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Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus
Abstract
Physical activity induces adult hippocampal neurogenesis. We here show that the acute up-regulating effect of voluntary wheel running on precursor cell proliferation decreases with continued exercise, but that continued exercise reduces the age-dependent decline in adult neurogenesis. Cell proliferation peaked at 3 days of running. After 32 days of exercise this response returned to baseline. Running-induced proliferation of transiently amplifying progenitor cells led to a consecutive increase in the number of more mature cells. Increasing age reduced adult neurogenesis at 9 months to 50% of the value at 6 weeks and to 17% at the age of 2 years. At both 1 and 2 years, precursor cell divisions remained inducible by physical activity. Exercise from 3 to 9 months of age significantly reduced the age-dependent decline in cell proliferation but (presumably in the absence of additional stimuli) did not maintain net neurogenesis at levels corresponding to a younger age. We propose that physical activity might contribute to successful aging by increasing the potential for neurogenesis represented by the pool of proliferating precursor cells.
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“In some of these cases, e.g., physical exercise, evidence suggests that the number of new neurons is increased by actions at multiple stages in the adult neurogenesis process, including by stimulating the proliferation of radial stem cells and amplifying progenitor cells, leading to an increase in the production of neuroblasts (Bednarczyk et al., 2010; Kronenberg et al., 2006; Lugert et al., 2010;”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Kronenberg et al., 2006
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“Exercise may also preserve neurons and promote neurogenesis, synaptogenesis, (48–50), and neuronal plasticity (51–55).”
From The Multidisciplinary Approach to Alzheimer’s Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment (2018) · cites this paper as [49]
Citations
Cites
The Ki-67 protein: From the known and the unknown
Scholzen, T. E., & Gerdes, J. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200003)182:3 · Cited by 4,707
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Self-citationAutoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,586
Self-citationKuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Cardiovascular fitness, cortical plasticity, and aging
Colcombe, S. J., Kramer, A. F., Erickson, K. I., Scalf, P., McAuley, E., Cohen, N. J., Webb, A., Jerome, G. J., Marquez, D. X., & Elavsky, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400266101 · Cited by 1,648
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
Jin, K., Zhu, Y., Sun, Y., Mao, X. O., Xie, L., & Greenberg, D. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182296499 · Cited by 1,507
Gould, E., McEwen, B. S., Tanapat, P., Galea, L. A. M., & Fuchs, E. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02492.1997 · Cited by 1,496
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495
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Lautenschlager, N. T., Cox, K. L., Flicker, L., Foster, J. K., van Bockxmeer, F. M., Xiao, J., Greenop, K. R., & Almeida, O. P. (2008) · JAMA · doi:10.1001/jama.300.9.1027 · Cited by 1,637
Miranda, M., Morici, J. F., Zanoni, M. B., & Bekinschtein, P. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00363 · Cited by 1,416
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Mandolesi, L., Polverino, A., Montuori, S., Foti, F., Ferraioli, G., Sorrentino, P., & Sorrentino, G. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00509 · Cited by 1,038
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Basso, J. C., & Suzuki, W. A. (2016) · Brain Plasticity · doi:10.3233/bpl-160040 · Cited by 911
