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apoE isoforms and measures of anxiety in probable AD patients and Apoe−/− mice

Robertson, Jennifer, Curley, Justine, Kaye, Jeffrey, Quinn, Joseph, Pfankuch, Timothy, Raber, Jacob·2005·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2004.06.003
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Abstract

Increased anxiety may occur in up to 70% of AD patients during the course of their illness. Here we show that human apoE isoforms, which differ in AD risk, have differential effects on measures of anxiety in adult Apoe-/- male mice expressing human apoE3 or apoE4 in their brains and male probable AD (PRAD) patients. Compared with wild-type mice, Apoe-/- mice without human apoE or with apoE4, but not apoE3, showed increased measures of anxiety. These behavioral alterations were associated with reduced microtubule-associated protein 2-positive neuronal dendrites in the central nucleus of the amygdala. Consistent with the mouse data, male and female PRAD patients with epsilon4/epsilon4 showed higher anxiety scores than those with epsilon3/epsilon3. We conclude that human apoE isoforms have differential effects on measures of anxiety.

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Crossref · 10.1016/j.neurobiolaging.2004.06.003

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Research works printed but not linked: 24

  1. Anderson, 1998, Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse, Neuroscience, 85, 93, 10.1016/S0306-4522(97)00598-8 · DOI · Paper page
  2. Balldin, 1983, Dexamethasone suppression test and serum prolactin in dementia disorders, Br J Psych, 143, 277, 10.1192/bjp.143.3.277 · DOI
  3. Barclay, 1985, Factors Associated with duration of survival in Alzheimer's disease, Biol Psych, 20, 93
  4. Bongers, 2004, Role of H3-receptor-mediated signaling in anxiety and cognition in wild-type and Apoe−/− mice, Neuropsychopharmacology, 29, 441, 10.1038/sj.npp.1300352 · DOI
  5. Burvill, 1991, The prognosis of depression in old age, Br J Psych, 20, 86
  6. Cummings, 1994, The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia, Neurology, 44, 2308, 10.1212/WNL.44.12.2308 · DOI · Paper page
  7. Cummings, 1997, The neuropsychiatric inventory: assessing psychopathology in dementia patients, Neurology, 48, S10, 10.1212/WNL.48.5_Suppl_6.10S · DOI
  8. Feretti, 2001, Anxiety and Alzheimer's disease, J Geriatr Psychiatr Neurol, 14, 52, 10.1177/089198870101400111 · DOI
  9. Gilley, 1991, Predictors of behavioral disturbances in Alzheimer's disease, J Gerontol, 46, 362, 10.1093/geronj/46.6.P362 · DOI
  10. Groenink, 2002, HPA axis dysregulation in mice overexpressing corticotropin releasing hormone, Biol Psych, 51, 875, 10.1016/S0006-3223(02)01334-3 · DOI
  11. den Heyer, 2002, Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes, Neurology, 59, 746, 10.1212/WNL.59.5.746 · DOI
  12. Lehtovirta, 1996, SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon 4 allele, J Neurol Neurosurg Psych, 60, 644, 10.1136/jnnp.60.6.644 · DOI
  13. Leon, 1997, Cortisol reduces hippocampal glucose metabolism in normal elderly, but not in Alzheimer's disease, J Clin Endocrinol Metab, 82, 3251, 10.1210/jc.82.10.3251 · DOI
  14. Mahley, 1988, Apolipoprotin E: cholesterol transport protein with expanding role in cell biology, Science, 240, 622, 10.1126/science.3283935 · DOI · Paper page
  15. Masliah, 1995, Neurodegeneration in the central nervous system of apoE-deficient mice, Exp Neurol, 136, 107, 10.1006/exnr.1995.1088 · DOI
  16. McKann, 1984, Clinical diagnosis of Alzheimer's disease; report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Serives Task Force on Alzheimer's disease, Neurology, 34, 939, 10.1212/WNL.34.7.939 · DOI · Paper page
  17. Morris, 1993, The Clinical Dementia Rating (CDR): current version and scoring rules, Neurology, 43, 2412, 10.1212/WNL.43.11.2412-a · DOI · Paper page
  18. Nijhuis, 1996, Differences in dexamathasone-sensitivity between lymphocytes from patiens with Alzheimer's disease and patients with multi-infarct dementia, Brain Beh Immun, 10, 115, 10.1006/brbi.1996.0012 · DOI
  19. Peskind, 2001, Increased CSF cortisol in AD is a function of APOE genotype, Neurology, 56, 1094, 10.1212/WNL.56.8.1094 · DOI
  20. Piedrahita, 1992, Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targetting in embryonic stem cells, Proc Natl Acad Sci USA, 89, 4471, 10.1073/pnas.89.10.4471 · DOI · Paper page
  21. Raber, 2000, Hypothalamic-pituitary-adrenal function in Apoe−/− mice: possible role in behavioral and metabolic alterations, J Neurosci, 20, 2064, 10.1523/JNEUROSCI.20-05-02064.2000 · DOI
  22. Raber, 2002, Androgens protect against apolipoprotein E4-induced cognitive deficits, J Neurosci, 22, 5204, 10.1523/JNEUROSCI.22-12-05204.2002 · DOI
  23. Teri, 1999, Anxiety of Alzheimer's disease: prevalence, and comorbidity, J Gerontol Series A–Biol Sci Med Sci., 54, 352, 10.1093/gerona/54.7.M348 · DOI
  24. Walker, 1997, Double dissociation between the involvement of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in startle increases produced by conditioned versus unconditioned fear, J Neurosci, 17, 9375, 10.1523/JNEUROSCI.17-23-09375.1997 · DOI · Paper page

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Metadata

Authors
Robertson, J., Curley, J., Kaye, J., Quinn, J., Pfankuch, T., & Raber, J.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2005-05
Volume
26
Issue
5
Pages
637-643
ISSN
0197-4580
DOI
10.1016/j.neurobiolaging.2004.06.003
Cited by
71
References
2
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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