Microglia and Astrocyte Function and Communication: What Do We Know in Humans?

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673 · see citing works

Exploring the full spectrum of macrophage activation

Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971 · see citing works

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493 · see citing works

Astrocytes: Biology and pathology

Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196 · see citing works

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175 · see citing works

Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease

(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336 · see citing works

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · see citing works

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786 · see citing works

<i>TREM2</i> Variants in Alzheimer's Disease

Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020 · see citing works

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O’Loughlin, E., Xu, Y., Fanek, Z., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.008 · Cited by 2,979 · see citing works

Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558 · see citing works

Reactive astrocyte nomenclature, definitions, and future directions

Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00783-4 · Cited by 2,533 · see citing works

Genomic analysis of reactive astrogliosis

Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6221-11.2012 · Cited by 2,404 · see citing works

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

Zhang, Y., Sloan, S. A., Clarke, L. E., Caneda, C., Plaza, C. A., Blumenthal, P. D., Vogel, H., Steinberg, G. K., Edwards, M. S. B., Li, G., et al. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.013 · Cited by 2,295 · see citing works

New tools for studying microglia in the mouse and human CNS

Bennett, M. L., Bennett, F. C., Liddelow, S. A., Ajami, B., Zamanian, J. L., Fernhoff, N. B., Mulinyawe, S. B., Bohlen, C. J., Adil, A., Tucker, A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525528113 · Cited by 1,804 · see citing works

Microglia emerge as central players in brain disease

Salter, M. W., & Stevens, B. (2017) · Nature Medicine · doi:10.1038/nm.4397 · Cited by 1,767 · see citing works

Microglia as a source and target of cytokines

Hanisch, U. (2002) · Glia · doi:10.1002/glia.10161 · Cited by 1,645 · cited 5× · see citing works

A polarizing question: do M1 and M2 microglia exist?

Ransohoff, R. M. (2016) · Nature Neuroscience · doi:10.1038/nn.4338 · Cited by 1,573 · see citing works

Uniquely Hominid Features of Adult Human Astrocytes

Oberheim, N. A., Takano, T., Han, X., He, W., Lin, J. H. C., Wang, F., Xu, Q., Wyatt, J. D., Pilcher, W., Ojemann, J. G., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4707-08.2009 · Cited by 1,488 · see citing works

Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function

Papadopoulos, V., Baraldi, M., Guilarte, T. R., Knudsen, T. B., Lacapère, J.-J., Lindemann, P., Norenberg, M. D., Nutt, D., Weizman, A., Zhang, M.-R., et al. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.06.005 · Cited by 1,389 · see citing works

Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease.

(2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.03.49 · Cited by 1,288 · see citing works

iPSC-derived human microglia-like cells to study neurological diseases

Abud, E. M., Ramirez, R. N., Martinez, E. S., Healy, L. M., Nguyen, C. H. H., Newman, S. A., Yeromin, A. V., Scarfone, V. M., Marsh, S. E., Fimbres, C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.042 · Cited by 1,154 · see citing works

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

Zhou, Y., Song, W. M., Andhey, P. S., Swain, A., Levy, T., Miller, K. R., Poliani, P. L., Cominelli, M., Grover, S., Gilfillan, S., et al. (2020) · Nature Medicine · doi:10.1038/s41591-019-0695-9 · Cited by 1,150 · see citing works

Systemic inflammation and disease progression in Alzheimer disease

Holmes, C., Cunningham, C., Zotova, E., Woolford, J., Dean, C., Kerr, S., Culliford, D., & Perry, V. H. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b6bb95 · Cited by 1,139 · see citing works

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

Lin, Y.-T., Seo, J., Gao, F., Feldman, H. M., Wen, H.-L., Penney, J., Cam, H. P., Gjoneska, E., Raja, W. K., Cheng, J., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.008 · Cited by 1,125 · see citing works

The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting

von Bartheld, C. S., Bahney, J., & Herculano‐Houzel, S. (2016) · Journal of Comparative Neurology · doi:10.1002/cne.24040 · Cited by 1,063 · see citing works

In-vivo measurement of activated microglia in dementia

Cagnin, A., Brooks, D. J., Kennedy, A. M., Gunn, R. N., Myers, R., Turkheimer, F. E., Jones, T., & Banati, R. B. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05625-2 · Cited by 1,054 · see citing works

Generation of human induced pluripotent stem cells from dermal fibroblasts

Lowry, W. E., Richter, L., Yachechko, R., Pyle, A. D., Tchieu, J., Sridharan, R., Clark, A. T., & Plath, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711983105 · Cited by 1,041 · see citing works

Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

Halldorsson, S., Lucumi, E., Gómez-Sjöberg, R., & Fleming, R. M. T. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.07.029 · Cited by 1,027 · see citing works

Broad Expression of Toll-Like Receptors in the Human Central Nervous System

Bsibsi, M., Ravid, R., Gveric, D. O., & van Noort, J. M. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.11.1013 · Cited by 1,000 · see citing works

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

Cunningham, C. L., Martínez-Cerdeño, V., & Noctor, S. C. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3441-12.2013 · Cited by 976 · see citing works

A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

Grubman, A., Chew, G., Ouyang, J. F., Sun, G., Choo, X. Y., McLean, C., Simmons, R. K., Buckberry, S., Vargas-Landin, D. B., Poppe, D., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0539-4 · Cited by 956 · see citing works

Exponential scaling of single-cell RNA-seq in the past decade

Svensson, V., Vento‐Tormo, R., & Teichmann, S. A. (2018) · Nature Protocols · doi:10.1038/nprot.2017.149 · Cited by 936 · see citing works

Astrocyte reactivity and reactive astrogliosis: costs and benefits

Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934 · see citing works

Review: Activation patterns of microglia and their identification in the human brain

Boche, D., Perry, V., & Nicoll, J. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12011 · Cited by 903 · see citing works

Biochemical and functional characterization of three activated macrophage populations

Edwards, J. P., Zhang, X., Frauwirth, K. A., & Mosser, D. M. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0406249 · Cited by 863 · see citing works

Layer V cortical neurons require microglial support for survival during postnatal development

Ueno, M., Fujita, Y., Tanaka, T., Nakamura, Y., Kikuta, J., Ishii, M., & Yamashita, T. (2013) · Nature Neuroscience · doi:10.1038/nn.3358 · Cited by 781 · see citing works

Astrocytic complexity distinguishes the human brain

Oberheim, N. A., Wang, X., Goldman, S., & Nedergaard, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.08.004 · Cited by 739 · see citing works

TLR signaling tailors innate immune responses in human microglia and astrocytes

Jack, C. S., Arbour, N., Manusow, J., Montgrain, V., Blain, M., McCrea, E., Shapiro, A., & Antel, J. P. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4320 · Cited by 734 · see citing works

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

Streit, W. J., Braak, H., Xue, Q.-S., & Bechmann, I. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0556-6 · Cited by 727 · see citing works

Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

Olah, M., Menon, V., Habib, N., Taga, M. F., Ma, Y., Yung, C. J., Cimpean, M., Khairallah, A., Coronas-Samano, G., Sankowski, R., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19737-2 · Cited by 722 · see citing works

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

Genin, E., Hannequin, D., Wallon, D., Sleegers, K., Hiltunen, M., Combarros, O., Bullido, M. J., Engelborghs, S., De Deyn, P., Berr, C., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.52 · Cited by 714 · see citing works

Extracellular vesicles round off communication in the nervous system

Budnik, V., Ruiz-Cañada, C., & Wendler, F. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.29 · Cited by 712 · see citing works

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

Bohlen, C. J., Bennett, F. C., Tucker, A. F., Collins, H. Y., Mulinyawe, S. B., & Barres, B. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.043 · Cited by 676 · see citing works

Efficient derivation of microglia-like cells from human pluripotent stem cells

Muffat, J., Li, Y., Yuan, B., Mitalipova, M., Omer, A., Corcoran, S., Bakiasi, G., Tsai, L.-H., Aubourg, P., Ransohoff, R. M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4189 · Cited by 651 · see citing works

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

Park, J., Wetzel, I., Marriott, I., Dréau, D., D’Avanzo, C., Kim, D. Y., Tanzi, R. E., & Cho, H. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0175-4 · Cited by 644 · see citing works

Astrocyte-Derived ATP Induces Vesicle Shedding and IL-1β Release from Microglia

Bianco, F., Pravettoni, E., Colombo, A., Schenk, U., Möller, T., Matteoli, M., & Verderio, C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7268 · Cited by 596 · see citing works

A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response

Haenseler, W., Sansom, S. N., Buchrieser, J., Newey, S. E., Moore, C. S., Nicholls, F. J., Chintawar, S., Schnell, C., Antel, J. P., Allen, N. D., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.05.017 · Cited by 593 · see citing works

Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review

Hopperton, K. E., Mohammad, D., Trépanier, M. O., Giuliano, V, & Bazinet, R. P. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.246 · Cited by 567 · see citing works

Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains

Walker, D. G., & Lue, L.-F. (2015) · Alzheimer's Research &amp; Therapy · doi:10.1186/s13195-015-0139-9 · Cited by 562 · see citing works

Early and protective microglial activation in Alzheimer’s disease: a prospective study using¹⁸F-DPA-714 PET imaging

