One-year Age Changes in MRI Brain Volumes in Older Adults
Abstract
Longitudinal studies indicate that declines in cognition and memory accelerate after age 70 years. The neuroanatomic and neurophysiologic underpinnings of cognitive change are unclear, as there is little information on longitudinal brain changes. We are conducting a longitudinal neuroimaging study of nondemented older participants in the Baltimore Longitudinal Study of Aging. This report focuses on age and sex differences in brain structure measured by magnetic resonance imaging during the first two annual evaluations. Cross-sectional results from 116 participants aged 59-85 years reveal significantly larger ventricular volumes and smaller gray and white matter volumes in older compared with younger participants and in men compared with women. Regional brain volumes show that the effects of age and sex are not uniform across brain regions. Age differences are greatest for the parietal region. Sex differences tend to be larger for frontal and temporal than parietal and occipital regions. Longitudinal analysis demonstrates an increase of 1526 mm(3) in ventricular volume over 1 year, but no detectable change in total or regional brain volumes. Definition of the pattern and rate of longitudinal brain changes will facilitate the detection of pathological brain changes, which may be predictors of dementia.
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The RAVENS approach has been extensively validated and applied in various studies.
“The RAVENS approach has been extensively validated and applied in various studies (Resnick et al. 2000;Beresford et al. 2006;Gur et al. 2006;Driscoll et al. 2009).”
From Imaging Patterns of Brain Development and their Relationship to Cognition (2015) · cites this paper as Resnick et al. 2000
The discrepancy in hippocampal findings may result from the samples selected, with preservation found when the sample covered a large life span and atrophy observed when age effects were evaluated within older samples.
“This discrepancy may result from the samples selected in these studies. Thus, preservation of the hippocampus was found when the sample covered a large life span (17-79 years in Good et al. [29] and 8-79 in Grieve et al. [31]), whereas atrophy was observed when age effects were evaluated within older samples, i.e. 50 or 60 years and over ([38,70,81, but see [84]).”
From Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging (2009) · cites this paper as [70]
In normal adults, global brain atrophy is generally more pronounced in frontal areas, often followed by parietal, temporal and insular gray matter loss.
“Overall, the literature consistently reports global brain atrophy in normal adults, generally more pronounced in frontal areas (for a review, [63]), often followed by parietal, temporal and insular gray matter (GM) loss [1,2,29,31,70,81,87].”
From Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging (2009) · cites this paper as [70]
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- Authors
- Resnick, S. M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Resnick, S. M.
- ORCID
- Resnick, S. M.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-05-01
- Volume
- 10
- Issue
- 5
- Pages
- 464-472
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2107287771
- Cited by
- 517
- References
- 42
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 10 · 2023: 15 · 2022: 19 · 2021: 19 · 2020: 14 · 2019: 16 · 2018: 12 · 2017: 15 · 2016: 19 · 2015: 24 · 2014: 22 · 2013: 25 · 2012: 30
- FWCI
- 14.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Keywords
- brain volume changes, aging, ventriculomegaly, gray matter volume, white matter volume, sex differences, regional brain differences, longitudinal brain changes, non-demented elderly, dementia prediction, cognitive decline, parietal lobe
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Brain, Cerebrovascular Circulation, Cognition Disorders, Cross-Sectional Studies, Female, Health Status, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Regression Analysis, Sex Factors, Tomography, Emission-Computed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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