Synaptic slaughter in Alzheimer's disease

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92338-8 · Cited by 1,267 · cited 1×

Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease

Coleman, P. D., & Flood, D. G. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90127-8 · Cited by 772

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

Braak, F., Braak, H., & Mandelkow, E. (1994) · Acta Neuropathologica · doi:10.1007/bf00293315 · Cited by 769

The molecular machinery for secretion is conserved from yeast to neurons.

Bennett, M. K., & Scheller, R. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.2559 · Cited by 650

A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter

Liu, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90425-c · Cited by 589

Dendritic Growth in the Aged Human Brain and Failure of Growth in Senile Dementia

Buell, S. J., & Coleman, P. D. (1979) · Science · doi:10.1126/science.493989 · Cited by 475

Quantitative assessment of cortical synaptic density in Alzheimer's disease

Scheff, S. W., DeKosky, S. T., & Price, D. A. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90059-9 · Cited by 446

Clathrin Assembly Lymphoid Myeloid Leukemia (CALM) Protein: Localization in Endocytic-coated Pits, Interactions with Clathrin, and the Impact of Overexpression on Clathrin-mediated Traffic

Tebar, F., Bohlander, S. K., & Sorkin, A. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.8.2687 · Cited by 320

Ongoing Research on the Role of Gintonin in the Management of Neurodegenerative Disorders

Ikram, M. A., Ullah, R., Khan, A., & Kim, M. O. (2020) · Cells · doi:10.3390/cells9061464 · Cited by 36

Effects of proNGF on Neuronal Viability, Neurite Growth and Amyloid-beta Metabolism

Wang, Y., Valadares, D., Sun, Y., Wang, X., Zhong, J., Liu, X., Majd, S., Chen, L., Gao, C., Chen, S., et al. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9098-x · Cited by 34

Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems

Balaji, V., Kaniyappan, S., Mandelkow�, E., Wang, Y., & Mandelkow, E.-M. (2018) · Autophagy · doi:10.1080/15548627.2018.1509607 · Cited by 33

Caspase-12 Activation is Involved in Amyloid-β Protein-Induced Synaptic Toxicity

Quiroz‐Baez, R., Ferrera, P., Rosendo‐Gutiérrez, R., Morán, J., Bermúdez‐Rattoni, F., & Arias, C. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110326 · Cited by 32

Effects of rTMS treatment on global cognitive function in Alzheimer's disease: A systematic review and meta-analysis

Zhang, T., Sui, Y., Lu, Q., Xu, X., Zhu, Y., Dai, W., Shen, Y., & Wang, T. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.984708 · Cited by 32

SO2 inhalation causes synaptic injury in rat hippocampus via its derivatives in vivo

Yun, Y., Yao, G., Yue, H., Guo, L., Qin, G., Li, G., & Sang, N. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.08.063 · Cited by 32

Protein Aggregation in Alzheimers Disease and Other Neoropathological Disorders

Dimakopoulos, A. C. (2005) · Current Alzheimer Research · doi:10.2174/1567205052772795 · Cited by 33

Selected microRNAs Increase Synaptic Resilience to the Damaging Binding of the Alzheimer’s Disease Amyloid Beta Oligomers

Zolochevska, O., & Taglialatela, G. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01868-8 · Cited by 30

Synaptic Compensation as a Probable Cause of Prolonged Mild Cognitive Impairment in Alzheimer’s Disease: Implications from a Transgenic Mouse Model of the Disease

Baazaoui, N., Flory, M. J., & Iqbal, K. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160845 · Cited by 31

The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline

Castonguay, D., Dufort‐Gervais, J., Ménard, C., Chatterjee, M., Quirion, R., Bontempi, B., Schneider, J. S., Arnsten, A. F. T., Nairn, A. C., Norris, C. M., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.047 · Cited by 30

Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease

Spires‐Jones, T. L., & Hannan, A. J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04275.x · Cited by 31

Presynaptic density determined by SV2A PET is closely associated with postsynaptic metabotropic glutamate receptor 5 availability and independent of amyloid pathology in early cognitive impairment

