The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer’s disease
Abstract
Epidemiological studies identified a higher risk of developing Alzheimer's disease (AD) among subjects with elevated cholesterol levels. This association may be caused by a modulation of the amyloid precursor protein (APP) processing in response to the cellular cholesterol content. High cholesterol levels may favor the amyloidogenic pathway by inhibition of the alpha-secretase probably leading to elevated beta-Amyloid (Abeta) production. The identification of a linkage peak on chromosome 10q using high Abeta as quantitative trait led us to examine polymorphisms of genes located on chromosome 10 involved in cholesterol metabolism, like Lipase A (LIPA), Cholesterol 25 hydroxylase (CH25H), and FLJ22476, a high density lipoprotein binding related protein. Using 286 patients with AD and 162 controls we analyzed several single nucleotide polymorphisms (SNPs) within LIPA, CH25H, and FLJ22476. None of the polymorphisms showed significant association with AD which contradicts recent findings on CH25H. From our results we conclude that the investigated genetic variations do not contribute to the genetic risk of AD.
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“However, the association of this rs13500 CH25H promoter polymorphism was not found in two subsequent studies [87, 88] nor has an association between CH25H and AD risk be observed in several large GWA studies, making this association “suggestive” at best [89–91].”
From 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner (2020) · cites this paper as [87]
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Cites
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Statins and the risk of dementia
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Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor
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Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons
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Hofman, A., Ott, A., Breteler, M. M., Bots, M. L., Slooter, A. J., van Harskamp, F., van Duijn, C. N., Van Broeckhoven, C., & Grobbee, D. E. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09328-2 · Cited by 1,062
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Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10
Kojro, E., Gimpl, G., Lammich, S., März, W., & Fahrenholz, F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081612998 · Cited by 804
Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model
Refolo, L. M., Pappolla, M. A., Malester, B., LaFrancois, J., Bryant-Thomas, T., Wang, R., Tint, G. S., Sambamurti, K., & Duff, K. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0304 · Cited by 783
GOLD—Graphical Overview of Linkage Disequilibrium
Abecasis, G. R., & Cookson, W. O. C. (2000) · Bioinformatics · doi:10.1093/bioinformatics/16.2.182 · Cited by 773
Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide
Haass, C., & Selkoe, D. J. (1993) · Cell · doi:10.1016/0092-8674(93)90312-e · Cited by 686
Cited by
Examination of the current top candidate genes for AD in a genome-wide association study
Feulner, T. M., Laws, S. M., Friedrich, P., Wagenpfeil, S., Wurst, S. H. R., Riehle, C., Kuhn, K. A., Krawczak, M., Schreiber, S., Nikolaus, S., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.141 · Cited by 128
25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner
Wong, M. Y., Lewis, M., Doherty, J. J., Shi, Y., Cashikar, A. G., Amelianchik, A., Tymchuk, S., Sullivan, P. M., Qian, M., Covey, D. F., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01869-3 · Cited by 121
On the formation and possible biological role of 25-hydroxycholesterol
Diczfalusy, U. (2013) · Biochimie · doi:10.1016/j.biochi.2012.06.016 · Cited by 87
Metadata
- Authors
- Riemenschneider, M., Mahmoodzadeh, S., Eisele, T., Klopp, N., Schwarz, S., Wagenpfeil, S., Diehl, J., Mueller, U., Foerstl, H., Illig, T., & Kurz, A.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 25
- Issue
- 10
- Pages
- 1305-1308
- ISSN
- 0197-4580
- Cited by
- 14
- References
- 21
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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