Cited by 251Advanced MRI Techniques and ApplicationsMetabolomics and Mass Spectrometry StudiesAdvanced Neuroimaging Techniques and Applications

Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T

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Kaiser, Lana G., Schuff, Norbert, Cashdollar, Nathan, Weiner, Michael W.·2005·Neurobiology of Aging

Abstract

Proton magnetic resonance spectroscopy was performed at 4 T to determine effects of age, region and gender on glutamate and glutamine in the normal human brain. Furthermore, glutamate and glutamine alterations with age were tested for correlations with other cerebral metabolites. Two 8 cm3 volumes were selected in corona radiata and mesial motor cortex in normal subjects (N = 24) between 24 and 68 years old. Older subjects had lower glutamate concentration in the motor cortex compared to younger subjects (p < 0.001). In corona radiata, older subjects demonstrated a trend in higher glutamine compared to younger subjects (p = 0.05). Glutamate in the motor cortex was positively correlated with glutamine, N-acetyl aspartate and creatine. Reduced glutamate and N-acetyl aspartate in the motor cortex is consistent with neuronal loss/shrinkage with age. In conclusion, different patterns in association with normal aging in these brain regions were detected in this study.

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Crossref · 10.1016/j.neurobiolaging.2004.07.001

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Authors
Kaiser, L. G., Schuff, N., Cashdollar, N., & Weiner, M. W.
Affiliations
University of California, San Francisco (US)
Corresponding author
Kaiser, Lana G.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2005-05
Volume
26
Issue
5
Pages
665-672
ISSN
0197-4580 (ISSN-L)
OpenAlex
W1998855584
Cited by
251
References
43
Citations by year
2026: 6 · 2025: 15 · 2024: 15 · 2023: 12 · 2022: 14 · 2021: 16 · 2020: 13 · 2019: 14 · 2018: 14 · 2017: 18 · 2016: 10 · 2015: 19 · 2014: 22 · 2013: 10 · 2012: 11
FWCI
5.03
Type
journal article
Language
en
Open access
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (P50AG023501)
  • National Institute of Neurological Disorders and Stroke (R01 NS 30321, F32 NS43153, F32NS043153)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
glutamate, glutamine, brain aging, normal human brain, motor cortex, corona radiata, N-acetylaspartate, creatine, brain metabolites, neuronal loss, age-related changes, 1H NMR
MeSH terms
Adult, Aged, Aging, Analysis of Variance, Aspartic Acid, Brain Chemistry, Creatine, Female, Glutamine, Humans, Male, Middle Aged, Motor Cortex, Magnetic Resonance Spectroscopy, Protons, Statistics as Topic, Glutamic Acid

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