Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression
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Common changes in signaling pathway–associated gene expression may explain why chronic pain or stress can lead to depression.
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LAMB2 participates in neuropathic pain and alters gene expression in brain pathways linked to depression.
“LAMB2 is involved in neuropathic pain and influencing gene expression changes in brain pathways implicated in depression.36”
From Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions (2021) · cites this paper as [36]
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Role of the Prefrontal Cortex in Pain Processing
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Self-citation
- Authors
- Descalzi, G., Mitsi, V., Purushothaman, I., Gaspari, S., Avrampou, K., Loh, Y.-H. E., Shen, L., & Zachariou, V.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Zachariou, Venetia
- ORCID
- Venue
- Science Signaling
- Published
- 2017-03-21
- Volume
- 10
- Issue
- 471
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC5524975
- OpenAlex
- W2600178581
- Cited by
- 188
- References
- 171
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 21 · 2023: 22 · 2022: 18 · 2021: 28 · 2020: 17 · 2019: 26 · 2018: 12 · 2017: 6
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (award287707)
- National Institute of Neurological Disorders and Stroke (award287708)
- Banting Research Foundation (award287709)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- neuropathic pain, depression, chronic stress, gene expression, transcriptome, nucleus accumbens, medial prefrontal cortex, periaqueductal gray, spared nerve injury, chronic unpredictable mild stress, signaling pathways, anxiety
- MeSH terms
- Adaptation, Physiological, Animals, Brain, Depression, Gene Expression Regulation, Mice, Inbred C57BL, Nerve Net, Neuralgia, Nucleus Accumbens, Periaqueductal Gray, Stress, Psychological, Signal Transduction, Cluster Analysis, Prefrontal Cortex, Mice, Knockout, Gene Expression Profiling, Chronic Pain
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