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Fiuza-Luces, C., Garatachea, N., Berger, N. A., & Lucia, A. (2013) · Physiology · doi:10.1152/physiol.00019.2013 · Cited by 791
Capitalizing on cortical plasticity: influence of physical activity on cognition and brain function
Kramer, A. F., & Erickson, K. I. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.06.009 · Cited by 741
The effects of aging in the hippocampus and cognitive decline
Bettio, L. E. B., Rajendran, L., & Gil‐Mohapel, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.030 · Cited by 700
Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years
Knoth, R., Singec, I., Ditter, M., Pantazis, G., Capetian, P., Meyer, R. P., Horvat, V., Volk, B., & Kempermann, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008809 · Cited by 650
Self-citationNeurogenesis and Exercise: Past and Future Directions
van Praag, H. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8028-z · Cited by 645
Groot, C., Hooghiemstra, A. M., Raijmakers, P. G. H. M., van Berckel, B. N. M., Scheltens, P., Scherder, E. J. A., van der Flier, W. M., & Ossenkoppele, R. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2015.11.005 · Cited by 616
Exercise and the brain: something to chew on
van Praag, H. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.12.007 · Cited by 599
Erickson, K. I., Miller, D. L., & Roecklein, K. A. (2011) · The Neuroscientist · doi:10.1177/1073858410397054 · Cited by 601
Environmental enrichment, new neurons and the neurobiology of individuality
Kempermann, G. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0120-x · Cited by 508
Self-citationVoelcker‐Rehage, C., & Niemann, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.028 · Cited by 481
Fabel, K. (2009) · Frontiers in Neuroscience · doi:10.3389/neuro.22.002.2009 · Cited by 429
When neurogenesis encounters aging and disease
Lazarov, O., Mattson, M. P., Peterson, D. A., Pimplikar, S. W., & van Praag, H. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.09.003 · Cited by 405
Cardiovascular fitness is associated with cognition in young adulthood
Åberg, M. A. I., Pedersen, N. L., Torén, K., Svartengren, M., Bäckstrand, B., Johnsson, T., Cooper-Kuhn, C. M., Åberg, N. D., Nilsson, M., & Kuhn, H. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905307106 · Cited by 382
Plümpe, T., Ehninger, D., Steiner, B., Klempin, F., Jessberger, S., Brandt, M., Römer, B., Rodriguez, G. R., Kronenberg, G., & Kempermann, G. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-77 · Cited by 394
Self-citationThe neurogenic reserve hypothesis: what is adult hippocampal neurogenesis good for?
Kempermann, G. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.01.002 · Cited by 372
Self-citationAll about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis
Vivar, C., Potter, M. C., & van Praag, H. (2012) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2012_220 · Cited by 370
Early age-related changes in adult hippocampal neurogenesis in C57 mice
Abdallah, N. M. ‐. B., Slomianka, L., Vyssotski, A. L., & Lipp, H. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.03.002 · Cited by 392
Adult Neural Stem Cells Bridge Their Niche
Fuentealba, L. C., Obernier, K., & Álvarez-Buylla, A. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.012 · Cited by 389
Influence of combined physical and cognitive training on cognition: a systematic review
Lauenroth, A., Ioannidis, A. E., & Teichmann, B. (2016) · BMC Geriatrics · doi:10.1186/s12877-016-0315-1 · Cited by 372
Law, L. L. F., Barnett, F., Yau, M. K.-S., & Gray, M. A. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.02.008 · Cited by 374
Why and how physical activity promotes experience-induced brain plasticity.
Kempermann, G., Fabel, K., Ehninger, D., Babu, H., Leal-Galicia, P., Garthe, A., & Wolf, S. A. (2010) · Frontiers in Neuroscience · doi:10.3389/fnins.2010.00189 · Cited by 334
Self-citationPhillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/3589271 · Cited by 370
