I: Longitudinal changes in aging brain function
Open accessAbstract
Changes in brain activity over time were evaluated in a group of older adults in the Baltimore Longitudinal Study of Aging who maintained good physical and cognitive health. Participants underwent PET scans during rest and delayed verbal and figural recognition memory performance at year 1 baseline and at year 9. While memory performance remained stable over the 8 years, longitudinal changes in regional cerebral blood flow were observed within each scan condition. Further analyses revealed distinctive patterns of change related specifically to verbal or figural recognition, as well as longitudinal changes common to all scan conditions. These findings demonstrate that the older brain undergoes functional reorganization with increasing age in healthy, cognitively stable individuals. In view of the stable memory performance, the task-dependent results suggest that age-related changes in brain activity help maintain cognitive function with advancing age.
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Most previous studies have reported decreased activity in frontal areas and the anterior cingulate gyrus with age.
“Most previous studies have reported decreased activity in frontal areas and the anterior cingulate gyrus with age, using SPECT [44], [ 15 O]H2O-PET [5,12,42,48,54] or 18 FDG-PET [28,32,49,58,86,87,89].”
From Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging (2009) · cites this paper as [5]
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Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging
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- Authors
- Beason-Held, L. L., Kraut, M. A., & Resnick, S. M.
- Affiliations
- Johns Hopkins University (US)
- National Institutes of Health (US)
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 29
- Issue
- 4
- Pages
- 483-496
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC2535938
- OpenAlex
- W1965968374
- Cited by
- 63
- References
- 80
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 5 · 2012: 9
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Johns Hopkins University
- Pontificia Universidad Católica del Ecuador
- National Institutes of Health (Z99 AG999999)
- National Institute on Aging (N01-AG-32124, Z01AG000191)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- brain aging, regional cerebral blood flow, recognition memory, verbal recognition memory, functional reorganization, cognitive aging, older adults, longitudinal brain changes, positron emission tomography
- MeSH terms
- Aged, Aging, Brain, Cerebrovascular Circulation, Female, Humans, Longitudinal Studies, Male, Memory, Middle Aged, Neuropsychological Tests, Positron-Emission Tomography
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