Cited by 188Pain Mechanisms and TreatmentsStress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression

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Descalzi, Giannina, Mitsi, Vasiliki, Purushothaman, Immanuel, Gaspari, Sevasti, Avrampou, Kleopatra, Loh, Yong-Hwee Eddie, Shen, Li, Zachariou, Venetia·2017·Science Signaling

Abstract

Common changes in signaling pathway–associated gene expression may explain why chronic pain or stress can lead to depression.

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Authors
Descalzi, G., Mitsi, V., Purushothaman, I., Gaspari, S., Avrampou, K., Loh, Y.-H. E., Shen, L., & Zachariou, V.
Affiliations
Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Zachariou, Venetia
Venue
Science Signaling
Published
2017-03-21
Volume
10
Issue
471
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
OpenAlex
W2600178581
Cited by
188
References
171
Citations by year
2026: 15 · 2025: 21 · 2024: 21 · 2023: 22 · 2022: 18 · 2021: 28 · 2020: 17 · 2019: 26 · 2018: 12 · 2017: 6
FWCI
12.34
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Drug Abuse (award287707)
  • National Institute of Neurological Disorders and Stroke (award287708)
  • Banting Research Foundation (award287709)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
neuropathic pain, depression, chronic stress, gene expression, transcriptome, nucleus accumbens, medial prefrontal cortex, periaqueductal gray, spared nerve injury, chronic unpredictable mild stress, signaling pathways, anxiety
MeSH terms
Adaptation, Physiological, Animals, Brain, Depression, Gene Expression Regulation, Mice, Inbred C57BL, Nerve Net, Neuralgia, Nucleus Accumbens, Periaqueductal Gray, Stress, Psychological, Signal Transduction, Cluster Analysis, Prefrontal Cortex, Mice, Knockout, Gene Expression Profiling, Chronic Pain

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