Neuroplastic changes in depression: A role for the immune system
Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319
Marlatt, M. W., Potter, M. C., Lucassen, P. J., & van Praag, H. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22009 · Cited by 314
Hodge, R. D., Kowalczyk, T., Wolf, S. A., Encinas, J. M., Rippey, C., Enikolopov, G., Kempermann, G., & Hevner, R. F. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4280-07.2008 · Cited by 317
Self-citationZucchella, C., Sinforiani, E., Tamburin, S., Federico, A., Mantovani, E., Bernini, S., Casale, R., & Bartolo, M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01058 · Cited by 297
Wiskott, L., Rasch, M. J., & Kempermann, G. (2006) · Hippocampus · doi:10.1002/hipo.20167 · Cited by 301
Self-citationWolf, S. A., Kronenberg, G., Lehmann, K., Blankenship, A., Overall, R., Staufenbiel, M., & Kempermann, G. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.004 · Cited by 288
Self-citationExercise counteracts declining hippocampal function in aging and Alzheimer's disease
Intlekofer, K. A., & Cotman, C. W. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.06.011 · Cited by 300
Mortimer, J. A., Ding, D., Borenstein, A. R., DeCarli, C., Guo, Q., Wu, Y., Zhao, Q., & Chu, S. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-120079 · Cited by 281
Physical Activity and the Regulation of Neurogenesis in the Adult and Aging Brain
Fabel, K., & Kempermann, G. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8031-4 · Cited by 277
Self-citationStein, L. R., & Imai, S. (2014) · The EMBO Journal · doi:10.1002/embj.201386917 · Cited by 265
Neuroplasticity and cognitive aging: The scaffolding theory of aging and cognition
Goh, J. O., & Park, D. C. (2009) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2009-0493 · Cited by 253
Lövdén, M., Schaefer, S., Noack, H., Bodammer, N., Kühn, S., Heinze, H., Düzel, E., Bäckman, L., & Lindenberger, U. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.02.013 · Cited by 272
Hattiangady, B., & Shetty, A. K. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.09.015 · Cited by 258
Rao, M. S., Hattiangady, B., & Shetty, A. K. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00243.x · Cited by 241
Kirby, E. D., Muroy, S. E., Sun, W. G., Covarrubias, D., Leong, M. J., Barchas, L. A., & Kaufer, D. (2013) · eLife · doi:10.7554/elife.00362 · Cited by 250
Adult neurogenesis, glia, and the extracellular matrix
Cope, E. C., & Gould, E. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.03.023 · Cited by 236
Serotonin is required for exercise-induced adult hippocampal neurogenesis
Klempin, F., Beis, D., Mosienko, V., Kempermann, G., Bader, M., & Alenina, N. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5855-12.2013 · Cited by 235
Self-citationDiminished adult neurogenesis in the marmoset brain precedes old age
Leuner, B., Kozorovitskiy, Y., Gross, C. G., & Gould, E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708228104 · Cited by 240
The Neuroprotective Effects of Exercise: Maintaining a Healthy Brain Throughout Aging
Vecchio, L. M., Meng, Y., Xhima, K., Lipsman, N., Hamani, C., & Aubert, I. (2018) · Brain Plasticity · doi:10.3233/bpl-180069 · Cited by 244
Goh, J. O. S. (2011) · Europe PMC (PubMed Central) · Cited by 221
Zeng, C., Pan, F., Jones, L. A., Lim, M. M., Griffin, E., Sheline, Y. I., Mintun, M. A., Holtzman, D. M., & Mach, R. H. (2010) · Brain Research · doi:10.1016/j.brainres.2009.12.092 · Cited by 213
Curlik, D. M., & Shors, T. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.07.027 · Cited by 223
Hamilton, A., Patterson, S., Porter, D., Gault, V. A., & Holscher, C. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22565 · Cited by 210
Hippocampal neurogenesis and gene expression depend on exercise intensity in juvenile rats
Lou, S., Liu, J., Chang, H., & Chen, P. (2008) · Brain Research · doi:10.1016/j.brainres.2008.02.080 · Cited by 212
Physical inactivity: associated diseases and disorders.
