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Cited by 217Phytochemicals and Antioxidant ActivitiesAntioxidants, Aging, Portulaca oleraceaMedicinal Plants and Neuroprotection

The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.

The beneficial effects of fruit polyphenols on brain aging

Lau, Francis C., Shukitt-Hale, Barbara, Joseph, James A.·2005·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2005.08.007
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Abstract

Brain aging is characterized by the continual concession to battle against insults accumulated over the years. One of the major insults is oxidative stress, which is the inability to balance and to defend against the cellular generation of reactive oxygen species (ROS). These ROS cause oxidative damage to nucleic acid, carbohydrate, protein, and lipids. Oxidative damage is particularly detrimental to the brain, where the neuronal cells are largely post-mitotic. Therefore, damaged neurons cannot be replaced readily via mitosis. During normal aging, the brain undergoes morphological and functional modifications resulting in the observed behavioral declines such as decrements in motor and cognitive performance. These declines are augmented by neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and Parkinson's disease (PD). Research from our laboratory has shown that nutritional antioxidants, such as the polyphenols found in blueberries, can reverse age-related declines in neuronal signal transduction as well as cognitive and motor deficits. Furthermore, we have shown that short-term blueberry (BB) supplementation increases hippocampal plasticity. These findings are briefly reviewed in this paper.

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Crossref · 10.1016/j.neurobiolaging.2005.08.007

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Research works printed but not linked: 1

  1. Shukitt-Hale, 2003, Mechanisms involved in blueberry enhancements of motor and cognitive function in young and old rats, Soc Neurosci Abs, 29, 633.14

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Metadata

Authors
Lau, F. C., Shukitt-Hale, B., & Joseph, J. A.
Affiliations
Tufts University (US)
Corresponding author
Joseph, James A.
ORCID
Joseph, James A.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2005-12
Volume
26
Issue
1
Pages
128-132
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/j.neurobiolaging.2005.08.007
OpenAlex
W2060210126
Cited by
217
References
94
Citations by year
2026: 1 · 2025: 1 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 10 · 2017: 9 · 2016: 8 · 2015: 14 · 2014: 19 · 2013: 11 · 2012: 10
FWCI
8.84
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
brain aging, fruit polyphenols, blueberry, oxidative stress, reactive oxygen species, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, hippocampal plasticity, cognitive decline, motor impairment, neuronal transduction, dietary antioxidants
MeSH terms
Aging, Animals, Brain, Flavonoids, Fruit, Humans, Motor Activity, Neurons, Phenols, Signal Transduction, Neuroprotective Agents, Polyphenols

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