Hamelin, L., Lagarde, J., Dorothée, G., Leroy, C., Labit, M., Comley, R. A., de Souza, L. C., Corne, H., Dauphinot, L., Bertoux, M., et al. (2016) · Brain · doi:10.1093/brain/aww017 · Cited by 519 · see citing works

Cholesterol metabolism in neurons and astrocytes

Pfrieger, F. W., & Ungerer, N. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.06.002 · Cited by 500 · see citing works

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer’s Disease

Serrano-Pozo, A., Mielke, M. L., Gómez-Isla, T., Betensky, R. A., Growdon, J. H., Frosch, M. P., & Hyman, B. T. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.05.047 · Cited by 488 · see citing works

Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain

Cosenza‐Nashat, M., Zhao, M. ‐., Suh, H. ‐., Morgan, J., Natividad, R., Morgello, S., & Lee, S. C. (2009) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.01006.x · Cited by 459 · see citing works

Bidirectional Microglia–Neuron Communication in Health and Disease

Szepesi, Z., Manouchehrian, O., Bachiller, S., & Deierborg, T. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00323 · Cited by 459 · see citing works

Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by ¹¹ C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining ¹¹ C-Pittsburgh Compound B and ¹⁸ F-FDG

Carter, S. F., Schöll, M., Almkvist, O., Wall, A., Engler, H., Långström, B., & Nordberg, A. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.087031 · Cited by 442 · see citing works

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

NBB-Psy, Böttcher, C., Schlickeiser, S., Sneeboer, M. A. M., Kunkel, D., Knop, A., Paza, E., Fidzinski, P., Kraus, L., Snijders, G. J. L., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0290-2 · Cited by 436 · see citing works

An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells

TCW, J., Wang, M., Pimenova, A. A., Bowles, K. R., Hartley, B. J., Lacin, E., Machlovi, S. I., Abdelaal, R., Karch, C. M., Phatnani, H., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.06.018 · Cited by 435 · see citing works

An Introduction to the Performance of Immunohistochemistry

Magaki, S., Hojat, S. A., Wei, B., So, A., & Yong, W. H. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8935-5_25 · Cited by 421 · see citing works

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

TCW, J., Qian, L., Pipalia, N. H., Chao, M. J., Liang, S. A., Shi, Y., Jain, B. R., Bertelsen, S. E., Kapoor, M., Marcora, E., et al. (2022) · Cell · doi:10.1016/j.cell.2022.05.017 · Cited by 411 · see citing works

Human Astrocytes: Secretome Profiles of Cytokines and Chemokines

Choi, S. S., Lee, H. J., Lim, I., Satoh, J., & Kim, S. U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092325 · Cited by 411 · see citing works

Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro

Lue, L., Rydel, R. E., Brigham, E. F., Yang, L., Hampel, H. J., Murphy, G. M., Brachova, L., Yan, S., Walker, D. G., Shen, Y., et al. (2001) · Glia · doi:10.1002/glia.1072 · Cited by 382 · see citing works

Toll‐like receptors in central nervous system glial inflammation and homeostasis

Kielian, T. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20767 · Cited by 363 · see citing works

Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes

Rostami, J., Holmqvist, S., Lindström, V., Sigvardson, J., Westermark, G. T., Ingelsson, M., Bergström, J., Roybon, L., & Erlandsson, A. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.0983-17.2017 · Cited by 339 · see citing works

Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: An immunohistochemical study

Núñez, E., Benito, C., Pazos, M. R., Barbáchano, A., Fajardo, O., González, S. R., Tolón, R. M., & Romero, J. (2004) · Synapse · doi:10.1002/syn.20050 · Cited by 334 · see citing works

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

Oksanen, M., Petersen, A. J., Naumenko, N., Puttonen, K., Lehtonen, Š., Gubert Olivé, M., Shakirzyanova, A., Leskelä, S., Sarajärvi, T., Viitanen, M., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.10.016 · Cited by 332 · see citing works

Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans

Thrupp, N., Sala Frigerio, C., Wolfs, L., Skene, N. G., Fattorelli, N., Poovathingal, S., Fourne, Y., Matthews, P. M., Theys, T., Mancuso, R., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108189 · Cited by 329 · cited 1× · see citing works

P2Y ₁₂ receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases: P2Y ₁₂ Expression on Human Microglia

Mildner, A., Huang, H., Radke, J., Stenzel, W., & Priller, J. (2017) · Glia · doi:10.1002/glia.23097 · Cited by 301 · see citing works

The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease

Hopp, S. C., Lin, Y., Oakley, D., Roe, A. D., DeVos, S. L., Hanlon, D., & Hyman, B. T. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1309-z · Cited by 286 · see citing works

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

Dickens, A. M., Tovar-y-Romo, L. B., Yoo, S.-W., Trout, A. L., Bae, M., Kanmogne, M., Megra, B., Williams, D. W., Witwer, K. W., Gacias, M., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aai7696 · Cited by 285 · see citing works

Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer’s disease

Rodriguez-Vieitez, E., Saint-Aubert, L., Carter, S. F., Almkvist, O., Farid, K. A., Schöll, M., Chiotis, K., Thordardottir, S., Graff, C., Wall, A., et al. (2016) · Brain : a journal of neurology · doi:10.1093/brain/awv404 · Cited by 285 · see citing works

Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders

Werry, E. L., Bright, F., Piguet, O., Ittner, L. M., Halliday, G. M., Hodges, J. R., Kiernan, M. C., Loy, C. T., Kril, J. J., & Kassiou, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133161 · Cited by 282 · see citing works

Deciphering the astrocyte reaction in Alzheimer's disease

Perez-Nievas, B. G., & Serrano-Pozo, A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00114 · Cited by 282 · see citing works

Astrocytes Provide Cysteine to Neurons by Releasing Glutathione

Wang, X. F., & Cynader, M. S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741434.x · Cited by 281 · see citing works

Glial activation and inflammation along the Alzheimer’s disease continuum

Nordengen, K., Kirsebom, B.-E., Henjum, K., Selnes, P., Gísladóttir, B., Wettergreen, M., Torsetnes, S. B., Grøntvedt, G. R., Waterloo, K. K., Aarsland, D., et al. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1399-2 · Cited by 274 · see citing works

Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: A potential mechanism leading to chronic inflammation

Walker, D. G., Dalsing-Hernandez, J. E., Campbell, N. A., & Lue, L. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.09.003 · Cited by 268 · see citing works

Immunohistochemical Study of the β-Chemokine Receptors CCR3 and CCR5 and Their Ligands in Normal and Alzheimer's Disease Brains

Xia, M., Qin, S., Wu, L.-J., Mackay, C., & Hyman, B. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65542-3 · Cited by 267 · see citing works

Efficient Generation of Astrocytes from Human Pluripotent Stem Cells in Defined Conditions

Shaltouki, A., Peng, J., Liu, Q., Rao, M. S., & Zeng, X. (2013) · Stem Cells · doi:10.1002/stem.1334 · Cited by 264 · see citing works

Single-nucleus RNA-seq identifies Huntington disease astrocyte states

Al-Dalahmah, O., Sosunov, A. A., Shaik, A., Ofori, K., Liu, Y., Vonsattel, J. P., Adorjan, I., Menon, V., & Goldman, J. E. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-0880-6 · Cited by 264 · see citing works

Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions

Cserép, C., Pósfai, B., & Dénes, Á. (2021) · Neuron · doi:10.1016/j.neuron.2020.11.007 · Cited by 256 · see citing works

Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T

Kaiser, L. G., Schuff, N., Cashdollar, N., & Weiner, M. W. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.07.001 · Cited by 251 · see citing works

Etanercept in Alzheimer disease

Butchart, J., Brook, L., Hopkins, V., Teeling, J. L., Püntener, U., Culliford, D. J., Sharples, R., Sharif, S., McFarlane, B., Raybould, R., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001617 · Cited by 249 · see citing works

YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias

Llorens, F., Thüne, K., Tahir, W., Kanata, E., Diaz-Lucena, D., Xanthopoulos, K., Kovatsi, E., Pleschka, C., Garcia-Esparcia, P., Schmitz, M., et al. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0226-4 · Cited by 249 · see citing works

A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation

Goshi, N., Morgan, R. K., Lein, P. J., & Şeker, E. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01819-z · Cited by 248 · see citing works

Differential Relationships of Reactive Astrocytes and Microglia to Fibrillar Amyloid Deposits in Alzheimer Disease

Serrano-Pozo, A., Muzikansky, A., Gómez-Isla, T., Growdon, J. H., Betensky, R. A., Frosch, M. P., & Hyman, B. T. (2013) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1097/nen.0b013e3182933788 · Cited by 226 · see citing works

Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates

Rostami, J., Mothes, T., Kolahdouzan, M., Eriksson, O., Moslem, M., Bergström, J., Ingelsson, M., O’Callaghan, P., Healy, L. M., Falk, A., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02158-3 · Cited by 224 · cited 2× · see citing works

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

Zhao, J., Davis, M. D., Martens, Y. A., Shinohara, M., Graff-Radford, N. R., Younkin, S. G., Wszolek, Z. K., Kanekiyo, T., & Bu, G. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx155 · Cited by 221 · see citing works

Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease

Gomez‐Arboledas, A., Davila, J. C., Sanchez‐Mejias, E., Navarro, V., Nuñez‐Diaz, C., Sanchez‐Varo, R., Sanchez‐Mico, M. V., Trujillo‐Estrada, L., Fernandez‐Valenzuela, J. J., Vizuete, M., et al. (2018) · Glia · doi:10.1002/glia.23270 · Cited by 220 · see citing works