Knight, J. A. (2012) · PubMed · Cited by 208
Brett, J. O., Renault, V. M., Rafalski, V. A., Webb, A. E., & Brunet, A. (2011) · Aging · doi:10.18632/aging.100285 · Cited by 207
Molecular mechanisms in the regulation of adult neurogenesis during stress
Egeland, M., Zunszain, P. A., & Pariante, C. M. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3855 · Cited by 203
Wu, C.-W. J., Chang, Y.-T., Yu, L., Chen, H., Jen, C. J., Wu, S.-Y., Lo, C., & Kuo, Y. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90775.2008 · Cited by 210
Neuronal and Cognitive Plasticity: A Neurocognitive Framework for Ameliorating Cognitive Aging
Greenwood, P. M., & Parasuraman, R. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00150 · Cited by 226
Niemann, C., Godde, B., & Voelcker-Rehage, C. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00170 · Cited by 190
Factors that influence adult neurogenesis as potential therapy
Shohayeb, B., Diab, M., Ahmed, M., & Ng, D. C. H. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0109-9 · Cited by 206
Jin, W.-N., Shi, K., He, W., Sun, J.-H., Van Kaer, L., Shi, F.-D., & Liu, Q. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00745-w · Cited by 179
Mustroph, M. L., Chen, S., Desai, S. C., Cay, E. B., DeYoung, E. K., & Rhodes, J. S. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.06.007 · Cited by 190
Ryan, S. M., & Nolan, Y. M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.12.004 · Cited by 205
L’Episcopo, F., Tirolo, C., Testa, N., Caniglia, S., Morale, M. C., Cossetti, C., D’Adamo, P., Zardini, E., Andreoni, L., Ihekwaba, A., et al. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.10.023 · Cited by 189
Low‐intensity daily walking activity is associated with hippocampal volume in older adults
Varma, V. R., Chuang, Y., Harris, G. C., Tan, E. J., & Carlson, M. C. (2015) · Hippocampus · doi:10.1002/hipo.22397 · Cited by 188
Speisman, R. B., Kumar, A., Rani, A., Foster, T. C., & Ormerod, B. K. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.09.013 · Cited by 187
Amrein, I., Isler, K., & Lipp, H. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07804.x · Cited by 198
A new chapter in the field of memory: adult hippocampal neurogenesis
Koehl, M., & Abrous, D. N. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07609.x · Cited by 198
Molecular and cellular pathways contributing to brain aging
Zia, A., Pourbagher‐Shahri, A. M., Farkhondeh, T., & Samarghandian, S. (2021) · Behavioral and Brain Functions · doi:10.1186/s12993-021-00179-9 · Cited by 195
Recalibrating the Relevance of Adult Neurogenesis
Snyder, J. S. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2018.12.001 · Cited by 201
The effects of exercise and stress on the survival and maturation of adult‐generated granule cells
Snyder, J. S., Glover, L. R., Sanzone, K. M., Kamhi, J. F., & Cameron, H. A. (2009) · Hippocampus · doi:10.1002/hipo.20552 · Cited by 193
Adult Hippocampal Neurogenesis: A Coming-of-Age Story
Kuhn, H. G., Toda, T., & Gage, F. H. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2144-18.2018 · Cited by 195
Steiner, B., Zurborg, S., Hörster, H., Fabel, K., & Kempermann, G. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.023 · Cited by 165
Self-citationPhysical exercise, reactive oxygen species and neuroprotection
Radak, Z., Suzuki, K., Higuchi, M., Balogh, L., Boldogh, I., & Koltai, E. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.01.024 · Cited by 167
Lucassen, P. J., Oomen, C. A., Naninck, E. F. G., Fitzsimons, C. P., van Dam, A.-M., Czeh, B., & Korosi, A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021303 · Cited by 166
Neurotoxicity of Anesthetic Drugs in the Developing Brain
Stratmann, G. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318232066c · Cited by 169
Physical activity and the maintenance of cognition: Learning from animal models
Cotman, C. W., & Berchtold, N. C. (2007) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2007.01.013 · Cited by 175
Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates
Baptista, P., & Andrade, J. P. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00044 · Cited by 170
Muscari, A., Giannoni, C., Pierpaoli, L., Berzigotti, A., Latessa, P. M., Foschi, E., Ravaioli, C., Poggiopollini, G., Bianchi, G. P., Magalotti, D., et al. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2462 · Cited by 163
On the Run for Hippocampal PlasticityPreprint
Cooper, C. P., Moon, H. Y., & van Praag, H. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029736 · Cited by 168
Kidd, P. M. (2008) · PubMed · Cited by 158