Wang, J., Huang, Q., He, K., Li, J., Guo, T., Yang, Y., Lin, Z., Li, S., Vanderlinden, G., Huang, Y. H., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13817 · Cited by 26

Smilagenin attenuates beta amyloid (25–35)-induced degeneration of neuronal cells via stimulating the gene expression of brain-derived neurotrophic factor

Zhang, R., Wang, Z., Howson, P. A., Xia, Z., Zhou, S. Y., Wu, E., Xia, Z., & Hu, Y. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.017 · Cited by 28

Neuro-regeneration Therapeutic for Alzheimer’s Dementia: Perspectives on Neurotrophic Activity

Sun, M., & Alkon, D. L. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.07.008 · Cited by 31

The Role of Synaptic Dysfunction in Alzheimer’s Disease

Pei, Y. A., Davies, J., Zhang, M., & Zhang, H. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191334 · Cited by 29

Cholinergic neurodegeneration in Alzheimer disease mouse models

Shekari, A., & Fahnestock, M. L. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819973-2.00013-7 · Cited by 30

ApoE4 Induces Synaptic and ERG Impairments in the Retina of Young Targeted Replacement ApoE4 Mice

Antes, R., Ezra-Elia, R., Weinberger, D., Solomon, A., Ofri, R., & Michaelson, D. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064949 · Cited by 29

Sex Impact on Tau-Aggregation and Postsynaptic Protein Levels in the P301L Mouse Model of Tauopathy

Buccarello, L., Grignaschi, G., Castaldo, A., Giancamillo, A. D., Domeneghini, C., Melcangi, R. C., & Borsello, T. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161087 · Cited by 30

Long-Term DL-3-n-Butylphthalide Treatment Alleviates Cognitive Impairment Correlate With Improving Synaptic Plasticity in SAMP8 Mice

Lv, C., Ma, Q., Han, B., Li, J., Geng, Y., Zhang, X., & Wang, M. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00200 · Cited by 28

Rit signaling contributes to interferon‐γ‐induced dendritic retraction via p38 mitogen‐activated protein kinase activation

Andres, D., Shi, G., Bruun, D. A., Barnhart, C., & Lein, P. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05708.x · Cited by 28

Changes in Neurons and Synapses in Hippocampus of Streptozotocin‐Induced Type 1 Diabetes Rats: A Stereological Investigation

Zhao, F., Li, J., Mo, L., Tan, M. F., Zhang, T., Tang, Y. C., & Zhao, Y. (2016) · The Anatomical Record · doi:10.1002/ar.23344 · Cited by 27

Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies

Akwa, Y., Malta, C. D., Zallo, F., Gondard, E., Lunati, A., Diaz-de-Grenu, L. Z., Zampelli, A., Boiret, A., Santamaria, S., Martinez-Preciado, M., et al. (2022) · Autophagy · doi:10.1080/15548627.2022.2095791 · Cited by 27

Alzheimer’s Disease: Challenges and a Therapeutic Opportunity to Treat It with a Neurotrophic Compound

Baazaoui, N., & Iqbal, K. (2022) · Biomolecules · doi:10.3390/biom12101409 · Cited by 27

Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia

Vallortigara, J., Rangarajan, S., Whitfield, D., Alghamdi, A. A., Howlett, D. R., Hortobágyi, T., Johnson, M. A., Attems, J., Ballard, C. G., Thomas, A. J., et al. (2014) · F1000Research · doi:10.12688/f1000research.3786.1 · Cited by 27

NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model

Latina, V., Caioli, S., Zona, C., Ciotti, M. T., Borreca, A., Calissano, P., & Amadoro, G. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00487 · Cited by 26

In vivo imaging of synaptic density with [11C]UCB-J PET in two mouse models of neurodegenerative disease

Xiong, M., Roshanbin, S., Rokka, J., Schlein, E., Ingelsson, M., Sehlin, D., Eriksson, J., & Syvänen, S. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118302 · Cited by 24

Amyloid-β in Alzheimer’s disease – front and centre after all?

