Synaptic slaughter in Alzheimer's disease

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

West, M. J., Coleman, P. D., Flood, D. G., & Troncoso, J. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92338-8 · Cited by 1,267 · cited 1×

Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease

Coleman, P. D., & Flood, D. G. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90127-8 · Cited by 772

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

Braak, F., Braak, H., & Mandelkow, E. (1994) · Acta Neuropathologica · doi:10.1007/bf00293315 · Cited by 769

The molecular machinery for secretion is conserved from yeast to neurons.

Bennett, M. K., & Scheller, R. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.2559 · Cited by 650

A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter

Liu, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90425-c · Cited by 589

Dendritic Growth in the Aged Human Brain and Failure of Growth in Senile Dementia

Buell, S. J., & Coleman, P. D. (1979) · Science · doi:10.1126/science.493989 · Cited by 475

Quantitative assessment of cortical synaptic density in Alzheimer's disease

Scheff, S. W., DeKosky, S. T., & Price, D. A. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90059-9 · Cited by 446

Clathrin Assembly Lymphoid Myeloid Leukemia (CALM) Protein: Localization in Endocytic-coated Pits, Interactions with Clathrin, and the Impact of Overexpression on Clathrin-mediated Traffic

Tebar, F., Bohlander, S. K., & Sorkin, A. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.8.2687 · Cited by 320

Single administration of a novel γ-secretase modulator ameliorates cognitive dysfunction in aged C57BL/6J mice

Hayama, T., Murakami, K., Watanabe, T., Maeda, R., Kamata, M., & Kondo, S. (2015) · Brain Research · doi:10.1016/j.brainres.2015.12.020 · Cited by 2

Advances in MicroRNAs and Alzheimer’s Disease Research

Ruberti, F., Pezzola, S., & Barbato, C. (2011) · InTech eBooks · doi:10.5772/17635 · Cited by 2

Senile Dementia

Pedersen, W. A. (2007) · xPharm: The Comprehensive Pharmacology Reference · doi:10.1016/b978-008055232-3.60662-2 · Cited by 1

Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia

Vallortigara, J., Rangarajan, S., Whitfield, D., Alghamdi, A., Howlett, D. C., Hortobágyi, T., Johnson, M. A., Attems, J., Ballard, C. G., Thomas, A. J., et al. (2014) · F1000Research · doi:10.12688/f1000research.4055 · Cited by 1

The Role of Acupuncture Improving Cognitive Deficits through Regulating Neuroplasticity

Ji, S., Duan, J., Tan, M., Zhang, Y., & Chan, P. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1010850 · Cited by 1

Differences in blood levels of neuroligin-derived peptides in a cohort for early detection of Alzheimer’s disease

Fernandes, M. G. F., Pinard, M., Sokullu, E., Tremblay, C., Gagnon, J., Calon, F., Coulombe, B., & Brouillette, J. (2026) · The Journals of Gerontology Series A · doi:10.1093/gerona/glag009 · Cited by 1

Overexpression of miR-455-3p enhances mitophagy, synaptic and mitochondrial proteins in Alzheimer’s disease

Pradeepkiran, J. A., Bandaru, M., Islam, M. A., Kshirsagar, S., Alvir, R. V., Mukherjee, U., & Reddy, P. H. (2026) · Mitochondrion · doi:10.1016/j.mito.2026.102151 · Cited by 1

Tau and Intracellular Transport in Neurons

Mandelkow, E., Thies, E., Konzack, S., & Mandelkow, E. (2009) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-540-87941-1_5 · Cited by 1

The potential role of presenilin 1 in regulation of synaptic function

Schwarzman, A. L., Sarantseva, S. V., & Vitek, M. P. (2012) · Cell and Tissue Biology · doi:10.1134/s1990519x12010117 · Cited by 1

Pathology of synapses in neurological diseases

Schwarzman, A. L., & Sarantseva, S. V. (2014) · Biology Bulletin Reviews · doi:10.1134/s2079086415020085 · Cited by 1

Alzheimer’s Disease and Mechanism-Based Attempts to Enhance Cognition

Draffin, J. E., Knafo, S., & Heneka, M. T. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-417042-1.00009-7 · Cited by 1

Vigour of CRISPR/Cas9 Gene Editing in Alzheimer’s Disease

Jes, P. (2018) · Journal of Neuroscience and Neurological Disorders · doi:10.29328/journal.jnnd.1001014 · Cited by 1

Repeated recall on source misattribution in Alzheimer’s disease

Haj, M. E., & Robin, F. (2021) · Memory · doi:10.1080/09658211.2021.1985521 · Cited by 1

