardinoğlu, A. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13990 · Cited by 6

GRIN3A and MAPT stimulate nerve overgrowth in macrodactyly

Shi, X., Lu, L., Jin, X., Liu, B., Sun, X., Lu, L., & Jiang, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5923 · Cited by 6

Energetic mixing of anti‐SNAP25 on lipid monolayers: degree of saturation of C18 fatty acids

Gew, L. T., & Misran, M. (2016) · Surface and Interface Analysis · doi:10.1002/sia.6144 · Cited by 6

Dopaminergic Identity of SH-SY5Y Cells Across Differentiation Protocols in Parkinson’s Disease Research: A Systematic Review

Artimagnella, O., Floramo, A., Cipriano, G. L., Argento, V., & Lui, M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083355 · Cited by 5

Necroptosis in aluminum-induced neural cells and animal models of Alzheimer's disease

Zhang, Q., & Niu, Q. L. (2024) · Journal of Trace Elements and Minerals · doi:10.1016/j.jtemin.2024.100125 · Cited by 5

Alteration of mature neuronal marker of β-III tubulin expression in differentiated SH-SY5Y cells by refinement of foetal bovine serum concentration

Nasir, N. F. M., Hazli, M. S. H. M., Shamsuddin, S., & Zainuddin, A. (2024) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-024-00547-0 · Cited by 5

Differentiated and mature neurons are more responsive to neurotoxicant exposure at both transcriptional and translational levels

Sarkar, S., Pandey, A. K., Yadav, S. K., Siddiqui, M. H., Pant, A. B., & Yadav, S. R. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.11.017 · Cited by 5

Retinoic Acid Promotes Neuronal Differentiation While Increasing Proteins and Organelles Related to Autophagy

Lazzeri, G., Lenzi, P., Signorini, G., Raffaelli, S., Giammattei, E., Natale, G., Ruffoli, R., Fornai, F., & Ferrucci, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041691 · Cited by 6

Expression of Gas1 in Mouse Brain: Release and Role in Neuronal Differentiation

Bautista, E., Zarco, N., Aguirre-Pineda, N., Lara-Lozano, M., Vergara, P., González-Barrios, J. A., Aguilar‐Roblero, R. A., & Segovia, J. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0559-0 · Cited by 5

GPD2: The relationship with cancer and neural stemness

Mikeli, M., Fujikawa, M., & Tanabe, T. (2022) · Cells and Development · doi:10.1016/j.cdev.2022.203824 · Cited by 5

Antiparkinsonian Agents in Investigational Polymeric Micro- and Nano-Systems

Paccione, N., Rahmani, M., Barcia, E., & Negro, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010013 · Cited by 5

Lipid levels correlate with neuronal and dopaminergic markers during the differentiation of SH-SY5Y cells

Marlet, F. R., Muñoz, S. S., Sotiraki, N., Eliasen, J. N., Woessmann, J., Weicher, J., Dreier, J. E., Schoof, E. M., Kohlmeier, K. A., Maeda, K., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167212 · Cited by 6

KLF 7 promotes neuroblastoma differentiation through the GTP ase signaling pathway by upregulating neuroblast differentiation‐associated protein AHNAK s and glycerophosphodiesterase GDPD 5

Qiao, S., Jia, Y., Xie, L. H., Jing, W., Xia, Y., Song, Y., Zhang, J., Cao, T., Song, H., Meng, L., et al. (2024) · FEBS Journal · doi:10.1111/febs.17208 · Cited by 5

Effects of quercetin and derivatives on NAMPT/Sirtuin-1 metabolic pathway in neuronal cells: an approach to mitigate chemotherapy-induced cognitive impairment

John, J., Das, S., Kunnath, A., Mudgal, J., & Nandakumar, K. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01567-0 · Cited by 6

Polyelectrolyte-coated nanocapsules containing cyclosporine A protect neuronal-like cells against oxidative stress-induced cell damage

