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Cited by 860

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

Fassbender, K., Simons, M., Bergmann, C., Stroick, M., Lütjohann, D., Keller, P., Runz, H., Kühl, S., Bertsch, T., von Bergmann, K., Hennerici, M., Beyreuther, K., Hartmann, T.·2001·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.081620098
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Abstract

Recent epidemiological studies show a strong reduction in the incidence of Alzheimer's disease in patients treated with cholesterol-lowering statins. Moreover, elevated Aβ42 levels and the ɛ4 allele of the lipid-carrier apolipoprotein E are regarded as risk factors for sporadic and familial Alzheimer's disease. Here we demonstrate that the widely used cholesterol-lowering drugs simvastatin and lovastatin reduce intracellular and extracellular levels of Aβ42 and Aβ40 peptides in primary cultures of hippocampal neurons and mixed cortical neurons. Likewise, guinea pigs treated with high doses of simvastatin showed a strong and reversible reduction of cerebral Aβ42 and Aβ40 levels in the cerebrospinal fluid and brain homogenate. These results suggest that lipids are playing an important role in the development of Alzheimer's disease. Lowered levels of Aβ42 may provide the mechanism for the observed reduced incidence of dementia in statin-treated patients and may open up avenues for therapeutic interventions.

Overview

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Crossref · 10.1073/pnas.081620098

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7 of 7 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 41

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Metadata

Authors
Fassbender, K., Simons, M., Bergmann, C., Stroick, M., Lütjohann, D., Keller, P., Runz, H., Kühl, S., Bertsch, T., von Bergmann, K., Hennerici, M., Beyreuther, K., & Hartmann, T.
Affiliations
Departments of Neurology and Clinical Chemistry, Clinic Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany; Department of Neurology, University of Tübingen, Hoppe-Seyler Strasse 3, D-72076 Tübingen, Germany; Center for Molecular Biology Heidelberg (ZMBH), University of Heidelberg, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany; Department of Clinical Pharmacology, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany; and Cell Biology...
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2001-04-10
Volume
98
Issue
10
Pages
5856-5861
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.081620098
Cited by
860
References
7
Language
en

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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