Weglinski, C., & Jeans, A. F. (2022) · Neuronal Signaling · doi:10.1042/ns20220086 · Cited by 24

Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer’s disease

Honarnejad, K., Daschner, A., Gehring, A. P., Szybińska, A., Giese, A., Kuźnicki, J., Bracher, F., & Herms, J. W. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.132 · Cited by 24

Protective effect of S14G-humanin against beta-amyloid induced LTP inhibition in mouse hippocampal slices

Zhang, W., Miao, J., Hao, J., Li, Z., Jiang, X., Liu, R. G., Cao, F., Wang, R., Chen, J., & Li, Z. (2009) · Peptides · doi:10.1016/j.peptides.2009.02.017 · Cited by 24

Aberrant Co-localization of Synaptic Proteins Promoted by Alzheimer’s Disease Amyloid-β Peptides: Protective Effect of Human Serum Albumin

Domínguez-Prieto, M., Velasco, A. L., Vega, L., Tabernero, A., & Medina, J. M. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160346 · Cited by 24

Protective Effects of Donepezil Against Alcohol-Induced Toxicity in Cell Culture: Role of Caspase-3

Getachew, B., Hudson, T., Heinbockel, T., Csoka, A. B., & Tizabi, Y. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9913-3 · Cited by 24

“Olfactory three-needle” acupuncture enhances synaptic function in A𝜷1-42-induced Alzheimer’s disease via activating PI3K/AKT/GSK-3𝜷 signaling pathway

Wang, Y., Zheng, A., Yang, H., Wang, Q., Ren, B. X., Guo, T., Qiang, J., Cao, H., Gao, Y., Xu, L., et al. (2021) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2021.01.224 · Cited by 23

Inhibiting amyloid beta (1–42) peptide-induced mitochondrial dysfunction prevents the degradation of synaptic proteins in the entorhinal cortex

Olajide, O. J., Rue, C. L., Bergdahl, A., & Chapman, C. A. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.960314 · Cited by 24

Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer’s-like impairment in mice

Sell, G. L., Schaffer, T. B., & Margolis, S. S. (2017) · Journal of Clinical Investigation · doi:10.1172/jci85504 · Cited by 25

Amyloid-β1–40 Inhibits Amyloid-β1–42 Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Degeneration

Bate, C., & Williams, A. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100528 · Cited by 23

Insulin‐like growth factor‐2 is a promising candidate for the treatment and prevention of Alzheimer's disease

Fitzgerald, G. S., Chuchta, T. G., & McNay, E. C. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14160 · Cited by 22

Matrix metalloproteinase-7 modulates synaptic vesicle recycling and induces atrophy of neuronal synapses

Szklarczyk, A., Conant, K. E., Owens, D. F., Ravin, R., McKay, R. D. G., & Gerfen, C. R. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.07.032 · Cited by 22

BACE1 activity impairs neuronal glucose oxidation: rescue by beta-hydroxybutyrate and lipoic acid

Findlay, J. A., Hamilton, D. L., & Ashford, M. L. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00382 · Cited by 22

Development and Implementation of a High-Throughput Compound Screening Assay for Targeting Disrupted ER Calcium Homeostasis in Alzheimer's Disease

Honarnejad, K., Daschner, A., Giese, A., Zall, A., Schmidt, B., Szybińska, A., Kuźnicki, J., & Herms, J. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080645 · Cited by 23

SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1

Kurkinen, K. M. A., Marttinen, M., Turner, L. J., Natunen, T., Mäkinen, P. M., Haapalinna, F., Sarajärvi, T., Gabbouj, S., Kurki, M., Paananen, J., et al. (2016) · Journal of Cell Science · doi:10.1242/jcs.185215 · Cited by 21

GABA-A receptor modulating steroids in acute and chronic stress; relevance for cognition and dementia?