Piotrowski, M., Jantas, D., Leśkiewicz, M., Szczepanowicz, K., Warszyński, P., & Lasoń, W. (2018) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2018.07.005 · Cited by 5

Neuroprotective and Neurite Outgrowth Stimulating Effects of New Low-Basicity 5-HT7 Receptor Agonists: In Vitro Study in Human Neuroblastoma SH-SY5Y Cells

Jakubowska, K., Hogendorf, A. S., Gołda, S., & Jantas, D. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04159-z · Cited by 4

Concentration‐Based Analysis of Metal‐Induced Tau Fibrillar versus non‐fibrillar Aggregation: Implications for Neurotoxicity in Alzheimer's Disease

Irandoust, M., Anbaraki, A., Dindar, Z., Ghasemi, A., Saboury, A. A., Rayati, S., & Seyedarabi, A. (2025) · ChemistryOpen · doi:10.1002/open.202400493 · Cited by 4

Differentiated SH-SY5Y cells exhibit neuronal features but lack synaptic maturity

Leuenberger, J., Ott, G., Nevian, T., Zuber, B., & Rostami, I. (2026) · Cell Death Discovery · doi:10.1038/s41420-026-03094-y · Cited by 4

Electrospun membranes from natural polymers with Quercetin: design and characterization, antioxidant and antimicrobial activity, and potential for skin reinnervation in chronic wounds

Correia, C., Pádua, A. S., Matela, C., Gonçalves, I. C., Soares, P. I. P., Henriques, C., Sá‐Nogueira, I., Silva, J. A. M. D. C., & Vieira, T. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126062 · Cited by 4

Comparing the enantioselective toxicity on cell cycle and apoptosis of DL-glufosinate and L-glufosinate to SH-SY5Y cells

Zhu, Y., Xu, Y., Dai, Y., Zhang, G., Ji, C., Zhang, Q., & Zhao, M. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.165106 · Cited by 4

Functional Expression of NMDA Receptors in SH-SY5Y Neuroblastoma Cells Following Long-Term RA/BDNF-Induced Differentiation

Wang, Y., Chen, Y., Hwang, E., Yeh, C., Liu, Y.-X., Chen, H., & Wu, S. (2025) · NeuroSci · doi:10.3390/neurosci6020047 · Cited by 5

Early life exposure to poly I:C impairs striatal DA-D2 receptor binding, myelination and associated behavioural abilities in rats

Singh, B., Dhuriya, Y. K., Patro, N., Thakur, M. K., Khanna, V. K., & Patro, I. K. (2021) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2021.102035 · Cited by 6

Neuroprotective Effects of Wharton Jelly Stem Cell-Derived Exosomes Developed as Nano-Drug Delivery System in 6-OHDA-Induced Neurotoxicity in 2D and 3D Neuronal Cell Line

Yavuz, B., Yildiz, A. P. Z., Abamor, E. Ş., Darıcı, H., & Allahverdiyev, A. (2023) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-023-00322-0 · Cited by 4

High OXPHOS efficiency in RA-FUdr-differentiated SH-SY5Y cells: involvement of cAMP signalling and respiratory supercomplexes

Matrella, M. L., Valletti, A., Gigante, I., Rasmo, D. D., Signorile, A., Russo, S., Lobasso, S., Lobraico, D., Dibattista, M., Pacelli, C., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-57613-x · Cited by 5

FABP5-binding lipids regulate autophagy in differentiated SH-SY5Y cells

Soto-Avellaneda, A., Oxford, A. E., Halla, F., Vasquez, P., Oe, E., Pugel, A. D., Schoenfeld, A. M., Tillman, M. C., Cuevas, A. R., Ortlund, E. A., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0300168 · Cited by 4

The degradation of α--synuclein is limited by dynein to drive the AALP pathway through HDAC6 upon paraquat exposure

Ai, Q., Wang, K., Li, Y., Hu, R., Hu, G., Li, Y., Shi, G., & Huang, M. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116841 · Cited by 4