Influence of β-Amyloid Plaques on the Local Network Activity in the APP/PS1 Mouse Model of Alzheimer’s Disease

Castano-Prat, P., Aparicio-Torres, G., Muñoz, A., & Sanchez-Vives, M. V. (2018) · Advances in cognitive neurodynamics · doi:10.1007/978-981-10-8854-4_31 · Cited by 1

Cell Models of Tauopathy

Biernat, J., Khlistunova, I., Wang, Y.-P., Pickhardt, M., von Bergen�, M., Gažová, Z., Mandelkow, E., & Mandelkow, E. (2007) · Springer eBooks · doi:10.1007/978-0-387-72076-0_34

Effects of A-beta immunotherapy and Omega-3 fatty acid administration in Alzheimer's transgenic mice

Jensen, M. (2006)

Modeling Amyloid Diseases in Fruit Fly Drosophila Melanogaster

Sarantseva, S. V., & Schwarzm, A. (2011) · InTech eBooks · doi:10.5772/20102

Pathophysiology of Late Onset Alzheimer Disease

Turan, A. S., & Refik, M. (2011) · InTech eBooks · doi:10.5772/16675

Dissecting out the contribution of cognitive, social, and physical activities to environmental enrichment's ability to protect Alzheimer's mice against cognitive impairment

Cracchiolo, J. R. (2005) · Digital Commons - University of South Florida (University of South Florida)

Mechanisms of Brain Region-Specific Amyloid-beta Deposition

Bero, A. W. (2011) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7cj8bh2

Epigenetic dysregulation and the pathophysiology of Alzheimer’s disease

Mastroeni, D. (2013) · doi:10.26481/dis.20130503dm

Pathologische Veränderungen im Thalamus in einem Tiermodell für die Alzheimer-Krankheit

Flohr, J.-C. A. (2010) · doi:10.53846/goediss-845

Correlati neurobiologici nell'anziano con malattia di alzheimer e altre demenze

Guaita, A. (2013) · RICERCHE DI PSICOLOGIA · doi:10.3280/rip2012-002016

Charakterisierung der Proteinphosphatase 1E (PPM1E) - Lokalisierung und Trunkation in Gehirngewebe und Effekte auf neuronale Morphologie in primärer Neuronenkultur

Jessen, A. L. (2010) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-406

The involvement of degradation pathways and neuron-to-neuron transmission in Alzheimer’s disease

Agholme, L. (2012) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Der Einfluss des Geschlechts auf die Neuronenanzahl in einem APP/PS1- doppeltransgenen Mausmodell der Alzheimer-Krankheit

Neurobiologie, A. F. (2006)

Intraneuronal Amyloid and Cognitive Impairment

D’Andrea, M. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804256-4.00006-1

Alzheimer’s Disease and white matter

Filley, C. M. (2016) · Cambridge University Press eBooks · doi:10.1017/cbo9781139548878.016

MEDICAL DEPRESSIVE DISORDER, ALZHEIMER’S, EPILEPSY AND THEIR CURRENT TREATMENTS AVAILABLE IN INDIA

Al-Ghamdi, S. B. A., & Yusuf, M. (2016) · Indian Research Journal of Pharmacy and Science · doi:10.21276/irjps.2016.3.3.3

Research Progress on Chemical Constituents of Acorus tatarinowii schott and Their Pharmacological Activities on Central Nervous System

杨, 洁. (2017) · Pharmacy Information · doi:10.12677/pi.2017.65022

Untersuchung genetischer und geschlechtlicher Einflüsse in der Alzheimerpathologie anhand des Maustiermodells 5XFAD

Kratz, S. R. A. (2010) · doi:10.53846/goediss-871

Metaplasticity Tunes Functional Plasticity in the Rodent Hippocampus

Li, Q. (2015) · Digitale Bibliothek Braunschweig (Verbundzentrale Göttingen (VZG)) · doi:10.24355/dbbs.084-201503260942-0

Electron Microscopy Analysis of hAPP-Induced Neurodegeneration in the Glomerular NetworkPreprint

Robbins, A., Lehmann, K. S., Bai, L., & Belluscio, L. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/444265

Characterization of functional protein complexes from Alzheimer’s disease and healthy brain by mass spectrometry-based proteome analysis

Hasan, B., Ayesha, K., Lenz, C., Asif, A. R., & Ahmed, N. (2021) · Scientific Reports · doi:10.1038/s41598-021-93356-9

Studies on the Involvement of the Immune system in Alzheimer's disease

Marcello, A. (2010) · doi:10.53846/goediss-3277

Faculty Opinions recommendation of Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease.