Bengtsson, S. K. S., Bäckström, T. C., Brinton, R. D., Irwin, R. W., Johansson, M., Sjöstedt, J., & Wang, M. D. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100206 · Cited by 22

Interference With Complex IV as a Model of Age-Related Decline in Synaptic Connectivity

Kriebel, M., Ebel, J., Battke, F., Griesbach, S., & Volkmer, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00043 · Cited by 21

The associations between synaptic density and “A/T/N” biomarkers in Alzheimer’s disease: An 18 F-SynVesT-1 PET/MR study

Li, J., Huang, Q., Qi, N., He, K., Li, S., Huang, L., Pan, F., Ren, S., Hua, F., Huang, Y. H., et al. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241230733 · Cited by 19

The Dichotomy of Alzheimer’s Disease Pathology: Amyloid-β and Tau

Ashford, J. W. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181198 · Cited by 19

Rescue of tau-induced synaptic transmission pathology by paclitaxel

Erez, H., Shemesh, O. A., & Spira, M. E. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00034 · Cited by 22

A high-throughput model for investigating neuronal function and synaptic transmission in cultured neuronal networks

Virdee, J. K., Sarò, G., Fouillet, A., Findlay, J. D., Ferreira, F. M., Eversden, S., O’Neill, M. J., Wolak, J., & Ursu, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-15171-5 · Cited by 18

Lipid Peroxidation Induced ApoE Receptor-Ligand Disruption as a Unifying Hypothesis Underlying Sporadic Alzheimer’s Disease in Humans

Ramsden, C. E., Keyes, G. S., Calzada, E., Horowitz, M. S., Zamora, D., Jahanipour, J., Sedlock, A., Indig, F. E., Moaddel, R., Kapogiannis, D., et al. (2022) · Journal of Alzheimer's Disease · doi:10.3233/jad-220071 · Cited by 19

An exploration of the potential mechanisms and translational potential of five medicinal plants for applications in Alzheimer's disease.

Shakir, T., Coulibaly, A. Y., & Kehoe, P. G. (2013) · Europe PMC (PubMed Central) · Cited by 19

Alzheimer’s Disease Is Responsible for Progressive Age-Dependent Differential Expression of Various Protein Cascades in Retina of Mice

Iqbal, J., Zhang, K., Jin, N., Zhao, Y., Liu, X., Liu, Q., Ni, J., & Shen, L. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00710 · Cited by 18

Zinc Ortho Methyl Carbonodithioate Improved Pre and Post-Synapse Memory Impairment via SIRT1/p-JNK Pathway against Scopolamine in Adult Mice

Jahan, R., Yousaf, M., Khan, H., Shah, S. A., Khan, A. A., Bibi, N., Javed, F. T., Ijaz, M., Ali, A., & Wei, D.-Q. (2023) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-023-10067-w · Cited by 18

The n-terminal 5-MER peptide analogue P165 of amyloid precursor protein exerts protective effects on SH-SY5Y cells and rat hippocampus neuronal synapses

Wang, P., Jiang, S. J. Y. G., Cui, Y. B., Yue, Z., Su, C., Sun, J., Sheng, S., & Tian, J. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.069 · Cited by 18

FRET-Based Calcium Imaging: A Tool for High-Throughput/Content Phenotypic Drug Screening in Alzheimer Disease

Honarnejad, K., Kirsch, A. K., Daschner, A., Szybińska, A., Kuźnicki, J., & Herms, J. W. (2013) · SLAS DISCOVERY · doi:10.1177/1087057113502672 · Cited by 18

Genistein inhibits Aβ25–35‐induced SH‐SY5Y cell damage by modulating the expression of apoptosis‐related proteins and Ca2+ influx through ionotropic glutamate receptors

Xu, H., Li, L., Wang, Y., Wang, H., An, D., Heng, B., & Liu, Y. (2018) · Phytotherapy Research · doi:10.1002/ptr.6239 · Cited by 17

PQM130, a Novel Feruloyl–Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer’s Disease

Morroni, F., Sita, G., Graziosi, A., Ravegnini, G., Molteni, R., Paladini, M. S., Dias, K. S. T., dos Santos, A. F., Viegas, C., Camps, I., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00658 · Cited by 17