Benchmarking In-Cell Proteomics for Profiling Neuroblastoma Cell Differentiation and the Ubiquitin-Proteasome System

Moafian, Z., Marino, M. J., Yu, Y., & Zhuang, Z. (2025) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5c00634 · Cited by 4

Regulation of Calcium-Independent Phospholipase A2 Expression by Adrenoceptors and Sterol Regulatory Element Binding Protein—Potential Crosstalk Between Sterol and Glycerophospholipid Mediators

Chew, W.-S., & Ong, W. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9026-9 · Cited by 4

Normalization of Enzyme Expression and Activity Regulating Vitamin A Metabolism Increases RAR-Beta Expression and Reduces Cellular Migration and Proliferation in Diseases Caused by Tuberous Sclerosis Gene Mutations

Abdelwahab, E. M. M., Bóvári‐Biri, J., Smuk, G., Harkó, T., Fillinger, J., Moldvay, J., Krymskaya, V. P., & Pongracz, J. E. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.644592 · Cited by 4

Mechanical Properties and Electrical Behavior of Neuroblastoma Cells Characterized by Atomic Force Microscopy

Xie, Y. M., Qu, Y., Wang, Y., Wang, J., Tian, L., Wang, L., Li, L., & Wang, Z. (2021) · NANO · doi:10.1142/s179329202150140x · Cited by 4

In silico design of HDAC6 inhibitors with neuroprotective effects

Sixto‐López, Y., Gómez-Vidal, J. A., de Pedro, N., Bello, M., Rosales‐Hernández, M. C., & Correa‐Basurto, J. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.2001378 · Cited by 4

Epigallocatechin-3-gallate and resveratrol attenuate hydrogen peroxide induced damage in neuronal cells

Cosar, M. Y., Erdoğan, M. A., & YILMAZ, O. (2023) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2023_033 · Cited by 4

Cell death induced by nicotine in human neuroblastoma SH-SY5Y cells is mainly attributed to cytoplasmic vacuolation originating from the trans-Golgi network

Li, J., Wang, H., Chen, H., Li, X., Liu, Y., Hou, H., & Hu, Q. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.114431 · Cited by 4

HN1 is a novel dedifferentiation factor involved in regulating the cell cycle and microtubules in SH‐SY5Y neuroblastoma cells

Özar, T., Javed, A., Özduman, G., & Korkmaz, K. (2024) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30569 · Cited by 4

Which Medium and Ingredients Provide Better Morphological Differentiation of SH-SY5Y Cells?

Serdar, B. S., Erkmen, T., Ergür, B. U., Akan, P., & Koçtürk, S. (2018) · International Cell Death Research Congress · doi:10.3390/proceedings2251577 · Cited by 4

Neuroprotective Effects of 7-Geranyloxycinnamic Acid from Melicope lunu ankenda Leaves

Mohamed, Z. A., Eliaser, E. M., Mohammed, J. S., Nordin, N., Ioannides, C., & Razis, A. F. A. (2020) · Molecules · doi:10.3390/molecules25163724 · Cited by 5

Force spectroscopy of membrane hardness of SH-SY5Y neuroblastoma cells before and after differentiation

Kwon, S., Yang, W., Choi, Y. K., & Park, J. K. (2014) · Journal of the Korean Physical Society · doi:10.3938/jkps.64.1595 · Cited by 4

Alteration in Long Noncoding RNAs in Response to Oxidative Stress and Ladostigil in SH-SY5Y CellsPreprint

Zohar, K., Giladi, E., Eliyahu, T., & Michal Linial, B. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.20.481187 · Cited by 4

Discovery of Novel Antiepileptic Agents Targeting the α1β2γ2 GABAA Receptor

Gao, Y., Noraddin, A., Li, X., Zhu, C., Zhang, Y., Jin, Y., Zhang, M., Yu, Y., Wang, X., Wang, K., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c01770 · Cited by 3