Microglial immunophenotype in dementia with Alzheimer’s pathology

CFAS, M., Minett, T., Classey, J., Matthews, F. E., Fahrenhold, M., Taga, M., Brayne, C., Ince, P. G., Nicoll, J. A. R., & Boche, D. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0601-z · Cited by 219 · see citing works

Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease

Peskind, E. R., Griffin, W. S. T., Akama, K. T., Raskind, M. A., & Eldik, L. J. V. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00048-1 · Cited by 215 · see citing works

Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer’s disease

Galimberti, D., Fenoglio, C., Lovati, C., Venturelli, E., Guidi, I., Corrà, B., Scalabrini, D., Clerici, F., Mariani, C., Bresolin, N., et al. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.007 · Cited by 209 · see citing works

Differential Production of and Migratory Response to Chemokines by Human Microglia and Astrocytes

Peterson, P. K., Hu, S., Salak‐Johnson, J. L., Molitor, T. W., & Chao, C. C. (1997) · The Journal of Infectious Diseases · doi:10.1093/infdis/175.2.478 · Cited by 209 · see citing works

Human Stem Cell-Derived Spinal Cord Astrocytes with Defined Mature or Reactive Phenotypes

Roybon, L., Lamas, N. J., Garcia-Diaz, A., Yang, E. J., Sattler, R., Jackson-Lewis, V., Kim, Y. A., Kachel, C. A., Rothstein, J. D., Przedborski, S., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.06.021 · Cited by 208 · see citing works

CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes

Barbar, L., Jain, T., Zimmer, M., Kruglikov, I., Sadick, J. S., Wang, M., Kalpana, K., Rose, I. V. L., Burstein, S. R., Rusielewicz, T., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.05.014 · Cited by 206 · see citing works

Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-l-deprenyl using whole hemisphere autoradiography

Gulyás, B. Z., Pavlova, E. L., Kása, P., Gulya, K., Bakota, L., Várszegi, S., Keller, É., Horváth, M. C., Nag, S., Hermecz, I., et al. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.10.013 · Cited by 203 · see citing works

Degradation of the Amyloid β-Protein by the Novel Mitochondrial Peptidasome, PreP

Falkevall, A., Alikhani, N., Bhushan, S., Pavlov, P. F., Busch, K., Johnson, K. A., Eneqvist, T., Tjernberg, L. O., Ankarcrona, M., & Glaser, E. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602532200 · Cited by 202 · see citing works

Alzheimer’s disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes

Sekar, S., McDonald, J., Cuyugan, L., Aldrich, J., Kurdoglu, A., Adkins, J., Serrano, G., Beach, T. G., Craig, D. W., Valla, J., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.09.027 · Cited by 199 · see citing works

Novel CSF biomarkers for Alzheimer’s disease and mild cognitive impairment

Hu, W. T., Chen‐Plotkin, A. S., Arnold, S. E., Grossman, M., Clark, C. M., Shaw, L. M. J., Pickering, E. H., Kühn, M., Chen, Y., McCluskey, L. F., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0667-0 · Cited by 196 · see citing works

Plasma MCP-1 and Cognitive Decline in Patients with Alzheimer’s Disease and Mild Cognitive Impairment: A Two-year Follow-up Study

Lee, W., Liao, Y., Wang, Y.-F., Lin, I.-F., Wang, S., & Fuh, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-19807-y · Cited by 193 · see citing works

Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia

Brownjohn, P. W., Smith, J., Solanki, R., Lohmann, E., Houlden, H., Hardy, J., Dietmann, S., & Livesey, F. J. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.03.003 · Cited by 193 · see citing works

Distribution of the Immune Inhibitory Molecules CD200 and CD200R in the Normal Central Nervous System and Multiple Sclerosis Lesions Suggests Neuron-Glia and Glia-Glia Interactions

Koning, N., Swaab, D. F., Hoek, R. M., & Huitinga, I. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181964113 · Cited by 188 · see citing works

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer’s pathology and APOE genotype

Simpson, J. E., Ince, P. G., Shaw, P. J., Heath, P. R., Raman, R., Garwood, C. J., Gelsthorpe, C., Baxter, L., Forster, G., Matthews, F. E., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.04.013 · Cited by 188 · see citing works

Aberrant iPSC-derived human astrocytes in Alzheimer's disease

Jones, V. C., Atkinson-Dell, R., Verkhratsky, A., & Mohamet, L. (2017) · Cell Death &amp; Disease · doi:10.1038/cddis.2017.89 · Cited by 186 · see citing works

Phenotypic Heterogeneity and Plasticity of Isocortical and Hippocampal Astrocytes in the Human Brain

Sosunov, A. A., Wu, X., Tsankova, N. M., Guilfoyle, E., McKhann, G. M., & Goldman, J. E. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4037-13.2014 · Cited by 185 · see citing works

Cytokine, chemokine and growth factor gene profiling of cultured human astrocytes after exposure to proinflammatory stimuli

Meeuwsen, S., Persoon‐Deen, C., Bsibsi, M., Ravid, R., & Noort, J. M. V. (2003) · Glia · doi:10.1002/glia.10259 · Cited by 185 · see citing works

Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients

Kenkhuis, B., Somarakis, A., de Haan, L., Dzyubachyk, O., IJsselsteijn, M. E., de Miranda, N. F. C. C., Lelieveldt, B. P. F., Dijkstra, J., van Roon-Mom, W. M. C., Höllt, T., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01126-5 · Cited by 184 · see citing works

Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain

Galea, I., Palin, K., Newman, T. A., van Rooijen, N., Perry, V. H., & Boche, D. (2004) · Glia · doi:10.1002/glia.20124 · Cited by 183 · see citing works

Extracellular Vesicles and a Novel Form of Communication in the Brain

Basso, M., & Bonetto, V. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00127 · Cited by 179 · see citing works

Astrocyte and Macrophage Regulation of YKL‐40 Expression and Cellular Response in Neuroinflammation

Bonneh‐Barkay, D., Bissel, S. J., Kofler, J., Starkey, A., Wang, G., & Wiley, C. A. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00550.x · Cited by 179 · see citing works

Expression of chemokines and their receptors in human and simian astrocytes: Evidence for a central role of TNFα and IFNγ in CXCR4 and CCR5 modulation

Croitoru‐Lamoury, J., Guillemin, G. J., Boussin, F. D., Mognetti, B., Gigout, L. I., Chéret, A., Vaslin, B., Grand, R. L., Brew, B. J., & Dormont, D. (2003) · Glia · doi:10.1002/glia.10181 · Cited by 177 · see citing works

<scp> <i>APOE</i> </scp> ε2 is associated with milder clinical and pathological <scp>A</scp> lzheimer disease

Serrano‐Pozo, A., Qian, J., Monsell, S. E., Betensky, R. A., & Hyman, B. T. (2015) · Annals of Neurology · doi:10.1002/ana.24369 · Cited by 176 · see citing works

Activated human astrocyte‐derived extracellular vesicles modulate neuronal uptake, differentiation and firing

You, Y., Borgmann, K., Edara, V. V., Stacy, S., Ghorpade, A., & Ikezu, T. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1706801 · Cited by 176 · see citing works

Soluble phospho-tau from Alzheimer’s disease hippocampus drives microglial degeneration

Sanchez-Mejias, E., Navarro, V., Jimenez, S., Sanchez-Mico, M., Sanchez-Varo, R., Nuñez-Diaz, C., Trujillo-Estrada, L., Davila, J. C., Vizuete, M., Gutierrez, A., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1630-5 · Cited by 175 · see citing works

Immunohistochemical Analysis of CCR2, CCR3, CCR5, and CXCR4 in the Human Brain: Potential Mechanisms for HIV Dementia

van der Meer, P., Ulrich, A. M., González‐Scarano, F., & Lavi, E. (2000) · Experimental and Molecular Pathology · doi:10.1006/exmp.2000.2336 · Cited by 174 · see citing works

A Phenotypic Change But Not Proliferation Underlies Glial Responses in Alzheimer Disease

Serrano-Pozo, A., Gómez-Isla, T., Growdon, J. H., Frosch, M. P., & Hyman, B. T. (2013) · The American Journal of Pathology · doi:10.1016/j.ajpath.2013.02.031 · Cited by 169 · see citing works

Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system

Hyvärinen, T., Hagman, S., Ristola, M., Sukki, L., Veijula, K., Kreutzer, J., Kallio, P., & Narkilahti, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-53414-9 · Cited by 168 · see citing works

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

Garcia-Reitboeck, P., Phillips, A., Piers, T. M., Villegas-Llerena, C., Butler, M., Mallach, A., Rodrigues, C., Arber, C. E., Heslegrave, A., Zetterberg, H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.094 · Cited by 162 · see citing works

Genetics ignite focus on microglial inflammation in Alzheimer’s disease

Malik, M., Parikh, I., Vasquez, J. B., Smith, C., Tai, L., Bu, G., LaDu, M. J., Fardo, D. W., Rebeck, G. W., & Estus, S. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0048-1 · Cited by 161 · see citing works

YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies

Querol-Vilaseca, M., Colom-Cadena, M., Pegueroles, J., San Martín-Paniello, C., Clarimon, J., Belbin, O., Fortea, J., & Lleó, A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0893-7 · Cited by 158 · see citing works

Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease

Zeineh, M. M., Chen, Y., Kitzler, H. H., Hammond, R., Vogel, H., & Rutt, B. K. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.05.022 · Cited by 151 · see citing works

Molecular Mechanisms of Microglial Motility: Changes in Ageing and Alzheimer’s Disease

Franco-Bocanegra, D. K., McAuley, C., Nicoll, J. A. R., & Boche, D. (2019) · Cells · doi:10.3390/cells8060639 · Cited by 147 · see citing works

Post-mortem analysis of neuroinflammatory changes in human Alzheimer’s disease

Gomez-Nicola, D., & Boche, D. (2015) · Alzheimer's Research &amp; Therapy · doi:10.1186/s13195-015-0126-1 · Cited by 147 · see citing works

Microglial Implication in Parkinson’s Disease: Loss of Beneficial Physiological Roles or Gain of Inflammatory Functions?

