Tau protein abnormalities associated with the progression of alzheimer disease type dementia

“Mini-mental state”

Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works

The Clinical Dementia Rating (CDR): Current version and scoring rules

Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works

A New Clinical Scale for the Staging of Dementia

Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056 · see citing works

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works

Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

Fillenbaum, G., & Heyman, A. (2002) · doi:10.1002/0470846410.ch42(iii · Cited by 2,859 · see citing works

Staging of alzheimer's disease-related neurofibrillary changes

Braak, H., & Braak, E. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00021-6 · Cited by 2,357 · see citing works

Observations on the brains of demented old people

Tomlinson, B. E., Blessed, G., & Roth, M. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90063-8 · Cited by 2,084 · see citing works

Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

Näslund, J. (2000) · JAMA · doi:10.1001/jama.283.12.1571 · Cited by 1,268 · see citing works

Tau pathology in Alzheimer disease and other tauopathies

Iqbal, K., del C. Alonso, A., Chen, S., Chohan, M. O., El-Akkad, E., Gong, C.-X., Khatoon, S., Li, B., Liu, F., Rahman, A., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.008 · Cited by 1,037 · see citing works

Evolution of the neuropathology of Alzheimer's disease

Braak, H., & Braak, E. (1996) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb05866.x · Cited by 710 · see citing works

Consensus Report of the Working Group on: “Molecular and Biochemical Markers of Alzheimer’s Disease”

The Ronald and Nancy Reagan Research Institute of the Alzheimer’s Association and, & National Institute on Aging Working Group (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00022-0 · Cited by 702 · see citing works

Observations on the brains of non-demented old people

Tomlinson, B. E., Blessed, G., & Roth, M. (1968) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(68)90154-8 · Cited by 681 · see citing works

Neuropathology of Cognitively Normal Elderly

Knopman, D. S., Parisi, J. E., Salviati, A., Floriach-Robert, M., Boeve, B. F., Ivnik, R. J., Smith, G. E., Dickson, D. W., Johnson, K. A., Petersen, L. E., et al. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.11.1087 · Cited by 674 · see citing works

Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia: A quantitative study

Ball, M. J. (1977) · Acta Neuropathologica · doi:10.1007/bf00692056 · Cited by 639 · see citing works

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.

Greenberg, S. G., Davies, P., Schein, J., & Binder, L. I. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48531-6 · Cited by 542 · see citing works

Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function

Bennett, D. A., Schneider, J. A., Wilson, R. S., Bienias, J. L., & Arnold, S. E. (2004) · Archives of Neurology · doi:10.1001/archneur.61.3.378 · Cited by 526 · see citing works

Cholinergic Markers in Elderly Patients With Early Signs of Alzheimer Disease

Davis, K. L. (1999) · JAMA · doi:10.1001/jama.281.15.1401 · Cited by 492 · see citing works

The importance of neuritic plaques and tangles to the development and evolution of AD

Tiraboschi, P., Hansen, L. A., Thal, L. J., & Corey-Bloom, J. (2004) · Neurology · doi:10.1212/01.wnl.0000129697.01779.0a · Cited by 477 · see citing works

Tau, tangles, and Alzheimer's disease.

Binder, L., Guillozet-Bongaarts, A. L., García-Sierra, F., & Berry, R. (2005) · Biochimica et Biophysica Acta · doi:10.1016/j.bbadis.2004.08.014 · Cited by 443 · see citing works

Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease

Rogers, J., & Morrison, J. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-10-02801.1985 · Cited by 410 · see citing works

Correlations of synaptic and pathological markers with cognition of the elderly

Dickson, D. W., Crystal, H. A., Bevona, C., Honer, W., Vincent, I., & Davies, P. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00013-5 · Cited by 410 · see citing works

The Structural Basis of Monoclonal Antibody Alz50's Selectivity for Alzheimer's Disease Pathology

Carmel, G., Mager, E. M., Binder, L. I., & Kuret, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32789 · Cited by 402 · see citing works

Colocalization of Tau and Alpha-Synuclein Epitopes in Lewy Bodies

Ishizawa, T., Mattila, P. M., Davies, P., Wang, D., & Dickson, D. W. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.4.389 · Cited by 391 · see citing works

Conformational change as one of the earliest alterations of tau in Alzheimer's disease

Weaver, C. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00157-3 · Cited by 310 · see citing works

Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease

Haroutunian, V. (1998) · Archives of Neurology · doi:10.1001/archneur.55.9.1185 · Cited by 289 · see citing works

A Conformation‐ and Phosphorylation‐Dependent Antibody Recognizing the Paired Helical Filaments of Alzheimer's Disease

Jicha, G. A., Lane, E., Vincent, I. J., Ötvös, L., Hoffmann, R., & Davies, P. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69052087.x · Cited by 264 · see citing works

Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease

Mitchell, T. W., Mufson, E. J., Schneider, J. A., Cochran, E. J., Nissanov, J., Han, L., Bienias, J. L., Lee, V. M. ‐., Trojanowski, J. Q., Bennett, D. A., et al. (2002) · Annals of Neurology · doi:10.1002/ana.10086 · Cited by 249 · see citing works