Identification of Novel JAK2 Inhibitors from Amino Derivatives of Epoxyalantolactone: In Silico and In Vitro Studies

Todsaporn, D., Sanachai, K., Aonbangkhen, C., Poo-arporn, R. P., Kartsev, V. G., Pukhov, S. A., Afanasyeva, S., Geronikaki, A. A., & Rungrotmongkol, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010329 · Cited by 3

Neurons in a Dish: A Review of In Vitro Cell Models for Studying Neurogenesis

Vassal, M., Cruz, A. C., Rebelo, S., & Martins, F. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70344 · Cited by 4

Cybrids for Mitochondrial DNA Pharmacogenomics

Iglesias, E., Llobet, L., Pacheu‐Grau, D., Gómez-Durán, A., & Ruiz‐Pesini, E. (2012) · Drug Development Research · doi:10.1002/ddr.21037 · Cited by 3

Phosphatidylcholine-Plasmalogen-Oleic Acid Has Protective Effects against Arachidonic Acid-Induced Cytotoxicity

Yamagiwa, N., Kobayashi, H., Okabayashi, H., Yasuda, M., Fukushima, K., Kawamura, J., Kotoura, S., & Fujino, H. (2022) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b22-00035 · Cited by 3

Lysoglycosphingolipids have the ability to induce cell death through direct PI3K inhibition

Watanabe, R., Tsuji, D., Tanaka, H., Uno, M. S., Ohnishi, Y., Kitaguchi, S., Matsugu, T., Nakae, R., Teramoto, H., Yamamoto, K., et al. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16012 · Cited by 3

Exploring therapeutic potential of Bacopa monnieri bioactive compounds against Alzheimer’s and Parkinson’s diseases

Shukla, R., Misra, K., & Singh, S. (2025) · 3 Biotech · doi:10.1007/s13205-025-04224-6 · Cited by 3

Differential gene expression by lithium chloride induction of adipose-derived stem cells into neural phenotype cells.

Farrokhfar, S., Tiraihi, T., Movahedin, M., & Azizi, H. (2020) · PubMed Central · doi:10.22038/ijbms.2020.41582.9820 · Cited by 3

Acyclic retinoid peretinoin reduces hemorrhage-associated brain injury in vitro and in vivo

Nakanishi, S., Kinoshita, K., Kurauchi, Y., Seki, T., Kimura, Y., Suzuki, M., Suzuki, K., Koyama, H., Kagechika, H., & Katsuki, H. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175899 · Cited by 3

Structural insights into the recognition of the A/T‐rich motif in target gene promoters by the LMX 1a homeobox domain

Lin, L., Deng, J., Peng, J., Cui, J., Wang, L., Zhang, M., Gao, J., Li, F., Shi, Y., & Lv, M. (2024) · FEBS Journal · doi:10.1111/febs.17118 · Cited by 3

Beyond boundaries: Neuroprotective effects of steroids and ecdysteroids in SH‐SY5Y cells ‐ A systematic review

Tayeb, B. A., Njangiru, I. K., & Minorics, R. (2024) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.37 · Cited by 3

Neuroprotective Potential of Photobiomodulation Therapy: Mitigating Amyloid-Beta Accumulation and Modulating Acetylcholine Levels in an In Vitro Model of Alzheimer’s Disease

Thammasart, S., Namchaiw, P., Viravaidya‐Pasuwat, K., Tonsomboon, K., & Khantachawana, A. (2024) · Photobiomodulation Photomedicine and Laser Surgery · doi:10.1089/pho.2024.0042 · Cited by 3

Lactuca racemosa Willd., Source of Antioxidants with Diverse Chemical Structures

Michalska, K., Jantas, D., Malarz, J., Jakubowska, K., Paul, W., & Stojakowska, A. (2024) · Molecules · doi:10.3390/molecules29245975 · Cited by 3

A Bioluminescence Reporter Assay for Retinoic Acid Control of Translation of the GluR1 Subunit of the AMPA Glutamate Receptor