Lecours, C., Bordeleau, M., Cantin, L., Parent, M., Paolo, T. D., & Tremblay, M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00282 · Cited by 143 · see citing works

Complement 3(+)-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia

Hartmann, K., Sepulveda-Falla, D., Rose, I. V. L., Madore, C., Muth, C., Matschke, J., Butovsky, O., Liddelow, S., Glatzel, M., & Krasemann, S. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0735-1 · Cited by 141 · see citing works

Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

Beaino, W., Janssen, B., Kooij, G., van der Pol, S. M. A., Hof, B. V. H., van Horssen, J., Windhorst, A. D., & de Vries, H. E. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1034-z · Cited by 141 · see citing works

Transcriptional profiling of microglia; current state of the art and future perspectives

Gerrits, E., Heng, Y., Boddeke, E. W. G. M., & Eggen, B. J. L. (2020) · Glia · doi:10.1002/glia.23767 · Cited by 140 · see citing works

Monoamine oxidase‐B in astrocytes

Ekblom, J., Jossan, S. S., Bergstrüm, M., Oreland, L., Walum, E., & Aquilonius, S. (1993) · Glia · doi:10.1002/glia.440080208 · Cited by 139 · see citing works

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation

Ewers, M., Biechele, G., Suárez‐Calvet, M., Sacher, C., Blume, T., Morenas‐Rodriguez, E., Deming, Y., Piccio, L., Cruchaga, C., Kleinberger, G., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012308 · Cited by 133 · see citing works

Phenotyping primary human microglia: tight regulation of LPS responsiveness

Melief, J., Koning, N., Schuurman, K. G., Van De Garde, M. D. B., Smolders, J., Hoek, R. M., Van Eijk, M., Hamann, J., & Huitinga, I. (2012) · Glia · doi:10.1002/glia.22370 · Cited by 132 · see citing works

Characterization of the 18 kDa translocator protein (TSPO) expression in <i>post‐mortem</i> normal and Alzheimer's disease brains

Gui, Y., Marks, J. D., Das, S., Hyman, B. T., & Serrano‐Pozo, A. (2020) · Brain Pathology · doi:10.1111/bpa.12763 · Cited by 126 · see citing works

Diversity of transcriptomic microglial phenotypes in aging and Alzheimer's disease

Boche, D., & Gordon, M. N. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12389 · Cited by 117 · see citing works

Cerebrospinal fluid S100B correlates with brain atrophy in Alzheimer's disease

Petzold, A., Jenkins, R., Watt, H., Green, A. J. E., Thompson, E. J., Keir, G., Fox, N. C., & Rossor, M. N. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01257-0 · Cited by 115 · see citing works

A Comprehensive Review of the 1H-MRS Metabolite Spectrum in Autism Spectrum Disorder

Ford, T. C., & Crewther, D. P. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00014 · Cited by 113 · see citing works

Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables

Mizee, M. R., Miedema, S. S. M., van der Poel, M., Adelia, Schuurman, K. G., van Strien, M. E., Melief, J., Smolders, J., Hendrickx, D. A. E., Heutinck, K. M., et al. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0418-8 · Cited by 113 · see citing works

Pro‐inflammatory activation of microglia in the brain of patients with sepsis

Zrzavy, T., Höftberger, R., Berger, T., Rauschka, H., Butovsky, O., Weiner, H. L., & Lassmann, H. (2018) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12502 · Cited by 112 · see citing works

Identification of FcγRI, II and III on normal human brain ramified microglia and on microglia in senile plaques in Alzheimer's disease

Peress, N. S., Fleit, H. B., Perillo, E., Kuljiš, R. O., & Pezzullo, C. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90060-c · Cited by 111 · see citing works

Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain

Emir, U. E., Raatz, S. K., McPherson, S. E., Hodges, J. S., Torkelson, C. J., Tawfik, P. N., White, T. J. H., & Terpstra, M. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1646 · Cited by 109 · see citing works

Imaging of translocator protein upregulation is selective for pro‐inflammatory polarized astrocytes and microglia

Pannell, M., Economopoulos, V., Wilson, T. C., Kersemans, V., Isenegger, P. G., Larkin, J. R., Smart, S., Gilchrist, S., Gouverneur, V., & Sibson, N. R. (2020) · Glia · doi:10.1002/glia.23716 · Cited by 109 · see citing works

Deletion of CD14 Attenuates Alzheimer's Disease Pathology by Influencing the Brain's Inflammatory Milieu

Reed-Geaghan, E. G., Reed, Q. W., Cramer, P. E., & Landreth, G. E. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2637-10.2010 · Cited by 104 · see citing works

Inhibition of microglial cell RANTES production by IL-10 and TGF-β

Hu, S., Chao, C. C., Ehrlich, L. C., Sheng, W. S., Sutton, R. L., Rockswold, G. L., & Peterson, P. K. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.6.815 · Cited by 104 · see citing works

Mapping microglia and astrocyte activation in vivo using diffusion MRI

Garcia-Hernandez, R., Cerdán Cerdá, A., Trouve Carpena, A., Drakesmith, M., Koller, K., Jones, D. K., Canals, S., & De Santis, S. (2022) · Science Advances · doi:10.1126/sciadv.abq2923 · Cited by 102 · see citing works

The Cerebrospinal Fluid Level of Glial Fibrillary Acidic Protein Is Increased in Cerebrospinal Fluid from Alzheimer’s Disease Patients and Correlates with Severity of Dementia

Fukuyama, R., Izumoto, T., & Fushiki, S. (2001) · European Neurology · doi:10.1159/000050753 · Cited by 100 · see citing works

Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain

Kobayashi, E., Nakano, M., Kubota, K., Himuro, N., Mizoguchi, S., Chikenji, T., Otani, M., Mizue, Y., Nagaishi, K., & Fujimiya, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-19442-7 · Cited by 98 · see citing works

Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson’s disease: an in vivo11C-BU99008 PET study

Wilson, H., Dervenoulas, G., Pagano, G., Tyacke, R. J., Polychronis, S., Myers, J., Gunn, R. N., Rabiner, E. A., Nutt, D., & Politis, M. (2019) · Brain · doi:10.1093/brain/awz260 · Cited by 93 · see citing works

Increases in a Pro-inflammatory Chemokine, MCP-1, Are Related to Decreases in Memory Over Time

Bettcher, B. M., Neuhaus, J. M., Wynn, M. J., Elahi, F. M., Casaletto, K. B., Saloner, R., Fitch, R., Karydas, A., & Kramer, J. H. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00025 · Cited by 90 · see citing works

MCP‐1 and eotaxin‐1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes

Bettcher, B. M., Fitch, R., Wynn, M. J., Lalli, M. A., Elofson, J., Jastrzab, L., Mitic, L., Miller, Z. A., Rabinovici, G. D., Miller, B. L., et al. (2016) · Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring · doi:10.1016/j.dadm.2016.05.004 · Cited by 89 · see citing works

Severity of gliosis in Pick's disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders

Schofield, E. C. (2003) · Brain · doi:10.1093/brain/awg085 · Cited by 86 · see citing works

Decreased in vivo availability of the cannabinoid type 2 receptor in Alzheimer’s disease

Ahmad, R. U., Postnov, A. A., Bormans, G. M., Versijpt, J. J., Vandenbulcke, M., & Laere, K. V. (2016) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-016-3457-7 · Cited by 85 · see citing works

Microglial morphology in Alzheimer’s disease and after Aβ immunotherapy

Franco-Bocanegra, D., Gourari, Y., McAuley, C., Chatelet, D. S., Johnston, D. A., Nicoll, J. A. R., & Boche, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-95535-0 · Cited by 85 · see citing works

Proliferation in the Alzheimer Hippocampus Is due to Microglia, Not Astroglia, and Occurs at Sites of Amyloid Deposition

Marlatt, M. W., Bauer, J., Aronica, E., van Haastert, E. S., Hoozemans, J. J. M., Joels, M., & Lucassen, P. J. (2014) · Neural Plasticity · doi:10.1155/2014/693851 · Cited by 83 · see citing works

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 Binding Site in Human Brain

Tyacke, R. J., Myers, J., Venkataraman, A. V., Mick, I., Turton, S., Passchier, J., Husbands, S. M., Rabiner, E. A., Gunn, R. N., Murphy, P. S., et al. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.208009 · Cited by 83 · see citing works

hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury

Jiang, P., Chen, C., Wang, R., Chechneva, O. V., Chung, S., Rao, M. S., Pleasure, D., Liu, Y., Zhang, Q., & Deng, W. (2013) · Nature Communications · doi:10.1038/ncomms3196 · Cited by 82 · see citing works