Chapter 37 Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease

Morrison, J. H., & Hof, P. R. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)36039-4 · Cited by 241 · see citing works

Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease

Haroutunian, V., Purohit, D. P., Perl, D. P., Marin, D., Khan, K., Lantz, M., Davis, K. L., & Mohs, R. C. (1999) · Archives of Neurology · doi:10.1001/archneur.56.6.713 · Cited by 201 · see citing works

Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease

Ghoshal, N. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.8014 · Cited by 192 · see citing works

Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: Stereologic analysis of prefrontal cortex area 9

Bussière, T., Giannakopoulos, P., Bouras, C., Perl, D. P., Morrison, J. H., & Hof, P. R. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10760 · Cited by 185 · see citing works

Conformational changes and truncation of tau protein during tangle evolution in Alzheimer's disease

García-Sierra, F., Ghoshal, N., Quinn, B., Berry, R., & Binder, L. (2003) · Journal of Alzheimer's Disease · doi:10.3233/jad-2003-5201 · Cited by 179 · see citing works

Regional synaptic pathology in Alzheimer's disease

Honer, W. G., Dickson, D. W., Gleeson, J., & Davies, P. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90111-a · Cited by 179 · see citing works

Alzheimer‐related neuronal protein A68: Specificity and distribution

Wolozin, B. L., & Davies, P. (1987) · Annals of Neurology · doi:10.1002/ana.410220412 · Cited by 178 · see citing works

Alz‐50 Antibody recognizes alzheimer‐related neuronal changes

Hyman, B. T., Hoesen, G. W. V., Wolozin, B. L., Davies, P., Vogt, L. J., & Damasio, A. R. (1988) · Annals of Neurology · doi:10.1002/ana.410230410 · Cited by 176 · see citing works

AD2, a phosphorylation-dependent monoclonal antibody directed against tau proteins found in Alzheimer's disease

Buée‐Scherrer, V., Condamines, O., Mourton-Gilles, C., Jakes, R., Goedert, M., Pau, B., & Delacourte, A. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00003-4 · Cited by 155 · see citing works

The Relative Frequency of "Dementia of Unknown Etiology" Increases With Age and Is Nearly 50% in Nonagenarians

Crystal, H. A., Dickson, D., Davies, P., Masur, D., Grober, E., & Lipton, R. B. (2000) · Archives of Neurology · doi:10.1001/archneur.57.5.713 · Cited by 152 · see citing works

The Neuropathological Diagnosis of Alzheimer’s Disease: Clinical-Pathological Studies

Hyman, B. T. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00066-3 · Cited by 143 · see citing works

Tau as a marker for Alzheimer's disease

Mandelkow, E., & Mandelkow�, E. (1993) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(93)90011-b · Cited by 130 · see citing works

Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease

Jicha, G. A., Berenfeld, B., & Davies, P. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990315)55:6 · Cited by 123 · see citing works

Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer’s disease

Bussire, T., Gold, G., Kvari, E., Giannakopoulos, P., Bouras, C., Perl, D. P., Morrison, J. H., & Hof, P. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00942-9 · Cited by 122 · see citing works

Age, neurofibrillary changes, Aβ-amyloid and the onset of Alzheimer's disease

Braak, H., Braak, E., Böhl, J., & Reintjes, R. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12668-9 · Cited by 117 · see citing works

Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease.

Wolozin, B. L., Scicutella, A., & Davies, P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.16.6202 · Cited by 104 · see citing works

Neuropathological diagnostic criteria for Alzheimer's disease

Murayama, S., & Saito, Y. (2004) · Neuropathology · doi:10.1111/j.1440-1789.2004.00571.x · Cited by 92 · see citing works

Abnormally phosphorylated tau protein in Alzheimer's disease: Heterogeneity of individual regional distribution and relationship to clinical severity

Holzer, M., Holzapfel, H.-P., Zedlick, D., Brückner, M. K., & Arendt, T. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90546-0 · Cited by 82 · see citing works

Bilateral Symmetry of Morphologic Lesions in Alzheimer's Disease

Moossy, J. J., Zubenko, G. S., Martinez, A. J., & Rao, G. R. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520270025015 · Cited by 80 · see citing works

Formation of diffuse and fibrillar tangles in aging and early Alzheimer’s disease☆

Uboga, N. V., & Price, J. L. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00091-9 · Cited by 44 · see citing works

Constructional apraxia in Alzheimer's disease correlates with neuritic neuropathology in occipital cortex

Nielson, K. A., Cummings, B. J., & Cotman, C. W. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00983-3 · Cited by 41 · see citing works

Bilateral Symmetry of Cholinergic Deficits in Alzheimer's Disease

Zubenko, G. S., Moossy, J. J., Hanin, I., et al. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520270029016 · Cited by 30 · see citing works

Characterization of a synaptic antigen of interest in neuropsychiatric illness

Honer, W. G., Kaufmann, C. A., & Davies, P. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90201-a · Cited by 23 · see citing works

Regional Analysis of Differently Phosphorylated Tau Proteins in Brains from Patients with Alzheimer’s Disease

Nakano, H., Kobayashi, K., Sugimori, K., Shimazaki, M., Miyazu, K., Hayashi, M., & Furuta, H. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000076344 · Cited by 19 · see citing works

Binding of Alz 50 depends on Phe8 in tau synthetic peptides and varies between native and denatured tau proteins.