Khatib, T., Whiting, A., Chisholm, D. R., Redfern, C. P. F., Müller, B., & McCaffery, P. J. A. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1571-9 · Cited by 4

The double deficiency of the SNARE proteins vti1a and vti1b affects neurite outgrowth and signaling in N1E-115 neuroblastoma cells

Kotschnew, K., Winkler, D., Reckmann, J., Mann, C., Schweigert, A., Tellkamp, G., Müller, K. M., & von Mollard, G. F. (2024) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2024.151461 · Cited by 2

Establishing a 3D Spheroid Model of Cholinergic Neurons from SH-SY5Y Cells for Neurotoxicity Assessment

Franco-Campos, F., Fernández-Franzón, M., Rodríguez-Carrasco, Y., & Ruiz, M.-J. (2025) · Toxins · doi:10.3390/toxins17070336 · Cited by 2

Tamibarotene promotes differentiation of neuroblastoma SH-SY5Y cells into neurons, which is associated with activation of the PI3K/AKT signaling pathway

Zhang, J., XiangWei, W., Zhang, F., Yi, H., Yan, W., Li, X., Gao, K., & Jiang, Y. (2025) · BMC Neuroscience · doi:10.1186/s12868-025-00962-8 · Cited by 2

Structural and molecular differentiation of cultured human neurons is accompanied by alterations of spontaneous and evoked calcium dynamics

Negi, D., Shorter, S. A., Goodhall, I., Razansky, D., Shergill, S. S., & Ovsepian, S. V. (2025) · Scientific Reports · doi:10.1038/s41598-025-15561-0 · Cited by 3

KIF5A upregulation by FAK ‐mediated downregulation of epigenetic modifiers promotes mitochondrial dynamics in neuronal differentiation

Manna, S., Kirtana, R., Mishra, J., & Patra, S. K. (2025) · FEBS Letters · doi:10.1002/1873-3468.70177 · Cited by 2

Human dental pulp stem cell-derived mitochondria restore mitochondrial function and promote neuroregeneration in a cellular model of Parkinson’s disease

Gonmanee, T., Petcharat, P., Manprasong, S., Sangkhamanee, S. S., Arayapisit, T., Sritanaudomchai, H., Khwanraj, K., & Dharmasaroja, P. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04702-x · Cited by 3

Dynamic redox monitoring in differentiated human neuroblastoma models of Parkinson’s disease

Lim, J., Zhou, X., Pamujula, S., Liaqat, R., Achanta, A. S., Looger, L. L., Campbell, B. C., & Campbell, M. M. (2025) · Redox Report · doi:10.1080/13510002.2025.2595781 · Cited by 2

PCB 153 Modulates Genes Involved in Proteasome and Neurodegeneration-Related Pathways in Differentiated SH-SY5Y Cells: A Transcriptomic Study

Minuti, A., Silvestro, S., Muscarà, C., Scuruchi, M., & D’Angiolini, S. (2026) · Cells · doi:10.3390/cells15030217 · Cited by 2

Human platelet lysate supports SH‐SY5Y neuroblastoma cell proliferation and differentiation into a dopaminergic‐like neuronal phenotype under xenogeneic‐free culture conditions

Ribeiro, M. A., Campos, J., Pinho, T. S., Sampaio‐Marques, B., Barata‐Antunes, S., Cibrão, J. R., Araújo, R., Duarte‐Silva, S., Moreira, E., Sousa, R. A., et al. (2024) · Biotechnology Journal · doi:10.1002/biot.202400068 · Cited by 2

Diverse effects of synthetic glucocorticoid species on cell viability and stress response of neuroblastoma cells

Zerillo, L., Polvere, I., Stilo, R., Vito, P., Rinaldi, M., Zotti, T., & Costagliola, C. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.07.010 · Cited by 2

Evaluation of SK-N-SH Cells as a Model for NMDA Receptor Induced Toxicity

Schreiber, J. A., & Goerges, G. (2024) · Cellular Physiology and Biochemistry · doi:10.33594/000000722 · Cited by 2

