Cited by 279Dementia and Cognitive Impairment ResearchAdvanced Neuroimaging Techniques and ApplicationsAlzheimer's disease research and treatments

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White matter pathology isolates the hippocampal formation in Alzheimer's disease

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Salat, D.H., Tuch, D.S., van der Kouwe, A.J.W., Greve, D.N., Pappu, V., Lee, S.Y., Hevelone, N.D., Zaleta, A.K., Growdon, J.H., Corkin, S., Fischl, B., Rosas, H.D.·2010·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2008.03.013PMC PMC3038572

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Abstract

Prior work has demonstrated that the memory dysfunction of Alzheimer's disease (AD) is accompanied by marked cortical pathology in medial temporal lobe (MTL) gray matter. In contrast, changes in white matter (WM) of pathways associated with the MTL have rarely been studied. We used diffusion tensor imaging (DTI) to examine regional patterns of WM tissue changes in individuals with AD. Alterations of diffusion properties with AD were found in several regions including parahippocampal WM, and in regions with direct and secondary connections to the MTL. A portion of the changes measured, including effects in the parahippocampal WM, were independent of gray matter degeneration as measured by hippocampal volume. Examination of regional changes in unique diffusion parameters including anisotropy and axial and radial diffusivity demonstrated distinct zones of alterations, potentially stemming from differences in underlying pathology, with a potential myelin specific pathology in the parahippocampal WM. These results demonstrate that deterioration of neocortical connections to the hippocampal formation results in part from the degeneration of critical MTL and associated fiber pathways.

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Authors: Salat, D. H., Tuch, D. S., van der Kouwe, A. J. W., Greve, D. N., Pappu, V., Lee, S. Y., Hevelone, N. D., Zaleta, A. K., Growdon, J. H., Corkin, S., Fischl, B., & Rosas, H. D.
Affiliations: Massachusetts General Hospital (US)
Corresponding author: Salat, D.H.
ORCID: Salat, D.H.
van der Kouwe, A.J.W.
Greve, D.N.
Hevelone, N.D.
Zaleta, A.K.
Fischl, B.
Rosas, H.D.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2010-02
Volume: 31
Issue: 2
Pages: 244-256
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2008.03.013
PMC: PMC3038572
OpenAlex: W2168247374
Cited by: 279
References: 92
Citations by year: 2026: 2 · 2025: 8 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 6 · 2020: 13 · 2019: 10 · 2018: 11 · 2017: 14 · 2016: 20 · 2015: 23 · 2014: 17 · 2013: 26 · 2012: 32
FWCI: 17.57
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (F32AG005886, K01AG024898, AG 05886)
National Institute of Nursing Research (R01NR010827)
National Institute of Biomedical Imaging and Bioengineering (U54 EB05149, U54EB005149)
National Center for Research Resources (P41-RR-14075, P41RR014075)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: Alzheimer's disease, white matter pathology, hippocampal formation, medial temporal lobe, diffusion tensor imaging, fractional anisotropy, axial and radial diffusivity, myelin degeneration, memory impairment, hippocampal volume
MeSH terms: Aged, Alzheimer Disease, Brain, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Male, Nerve Fibers, Myelinated, Neural Pathways, Organ Size, Anisotropy, Parahippocampal Gyrus, Nerve Fibers, Unmyelinated, Diffusion Tensor Imaging

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