The influence of exercise on brain aging and dementia
Lautenschlager, N. T., Cox, K. L., & Cyarto, E. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.07.010 · Cited by 166
A review of cardiorespiratory fitness-related neuroplasticity in the aging brain
Hayes, S. M., Hayes, J. P., Cadden, M., & Verfaellie, M. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00031 · Cited by 154
Exercise for Brain Health: An Investigation into the Underlying Mechanisms Guided by Dose
Cabral, D. F., Rice, J., Morris, T. P., Rundek, T., Pascual‐Leone, Á., & Gomes‐Osman, J. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00749-w · Cited by 169
Nerve growth factor promotes survival of new neurons in the adult hippocampus
Frielingsdorf, H., Simpson, D. R., Thal, L. J., & Pizzo, D. P. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.11.015 · Cited by 151
Wenger, E., Mårtensson, J., Noack, H., Bodammer, N. C., Kühn, S., Schaefer, S., Heinze, H., Düzel, E., Bäckman, L., Lindenberger, U., et al. (2014) · Human Brain Mapping · doi:10.1002/hbm.22473 · Cited by 151
Acute Exercise Improves Prefrontal Cortex but not Hippocampal Function in Healthy Adults
Basso, J. C., Shang, A., Elman, M., Karmouta, R., & SUZUKI, W. A. (2015) · Journal of the International Neuropsychological Society · doi:10.1017/s135561771500106x · Cited by 169
Rai, K. S., Hattiangady, B., & Shetty, A. K. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05820.x · Cited by 144
Xu, L., Gu, H., Cai, X., Zhang, Y., Hou, X., Yu, J., & Sun, T. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20021088 · Cited by 182
Wong‐Goodrich, S. J. E., Pfau, M. L., Flores, C., Fraser, J. A., Williams, C. L., & Jones, L. W. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1854 · Cited by 146
Adult hippocampal neurogenesis and aging
Klempin, F., & Kempermann, G. (2007) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0731-5 · Cited by 152
Self-citationYágüez, L., Shaw, K. N., Morris, R. G., & Matthews, D. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2510 · Cited by 138
Impact of social relationships on Alzheimer’s memory impairment: mechanistic studies
Hsiao, Y., Chang, C., & Gean, P. W. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0404-x · Cited by 152
Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function
Siwak, C. T., Head, E., Muggenburg, B. A., Milgram, N. W., & Cotman, C. W. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.05.001 · Cited by 140
Stem Cell Review Series: Role of neurogenesis in age‐related memory disorders
Drapeau, E., & Abrous, D. N. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00369.x · Cited by 148
Kim, H. K., Lee, S., Kim, S., Yoo, J. B., & Kim, C. (2007) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.03.003 · Cited by 138
Parthsarathy, V., & Hölscher, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058784 · Cited by 135
Epigenetic regulation of aging stem cells
Pollina, E. A., & Brunet, A. (2011) · Oncogene · doi:10.1038/onc.2011.45 · Cited by 111
Leiter, O., Brici, D., Fletcher, S. J., Yong, X. L. H., Widagdo, J., Matigian, N., Schroer, A. B., Bieri, G., Blackmore, D. G., Bartlett, P. F., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39873-9 · Cited by 139
Brioni, J. D., Esbenshade, T. A., Garrison, T. R., Bitner, S. R., & Cowart, M. (2010) · Cited by 125
Interaction between Neurogenesis and Hippocampal Memory System: New VistasPreprint
Abrous, D. N., & Wojtowicz, J. M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018952 · Cited by 128
Metadata
- Authors
- Kronenberg, G., Bick-Sander, A., Bunk, E., Wolf, C., Ehninger, D., & Kempermann, G.
- Affiliations
- Max Delbrück Center (DE)
- Volkswagen Foundation (DE)
- Corresponding author
- Kempermann, Gerd
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 27
- Issue
- 10
- Pages
- 1505-1513
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2002161951
- Cited by
- 477
- References
- 62
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 11 · 2023: 18 · 2022: 17 · 2021: 30 · 2020: 14 · 2019: 19 · 2018: 22 · 2017: 32 · 2016: 32 · 2015: 32 · 2014: 30 · 2013: 29 · 2012: 38
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- physical activity, adult hippocampal neurogenesis, dentate gyrus, precursor cell proliferation, aging, voluntary wheel running, age-related decline, successful aging
- MeSH terms
- Aging, Animals, Cell Differentiation, Cerebellar Nuclei, Exercise Therapy, Physical Exertion, Male, Mice, Inbred C57BL, Nerve Regeneration, Neurons, Physical Conditioning, Animal, Stem Cells, Dentate Gyrus, Cell Proliferation, Mice
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