A peptide against the N-terminus of myristoylated alanine-rich C kinase substrate promotes neuronal differentiation in SH-SY5Y human neuroblastoma cells

Ferdous, J., Naitou, K., & Shiraishi, M. (2024) · Journal of Veterinary Medical Science · doi:10.1292/jvms.24-0276 · Cited by 2

DNA aptamers that modulate biological activity of model neurons

Rolli, J., Pearson, K. S., Wilbanks, B. A., Hrstka, S., Minotti, A. P., Studer, L., Warrington, A. E., Staff, N. P., & Maher, L. J., III (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102392 · Cited by 2

Clioquinol induces mitochondrial toxicity in SH ‐ SY5Y neuroblastoma cells by affecting the respiratory chain complex IV and OPA1 dynamin‐like GTPase

Katsuyama, M., Arakawa, N., Yaoi, T., Kimura, E., Matsumoto, M., Iwata, K., Umemura, A., & Yabe‐Nishimura, C. (2025) · FEBS Letters · doi:10.1002/1873-3468.70033 · Cited by 2

Neuroprotective Effects of Different Lavandula stoechas L. Extracts Against Hydrogen Peroxide Toxicity in vitro

Erdo, M. A., Bayar, C., Ozkaya, E., Metin, A., Birim, D., Armağan, G., Demir, S., & Cebe, G. E. (2022) · International Journal of Pharmacology · doi:10.3923/ijp.2022.883.896 · Cited by 2

Serum-Derived Exosomes of Patients with Depression with Increased miR-96-5p Inhibit Neuronal Differentiation by Targeting RAC1

Wu, S., Chen, Z., Xuan, Z., Zhou, Y., Zou, C., Wang, Y., Ye, J., Zhao, P., Xiao, A., Yu, L., et al. (2023) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2023.3527 · Cited by 2

HOTAIRM1 regulates neuronal differentiation by modulating NEUROGENIN 2 and the downstream neurogenic cascade

Rea, J. N. (2020) · doi:10.26226/morressier.5ebd45acffea6f735881aff1 · Cited by 2

Quantifying Morphology of a Differentiating Neuroblastoma Cell Line

Fang, J., Kuwamoto, W. N., Miranda, G., Rajagopalan, V., & Elul, T. (2023) · PubMed Central · doi:10.17912/micropub.biology.001099 · Cited by 1

Isobolographic Analysis of the Cytoprotective Effect of Dapsone and Cannabidiol Alone or Combination upon Oxygen–Glucose Deprivation/Reoxygenation Model in SH-SY5Y Cells

Islas-Cortez, M., Rı́os, C., Manzanares, J., Dı́az-Ruiz, A., & Pérez-Pastén-Borja, R. (2024) · Antioxidants · doi:10.3390/antiox13060705 · Cited by 1

Immortalized neuronal lines versus human induced pluripotent stem cell-derived neurons as in vitro toxicology models

Tang, X.-Q., & Bowman, A. B. (2024) · Advances in neurotoxicology · doi:10.1016/bs.ant.2024.07.004 · Cited by 1

Detoxification of paraoxon-ethyl by Lysiphyllum strychnifolium extracts in undifferentiated human neuroblastoma SH-SY5Y cells

Ekaratcharoenchai, N., Nualsanit, T., & Krajarng, A. (2024) · Pharmaceutical Biology · doi:10.1080/13880209.2024.2430262 · Cited by 1

Application of mRNA technology in neuronal protection of human mature brain-derived neurotrophic factor

Wang, L., Su, F., Huang, H., Jiang, Q., Kong, H., & Pei, Z. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.102788 · Cited by 1

Synthetic Retinoids for the Modulation of Genomic and Nongenomic Processes in Neurodegenerative Diseases