The Effect of a Multimodal Occupational Therapy Program with Cognition-Oriented Approach on Cognitive Function and Activities of Daily Living in Patients with Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Ham, M.-J., Kim, S., Jo, Y.-J., Park, C., Nam, Y., Yoo, D., & Moon, M. (2021) · Biomedicines · doi:10.3390/biomedicines9121951 · Cited by 16

C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction

Huber, N., Hoffmann, D. B., Giniatullina, R., Rostalski, H., Leskelä, S., Takalo, M., Natunen, T., Solje, E., Remes, A. M., Giniatullin, R. A., et al. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105584 · Cited by 17

Amyloid solutions: lecanemab, gantenerumab, and donanemab in the treatment of Alzheimer's disease

Ameen, T. B., Ali, U., Salma, O., Samee, M. A., Abbas, S. M. I., Kashif, S. N., Arifi, M. A., Ali, M., Khowaja, M., Ali, S. M. S., et al. (2025) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-025-00968-3 · Cited by 20

MKC-231, a choline uptake enhancer: (2) Effect on synthesis and release of acetylcholine in AF64A-treated rats

Takashina, K., Bessho, T., Mori, R., Eguchi, J., & Saito, K.-I. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0048-1 · Cited by 15

PhIP exposure in rodents produces neuropathology potentially relevant to Alzheimer’s disease

Syeda, T., Foguth, R. M., Llewellyn, E., & Cannon, J. R. (2020) · Toxicology · doi:10.1016/j.tox.2020.152436 · Cited by 15

Pros and Cons of APOE4 Homozygosity and Effects on Neuroplasticity, Malnutrition, and Infections in Early Life Adversity, Alzheimer’s Disease, and Alzheimer’s Prevention

Oriá, R. B., Smith, C. J., Ashford, J. W., Vitek, M. P., & Guerrant, R. L. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240888 · Cited by 16

Extract of Cynomorium songaricum ameliorates mitochondrial ultrastructure impairments and dysfunction in two different in vitro models of Alzheimer’s disease

Cheng, D., Su, L., Wang, X., Li, X., Li, L., Hu, M., & Lu, Y. (2021) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-021-03375-2 · Cited by 14

Is CREB the Angry Bird that Releases Memory in Alzheimer's?

Wang, A. R., & Bibb, J. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.126 · Cited by 13

Cornel iridoid glycoside induces autophagy to protect against tau oligomer neurotoxicity induced by the activation of glycogen synthase kinase-3β

Yang, C., Li, X., Zhang, L., Li, Y., Li, L., & Zhang, L. (2019) · Journal of Natural Medicines · doi:10.1007/s11418-019-01318-3 · Cited by 13

Ablation of p75NTR signaling strengthens gamma–theta rhythm interaction and counteracts Aβ-induced degradation of neuronal dynamics in mouse hippocampus in vitro

Andrade‐Talavera, Y., Balleza‐Tapia, H., Dolz-Gaitón, P., Chen, G., Johansson, J., & Fisahn, A. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01332-8 · Cited by 13

Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers

Wang, J., Huang, Q., Chen, X., You, Z., He, K., Mao, X., Huang, Y. H., Franzmeier, N., Schöll, M., Guo, T., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70333 · Cited by 12

Tortoise Plastron and Deer Antler Gelatin Prevents Against Neuronal Mitochondrial Dysfunction In Vitro: Implication for a Potential Therapy of Alzheimer’s Disease

Cheng, D., Yang, X., Zhang, L., Qin, Z., Li, W., Xu, H.-C., & Zhang, Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.690256 · Cited by 12

The neuroprotective N-terminal amyloid-β core hexapeptide reverses reactive gliosis and gliotoxicity in Alzheimer’s disease pathology models

Lantz, M. J., Roberts, A. M., Delgado, D. D., & Nichols, R. A. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02807-9 · Cited by 13

Deficits in Aversive but not in Safe Taste Memory in the APPswe/PS1dE9 mice

Ramı́rez-Lugo, L., Jensen, M. S., Søderman, A., & West, M. J. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1141 · Cited by 13

Effects of repetitive transcranial magnetic stimulation combined with cognitive training on cognitive function in patients with Alzheimer’s disease: a systematic review and meta-analysis