Neocortical Glial Cell Numbers in Alzheimer’s Disease

Pelvig, D. P., Pakkenberg, H., Regeur, L., Oster, S., & Pakkenberg, B. (2003) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000072805 · Cited by 81 · see citing works

Systemic infection modifies the neuroinflammatory response in late stage Alzheimer’s disease

Rakić, S., Hung, Y. M. A., Smith, M., So, D., Tayler, H. M., Varney, W., Wild, J., Harris, S., Holmes, C., Love, S., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0592-3 · Cited by 80 · see citing works

Profiling Microglia From Alzheimer’s Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue

Alsema, A. M., Jiang, Q., Kracht, L., Gerrits, E., Dubbelaar, M. L., Miedema, A., Brouwer, N., Hol, E. M., Middeldorp, J., van Dijk, R. E., et al. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00134 · Cited by 79 · see citing works

Glutamine Synthetase in Cerebrospinal Fluid, Serum, and Brain

Tumani, H., Shen, G., Peter, J. B., & Brück, W. (1999) · Archives of Neurology · doi:10.1001/archneur.56.10.1241 · Cited by 74 · see citing works

TREM2 expression in the human brain: a marker of monocyte recruitment?

Fahrenhold, M., Rakić, S., Classey, J. D., Brayne, C., Ince, P. G., Nicoll, J. A. R., Boche, D., & MRC‐CFAS (2017) · Brain Pathology · doi:10.1111/bpa.12564 · Cited by 73 · see citing works

In vivo imaging of astrocytosis in Alzheimer’s disease: an 11C-L-deuteriodeprenyl and PIB PET study

Santillo, A. F., Gambini, J. P., Lannfelt, L., Långström, B., Ulla-Marja, L., Kilander, L., & Engler, H. (2011) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-011-1895-9 · Cited by 71 · see citing works

Role of P2X7 Receptors in Immune Responses During Neurodegeneration

Oliveira-Giacomelli, Á., Petiz, L. L., Andrejew, R., Turrini, N., Silva, J. B., Sack, U., & Ulrich, H. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.662935 · Cited by 68 · see citing works

Functional expression of CCR2 by human fetal astrocytes

Andjelkovic, A. V., Song, L., Dzenko, K. A., Cong, H., & Pachter, J. S. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10372 · Cited by 68 · see citing works

Quantitative immunohistochemical analysis of myeloid cell marker expression in human cortex captures microglia heterogeneity with anatomical context

Swanson, M. E. V., Murray, H. C., Ryan, B., Faull, R. L. M., Dragunow, M., & Curtis, M. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-68086-z · Cited by 65 · see citing works

Non-adrenoceptor [3H]idazoxan binding sites (I2-imidazoline sites) are increased in postmortem brain from patients with Alzheimer's disease.

Ruiz, J., Martin, I., Callado, L., Meana, J., Barturen, F., & García-Sevilla, J. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90925-b · Cited by 64 · see citing works

Microglial motility in Alzheimer’s disease and after Aβ42 immunotherapy: a human post-mortem study

Franco-Bocanegra, D. K., George, B., Lau, L. C., Holmes, C., Nicoll, J. A. R., & Boche, D. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0828-x · Cited by 64 · see citing works

Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer's disease

Wang, Q., Wang, Y., Liu, J., Sutphen, C. L., Cruchaga, C., Blazey, T., Gordon, B. A., Su, Y., Chen, C., Shimony, J. S., et al. (2019) · NeuroImage: Clinical · doi:10.1016/j.nicl.2019.101767 · Cited by 63 · see citing works

Longitudinal association between astrocyte function and glucose metabolism in autosomal dominant Alzheimer’s disease

Carter, S. F., Chiotis, K., Nordberg, A. K., & Rodriguez‐Vieitez, E. (2018) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-018-4217-7 · Cited by 62 · see citing works

Cortical microstructural correlates of astrocytosis in autosomal-dominant Alzheimer disease

Vilaplana, E., Rodriguez-Vieitez, E., Ferreira, D., Montal, V., Almkvist, O., Wall, A., Lleó, A., Westman, E., Graff, C., Fortea, J., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000009405 · Cited by 61 · see citing works

Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease.

Gatto, N., Dos Santos Souza, C., Shaw, A. C., Bell, S. M., Myszczynska, M. A., Powers, S., Meyer, K., Castelli, L. M., Karyka, E., Mortiboys, H., et al. (2021) · Aging Cell · doi:10.1111/acel.13281 · Cited by 58 · see citing works

Glutamate Transporter GLT1 Expression in Alzheimer Disease and Dementia With Lewy Bodies

Garcia‐Esparcia, P., Lucena, D. D., Ainciburu, M., Torrejón-Escribano, B., Carmona, M., Llorens, F., & Ferrer, I. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00122 · Cited by 56 · see citing works

Immune environment of the brain in schizophrenia and during the psychotic episode: A human post-mortem study

Picker, L. D., Victoriano, G. M., Richards, R., Gorvett, A. J., Lyons, S., Buckland, G. R., Tofani, T., Norman, J. L., Chatelet, D. S., Nicoll, J. A. R., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.017 · Cited by 56 · see citing works

Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer’s disease

Faculty, O. B. O. T. M., Boche, D., Gerhard, A., & Rodriguez-Vieitez, E. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04462-w · Cited by 55 · cited 2× · see citing works

Expression profiles of cholesterol metabolism-related genes are altered during development of experimental autoimmune encephalomyelitis in the rat spinal cord

Lavrnja, I., Smiljanic, K., Savic, D., Mladenovic-Djordjevic, A., Tesovic, K., Kanazir, S., & Pekovic, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-02638-8 · Cited by 54 · see citing works

Gene expression profiling of the astrocyte transcriptome in multiple sclerosis normal appearing white matter reveals a neuroprotective role

Waller, R., Woodroofe, M. N., Wharton, S. B., Ince, P. G., Francese, S., Heath, P. R., Cudzich-Madry, A., Thomas, R. H., Rounding, N., Sharrack, B., et al. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.09.010 · Cited by 54 · see citing works

Microglial derived extracellular vesicles activate autophagy and mediate multi‐target signaling to maintain cellular homeostasis

den Broek, B. V., Pintelon, I., Hamad, I., Kessels, S., Haidar, M., Hellings, N., Hendriks, J. J. A., Kleinewietfeld, M., Brône, B., Timmerman, V., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12022 · Cited by 54 · see citing works

Cerebrospinal Fluid Cytokine Dynamics Differ Between Alzheimer Disease Patients and Elderly Controls

Llano, D. A., Li, J., Waring, J. F., Ellis, T. A., Devanarayan, V., Witte, D. G., & Lenz, R. A. (2011) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31823b2728 · Cited by 49 · see citing works

Neocortical and hippocampal TREM2 protein levels during the progression of Alzheimer's disease

Perez, S. E., Nadeem, M., He, B., Miguel, J. C., Malek‐Ahmadi, M. H., Chen, K., & Mufson, E. J. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.02.012 · Cited by 49 · see citing works

Innate Immune Anti-Inflammatory Response in Human Spontaneous Intracerebral Hemorrhage

Shtaya, A., Bridges, L., Williams, R. A., Trippier, S., Zhang, L., Pereira, A. C., Nicoll, J. A. R., Boche, D., & Hainsworth, A. H. (2021) · Stroke · doi:10.1161/strokeaha.121.034673 · Cited by 41 · see citing works

Glial cells and adaptive immunity in frontotemporal dementia with tau pathology

Hartnell, I. J., Blum, D. L., Nicoll, J. A. R., Dorothée, G., & Boche, D. (2020) · Brain · doi:10.1093/brain/awaa457 · Cited by 40 · see citing works

Association of CD14 with incident dementia and markers of brain aging and injury

Pase, M. P., Himali, J. J., Beiser, A., DeCarli, C. S., McGrath, E. R., Satizábal, C. L., Aparicio, H. J., Adams, H. H. H., Reiner, A. P., Longstreth, W. T., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000008682 · Cited by 38 · see citing works

Role of soluble CD14 in cerebrospinal fluid as a regulator of glial functions

Yin, G. N., Jeon, H., Lee, S., Lee, H., Cho, J., & Suk, K. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22081 · Cited by 35 · see citing works

Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer’s Disease

García‐León, J. A., Cáceres-Palomo, L., Sánchez‐Mejías, E., Mejias‐Ortega, M., Nuñez‐Diaz, C., Fernandez-Valenzuela, J. J., Sanchez-Varo, R. M., Dávila, J. C., Vitórica, J., & Gutiérrez, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186867 · Cited by 35 · see citing works

Microglia Development and Maturation and Its Implications for Induction of Microglia-Like Cells from Human iPSCs

Wurm, J., Konttinen, H., Andressen, C., Malm, T., & Spittau, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063088 · Cited by 34 · see citing works

Innate immunity in Alzheimer’s disease: the relevance of animal models?