Butler, A. M., Chisholm, D. R., Tomlinson, C. W. E., Khatib, T., Clark, J., Wan, S., Coveney, P. V., Greig, I. R., McCaffery, P. J. A., Pohl, E., et al. (2025) · ACS Omega · doi:10.1021/acsomega.5c00934 · Cited by 1

New Terpenoids and Polyphenolic Profile of Carpesium cernuum L. of European Origin

Malarz, J., Jantas, D., Jakubowska, K., Bugno, R., Kiss, A. K., & Stojakowska, A. (2025) · Molecules · doi:10.3390/molecules30122506 · Cited by 1

Cobalt complexes as modulators against amyloid-β aggregation

Yoo, J., Suh, J., Kim, G., Bernard, H., Tripier, R., Kim, D., Kim, M., & Lim, M. H. (2025) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2025.112972 · Cited by 1

TLR3 regulation and cytokine response during BoAHV-1 and BoAHV-5 infection of neuronal-like cells

Brunner, M. B., Rosales, J. J., Ladera, M., Farías, M. V. N., Verna, A., & Pérez, S. (2025) · Microbes and Infection · doi:10.1016/j.micinf.2025.105558 · Cited by 1

IFIT3 activation significantly contributes to HIV-1-associated neurodegenerative disorder-mediated neuroinflammation

Das, R. K., Sahoo, N., Roy, D., Xu, C., Galarza, J., Garza, M. C. M., Rodrigo, H., Duttaroy, A. K., & Roy, U. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1532318 · Cited by 1

Cinnarizine, a Calcium Channel Blocker, Partially Prevents the Striatal Dopamine Decline and Loss of Nigral Dopamine Neurons in the Lactacystin-Induced Rat Model of Parkinson’s Disease

Lorenc‐Koci, E., Lenda, T., Konieczny, J., Jantas, D., & Domin, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188833 · Cited by 1

Complex II inhibition suppresses RSL3-induced ferroptosis by restoring mitochondrial bioenergetics

Lee, S. C., Lee, S. K., Kim, H., & Park, K.-S. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152970 · Cited by 1

RNAi-Induced Expression of Paternal UBE3A

Kang, H. R., Zaric, V., Rybalchenko, V., Gray, S. J., & Butler, R. K. (2026) · Genes · doi:10.3390/genes17020156 · Cited by 2

Targeting Peptidylarginine Deiminases in Neurons and Astrocytes in Central Nervous System Injury—Effects of Pan-PAD Inhibitor Cl-Amidine in an Oxygen–Glucose Deprivation Model of Ischaemia (OGD/R) and LPS Stimulation In Vitro

Ahmed, D., Getting, S. J., Ashioti, M., & Lange, S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27115118 · Cited by 1

In-vitro modelling of Alzheimer’s disease using cholinergic neurons derived from human neuroblastoma (SH-SY5Y) retinoic acid-induced differentiation

Zainuddin, M.-S., Magalingam, K. B., Pamidi, N., Azman, A. S., & Bhuvanendran, S. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12156-4 · Cited by 2

Minocycline exerts a neuroprotective action against 6-OHDA-induced neurotoxicity: in vivo and in vitro studies

Ferreira, P. L. F. T., & Viana, G. S. D. B. (2015) · Neurology and Neuroscience · doi:10.3823/348 · Cited by 1

The Role of CDKN3 in Neuroblastoma Differentiation

Partridge, V. R., & Du, L. (2017) · The FASEB Journal · doi:10.1096/fasebj.31.1_supplement.933.7 · Cited by 1

Dyngo-4a Induces Neuroblastoma Cell Differentiation Through The AKT and ERK1/2 Pathway

Huang, J.-X., Zhou, Y., Zeng, S., Xu, J., Liu, L., Grothusen, J. R., & Liu, R. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666221202145437 · Cited by 1

Effects of ellagic acid in human neuroblastoma cells

Alfredsson, C. F. (2013) · Cited by 1

Exploring the Active Components of Ziziphus jujuba Mill. in Treatment of Depression by Network Pharmacology Combined with Neuroprotective Effects in SH-SY5Y Cells

