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The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study

Hofman, Albert, Ott, Alewijn, Breteler, Monique MB, Bots, Michiel L, Slooter, Arjen JC, van Harskamp, Frans, van Duijn, Cornelia N, Van Broeckhoven, Christine, Grobbee, Diederick E·1997·The Lancet
DOI 10.1016/s0140-6736(96)09328-2
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Abstract

Background Vascular disorders have been implicated in dementia, but whether atherosclerosis is related to the most frequent type of dementia, Alzheimer's disease, is not known. The apolipoprotein-E genotype has been associated with Alzheimer's disease, and we postulate that it plays a part, together with atherosclerosis, in the aetiology of Alzheimer's disease. We investigated the frequency of dementia and its subtypes in relation to atherosclerosis and apolipoprotein E. Methods We did a population-based study of 284 patients with dementia, 207 of whom had Alzheimer's disease, and 1698 individuals who were not demented. Indicators of atherosclerosis included vessel wall thickness and plaques of the carotid arteries, assessed by ultrasonography, and the ratio of ankle-to-brachial systolic blood pressure as a measure of generalised atherosclerosis. Based on these indicators participants were scored from 0 (no atherosclerosis) to 3 (severe atherosclerosis) for degree of atherosclerosis. Apolipoprotein-E polymorphisms were assessed in 246 patients and in 928 controls. Findings All indicators of atherosclerosis were associated with dementia (odds ratios ranging from 1.3 to 1.9) and its major subtypes Alzheimer's disease (odds ratios 1.3-1.8) and vascular dementia (odds ratios 1.9-3.2). The frequencies of all dementia. Alzheimer's disease, and vascular dementia increased with the degree of atherosclerosis. The odds ratio for Alzheimer's disease in those with severe atherosclerosis…

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Research works printed but not linked: 23

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Metadata

Authors
Hofman, A., Ott, A., Breteler, M. M., Bots, M. L., Slooter, A. J., van Harskamp, F., van Duijn, C. N., Van Broeckhoven, C., & Grobbee, D. E.
Venue
The Lancet
Publisher
Elsevier BV
Published
1997-01
Volume
349
Issue
9046
Pages
151-154
ISSN
0140-6736
DOI
10.1016/s0140-6736(96)09328-2
Cited by
1,062
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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