Cited by 217Phytochemicals and Antioxidant ActivitiesAntioxidants, Aging, Portulaca oleraceaMedicinal Plants and Neuroprotection

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The beneficial effects of fruit polyphenols on brain aging

Lau, Francis C., Shukitt-Hale, Barbara, Joseph, James A.·2005·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2005.08.007

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Abstract

Brain aging is characterized by the continual concession to battle against insults accumulated over the years. One of the major insults is oxidative stress, which is the inability to balance and to defend against the cellular generation of reactive oxygen species (ROS). These ROS cause oxidative damage to nucleic acid, carbohydrate, protein, and lipids. Oxidative damage is particularly detrimental to the brain, where the neuronal cells are largely post-mitotic. Therefore, damaged neurons cannot be replaced readily via mitosis. During normal aging, the brain undergoes morphological and functional modifications resulting in the observed behavioral declines such as decrements in motor and cognitive performance. These declines are augmented by neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and Parkinson's disease (PD). Research from our laboratory has shown that nutritional antioxidants, such as the polyphenols found in blueberries, can reverse age-related declines in neuronal signal transduction as well as cognitive and motor deficits. Furthermore, we have shown that short-term blueberry (BB) supplementation increases hippocampal plasticity. These findings are briefly reviewed in this paper.

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Authors: Lau, F. C., Shukitt-Hale, B., & Joseph, J. A.
Affiliations: Tufts University (US)
Corresponding author: Joseph, James A.
ORCID: Joseph, James A.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2005-12
Volume: 26
Issue: 1
Pages: 128-132
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2005.08.007
OpenAlex: W2060210126
Cited by: 217
References: 94
Citations by year: 2026: 1 · 2025: 1 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 10 · 2017: 9 · 2016: 8 · 2015: 14 · 2014: 19 · 2013: 11 · 2012: 10
FWCI: 8.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords: brain aging, fruit polyphenols, blueberry, oxidative stress, reactive oxygen species, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, hippocampal plasticity, cognitive decline, motor impairment, neuronal transduction, dietary antioxidants
MeSH terms: Aging, Animals, Brain, Flavonoids, Fruit, Humans, Motor Activity, Neurons, Phenols, Signal Transduction, Neuroprotective Agents, Polyphenols

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The beneficial effects of fruit polyphenols on brain aging

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