Gestational Exposure to Perfluorooctanoic Acid (PFOA): Alterations in Motor Related Behaviors
Open accessAbstract
Perfluoroalkyl and polyfluoroalkyl substances are used in commercial applications and developmental exposure has been implicated in alterations in neurobehavioral functioning. While associations between developmental perfluorooctanoic acid (PFOA) exposure and human outcomes have been inconsistent, studies in experimental animals suggest alterations in motor related behaviors. To examine a dose-response pattern of neurobehavioral effects following gestational exposure to PFOA, pregnant CD-1 mice received PFOA (0, 0.1, 0.3, 1.0mg/kg/day) via oral gavage from gestational day 1-17 and the male offspring examined. Motor activity assessments on postnatal day (PND)18, 19, and 20 indicated a shift in the developmental pattern with an elevated activity level observed in the 1.0mg/kg/day dose group on PND18. In the adult, no alterations were observed in body weights, activity levels, diurnal pattern of running wheel activity, startle response, or pre-pulse startle inhibition. In response to a subcutaneous injection of saline or nicotine (80μg/kg), all animals displayed a transient increase in activity likely associated with handling with no differences observed across dose groups. Inhibition of motor activity over 18days of 400μg/kg nicotine injection was not significantly different across dose groups. Hyperactivity induced by 2mg/kg (+)-methamphetamine hydrochloride intraperitoneal injection was significantly lower in the 1.0mg/kg/day PFOA dose group as compared to controls. Taken together, these data suggest that the effects on motor-related behaviors with gestational PFOA exposure do not mimic those reported for acute postnatal exposure. Changes were not observed at dose levels under 1.0mg/kg/day PFOA. Further examination of pathways associated with methamphetamine-induced activity is warranted.
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Goulding et al. (2017) did not observe any exposure-related effect in response to a subsequent nicotine challenge in adulthood.
“Goulding et al. (2017) did not observe any exposure related effect in response to the subsequent nicotine challenge in adulthood.”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Goulding et al., 2017
Gestational exposure to 1 mg/kg/day PFOA for 17 days in male mice induced a mild increase in locomotor activity at PND 18 compared to control animals.
“Another study assessing gestational exposure to 1 mg/kg/day PFOA for 17 days in male mice found that PFOA exposure induced a mild increase in locomotor activity at PND 18, compared to control animals (Goulding et al., 2017).”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Goulding et al., 2017
Goulding et al. (2017) reported a PFOA-related reduction in hyperactivity after administration of methamphetamine at 6 months of age compared to control animals.
“However, they did report a PFOA-related reduction in hyperactivity after administration of methamphetamine at 6 months of age, compared to control animals (Goulding et al., 2017).”
From A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior (2022) · cites this paper as Goulding et al., 2017
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- Authors
- Goulding, D. R., White, S. S., McBride, S. J., Fenton, S. E., & Harry, G. J.
- Affiliations
- National Institutes of Health (US)
- National Institute of Environmental Health Sciences (US)
- Social and Scientific Systems (United States) (US)
- Corresponding author
- Harry, G. Jean
- Venue
- NeuroToxicology
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 58
- Pages
- 110-119
- ISSN
- 0161-813X (ISSN-L)
- PMC
- PMC5345697
- OpenAlex
- W2556557351
- Cited by
- 42
- References
- 75
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 1
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroToxicology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Division of Intramural Research
- Division of the National Toxicology Program
- National Institute of Environmental Health Sciences
- National Institutes of Health, Department of Health and Human Services (#1Z01ES101623, ES021164, ES102785, HHSN273201500077U)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- perfluorooctanoic acid, per- and polyfluoroalkyl substances, prenatal exposure, developmental neurotoxicity, motor behavior, hyperactivity, nicotine, startle response, prepulse inhibition, dose-response relationship, ICR mice, offspring
- MeSH terms
- Motor Disorders, Analysis of Variance, Animals, Body Weight, Caprylates, Dose-Response Relationship, Drug, Environmental Pollutants, Female, Fluorocarbons, Gestational Age, Nicotine, Pregnancy, Prenatal Exposure Delayed Effects, Running, Reflex, Startle, Cohort Studies, Nicotinic Agonists, Mice
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