Franco-Bocanegra, D., Nicoll, J. A. R., & Boche, D. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1729-4 · Cited by 31 · see citing works

Cholesterol and matrisome pathways dysregulated in human APOE ε4 gliaPreprint

Julia, T. C. W., Liang, S., Lü, Q., Pipalia, N. H., Chao, M. J., Shi, Y., Bertelsen, S. E., Kapoor, M., Marcora, E. M., Sikora, E., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/713362 · Cited by 28 · see citing works

Amyloid, pTau, NfL, and GFAP as biomarkers for Alzheimer’s disease

Thijssen, E. H., Verberk, I. M. W., Stoops, E., Boxer, A. L., & Teunissen, C. E. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.038179 · Cited by 19 · see citing works

Total glutamine synthetase levels in cerebrospinal fluid of Alzheimer's disease patients are unchanged

Timmer, N., Herbert, M. K., Claassen, J. A. H. R., Kuiperij, H. B., & Verbeek, M. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.12.010 · Cited by 16 · see citing works

Mapping microglia and astrocytes activation in vivo using diffusion MRIPreprint

Garcia-Hernandez, R., Cerdá, A. C., Carpena, A. T., Drakesmith, M., Koller, K., Jones, D. K., Canals, S., & Santis, S. D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.07.938910 · Cited by 13 · see citing works

O5‐01‐05: RELATIONSHIP BETWEEN ASTROCYTE ACTIVATION USING [11C]BU99008 PET, GLUCOSE METABOLISM AND AMYLOID IN ALZHEIMER'S DISEASE: A DEMENTIA PLATFORM UK EXPERIMENTAL MEDICINE STUDY

Fan, Z., Calsolaro, V., Mayers, J., Tyacke, R. J., Venkataraman, A. V., Femminella, G. D., Perneczky, R., Gunn, R. N., Rabiner, E. A., Matthews, P. M., et al. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.06.2999 · Cited by 3 · see citing works

The duality of amyloid-β: its role in normal and Alzheimer’s disease states

Azargoonjahromi, A. (2024) · Molecular Brain · doi:10.1186/s13041-024-01118-1 · Cited by 173 · see citing works

Precision drug delivery to the central nervous system using engineered nanoparticles

Gao, J., Xia, Z. J., Gunasekar, S., Jiang, C., Karp, J. M., & Joshi, N. (2024) · Nature Reviews Materials · doi:10.1038/s41578-024-00695-w · Cited by 162 · see citing works

Microglial activation states and their implications for Alzheimer's Disease

Valiukas, Z., Tangalakis, K., Apostolopoulos, V., & Feehan, J. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2024.100013 · Cited by 155 · see citing works

Microglia-Astrocyte Communication in Alzheimer’s Disease

Wu, Y., & Eisel, U. L. M. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230199 · Cited by 118 · see citing works

Bidirectional Communication Between Microglia and Astrocytes in Neuroinflammation

Bhusal, A., Afridi, R., Lee, W., & Suk, K. (2022) · Current Neuropharmacology · doi:10.2174/1570159x21666221129121715 · Cited by 105 · see citing works

The potential role of HIV-1 latency in promoting neuroinflammation and HIV-1-associated neurocognitive disorder

Sreeram, S., Ye, F., García‐Mesa, Y., Nguyen, K., Sayed, A. E., Leskov, K., & Karn, J. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.06.003 · Cited by 86 · see citing works

The Impressive Anti-Inflammatory Activity of Cerium Oxide Nanoparticles: More than Redox?

Corsi, F., Tarquini, G. D., Urbani, M., Bejarano, I., Traversa, E., & Ghibelli, L. (2023) · Nanomaterials · doi:10.3390/nano13202803 · Cited by 82 · see citing works

Oxidative stress–mediated neuroinflammation in Alzheimer’s disease

Firdous, S. M., Khan, S. A., & Maity, A. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03188-3 · Cited by 85 · see citing works

Human iPSC-derived glia models for the study of neuroinflammation

Stöberl, N., Maguire, E., Salis, E., Shaw, B., & Hall-Roberts, H. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02919-2 · Cited by 71 · see citing works

Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology

Hartnell, I. J., Woodhouse, D., Jasper, W., Mason, L., Marwaha, P. K., Graffeuil, M., Lau, L. C., Norman, J. L., Chatelet, D. S., Buée, L., et al. (2023) · Brain · doi:10.1093/brain/awad309 · Cited by 54 · see citing works

Oxidative stress and inflammation cause auditory system damage via glial cell activation and dysregulated expression of gap junction proteins in an experimental model of styrene-induced oto/neurotoxicity

Paciello, F., Pisani, A., Rolesi, R., Montuoro, R., Hizam, V. M., Boni, G., Ripoli, C., Galli, J., Sisto, R., Fetoni, A. R., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02996-3 · Cited by 41 · see citing works

Neuroinflammaging: A Tight Line Between Normal Aging and Age-Related Neurodegenerative Disorders

Soraci, L., Corsonello, A., Paparazzo, E., Montesanto, A., Piacenza, F., Olivieri, F., Gambuzza, M. E., Savedra, E. V., Marino, S., Lattanzio, F., et al. (2024) · Aging and Disease · doi:10.14336/ad.2023.1001 · Cited by 46 · see citing works

Astrocytic Neuroimmunological Roles Interacting with Microglial Cells in Neurodegenerative Diseases

Gotoh, M., Miyamoto, Y., & Ikeshima‐Kataoka, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021599 · Cited by 39 · see citing works

Serum Biomarkers of a Pro-Neuroinflammatory State May Define the Pre-Operative Risk for Postoperative Delirium in Spine Surgery

Ruhnau, J., Müller, J., Nowak, S., Strack, S., Sperlich, D., POHL, A. W., Dilz, J., Saar, A., Veser, Y., Behr, F., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210335 · Cited by 34 · see citing works

Astrocytes as Neuroimmunocytes in Alzheimer’s Disease: A Biochemical Tool in the Neuron–Glia Crosstalk along the Pathogenetic Pathways

Stanca, S., Rossetti, M., & Bongioanni, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813880 · Cited by 34 · see citing works

Sleep, Glial Function, and the Endocannabinoid System: Implications for Neuroinflammation and Sleep Disorders

Camberos-Barraza, J., Camacho-Zamora, A., Bátiz-Beltrán, J. C., Osuna‐Ramos, J. F., Rábago-Monzón, Á. R., Valdez-Flores, M. A., Angulo‐Rojo, C., Guadrón‐Llanos, A. M., Picos-Cárdenas, V. J., Calderón-Zamora, L., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063160 · Cited by 32 · see citing works

SARS-CoV-2 envelope protein triggers depression-like behaviors and dysosmia via TLR2-mediated neuroinflammation in mice

Su, W., Ju, J., Gu, M., Wang, X., Liu, S., Yu, J., & Mu, D.-L. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02786-x · Cited by 33 · see citing works

HIV-Associated Neurocognitive Disorder: A Look into Cellular and Molecular Pathology

Thompson, L., Genovese, J., Hong, Z., Singh, M. V., & Singh, V. B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094697 · Cited by 35 · see citing works

Interleukin 1β receptor and synaptic dysfunction in recurrent brain infection with Herpes simplex virus type-1

Piacentini, R., & Grassi, C. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01690 · Cited by 30 · see citing works

Exploring neuroglial signaling: diversity of molecules implicated in microglia-to-astrocyte neuroimmune communication

Mohammad, Z. B., Yudin, S. C. Y., Goldberg, B. J., Serra, K. L., & Klegeris, A. (2024) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0081 · Cited by 32 · see citing works

Exosomes enriched with miR-124-3p show therapeutic potential in a new microfluidic triculture model that recapitulates neuron–glia crosstalk in Alzheimer’s disease

Évora, A., Garcia, G., Rubi, A., Vitis, E. D., Matos, A. T., Vaz, A. R., Gervaso, F., Gigli, G., Polini, A., & Brites, D. M. T. O. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1474012 · Cited by 30 · see citing works

Immunological Biomarkers in Autism Spectrum Disorder: The Role of TNF-Alpha and Dependent Trends in Serum IL-6 and CXCL8

Anastasescu, C. M., Gheorman, V., Stoicănescu, E. C., Popescu, F., Gheorman, V., & Udriștoiu, I. (2024) · Life · doi:10.3390/life14091201 · Cited by 28 · see citing works

Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction

Tizabi, Y., Getachew, B., Hauser, S. R., Tsytsarev, V., Manhães, A. C., & da Silva, V. D. A. (2024) · Brain Sciences · doi:10.3390/brainsci14060558 · Cited by 27 · see citing works

Microglia–neuron–vascular interactions in ischemia

Lénárt, N., Cserép, C., Császár, E., Pósfai, B., & Dénes, Á. (2023) · Glia · doi:10.1002/glia.24487 · Cited by 27 · see citing works

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

Soares, É. N., Costa, A. C. D. S., Ferrolho, G. D. J., Ureshino, R. P., Getachew, B., Costa, S. L., da Silva, V. D. A., & Tizabi, Y. (2024) · Cells · doi:10.3390/cells13060474 · Cited by 27 · see citing works

Glial Cell Dynamics in Neuroinflammation: Mechanisms, Interactions, and Therapeutic Implications

García‐Domínguez, M. (2026) · Biomedicines · doi:10.3390/biomedicines14010115 · Cited by 29 · see citing works

Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease

Miller, M. R., Landis, H. E., Miller, R. E., & Tizabi, Y. (2024) · Cells · doi:10.3390/cells13181554 · Cited by 24 · see citing works