Li, D., Li, W., Shi, W., Wu, X., Liu, X., & Gao, P. (2023) · Pharmaceutical Chemistry Journal · doi:10.1007/s11094-023-02942-w · Cited by 1

Effect of Pimecrolimus on apoptotic pathways in H2O2-treated neuron like differentiated-SH-SY5Y cells: a molecular docking and mechanistic study

Koçancı, F. G. (2024) · Toxicology Research · doi:10.1093/toxres/tfaf020 · Cited by 1

Manipulation and Study of Gene Expression in Neurotoxin- Treated Neuronal PC12 and SH-SY5Y Cells for In Vitro Studies of Parkinson’s Disease

Aimé, P., Sun, X., & Greene, L. A. (2018) · InTech eBooks · doi:10.5772/intechopen.71811 · Cited by 1

Toxicity study of complex CNT-PEG(-NH2)-DOX synthesis on neuroblastoma cells

Nurulhuda, I., Mazatulikhma, M. Z., Alrokayan, S., Khan, H. A., & RUSOP, M. (2018) · AIP conference proceedings · doi:10.1063/1.5036897 · Cited by 1

Calcium Oscillation Frequency Is a Potential Functional Complex Physiological Relevance Indicator for a Neuroblastoma-Based 3D Culture Model

Asthana, A., Ndyabawe, K., Mendez, D., Douglass, M. E., Haidekker, M. A., & Kisaalita, W. S. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01988 · Cited by 1

Pathophysiological, toxicological, and immunoregulatory roles of reactive oxygen and nitrogen species (RONS)

Madkour, L. H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-822481-6.00001-3 · Cited by 1

Retinoid Signaling in the Central Nervous System

McCaffery, P. J. A., & Krężel, W. (2015) · Wiley eBooks · doi:10.1002/9781118628003.ch19 · Cited by 1

The potential of human adipose tissue derived mesenchymal stem cells in cell therapy for retinal degenerative diseases

Singh, A. K. (2013) · doi:10.35376/10324/4380 · Cited by 1

Retinoic acid differentiated SH-SY5Y human neuroblastoma cells: an in vitro model to assess drug neurotoxicity.

Nicolini, G., Miloso, M., Zoia, C., Silvestro, A. D., Cavaletti, G., & Tredici, G. (1998) · PubMed · Cited by 64

RA Differentiation Enhances Dopaminergic Features, Changes Redox Parameters, and Increases Dopamine Transporter Dependency in 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells

Lopes, F. M., da Motta, L. L., Bastiani, M. A. D., Pfaffenseller, B., de Aguiar, B. W., de Souza, L. F., Zanatta, G., de Vargas, D. M., Schönhofen, P., Londero, G. F., et al. (2017) · Neurotoxicity Research · doi:10.1007/s12640-016-9699-0 · Cited by 62

Changes in Cell Cycle and Up-Regulation of Neuronal Markers During SH-SY5Y Neurodifferentiation by Retinoic Acid are Mediated by Reactive Species Production and Oxidative Stress

Kunzler, A., Zeidán‐Chuliá, F., Gasparotto, J., Girardi, C. S., Klafke, K., Petiz, L. L., Bortolin, R. C., Rostirolla, D. C., Zanotto‐Filho, A., Pasquali, M. A. D. B., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0189-4 · Cited by 40

Undifferentiated versus retinoic acid-differentiated SH-SY5Y cells in investigation of markers of neural function in toxicological research

Vulin, I., Tenji, D., Teodorović, I., & Kaišarević, S. (2024) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2024.2385968 · Cited by 6

Refinement of a differentiation protocol using neuroblastoma SH-SY5Y cells for use in neurotoxicology research

Simões, R. F., Ferrão, R., Silva, M. R., Pinho, S. L. C., Ferreira, L., Oliveira, P. J., & Cunha‐Oliveira, T. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.111967 · Cited by 50