Cited by 477Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroinflammation and Neurodegeneration Mechanisms

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Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus

Kronenberg, Golo, Bick-Sander, Anika, Bunk, Eva, Wolf, Claudia, Ehninger, Dan, Kempermann, Gerd·2006·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2005.09.016

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Abstract

Physical activity induces adult hippocampal neurogenesis. We here show that the acute up-regulating effect of voluntary wheel running on precursor cell proliferation decreases with continued exercise, but that continued exercise reduces the age-dependent decline in adult neurogenesis. Cell proliferation peaked at 3 days of running. After 32 days of exercise this response returned to baseline. Running-induced proliferation of transiently amplifying progenitor cells led to a consecutive increase in the number of more mature cells. Increasing age reduced adult neurogenesis at 9 months to 50% of the value at 6 weeks and to 17% at the age of 2 years. At both 1 and 2 years, precursor cell divisions remained inducible by physical activity. Exercise from 3 to 9 months of age significantly reduced the age-dependent decline in cell proliferation but (presumably in the absence of additional stimuli) did not maintain net neurogenesis at levels corresponding to a younger age. We propose that physical activity might contribute to successful aging by increasing the potential for neurogenesis represented by the pool of proliferating precursor cells.

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Authors: Kronenberg, G., Bick-Sander, A., Bunk, E., Wolf, C., Ehninger, D., & Kempermann, G.
Affiliations: Max Delbrück Center (DE)
Volkswagen Foundation (DE)
Corresponding author: Kempermann, Gerd
ORCID: Kronenberg, Golo
Ehninger, Dan
Kempermann, Gerd
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2006-10
Volume: 27
Issue: 10
Pages: 1505-1513
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2005.09.016
OpenAlex: W2002161951
Cited by: 477
References: 62
Citations by year: 2026: 5 · 2025: 15 · 2024: 11 · 2023: 18 · 2022: 17 · 2021: 30 · 2020: 14 · 2019: 19 · 2018: 22 · 2017: 32 · 2016: 32 · 2015: 32 · 2014: 30 · 2013: 29 · 2012: 38
FWCI: 4.57
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: physical activity, adult hippocampal neurogenesis, dentate gyrus, precursor cell proliferation, aging, voluntary wheel running, age-related decline, successful aging
MeSH terms: Aging, Animals, Cell Differentiation, Cerebellar Nuclei, Exercise Therapy, Physical Exertion, Male, Mice, Inbred C57BL, Nerve Regeneration, Neurons, Physical Conditioning, Animal, Stem Cells, Dentate Gyrus, Cell Proliferation, Mice

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Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus

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