Human iPSC-derived microglial cells protect neurons from neurodegeneration in long-term cultured adhesion brain organoids

Chen, X., Sun, G., Feng, L., Tian, E., & Shi, Y. (2025) · Communications Biology · doi:10.1038/s42003-024-07401-0 · Cited by 23 · see citing works

Innovative Therapeutic Strategies in Alzheimer’s Disease: A Synergistic Approach to Neurodegenerative Disorders

Niazi, S. K., Magoola, M., & Mariam, Z. (2024) · Pharmaceuticals · doi:10.3390/ph17060741 · Cited by 24 · see citing works

Escalating Bi-Directional Feedback Loops between Proinflammatory Microglia and Mitochondria in Ageing and Post-Diagnosis of Parkinson’s Disease

Ravenhill, S. M., Evans, A. H., & Crewther, S. G. (2023) · Antioxidants · doi:10.3390/antiox12051117 · Cited by 21 · see citing works

Heavy Metal Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease

Tizabi, Y., Bennani, S., Kouhen, N. E., Getachew, B., & Aschner, M. (2024) · Cells · doi:10.3390/cells13131144 · Cited by 17 · see citing works

Role of ginsenoside Rb1 in attenuating depression-like symptoms through astrocytic and microglial complement C3 pathway

Li, C., Zhang, Q.-P., Cheng, J., Xu, G., Zhu, J.-X., & Yi, L. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01392-x · Cited by 18 · see citing works

APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12

Sepulveda, J., Kim, J. Y., Binder, J., Vicini, S., & Rebeck, G. W. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00714-y · Cited by 19 · see citing works

Glial Cells in the Early Stages of Neurodegeneration: Pathogenesis and Therapeutic Targets

Ahremenko, E. A., Andreev, A., Apushkin, D., & Korkotian, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262411995 · Cited by 18 · see citing works

Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder

Csoka, A. B., Kouhen, N. E., Bennani, S., Getachew, B., Aschner, M., & Tizabi, Y. (2024) · Biomolecules · doi:10.3390/biom14040437 · Cited by 16 · see citing works

Neuron-glia crosstalk and inflammatory mediators in migraine pathophysiology

Song, Y., Zhao, S., Peng, P., Zhang, C., Liu, Y., Chen, Y., Luo, Y., Li, B., & Liu, L. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.10.006 · Cited by 16 · see citing works

Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions

Pak, V., Adewale, Q., Bzdok, D., Dadar, M., Zeighami, Y., & Iturria‐Medina, Y. (2024) · eLife · doi:10.7554/elife.89368.3 · Cited by 15 · see citing works

From cytokines to chemokines: Understanding inflammatory signaling in bacterial meningitis

Ibrahim, A., Saleem, N., Naseer, F., Ahmed, S., Munawar, N., & Nawaz, R. (2024) · Molecular Immunology · doi:10.1016/j.molimm.2024.07.004 · Cited by 15 · see citing works

Unraveling the ozone impact and oxidative stress on the nervous system

Rodríguez, P. M., López-Landa, A., Parra, H. R., Rubio‐Osornio, M., & Rubio, C. (2024) · Toxicology · doi:10.1016/j.tox.2024.153973 · Cited by 15 · see citing works

Intrathecal Injection of the Secretome from ALS Motor Neurons Regulated for miR-124 Expression Prevents Disease Outcomes in SOD1-G93A Mice

Barbosa, M., Santos, M., de Sousa, N., Duarte-Silva, S., Vaz, A. R., Salgado, A. J., & Brites, D. (2022) · Biomedicines · doi:10.3390/biomedicines10092120 · Cited by 14 · see citing works

Understanding the multifaceted role of miRNAs in Alzheimer’s disease pathology

Kaur, S., Verma, H., Kaur, S., Gangwar, P., Yadav, A., Yadav, B., Rao, R., Dhiman, M., & Mantha, A. K. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01265-9 · Cited by 15 · see citing works

Neurodegeneration and glial morphological changes are both prevented by TRPM2 inhibition during the progression of a Parkinson's disease mouse model

Ferreira, A. F. F., Ulrich, H., Feng, Z., Sun, H., & Britto, L. R. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114780 · Cited by 14 · see citing works

KLOTHO KL‐VS heterozygosity is associated with diminished age‐related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults

Driscoll, I. F., Lose, S. R., Ma, Y., Bendlin, B. B., Gallagher, C. L., Johnson, S. C., Asthana, S., Hermann, B. P., Sager, M. A., Blennow, K., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13912 · Cited by 14 · see citing works

Microglia in Circumventricular Organs: The Pineal Gland Example

Muñoz, E. M. (2022) · ASN NEURO · doi:10.1177/17590914221135697 · Cited by 13 · see citing works

Astrocytes in the Neuropathology of Bipolar Disorder: Review of Current Evidence

Dai, N., Jones, B. D. M., & Husain, M. I. (2022) · Brain Sciences · doi:10.3390/brainsci12111513 · Cited by 13 · see citing works

The Neuroimmune System and the Cerebellum

Gruol, D. L. (2023) · The Cerebellum · doi:10.1007/s12311-023-01624-3 · Cited by 13 · see citing works

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Rostamian, S., Raeisi, E., Heidari-Soureshjani, S., & Sherwin, C. M. T. (2023) · Neurochemical Journal · doi:10.1134/s1819712423040256 · Cited by 12 · see citing works

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Bougnères, P., & Le Stunff, C. (2025) · Genes · doi:10.3390/genes16050590 · Cited by 11 · see citing works

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Brooks, S. J., Dahl, K., Dudley-Jones, R., & Schiöth, H. B. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105580 · Cited by 11 · see citing works

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Ishibashi, K., & Hirata, E. (2024) · Cancer Science · doi:10.1111/cas.16241 · Cited by 11 · see citing works

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Benita, B. A., & Koss, K. M. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1443985 · Cited by 11 · see citing works

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Ahmed, M. E., Muffat, J., & Li, Y. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1158373 · Cited by 11 · see citing works

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Abghari, M., Vu, J. T. C. M., Eckberg, N., Aldana, B. I., & Kohlmeier, K. A. (2023) · Biomolecules · doi:10.3390/biom13101461 · Cited by 11 · see citing works

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Rommy von Bernhardi, M., & Eugenín, J. L. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110241 · Cited by 10 · see citing works

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Brezáni, V., Joshi, R., Ortega‐Ribera, M., Nagesh, P. T., Brezáni, V., Zivny, A., Kurt‐Jones, E. A., Golenbock, D. T., & Szabó, G. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03501-8 · Cited by 10 · see citing works

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Fowler, L. F., Burry, T. N., Maekawa, A. S., & Cahill, L. S. (2025) · Hormones and Behavior · doi:10.1016/j.yhbeh.2025.105818 · Cited by 11 · see citing works

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Sahu, B., Johnson, L. M., Sohrabi, M., Usatii, A. A., Craig, R. M. J., Kaelberer, J. B., Chandrasekaran, S. P., Kaur, H., Nookala, S., & Combs, C. K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411551 · Cited by 9 · see citing works

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Kim, H., Le, B., Goshi, N., Zhu, K., Grodzki, A. C., Lein, P. J., Zhao, M., & Şeker, E. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241291142 · Cited by 11 · see citing works

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Singh, A. K., Dhalayat, K., Dhobale, S. V., Ghosh, B., Datta, A., Borah, A., & Bhattacharya, P. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102780 · Cited by 9 · see citing works

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Brandi, G., Delbaldo, C., Deserti, M., Relli, V., Rimedio, S., Palloni, A., Deiana, C., Saccoccio, G., Ingenito, R., & Tavolari, S. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102802 · Cited by 9 · see citing works

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Ye, R., Zhang, Y., Jiao, X., Xu, W. X., Chen, Y., Nai, L., Guo, Q., Wang, J., Zhao, Z., Liu, S., et al. (2025) · Nano Research · doi:10.26599/nr.2025.94907836 · Cited by 9 · see citing works

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Li, L., Wang, Y., Feng, Q., Ma, C., He, C., Wan, W., & Tang, L. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251335572 · Cited by 9 · see citing works

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Vijayan, N., Veeraveedu, P. T., & Patel, S. (2025) · Drug Development Research · doi:10.1002/ddr.70111 · Cited by 8 · see citing works

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You, Y.-L., & Choi, H. (2023) · Food Science and Biotechnology · doi:10.1007/s10068-023-01245-w · Cited by 7 · see citing works

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Scheper, M., Anink, J. J., Jansen, F. E., Hecke, W. V., Mühlebner, A., Mills, J. D., & Aronica, E. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02113-w · Cited by 8 · see citing works

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Dembitskaya, Y., & Popov, A. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01706-7 · Cited by 7 · see citing works

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Qian, Z., Jiao, M., Zhang, N., Tang, X., Liu, S., Zhang, F., Wang, C., & Zheng, F. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-024-01279-y · Cited by 7 · see citing works

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Zhang, L., Verkhratsky, A., & Shi, F. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19102-2.00001-6 · Cited by 7 · see citing works

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Pradhan, A. K., Shi, Q., Tartler, K. J., & Rammes, G. (2022) · STAR Protocols · doi:10.1016/j.xpro.2022.101687 · Cited by 7 · see citing works

Astrocyte response in Alzheimer’s disease: Good or bad?

