Regional synaptic pathology in Alzheimer's disease
Abstract
Synaptic pathology in Alzheimer's disease (AD) may occur diffusely or may have regional predilections. A new antibody called EP10 which detects synaptophysin-like immunoreactivity was used to study synapses in postmortem brain tissue. Four brain regions from cases of AD and controls were studied. Controls with a wide range of ages were used to investigate the possibility of age-related changes in synaptophysin-like immunoreactivity. A significant reduction in the EP10 antigen was observed to occur with age in the control caudate but not in the hippocampus or temporal or occipital cortices. Antigen levels were significantly reduced in the hippocampus (77%) and the temporal cortex (54%) in AD. The expected abnormal pallor of the outer two-thirds of the dentate gyrus molecular layer was observed with immunocytochemistry. In the temporal cortex, the reduction in synaptophysin-like immunoreactivity was inversely correlated with the neurofibrillary tangle count. No such relationship existed in the hippocampus. These results suggest that at least certain components of the synaptic loss in AD occur regionally and are disproportionately large in the hippocampus.
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There are studies suggesting a strong correlation between the loss of synaptic markers and the presence of neurofibrillary tangles.
“Indeed, there are studies suggesting a strong correlation between the loss of synaptic markers and the presence of neurofibrillary tangles (Terry et al., 1991; Honer et al., 1992; Masliah et al., 1992; Wakabayashi et al., 1994; Lue et al., 1996; Samuel et al., 1997; Heffernan et al., 1998).”
From The influence of phospho-tau on dendritic spines of cortical pyramidal neurons in patients with Alzheimer’s disease (2013) · cites this paper as Honer et al., 1992
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- Authors
- Honer, W. G., Dickson, D. W., Gleeson, J., & Davies, P.
- Affiliations
- New York State Psychiatric Institute (US)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Honer, William G.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1992-05
- Volume
- 13
- Issue
- 3
- Pages
- 375-382
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2039005734
- Cited by
- 179
- References
- 2
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 5 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 10
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Alzheimer's disease, synaptic pathology, synaptophysin, hippocampus, temporal cortex, caudate nucleus, dentate gyrus molecular layer, neurofibrillary tangles, postmortem brain
- MeSH terms
- Alzheimer Disease, Analysis of Variance, Brain, Enzyme-Linked Immunosorbent Assay, Humans, Immunohistochemistry, Regression Analysis, Synapses, Immunoblotting, Neurofibrillary Tangles
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