Księżak-Reding, H., Leibowitz, R. L., Bowser, R., & Davies, P. (1995) · Brain Research · doi:10.1016/0006-8993(95)00785-o · Cited by 18 · see citing works

The State of Phosphorylation of Normal Adult Brain τ, Fetal τ, and τ from Alzheimer Paired Helical Filaments at Amino Acid Residue Ser262

Liu, W.-K., & Yen, S.-H. C. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66031131.x · Cited by 16 · see citing works

Amino Acid Residues 226–240 of τ Which Encompass the First Lys‐Ser‐Pro Site of τ, Are Partially Phosphorylated in Alzheimer Paired Helical Filament‐τ

Liu, W.-K., Dickson, D. W., & Yen, S.-H. C. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62031055.x · Cited by 12 · see citing works

Tangles precede plaques but don?t cause them

Terry, R. D. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.013 · Cited by 10 · see citing works

Untitled work

(1997) · doi:10.1002/(sici)1097-4547(19970415)48:2

Proteopathic tau seeding predicts tauopathy in vivo

Holmes, B. B., Furman, J. L., Mahan, T. E., Yamasaki, T. R., Mirbaha, H., Eades, W. C., Belaygorod, L., Cairns, N. J., Holtzman, D. M., & Diamond, M. I. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411649111 · Cited by 696 · see citing works

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Clos, A. L., Jackson, G. R., & Kayed, R. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-39 · Cited by 633 · see citing works

Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

Castillo-Carranza, D. L., Sengupta, U., Guerrero-Muñoz, M. J., Lasagna-Reeves, C. A., Gerson, J. E., Singh, G., Estes, D. M., Barrett, A. D. T., Dineley, K. T., Jackson, G. R., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3192-13.2014 · Cited by 278 · see citing works

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)

Rauch, J. N., Chen, J. J., Sorum, A. W., Miller, G. M., Sharf, T., See, S. K., Hsieh-Wilson, L. C., Kampmann, M., & Kosik, K. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-24904-z · Cited by 211 · see citing works

Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease

Watson, C. T., Roussos, P., Garg, P., Ho, D. J., Azam, N., Katsel, P. L., Haroutunian, V., & Sharp, A. J. (2016) · Genome Medicine · doi:10.1186/s13073-015-0258-8 · Cited by 201 · see citing works

P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice

Ruan, Z., Delpech, J.-C., Venkatesan Kalavai, S., Van Enoo, A. A., Hu, J., Ikezu, S., & Ikezu, T. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00396-2 · Cited by 150 · see citing works

Role of the neuropathology of Alzheimer disease in dementia in the oldest-old

Haroutunian, V., Schnaider-Beeri, M., Schmeidler, J., Wysocki, M., Purohit, D. P., Perl, D. P., Libow, L. S., Lesser, G. T., Maroukian, M., & Grossman, H. T. (2008) · Archives of Neurology · doi:10.1001/archneur.65.9.1211 · Cited by 154 · see citing works

Aerobic glycolysis in the primate brain: Reconsidering the implications for growth and maintenance

Bauernfeind, A. L., Barks, S. K., Duka, T., Grossman, L. I., Hof, P. R., & Sherwood, C. C. (2014) · Brain Structure and Function · doi:10.1007/s00429-013-0662-z · Cited by 105 · see citing works

A System-Level Transcriptomic Analysis of Schizophrenia Using Postmortem Brain Tissue Samples

Roussos, P., Katsel, P., Davis, K. L., Siever, L. J., & Haroutunian, V. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.704 · Cited by 92 · see citing works

Molecular and genetic evidence for abnormalities in the nodes of Ranvier in schizophrenia

Roussos, P. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.110 · Cited by 93 · see citing works

Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease

Lauterborn, J. C., Cox, C. D., Chan, S. W., Vanderklish, P. W., Lynch, G., & Gall, C. M. (2020) · Brain Pathology · doi:10.1111/bpa.12779 · Cited by 43 · see citing works

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

[The incidence of reversible dementia in 145 patients referred on suspicion of dementia].

Pw, N., Jw, K., Feilberg, J. B., et al. (2002) · PubMed · Cited by 1 · see citing works

Dementia Risk Prediction: Are We There Yet?

Kamat, S. M., Kamat, A. S., & Grossberg, G. T. (2010) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2009.12.001 · Cited by 18 · see citing works

Analyzing the chance of developing dementia among geriatric people: a cross‐sectional pilot study in Bangladesh

Uddin, M. S., Mamun, A. A., Takeda, S., Sarwar, M. S., & Begum, M. M. (2018) · Psychogeriatrics · doi:10.1111/psyg.12368 · Cited by 48 · see citing works

Challenges of Diagnosing Dementia in the Oldest Old Population

Slavin, M. J., Brodaty, H., & Sachdev, P. S. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt051 · Cited by 53 · see citing works