Tanzi, R. E. (2008) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1124019.581131

Alzheimer’s disease

Koychev, I. G., & Gallacher, J. (2020) · doi:10.1093/med/9780198713005.003.0040

Dementias☆

Anderson, H. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.05297-1

Additional file 1 of Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro

Ding, B., Lin, C., Liu, Q., He, Y., Ruganzu, J. B., Jin, H. Z., Peng, X., Ji, S., Ma, Y., & Yang, W. (2020) · Figshare · doi:10.6084/m9.figshare.13093892

Amyloid β oligomers enhance presynaptic exocytosis via CaV2.1 to drive disease progression in Alzheimer’s modelsPreprint

Jeans, A. F., Padamsey, Z., Weglinski, C., Taylor, H. B. C., Collins, H., Allison, S., Bannerman, D. M., Klein, W. L., van den Maagdenberg, A. M. J. M., & Emptage, N. J. (2024) · Research Square · doi:10.21203/rs.3.rs-1638917/v1

Alzheimer’s disease

Koychev, I. G., & Gallacher, J. (2020) · doi:10.1093/med/9780198713005.003.0040_update_001

Early Aβ-induced changes in the enteric nervous system and the gut: structure, function, and motilityPreprint

Gries, M., Puhl, H. R., Schulte, S., Christmann, A., Rommel, S., Baller, M. K., Martin, M., Hartmann, T., Grimm, M. O. W., & Schäfer, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.26.678722

Putative Survival Advantages in Infant, Child, and Young Adult Apolipoprotein ε4 Carriers

Smith, C. J., Ashford, J. W., & Perfetti, T. A. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_13-1

Neurological aging and neurodegenerative disease in humans and great apes

Edler, M. K., Hearn, C. J., Guevara, E. E., Mhatre‐Winters, I., Varghese, M., Freire‐Cobo, C., Sherwood, C. C., Richardson, J. R., Raghanti, M. A., & Hof, P. R. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27380-3.00074-9

Additional file 1 of Extract of Cynomorium songaricum ameliorates mitochondrial ultrastructure impairments and dysfunction in two different in vitro models of Alzheimer’s disease

Cheng, D., Su, L., Wang, X., Li, X., Li, L., Hu, M., & Lu, Y. (2021) · Figshare · doi:10.6084/m9.figshare.15139478

Neuroligin fragments as blood‐based biomarkers for early detection of Alzheimer's disease

Fernandes, M. G. F., Pinard, M., Sokullu, E., Gagnon, J., Calon, F., Coulombe, B., & Brouillette, J. (2025) · Alzheimer s & Dementia · doi:10.1002/alz70856_097403

Brain Neuroplasticity and Alzheimer’s Disease Prevention: Health Considerations for Those with an ApoE-ε4 Gene

Ashford, J. W., Smith, C. J., & Oriá, R. B. (2026) · Springer eBooks · doi:10.1007/978-3-031-52641-1_83-1

Validation préclinique de l'efficacité de l'ANAVEX2-73 dans des modèles transgénique et non transgénique de la maladie d'Alzheimer

Lahmy, V. (2014) · theses.fr (ABES) · doi:10.70675/23744d67zb26bz4a32zadbfz3931ecca70f5

Brain Neuroplasticity and Alzheimer’s Disease Prevention: Health Considerations for Those with an ApoE-ε4 Gene

Ashford, J. W., Smith, C. J., & Oriá, R. B. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_83

Modifications of the tau protein and their varied effects on aggregation and function

Combs, B. (2013) · KU ScholarWorks (The University of Kansas)

Investigation of BACE1 as a stress-induced regulator of neuronal metabolism

Findlay, J. A. (2014) · Discovery Research Portal (University of Dundee)

Synaptic frailty and clathrin-mediated synaptic vesicle trafficking in Alzheimer's disease

Yao, P. J. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.10.012 · Cited by 56

Staying Connected

Lee, H., Moreira, P. I., Zhu, X., Smith, M. A., & Perry, G. L. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63404-9 · Cited by 19

Synaptic degeneration in Alzheimer disease

Tzioras, M., McGeachan, R. I., Durrant, C. S., & Spires-Jones, T. L. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-022-00749-z · Cited by 504

Untitled work

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Patterns of synaptic and nerve cell pathology in Alzheimer's disease

Lassmann, H. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00215-4 · Cited by 24