Liu, G., Xue, B., Guan, Y., & Luo, X. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1254523 · Cited by 11

Investigation of the Circular Transcriptome in Alzheimer’s Disease Brain

Gao, Y., Xu, S.-M., Cheng, Y., Takenaka, K., Lindner, G., & Janitz, M. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02236-0 · Cited by 12

Correctness and response time distributions in the MemTrax continuous recognition task: Analysis of strategies and a reverse-exponential model

Ashford, J. W., Clifford, J. O., Anand, S., Bergeron, M., Ashford, C. B., & Bayley, P. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1005298 · Cited by 11

Relative expression of the p75 neurotrophin receptor, tyrosine receptor kinase A, and insulin receptor in SH-SY5Y neuroblastoma cells and hippocampi from Alzheimer's disease patients

Ito, S., Ménard, M., Atkinson, T. G., Brown, L., Whitfield, J., & Chakravarthy, B. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.09.015 · Cited by 10

Zinc mediates the neuronal activity–dependent anti-apoptotic effect

Qiu, M., Shentu, Y., Zeng, J., Wang, X., Yan, X., Zhou, X., Jing, X., Wang, Q., Man, H., Wang, J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182150 · Cited by 11

Evidence of Filamin A loss of solubility at the prodromal stage of neuropathologically-defined Alzheimer’s disease

Aumont, É., Tremblay, C., Levert, S., Bennett, D. A., Calon, F., & Leclerc, N. M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1038343 · Cited by 10

Roles of astrocytes in response to aging, Alzheimer’s disease and multiple sclerosis

Planas-Fontánez, T. M., Sainato, D. M., Sharma, I., & Dreyfus, C. F. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147464 · Cited by 11

Distinct calcium sources regulate temporal profiles of NMDAR and mGluR-mediated protein synthesis

Ramakrishna, S., Radhakrishna, B. K., Kaladiyil, A. P., Shah, N. M., Basavaraju, N., Freude, K., Kommaddi, R. P., & Muddashetty, R. S. (2024) · Life Science Alliance · doi:10.26508/lsa.202402594 · Cited by 9

Total flavonoids of Cynomorium songaricum attenuates cognitive defects in an Aβ1-42-induced Alzheimer’s disease rat model by activating BDNF/TrkB signaling transduction

Gu, Z., Lv, X., Yan, G., Qi, M., & Ge, B. (2023) · Neuroreport · doi:10.1097/wnr.0000000000001960 · Cited by 9

A new etiologic model for Alzheimers Disease

Schiel, K. A. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.12.015 · Cited by 9

The role of the Pin1-cis P-tau axis in the development and treatment of vascular contribution to cognitive impairment and dementia and preeclampsia

Qiu, C., Li, Z., Leigh, D. A., Duan, B., Stucky, J. E., Kim, N., Xie, G., Lu, K. P., & Zhou, X. Z. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1343962 · Cited by 9

Clinical Potential of Misshapen/NIKs-Related Kinase (MINK) 1—A Many-Sided Element of Cell Physiology and Pathology

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AmpliSeq Transcriptome of Laser Captured Neurons from Alzheimer Brain: Comparison of Single Cell Versus Neuron Pools

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THE COMBINATION OF SILVER TECHNIQUES FOR STUDYING THE PATHOLOGY OF ALZHEIMER'S DISEASE

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Imaging Amyloid‐β Membrane Interactions: Ion‐Channel Pores and Lipid‐Bilayer Permeability in Alzheimer's Disease

Viles, J. H. (2023) · Angewandte Chemie · doi:10.1002/ange.202215785 · Cited by 7

Electrophysiological Characterization of Neuromuscular Synaptic Dysfunction in Mice

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Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer’s disease tau

Hromádková, L., Kim, C., Haldiman, T., Peng, L., Zhu, X., Cohen, M. L., de Silva, R., & Safar, J. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01133-0 · Cited by 6

Transient elevation of synaptosomal mitoenergetic proteins and Hsp70 early in a rat model of chronic cerebrovascular hypoperfusion

Zhang, H. N., Wu, J., Jin, T., Chang, M. J. W., & Sun, L. (2012) · Neurological Sciences · doi:10.1007/s10072-012-1063-4 · Cited by 6

APOE ε4 Allele-associated Alzheimer's disease risk is consistent with increased lifetime exposure to a neurotoxic process

Smith, C. J., & Ashford, J. W. (2017) · Journal of Systems and Integrative Neuroscience · doi:10.15761/jsin.1000168 · Cited by 6

[Changes in structural and functional plasticity of the brain induced by environmental enrichment].