Ismail, A., Al-Kuraishy, H. M., Al-Gareeb, A. I., Albuhadily, A. K., Yassen, A. S. A., Alexiou, A. T., Papadakis, M., & Batiha, G. E. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149971 · Cited by 6 · see citing works

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Lu, W., Zhang, Y., Shi, C., Tao, Y., Li, S., Sun, Y., Ji, F., Chen, G., Snutch, T., & Tao, J. (2026) · The Journal of Headache and Pain · doi:10.1186/s10194-026-02272-8 · Cited by 8 · see citing works

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Musgrove, M. R. B., Mikhaylova, M., & Bredy, T. W. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16071 · Cited by 5 · see citing works

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Chmielarz, M., Bromke, M. A., Olbromski, M., Środa-Pomianek, K., Frej−Mądrzak, M., Dzięgiel, P., & Sobieszczańska, B. (2024) · Biomolecules · doi:10.3390/biom14101238 · Cited by 6 · see citing works

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Pak, V., Adewale, Q., Bzdok, D., Dadar, M., Zeighami, Y., & Iturria‐Medina, Y. (2023) · eLife · doi:10.7554/elife.89368 · Cited by 6 · see citing works

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Sandhu, G. K., Vipin, A., Leonardo, J., Zailan, F. Z., Tanoto, P., Lee, F. P. H. E., Sim, X. Y., Ghildiyal, S., Leow, Y. J., Liew, S. Y., et al. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100300 · Cited by 5 · see citing works

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Kopalli, S. R., Vadia, N., Varma, P., Mishra, S., Joshi, N., Bansal, P., Al-Hasnaawei, S., Chauhan, A. S., Jain, H., Nathiya, D., et al. (2025) · Brain Research · doi:10.1016/j.brainres.2025.150134 · Cited by 6 · see citing works

Nanoparticle Association with Brain Cells Is Augmented by Protein Coronas Formed in Cerebrospinal Fluid

Morshed, N., Morshed, N., Deng, W., Collins‐Praino, L. E., & Care, A. (2024) · Molecular Pharmaceutics · doi:10.1088/1361-6528/ad7b40 · Cited by 13 · see citing works

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Bishayee, K., Lee, S.-H., Heo, Y.-J., Cho, M., & Park, Y. S. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2024.102706 · Cited by 5 · see citing works

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Sirimaharaj, N., Thiankhaw, K., Chattipakorn, N., & Chattipakorn, S. C. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04904-7 · Cited by 5 · see citing works

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Navarro, N. V., Mundim, G. D. N., & Čudić, M. (2025) · Molecules · doi:10.3390/molecules30091895 · Cited by 5 · see citing works

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Tang, Y., Wang, C., Li, Q., Liu, G., Song, D. F., Quan, Z., Yan, Y., & Qing, H. (2024) · The Neuroscientist · doi:10.1177/10738584231223119 · Cited by 5 · see citing works

Disconnecting prefrontal cortical neurons from the ventral midline thalamus: Loss of specificity due to progressive neural toxicity of an AAV-Cre in the rat thalamus

Panzer, É., Boch, L., Cosquer, B., Grgurina, I., Boutillier, A., de Vasconcelos, A. P., Stéphan, A., & Cassel, J. (2024) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2024.110080 · Cited by 5 · see citing works

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Grijaldo-Alvarez, S. J. B., Alvarez, M. R., Schindler, R. L., Oloumi, A., Hernandez, N., Seales, T., Angeles, J. G. C., Nacario, R. C., Completo, G. C. J., Zivkovic, A. M., et al. (2024) · Food & Function · doi:10.1039/d4fo01598c · Cited by 5 · see citing works

Role of astrocytes in Alzheimer's disease pathogenesis and the impact of exercise-induced remodeling

Shao, J., Deng, Q., Feng, S., Wu, C., Liu, X., & Yang, L. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150418 · Cited by 5 · see citing works

Dual role of Apolipoprotein D as long-term instructive factor and acute signal conditioning microglial secretory and phagocytic responses

Corraliza-Gómez, M., Guilarte, B. B., Sandonís-Camarero, D., Mondejar-Duran, J., Villa, M., Poncela, M., Valero, J., Sánchez, D., & Ganfornina, M. D. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1112930 · Cited by 4 · see citing works

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Yenkoyan, K. B., Grigoryan, A., Kútna, V., Shorter, S. A., O’Leary, V. B., Asadollahi, R., & Ovsepian, S. V. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2024.102685 · Cited by 4 · see citing works

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Ozgür-Gunes, Y., Stunff, C. L., & Bougneres, P. F. (2024) · Cells · doi:10.3390/cells13231973 · Cited by 4 · see citing works

Differential Responses of Human iPSC-Derived Microglia to Stimulation with Diverse Inflammogens

Wolfbeisz, C., Suess, J., Dreser, N., Leisner, H., Brüll, M., Fandrich, M., Schneiderhan‐Marra, N., Poetz, O., Härtung, T., & Leist, M. (2025) · Cells · doi:10.3390/cells14211687 · Cited by 4 · see citing works

The Role of the CCR5 Receptor in Neuropathic Pain Modulation: Current Insights and Therapeutic Implications

García‐Domínguez, M. (2025) · Biomedicines · doi:10.3390/biomedicines13112650 · Cited by 3 · see citing works

DDT exposure induces microglial activation and disease-associated microglial signatures: Relevance to mechanisms of Alzheimer’s disease

Mhatre‐Winters, I., Eid, A., Blum, N., Han, Y., Sammoura, F. M., Wu, L., & Richardson, J. (2025) · NeuroToxicology · doi:10.1016/j.neuro.2025.103343 · Cited by 4 · see citing works

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Zhang, C., Song, Y., Cao, B., Pan, Y., Liu, Y. B., Wei, J., Zheng, L., & Liu, L. (2025) · The Journal of Headache and Pain · doi:10.1186/s10194-025-02222-w · Cited by 4 · see citing works

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Cárdenas‐Rodríguez, N., Ignacio‐Mejía, I., Mejía-Barradas, C. M., Ortega-Cuéllar, D., Muñoz-González, F., Vargas-Hernández, M. A., Méndez, E. M. A., Ibáñez-Cervantes, G., Medina‐Santillán, R., Hernández-Ortiz, A., et al. (2025) · Antioxidants · doi:10.3390/antiox14070840 · Cited by 4 · see citing works

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Dugast, E., Shah, S. P., & Laplaud, D. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012142 · Cited by 4 · see citing works

Oleuropein Has Modulatory Effects on Systemic Lipopolysaccharide-Induced Neuroinflammation in Male Rats

Şahin, S., Şahin, E., Esenülkü, G., Renda, G., Gürgen, S. G., Alver, A., Abidin, İ., & Cansu, A. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.02.017 · Cited by 4 · see citing works

Amyloid-β-regulated gene circuits for programmable Alzheimer’s disease therapyPreprint

Spetz, M. R., Kim, H., Ligocki, A. P., Shekharan, S. R., Brien, H. J., Chavarría, D., Conger, D. J., Shattuck-Brandt, R. L., Shostak, A., Embalabala, R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.12.642808 · Cited by 3 · see citing works

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Kowiański, P., Czuba-Pakuła, E., & Lietzau, G. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115533 · Cited by 4 · see citing works

Long-term NRF2-driven microglial repopulation mitigates microgliosis, neuronal loss and cognitive deficits in tauopathy

Viqueira, L., Navarro, E., Negredo, P., Bernal, J. A., Rodrı́guez-Franco, M. I., Tortosa, E., & López, M. G. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106253 · Cited by 2 · see citing works

A selective agonist of the prostacyclin receptor alleviates microglial and astroglial neuroinflammatory responses through P38 and NLRP3

Lee, H.-J., Kang, S., Jeong, Y. J., Jung, T.-M., Hwang, J.-W., Jang, J.-Y., Gu, C.-H., Oh, S., Song, J.-H., Moon, M., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1664119 · Cited by 2 · see citing works

Plant-Derived Peptides with Neuroprotective Activity: Advances and Perspectives in the Prevention of Neurodegenerative Diseases

Maia, M. E., Carvalho, M., Gomes, C. D. S., Arruda, M., de Magalhães, A. J. A., & Farias, D. F. (2026) · ACS Omega · doi:10.1021/acsomega.6c00495 · Cited by 2 · see citing works

Glial biomarkers improve classification of cognitive impairment: an explainable artificial intelligence study using CSF biomarkers

Şengül, M. T., & Nemutlu-Samur, D. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1787915 · Cited by 2 · see citing works

Molecular signaling pathways shaping astrocyte–microglia crosstalk in health and disease

Argente-Arizón, P., & Monge-Ochoa, B. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1828420 · Cited by 1 · see citing works

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Jha, M. K., Jo, M., Kim, J.-H., & Suk, K. (2019) · The Neuroscientist · doi:10.1177/1073858418783959 · Cited by 579 · see citing works

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Vainchtein, I. D., & Molofsky, A. V. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.01.003 · Cited by 450 · see citing works

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Matejuk, A., & Ransohoff, R. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01416 · Cited by 445 · see citing works

Defined human tri-lineage brain microtissues

Uenaka, T., Jung, S., Kumar, I., Vodehnal, K., Rastogi, M., Yoo, Y., Koontz, M., Thome, C., Li, W., Chan, T. C., et al. (2025) · Maryland Shared Open Access Repository (USMAI Consortium) · doi:10.13016/m2y2ln-j1l8