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Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus
Abstract
Physical activity induces adult hippocampal neurogenesis. We here show that the acute up-regulating effect of voluntary wheel running on precursor cell proliferation decreases with continued exercise, but that continued exercise reduces the age-dependent decline in adult neurogenesis. Cell proliferation peaked at 3 days of running. After 32 days of exercise this response returned to baseline. Running-induced proliferation of transiently amplifying progenitor cells led to a consecutive increase in the number of more mature cells. Increasing age reduced adult neurogenesis at 9 months to 50% of the value at 6 weeks and to 17% at the age of 2 years. At both 1 and 2 years, precursor cell divisions remained inducible by physical activity. Exercise from 3 to 9 months of age significantly reduced the age-dependent decline in cell proliferation but (presumably in the absence of additional stimuli) did not maintain net neurogenesis at levels corresponding to a younger age. We propose that physical activity might contribute to successful aging by increasing the potential for neurogenesis represented by the pool of proliferating precursor cells.
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“In some of these cases, e.g., physical exercise, evidence suggests that the number of new neurons is increased by actions at multiple stages in the adult neurogenesis process, including by stimulating the proliferation of radial stem cells and amplifying progenitor cells, leading to an increase in the production of neuroblasts (Bednarczyk et al., 2010; Kronenberg et al., 2006; Lugert et al., 2010;”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Kronenberg et al., 2006
In the citing paper
“Exercise may also preserve neurons and promote neurogenesis, synaptogenesis, (48–50), and neuronal plasticity (51–55).”
From The Multidisciplinary Approach to Alzheimer’s Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment (2018) · cites this paper as [49]
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Metadata
- Authors
- Kronenberg, G., Bick-Sander, A., Bunk, E., Wolf, C., Ehninger, D., & Kempermann, G.
- Affiliations
- Max Delbrück Center (DE)
- Volkswagen Foundation (DE)
- Corresponding author
- Kempermann, Gerd
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 27
- Issue
- 10
- Pages
- 1505-1513
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2002161951
- Cited by
- 477
- References
- 62
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 11 · 2023: 18 · 2022: 17 · 2021: 30 · 2020: 14 · 2019: 19 · 2018: 22 · 2017: 32 · 2016: 32 · 2015: 32 · 2014: 30 · 2013: 29 · 2012: 38
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- physical activity, adult hippocampal neurogenesis, dentate gyrus, precursor cell proliferation, aging, voluntary wheel running, age-related decline, successful aging
- MeSH terms
- Aging, Animals, Cell Differentiation, Cerebellar Nuclei, Exercise Therapy, Physical Exertion, Male, Mice, Inbred C57BL, Nerve Regeneration, Neurons, Physical Conditioning, Animal, Stem Cells, Dentate Gyrus, Cell Proliferation, Mice
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