Komleva, Y., Salmina, A., Prokopenko, S., Shestakova, L. A., Petrova, M., Malinovskaya, N. A., & Lopatina, O. (2013) · Vestnik Rossiiskoi akademii meditsinskikh nauk · doi:10.15690/vramn.v68i6.672 · Cited by 8

Omega-3 Docosahexaenoic Acid (DHA) and Mood Disorders: Why and How to Provide Supplementation?

Valenzuela, A., & Valenzuel, R. (2013) · InTech eBooks · doi:10.5772/53322 · Cited by 7

Amyloid-Beta, BDNF, and the Mechanism of Neurodegeneration in Alzheimer’s Disease

Rosa, E., & Fahnestock, M. L. (2014) · Springer eBooks · doi:10.1007/978-1-4614-5836-4_43 · Cited by 6

The Yin-Yang of sulfur dioxide: Effect on cognitive function

Dobariya, P., Smith, J. K., & More, S. S. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00633 · Cited by 4

Quantification of AMPA receptor subunits and RNA editing-related proteins in the J20 mouse model of Alzheimer’s disease by capillary western blotting

Milham, L. T., Morris, G. P., Konen, L. M., Rentsch, P., Avgan, N., & Vissel, B. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1338065 · Cited by 4

Shear-Induced Amyloid Formation in the Brain: IV. Effects on Synapses Surrounding Senile Plaque and in Plaque-Free Regions

Trumbore, C. N. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171080 · Cited by 4

Cofilin-mediated neurodegeneration in alzheimer’s disease and other amyloidopathies

Maloney, M. T., & Bamburg, J. R. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-0009-y · Cited by 4

Energy Metabolism in the Placenta and the Role of Disturbances in the Development of Placental Insufficiency at an Exacerbation of Cytomegalovirus Infection

Lucenko, M., Andrievskaya, I. A., & Dovzhikova, I. V. (2016) · Annals of the Russian academy of medical sciences · doi:10.15690/vramn534 · Cited by 4

The emergence of Ephexin5 as a therapeutic target in Alzheimer’s disease

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Neurochemical Aspects of Alzheimer’s Type of Dementia

Farooqui, A. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816347-4.00003-9 · Cited by 4

Tau and Axonal Transport

Mandelkow, E., Thies, E., & MANDELKOW, E. (2007) · Springer eBooks · doi:10.1007/978-0-387-35135-3_14 · Cited by 4

The therapeutic efficacy of transcranial direct current stimulation in managing Alzheimer’s disease: a systematic review and meta-analysis

Wang, X., & Tian, L. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1726469 · Cited by 2

Pin1 Protects Against Alzheimer's Disease: One Goal, Multiple Mechanisms

Pastorino, L., Kondo, A., Zhen, X., & Lu, K. P. (2013) · InTech eBooks · doi:10.5772/55085 · Cited by 2

Synaptic frailty and clathrin-mediated synaptic vesicle trafficking in Alzheimer's disease

Yao, P. J. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.10.012 · Cited by 56

Staying Connected

Lee, H., Moreira, P. I., Zhu, X., Smith, M. A., & Perry, G. L. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63404-9 · Cited by 19

Synaptic degeneration in Alzheimer disease

Tzioras, M., McGeachan, R. I., Durrant, C. S., & Spires-Jones, T. L. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-022-00749-z · Cited by 504

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Patterns of synaptic and nerve cell pathology in Alzheimer's disease

Lassmann, H. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00215-4 · Cited by 24